Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
Open accessAbstract
In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have taken genetic and reverse genetic approaches toward understanding the molecular basis for this induction. These studies have identified a set of genes with sequence similarity to genes that have been shown to be, or are implicated in, Wnt/Wingless signaling pathways in other systems. The C. elegans genes described here are related to wnt/wingless, porcupine, frizzled, beta-catenin/armadillo, and the human adenomatous polyposis coli gene, APC. We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In C. elegans, WRM-1 down-regulates, rather than activates, POP-1.
“whereas in C. elegans, WRM-1 down-regulates, rather than activates, POP-1 (16, 21, 22, 30).”
POP-1, a LEF-1/TCF-related protein, functions to repress gene expression.
“POP-1, a LEF-1/TCF-related protein, functions to repress gene expression, and Wnt signaling down-regulates the activity of POP-1 (15, 16, 21, 22, 30).”
Wnt signaling down-regulates the activity of POP-1.
“POP-1, a LEF-1/TCF-related protein, functions to repress gene expression, and Wnt signaling down-regulates the activity of POP-1 (15, 16, 21, 22, 30).”
Cited by
Sorted by citations
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274 · see citing works
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183 · see citing works
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257 · see citing works
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044 · see citing works
Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801 · see citing works
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764 · see citing works
Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 624 · see citing works
The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601 · see citing works
β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis
Gurley, K. A., Rink, J. C., & Alvarado, A. S. (2008) · Science · doi:10.1126/science.1150029 · Cited by 469 · see citing works
Casein kinase I transduces Wnt signals
Peters, J. M., McKay, R. M., McKay, J. P., & Graff, J. M. (1999) · Nature · doi:10.1038/43830 · Cited by 447 · see citing works
Tissue/planar cell polarity in vertebrates: new insights and new questions
Wang, Y., & Nathans, J. (2007) · Development · doi:10.1242/dev.02772 · Cited by 442 · see citing works
An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation
Wikramanayake, A. H., Hong, M., Lee, P. N., Pang, K., Byrum, C. A., Bince, J. M., Xu, R., & Martindale, M. Q. (2003) · Nature · doi:10.1038/nature02113 · Cited by 324 · see citing works
Djiane, A., Riou, J.-F., Umbhauer, M., Boucaut, J.-C., & Shi, D.-L. (2000) · Development · doi:10.1242/dev.127.14.3091 · Cited by 316 · see citing works
Dishevelled: at the crossroads of divergent intracellular signaling pathways
Boutros, M., & Mlodzik, M. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00046-5 · Cited by 275 · see citing works
Ishitani, T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1379-1389.2003 · Cited by 212 · see citing works
Lo, M.-C., Gay, F., Odom, R., Shi, Y., & Lin, R. (2004) · Cell · doi:10.1016/s0092-8674(04)00203-x · Cited by 138 · see citing works
Self-citationA <i>Drosophila Axin</i> homolog, <i>Daxin</i>, inhibits Wnt signaling
Willert, K., Logan, C. Y., Arora, A., Fish, M., & Nusse, R. (1999) · Development · doi:10.1242/dev.126.18.4165 · Cited by 117 · see citing works
Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway
Salinas, P. C. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.003 · Cited by 100 · see citing works
Röttinger, E., Croce, J., Lhomond, G., Besnardeau, L., Gache, C., & Lepage, T. (2006) · Development · doi:10.1242/dev.02603 · Cited by 54 · see citing works
Formation of the Murine Endoderm
Tremblay, K. D. (2010) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-381280-3.00001-4 · Cited by 21 · see citing works
YASUDA, J., & ICHIKAWA, H. (2007) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.83.16 · Cited by 6 · see citing works
- Authors
- Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.-H., Ali, M., Priess, J. R., & Mello, C. C.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Mello, Craig C
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 90
- Issue
- 4
- Pages
- 707-716
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2136449953
- Cited by
- 660
- References
- 0
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 20 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 12 · 2018: 18 · 2017: 11 · 2016: 13 · 2015: 15 · 2014: 22 · 2013: 18 · 2012: 18
- FWCI
- 21.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- Wnt signaling, endoderm specification, Caenorhabditis elegans embryo, anterior-posterior polarity, Wingless signaling, porcupines, Frizzled receptors, β-catenin, armadillos, adenomatous polyposis coli, gene redundancy
- MeSH terms
- Animals, Blastomeres, Cytoskeletal Proteins, Embryonic Induction, Endoderm, Membrane Proteins, Molecular Sequence Data, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Caenorhabditis elegans, Genes, Helminth, Insect Proteins, Adenomatous Polyposis Coli Protein, Drosophila Proteins, Caenorhabditis elegans Proteins, Receptors, G-Protein-Coupled, Wnt1 Protein, Frizzled Receptors, beta Catenin, Armadillo Domain Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
