Cited by 325Food composition and propertiesDiet, Metabolism, and DiseaseRegulation of Appetite and Obesity

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Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals

Pawlak, Dorota B, Kushner, Jake A, Ludwig, David S·2004·The Lancet

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Abstract

Background Clinical studies suggest a role for dietary glycaemic index (GI) in bodyweight regulation and diabetes risk. However, partly because manipulation of GI can produce changes in potentially confounding dietary factors such as fibre content, palatability, and energy density, its relevance to human health remains controversial. This study examined the independent effects of GI in animals.Methods Partially pancreatectomised male Sprague-Dawley rats were given diets with identical nutrients, except for the type of starch: high-GI (n=11) or low-GI (n=10). The animals were fed in a controlled way to maintain the same mean bodyweight in the two groups for 18 weeks. Further experiments examined the effects of GI in rats in a cross-over design and C57BL/6J mice in a parallel design.Findings Despite having similar mean bodyweight (547.9 [SE 13.4] vs 549.2 [15.2] g), rats given high-GI food had more body fat (97.8 [13.6] vs 57.3 [7.2] g; p=0.0152) and less lean body mass (450.1 [9.6] vs 491.9 [11.7] g; p=0.0120) than those given low-GI food. The high-GI group also had greater increases over time in the areas under the curve for blood glucose and plasma insulin after oral glucose, lower plasma adiponectin concentrations, higher plasma triglyceride concentrations, and severe disruption of islet-cell architecture. Mice on the high-GI diet had almost twice the body fat of those on the low-GI diet after 9 weeks.Interpretation These findings provide a mechanistic basis for interpretation of studies of GI in human beings.Relevance to practice The term GI describes how a food, meal, or diet affects blood sugar during the postprandial period. GI as an independent factor can cause obesity and increase risks of diabetes and heart disease in animals. Use of low-GI diets in prevention and treatment of human disease merits thorough examination.

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Dietary Fiber, Glycemic Load, and Risk of Non—insulin-dependent Diabetes Mellitus in Women
Salmerón, J. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540300040031 · Cited by 1,804
Untitled work
Ludwig (2002) · doi:10.1001/jama.287.18.2414 · Cited by 1,775
Self-citation
Dietary Fiber, Glycemic Load, and Risk of NIDDM in Men
Salmerón, J., Ascherio, A., Rimm, E. B., Colditz, G. A., Spiegelman, D., Jenkins, D. J., Stampfer, M. J., Wing, A. L., & Willett, W. C. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.545 · Cited by 1,426
A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women
Liu, S., Willett, W. C., Stampfer, M. J., Hu, F. B., Franz, M., Sampson, L., Hennekens, C. H., & Manson, J. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1455 · Cited by 1,166 · cited 1×
“3,8 For the mouse experiment, no partial pancreatectomy was done.”
Adiponectin and protection against type 2 diabetes mellitus
Spranger, J., Kroke, A., Möhlig, M., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12255-6 · Cited by 1,120
Cross-Over Trials in Clinical Research
Senn, S. J. (1994) · Technometrics · doi:10.1080/00401706.1994.10485798 · Cited by 777
High glycemic index foods, overeating, and obesity
Ludwig, D. S., Majzoub, J. A., Al-Zahrani, A., Dallal, G. E., Blanco, I., & Roberts, S. B. (1999) · Pediatrics · doi:10.1542/peds.103.3.e26 · Cited by 699
Self-citation
Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.
Klöppel, G., Löhr, M., Habich, K., Oberholzer, M., & Heitz, P. (1985) · Survey and Synthesis of Pathology Research · doi:10.1159/000156969 · Cited by 645

Show all 35 references

Research works printed but not linked: 1

Pirozzo, 2002, Advice on low-fat diets for obesity (Cochrane Review)

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Matsuo, K., Arai, H., Muto, K., Fukaya, M., Sato, T., Mizuno, A., Sakuma, M., Yamanaka‐Okumura, H., Sasaki, H., Yamamoto, H., et al. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.40.234 · Cited by 29
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Resistant starch and health
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Dietary glycaemic carbohydrate in relation to the metabolic syndrome in adolescents: comparison of different metabolic syndrome definitions
O’Sullivan, T. A., Lyons‐Wall, P., Bremner, A., Ambrosini, G. L., Huang, R., Beilin, L. J., Mori, T. A., Blair, E. M., & Oddy, W. H. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03021.x · Cited by 27
Low-Versus High-Glycemic Index Diets in Women: Effects on Caloric Requirement, Substrate Utilization and Insulin Sensitivity
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The Gastrointestinal Tract as Prime Site for Cardiometabolic Protection by Dietary Polyphenols
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Type 2 diabetes mellitus is characterized by reduced postprandial adiponectin response: a possible link with diabetic postprandial dyslipidemia
Annuzzi, G., Bozzetto, L., Patti, L., Santangelo, C., Giacco, R., Marino, L. D., Natale, C. D., Masella, R., Riccardi, G., & Rivellese, A. A. (2009) · Metabolism · doi:10.1016/j.metabol.2009.08.020 · Cited by 26
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Role of low‐glycemic index diet in management of childhood obesity
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Glycaemic index, appetite and body weight
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Insulin sensitivity affects propensity to obesity in an ethnic-specific manner: results from two controlled weight loss intervention studies
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Dietary Composition and Weight Loss: Can We Individualize Dietary Prescriptions According to Insulin Sensitivity or Secretion Status?
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Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes
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Associations among tourist camp management, high and low tourist seasons, and welfare factors in female Asian elephants in Thailand
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Glucose metabolism and diet predict changes in adiposity and fat distribution in weight-reduced women
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Rheological characteristics of healthy sugar substituted spreadable strawberry product
Peinado, I., Rosa, E., Heredia, A. B., & Andrés, A. (2012) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2012.06.008 · Cited by 24
The rationale and design of the personal diet study, a randomized clinical trial evaluating a personalized approach to weight loss in individuals with pre-diabetes and early-stage type 2 diabetes
Popp, C. J., St‐Jules, D. E., Hu, L., Ganguzza, L., Illiano, P., Curran, M., Li, H., Schoenthaler, A., Bergman, M., Schmidt, A. M., et al. (2019) · Contemporary Clinical Trials · doi:10.1016/j.cct.2019.03.001 · Cited by 25
An overview of the role of rice in the UK diet
Schenker, S. (2012) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2012.02002.x · Cited by 23
Glycemic index role on visceral obesity, subclinical inflammation and associated chronic diseases.
Pereira, P. F., de Almeida, C. D. G., & Alfenas, R. D. C. G. (2014) · PubMed · doi:10.3305/nh.2014.30.2.7506 · Cited by 26
Role of diabetes, hypertension, and cigarette smoking on atherosclerosis
Mathur, R. K. (2010) · Journal of Cardiovascular Disease Research · doi:10.4103/0975-3583.64436 · Cited by 23
State of the Art Reviews : Glycemic Index, Obesity, and Chronic Disease
Marsh, K. A., & Brand-Miller, J. C. (2008) · American Journal of Lifestyle Medicine · doi:10.1177/1559827607311514 · Cited by 23
An update in prevention and treatment of pediatric obesity
Benavent, M. M. (2008) · World Journal of Pediatrics · doi:10.1007/s12519-008-0033-7 · Cited by 23
Effect of nCPAP therapy on heart rate in patients with obstructive sleep apnoea-hypopnoea
Sumi, K. (2006) · QJM · doi:10.1093/qjmed/hcl074 · Cited by 23
Impact of glycaemic index and dietary fibre on insulin sensitivity during the refeeding phase of a weight cycle in young healthy men
Lagerpusch, M., Enderle, J., Later, W., Eggeling, B., Pape, D., Müller, M. J., & Bosy‐Westphal, A. (2012) · British Journal Of Nutrition · doi:10.1017/s000711451200462x · Cited by 22
The Gluten-Free Diet and Glycaemic Index in the Management of Coeliac Disease Associated with Type 1 Diabetes
Krupa‐Kozak, U., & Lange, E. (2019) · Food Reviews International · doi:10.1080/87559129.2019.1584902 · Cited by 22
Energy Requirement Is Higher During Weight-Loss Maintenance in Adults Consuming a Low- Compared with High-Carbohydrate Diet
Ebbeling, C. B., Bielak, L., Lakin, P. R., Klein, G. L., Wong, J. M., Luoto, P. K., Wong, W. W., & Ludwig, D. S. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa150 · Cited by 22
Self-citation
Dietary glycaemic index from an epidemiological point of view
Feskens, E. J. M., & Du, H. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803495 · Cited by 22
Low Glycaemic Index Dietary Interventions in Youth with Cystic Fibrosis: A Systematic Review and Discussion of the Clinical Implications
Balzer, B. W. R., Graham, C., Craig, M. E., Selvadurai, H. C., Donaghue, K. C., Brand-Miller, J. C., & Steinbeck, K. S. (2012) · Nutrients · doi:10.3390/nu4040286 · Cited by 23
Impact of different protein sources in the glycemic and insulinemic responses.
de Oliveira, F. C. E., Volp, A. C. P., & Alfenas, R. D. C. G. (2011) · PubMed · doi:10.1590/s0212-16112011000400002 · Cited by 21
The relationship between carbohydrate quality and the prevalence of metabolic syndrome: challenges of glycemic index and glycemic load
Fontanelli, M. D. M., Sales, C. H., Carioca, A. A. F., Marchioni, D. M. L., & Fisberg, R. M. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1402-6 · Cited by 21
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Self-citation
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The carbohydrate-insulin model does not explain the impact of varying dietary macronutrients on the body weight and adiposity of mice
Hu, S., Wang, L., Togo, J., Yang, D., Xu, Y., Wu, Y., Douglas, A., & Speakman, J. R. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.010 · Cited by 20
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Insulin Resistance Status
Cummings, D. M., Henes, S. T., Kolasa, K. M., Olsson, J. M., & Collier, D. N. (2008) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.162.8.764 · Cited by 20
Relationship of glycaemic index with cardiovascular risk factors: analysis of the National Diet and Nutrition Survey for people aged 65 and older
Milton, J. E., Briche, B., Brown, I., Hickson, M., Robertson, C. E., & Frost, G. S. (2007) · Public Health Nutrition · doi:10.1017/s1368980007702914 · Cited by 21
Habitual- and Meal-Specific Carbohydrate Quality Index and Their Relation to Metabolic Syndrome in a Sample of Iranian Adults
Majdi, M., Imani, H., Bazshahi, E., Hosseini, F. S., Djafarian, K., Lesani, A., Akbarzade, Z., & Shab‐Bidar, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.763345 · Cited by 19
Obesity-Resistant Mice on a High-Fat Diet Display a Distinct Phenotype Linked to Enhanced Lipid Metabolism
Milhem, F., Skates, E., Wilson, M., & Komarnytsky, S. (2024) · Nutrients · doi:10.3390/nu16010171 · Cited by 22
Rats Prone to Obesity Under a High-Carbohydrate Diet have Increased Post-Meal CCK mRNA Expression and Characteristics of Rats Fed a High-Glycemic Index Diet
Chaumontet, C., Azzout‐Marniche, D., Blais, A., Chalvon‐Demersay, T., Nadkarni, N. A., Piedcoq, J., Fromentin, G., Tomé, D., & Even, P. C. (2015) · Frontiers in Nutrition · doi:10.3389/fnut.2015.00022 · Cited by 19
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Authors: Pawlak, D. B., Kushner, J. A., & Ludwig, D. S.
Affiliations: Boston Children's Hospital (US)
Harvard University (US)
Corresponding author: Ludwig, David S
ORCID: Kushner, Jake A
Ludwig, David S
Venue: The Lancet
Publisher: Elsevier BV
Published: 2004-08
Volume: 364
Issue: 9436
Pages: 778-785
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(04)16937-7
OpenAlex: W2074137713
Cited by: 325
References: 35
Citations by year: 2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 8 · 2020: 15 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 15 · 2014: 18 · 2013: 18 · 2012: 16
FWCI: 24.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2t32hd007277-06, 5r01dk059240-04)
National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK059240)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD07277)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: adiposity, fat mass, lean body mass, glucose homeostasis, insulin response, adiponectin, plasma triglycerides, partial pancreatectomy, obesity, diabetes risk, heart disease risk, low glycemic index diet
MeSH terms: Adipose Tissue, Animals, Blood Glucose, Body Composition, Body Weight, Dietary Carbohydrates, Glucose Tolerance Test, Homeostasis, Insulin, Islets of Langerhans, Male, Mice, Inbred C57BL, Obesity, Pancreatectomy, Proteins, Triglycerides, Rats, Sprague-Dawley, Postprandial Period, Leptin, Intercellular Signaling Peptides and Proteins, Glycemic Index, Mice, Rats, Adiponectin

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Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals

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