Cited by 832Heat shock proteins researchFungal and yeast genetics researchGenomics and Chromatin Dynamics

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Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation

Sorger, Peter K., Pelham, Hugh R.B.·1988·Cell

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Abstract

Heat shock promoters contain one or more binding sites for a specific heat shock factor (HSF). We report the cloning and sequence of the gene encoding yeast HSF, and demonstrate that HSF is required for growth at normal temperatures (15 degrees C-30 degrees C). The activity of a promoter containing a synthetic HSF binding site varies over a 200-fold range between 15 degrees C and 39 degrees C (heat shock). This change in activity is accompanied by multiple changes in the phosphorylation state of HSF, but all forms of HSF are able to bind DNA. We propose that the expression of heat shock genes in yeast is modulated by phosphorylation of DNA-bound HSF, and that this leads to a more efficient interaction of the factor with other components of the transcriptional machinery.

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Authors: Sorger, P. K., & Pelham, H. R. B.
Affiliations: MRC Laboratory of Molecular Biology (GB)
ORCID: Sorger, Peter K.
Pelham, Hugh R.B.
Venue: Cell
Publisher: Elsevier BV
Published: 1988-09
Volume: 54
Issue: 6
Pages: 855-864
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(88)91219-6
OpenAlex: W2005131012
Cited by: 832
References: 27
Citations by year: 2026: 8 · 2025: 6 · 2024: 12 · 2023: 6 · 2022: 21 · 2021: 10 · 2020: 16 · 2019: 11 · 2018: 15 · 2017: 10 · 2016: 22 · 2015: 9 · 2014: 15 · 2013: 25 · 2012: 17
FWCI: 24.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: heat shock transcription factor, Saccharomyces cerevisiae, heat shock promoter, protein phosphorylation, DNA binding, heat shock gene expression, transcriptional regulation, gene cloning
MeSH terms: Amino Acid Sequence, Base Sequence, Cell Survival, Cloning, Molecular, DNA-Binding Proteins, Gene Expression Regulation, Hot Temperature, Heat-Shock Proteins, Molecular Sequence Data, Molecular Weight, Phosphoproteins, Phosphorylation, Saccharomyces cerevisiae, Transcription Factors, Transcription, Genetic

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Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation

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