Cited by 325Food composition and propertiesDiet, Metabolism, and DiseaseRegulation of Appetite and Obesity

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Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals

Pawlak, Dorota B, Kushner, Jake A, Ludwig, David S·2004·The Lancet

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Abstract

Background Clinical studies suggest a role for dietary glycaemic index (GI) in bodyweight regulation and diabetes risk. However, partly because manipulation of GI can produce changes in potentially confounding dietary factors such as fibre content, palatability, and energy density, its relevance to human health remains controversial. This study examined the independent effects of GI in animals.Methods Partially pancreatectomised male Sprague-Dawley rats were given diets with identical nutrients, except for the type of starch: high-GI (n=11) or low-GI (n=10). The animals were fed in a controlled way to maintain the same mean bodyweight in the two groups for 18 weeks. Further experiments examined the effects of GI in rats in a cross-over design and C57BL/6J mice in a parallel design.Findings Despite having similar mean bodyweight (547.9 [SE 13.4] vs 549.2 [15.2] g), rats given high-GI food had more body fat (97.8 [13.6] vs 57.3 [7.2] g; p=0.0152) and less lean body mass (450.1 [9.6] vs 491.9 [11.7] g; p=0.0120) than those given low-GI food. The high-GI group also had greater increases over time in the areas under the curve for blood glucose and plasma insulin after oral glucose, lower plasma adiponectin concentrations, higher plasma triglyceride concentrations, and severe disruption of islet-cell architecture. Mice on the high-GI diet had almost twice the body fat of those on the low-GI diet after 9 weeks.Interpretation These findings provide a mechanistic basis for interpretation of studies of GI in human beings.Relevance to practice The term GI describes how a food, meal, or diet affects blood sugar during the postprandial period. GI as an independent factor can cause obesity and increase risks of diabetes and heart disease in animals. Use of low-GI diets in prevention and treatment of human disease merits thorough examination.

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Salmerón, J. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540300040031 · Cited by 1,804
Untitled work
Ludwig (2002) · doi:10.1001/jama.287.18.2414 · Cited by 1,775
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Dietary Fiber, Glycemic Load, and Risk of NIDDM in Men
Salmerón, J., Ascherio, A., Rimm, E. B., Colditz, G. A., Spiegelman, D., Jenkins, D. J., Stampfer, M. J., Wing, A. L., & Willett, W. C. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.545 · Cited by 1,426
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Liu, S., Willett, W. C., Stampfer, M. J., Hu, F. B., Franz, M., Sampson, L., Hennekens, C. H., & Manson, J. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1455 · Cited by 1,166 · cited 1×
“3,8 For the mouse experiment, no partial pancreatectomy was done.”
Adiponectin and protection against type 2 diabetes mellitus
Spranger, J., Kroke, A., Möhlig, M., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12255-6 · Cited by 1,120
Cross-Over Trials in Clinical Research
Senn, S. J. (1994) · Technometrics · doi:10.1080/00401706.1994.10485798 · Cited by 777
High glycemic index foods, overeating, and obesity
Ludwig, D. S., Majzoub, J. A., Al-Zahrani, A., Dallal, G. E., Blanco, I., & Roberts, S. B. (1999) · Pediatrics · doi:10.1542/peds.103.3.e26 · Cited by 699
Self-citation
Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.
Klöppel, G., Löhr, M., Habich, K., Oberholzer, M., & Heitz, P. (1985) · Survey and Synthesis of Pathology Research · doi:10.1159/000156969 · Cited by 645

Show all 35 references

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Pirozzo, 2002, Advice on low-fat diets for obesity (Cochrane Review)

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Self-citation
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Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo
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Self-citation
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Scribner, K. B., Pawlak, D. B., & Ludwig, D. S. (2007) · Obesity · doi:10.1038/oby.2007.260 · Cited by 69
Self-citation
Low-glycaemic index diets and body weight regulation
McMillan-Price, J., & Brand-Miller, J. C. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803491 · Cited by 70
Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice
Scribner, K. B., Pawlak, D. B., Aubin, C. M., Majzoub, J. A., & Ludwig, D. S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90487.2008 · Cited by 66
Self-citation
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Robertson, M. D. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005617 · Cited by 65
Food and Western Disease Health and Nutrition from an Evolutionary Perspective
Lindeberg, S. (2009) · Cited by 64
Bean Amylase Inhibitor and Other Carbohydrate Absorption Blockers: Effects on Diabesity and General Health
Preuss, H. G. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10719781 · Cited by 64
Convergence of obesity and high glycemic diet on compounding diabetes and cardiovascular risks in modernizing China: an emerging public health dilemma
Ding, E. L., & Malik, V. S. (2008) · Globalization and Health · doi:10.1186/1744-8603-4-4 · Cited by 61
“Notably a high GI/GL diet has been positively associated in multiple studies with weight gain and obesity in both animals [26] and humans [25,27,28], as well as higher levels of serum triglycerides, LDL cholesterol levels, and serum coagulation factors [25,29].”
Failure to Ferment Dietary Resistant Starch in Specific Mouse Models of Obesity Results in No Body Fat Loss
Zhou, J., Martin, R. J., Tulley, R. T., Raggio, A. M., Shen, L., Lissy, E., McCutcheon, K. L., & Keenan, M. J. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf901548e · Cited by 61
Body Mass Index and Outcomes from Pancreatic Resection: a Review and Meta-analysis
Ramsey, A. M., & Martin, R. C. G. (2011) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-011-1502-1 · Cited by 62
Effect of Dietary Resistant Starch on Prevention and Treatment of Obesity-related Diseases and Its Possible Mechanisms.
Zhang, L., Li, H. T., Shen, L., Fang, Q. C., Qian, L. L., & Jia, W. (2015) · PubMed · doi:10.3967/bes2015.040 · Cited by 62
Differences in Body Composition and Metabolic Status between White UK and Asian Indian Children (EarlyBird 24 and the Pune Maternal Nutrition Study)
Lakshmi, S., Metcalf, B., Joglekar, C., Yajnik, C., Fall, C., & Wilkin, T. J. (2012) · Pediatric obesity · doi:10.1111/j.2047-6310.2012.00063.x · Cited by 54
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Tzanetakou, I. P., Mikhailidis, D. P., & Perrea, D. N. (2011) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401105010103 · Cited by 54
Biologic responses to weight loss and weight regain: report from an American Diabetes Association research symposium.
Leibel, R. L., Seeley, R. J., Darsow, T., Berg, E. G., Smith, S. R., & Ratner, R. (2015) · Diabetes · doi:10.2337/db15-0004 · Cited by 52
Clinical update: the low-glycaemic-index diet
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Self-citation
Nutrigenomics: Concepts and Applications to Pharmacogenomics and Clinical Medicine
Kaput, J., Perlina, A., Hatipoğlu, B., Bartholomew, A. M., & Nikolsky, Y. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.4.369 · Cited by 50
The Cardiovascular Continuum in Asia-A New Paradigm for the Metabolic Syndrome
Cheung, B. M. Y. (2005) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000171752.43564.35 · Cited by 50
Dietary strategies for the prevention of obesity
Jebb, S. A. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005429 · Cited by 52
Weight loss on low-fat vs. low-carbohydrate diets by insulin resistance status among overweight adults and adults with obesity: a randomized pilot trial
Gardner, C. D., Offringa, L. C., Hartle, J. C., Kapphahn, K., & Cherin, R. (2016) · Obesity · doi:10.1002/oby.21331 · Cited by 47
The importance of dietary modulation of cAMP and insulin signaling in adipose tissue and the development of obesity
Madsen, L., & Kristiansen, K. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05262.x · Cited by 49
Effects of a high‐fat, low‐ versus high‐glycemic index diet: retardation of insulin resistance involves adipose tissue modulation
van Schothorst, E. M., Bunschoten, A., Schrauwen, P., Mensink, R. P., & Keijer, J. (2008) · The FASEB Journal · doi:10.1096/fj.08-117119 · Cited by 47
Effect of baking process on postprandial metabolic consequences: randomized trials in normal and type 2 diabetic subjects
Rizkalla, S. W., Laromiguière, M., Champ, M. M. J., Bruzzo, F., Boillot, J., & Slama, G. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602514 · Cited by 47
Dose-Dependent Inhibition of the Post-Prandial Glycaemic Response to a Standard Carbohydrate Meal following Incorporation of Alpha-Cyclodextrin
Buckley, J. D., Thorp, A. A., Murphy, K. J., & Howe, P. R. C. (2005) · Annals of Nutrition and Metabolism · doi:10.1159/000090498 · Cited by 47
Viscous Dietary Fiber Reduces Adiposity and Plasma Leptin and Increases Muscle Expression of Fat Oxidation Genes in Rats
Islam, A., Civitarese, A. E., Hesslink, R. L., & Gallaher, D. D. (2011) · Obesity · doi:10.1038/oby.2011.341 · Cited by 47
Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats
Brockman, D. A., Chen, X., & Gallaher, D. D. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-100 · Cited by 46
Dietary glycaemic index and glycaemic load in Danish children in relation to body fatness
Nielsen, B., Bjørnsbo, K. S., Tetens, I., & Heitmann, B. L. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051465 · Cited by 46
Gut microbiota modify risk for dietary glycemia-induced age-related macular degeneration
Rowan, S., & Taylor, A. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1435247 · Cited by 46
Low-Glycemic Index Carbohydrates
Burani, J., & Longo, P. J. (2006) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721705284743 · Cited by 45
Low-glycemic index diet may improve insulin sensitivity in obese children
Visuthranukul, C., Sirimongkol, P., Prachansuwan, A., Pruksananonda, C., & Chomtho, S. (2015) · Pediatric Research · doi:10.1038/pr.2015.142 · Cited by 45
Carbohydrates--the good, the bad and the whole grain.
Brand-Miller, J. C., McMillan-Price, J., Steinbeck, K. S., & Caterson, I. (2008) · PubMed · Cited by 44
Relationship of insulin dynamics to body composition and resting energy expenditure following weight loss: Insulin, Body Composition, and Energy Expenditure
Hron, B. M., Ebbeling, C. B., Feldman, H. A., & Ludwig, D. S. (2015) · Obesity · doi:10.1002/oby.21213 · Cited by 42
Self-citation

Authors: Pawlak, D. B., Kushner, J. A., & Ludwig, D. S.
Affiliations: Boston Children's Hospital (US)
Harvard University (US)
Corresponding author: Ludwig, David S
ORCID: Kushner, Jake A
Ludwig, David S
Venue: The Lancet
Publisher: Elsevier BV
Published: 2004-08
Volume: 364
Issue: 9436
Pages: 778-785
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(04)16937-7
OpenAlex: W2074137713
Cited by: 325
References: 35
Citations by year: 2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 8 · 2020: 15 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 15 · 2014: 18 · 2013: 18 · 2012: 16
FWCI: 24.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2t32hd007277-06, 5r01dk059240-04)
National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK059240)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD07277)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: adiposity, fat mass, lean body mass, glucose homeostasis, insulin response, adiponectin, plasma triglycerides, partial pancreatectomy, obesity, diabetes risk, heart disease risk, low glycemic index diet
MeSH terms: Adipose Tissue, Animals, Blood Glucose, Body Composition, Body Weight, Dietary Carbohydrates, Glucose Tolerance Test, Homeostasis, Insulin, Islets of Langerhans, Male, Mice, Inbred C57BL, Obesity, Pancreatectomy, Proteins, Triglycerides, Rats, Sprague-Dawley, Postprandial Period, Leptin, Intercellular Signaling Peptides and Proteins, Glycemic Index, Mice, Rats, Adiponectin

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Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals

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