Cited by 1,360Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

The DOI matches its Crossref record; 179 of the 181 references it cites were found in a registry or an index.

Polycystic ovary syndrome

Norman, Robert J, Dewailly, Didier, Legro, Richard S, Hickey, Theresa E·2007·The Lancet

DOI 10.1016/s0140-6736(07)61345-2

Open this paper in CoChat — free account

Abstract

Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects about one in 15 women worldwide. The major endocrine disruption is excessive androgen secretion or activity, and a large proportion of women also have abnormal insulin activity. Many body systems are affected in polycystic ovary syndrome, resulting in several health complications, including menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome. Women with this disorder have an established increased risk of developing type 2 diabetes and a still debated increased risk of cardiovascular disease. The diagnostic traits of polycystic ovary syndrome are hyperandrogenism, chronic anovulation, and polycystic ovaries, after exclusion of other conditions that cause these same features. A conclusive definition of the disorder and the importance of the three diagnostic criteria relative to each other remain controversial. The cause of polycystic ovary syndrome is unknown, but studies suggest a strong genetic component that is affected by gestational environment, lifestyle factors, or both.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(07)61345-2

Cites

179 of 179 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,776
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715
Clinical assessment of body hair growth in women.
Ferriman, D., & Gallwey, J. D. (1961) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem-21-11-1440 · Cited by 2,556
Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0178 · Cited by 2,143
Self-citation
Amenorrhea associated with bilateral polycystic ovaries
Stein, I. F., & Leventhal, M. L. (1935) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30642-6 · Cited by 2,121

Show all 181 references

Research works printed but not linked: 5

Azziz, 2006, Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess Society guideline, J Clin Endocrinol Metab, 91, 4237, 10.1210/jc.2006-0178 · DOI · Paper page
Legro, 1999, Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women, J Clin Endocrinol Metab, 84, 165
Legro, 2006, Pregnancy in polycystic ovary syndrome (PPCOS) baseline characteristics: effect of race and ethnicity on the PCOS phenotype, J Soc Gynecol Investig, 13, 268a
van Vloten, 2002, The effect of 2 combined oral contraceptives containing either drospirenone or cyproterone acetate on acne and seborrhea, Cutis, 69, 2
Hughes, 2000, Gonadotrophin-releasing hormone analogue as an adjunct to gonadotropin therapy for clomiphene-resistant polycystic ovarian syndrome, Cochrane Database Syst Rev, 2

Sorted by citations

Items 101–200 of 1,000

Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review
Paixão, L., Ramos, R. B., Lavarda, A., Morsch, D. M., & Spritzer, P. M. (2017) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-017-0231-z · Cited by 123
Low-Frequency Electro-Acupuncture and Physical Exercise Improve Metabolic Disturbances and Modulate Gene Expression in Adipose Tissue in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome
Mannerås, L., Jónsdóttir, I. H., Holmäng, A. B., Lönn, M., & Stener‐Victorin, E. (2008) · Endocrinology · doi:10.1210/en.2008-0053 · Cited by 122
Insulin resistance and polycystic ovary syndrome
Galluzzo, A., Amato, M. C., & Giordano, C. S. D. S. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.05.004 · Cited by 122
Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome
Jungheim, E. S., Lanzendorf, S. E., Odem, R. R., Moley, K. H., Chang, A. S., & Ratts, V. S. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.04.063 · Cited by 123
A 12-week treatment with the long-acting glucagon-like peptide 1 receptor agonist liraglutide leads to significant weight loss in a subset of obese women with newly diagnosed polycystic ovary syndrome
Jensterle, M., Kravos, N. A., Pfeifer, M., Kocjan, T., & Janez, A. (2015) · Hormones · doi:10.1007/bf03401383 · Cited by 117
Anti-Mullerian Hormone: Above and Beyond Conventional Ovarian Reserve Markers
Jamil, Z., Fatima, S. S., Ahmed, K., & Malik, R. (2016) · Disease Markers · doi:10.1155/2016/5246217 · Cited by 117
DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome
Sagvekar, P., Kumar, P., Mangoli, V. S., Desai, S. K., & Mukherjee, S. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0657-6 · Cited by 119
Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring
Hu, M., Richard, J. E., Maliqueo, M. A., Kokosar, M., Fornes, R., Benrick, A., Jansson, T., Ohlsson, C., Wu, X., Skibicka, K. P., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507514112 · Cited by 116
Loss of LH-induced down-regulation of anti-Mullerian hormone receptor expression may contribute to anovulation in women with polycystic ovary syndrome
Pierre, A., Peigné, M., Grynberg, M., Arouche, N., Taieb, J., Hesters, L., Gonzales, J., Picard, J., Dewailly, D., Fanchin, R. R. F., et al. (2013) · Human Reproduction · doi:10.1093/humrep/des460 · Cited by 121
Self-citation
Mesenchymal stem cells derived exosomal miR-323-3p promotes proliferation and inhibits apoptosis of cumulus cells in polycystic ovary syndrome (PCOS)
Zhao, Y., Tao, M., Wei, M., Du, S., Wang, H., & Wang, X. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1669619 · Cited by 115
Alternative splicing of the androgen receptor in polycystic ovary syndrome
Wang, F., Pan, J., Liu, Y., Meng, Q., Lv, P., Qu, F., Ding, G., Klausen, C., Leung, P. C. K., Chan, H. C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418216112 · Cited by 114
High prevalence of polycystic ovary syndrome in women born small for gestational age
de Melo, A. S., Vieira, C. S., Barbieri, M. A., Rosa-e-Silva, A. C. J. S., da Sílva, A. A. M., Cardoso, V. C., dos Reis, R. M., Ferriani, R. A., Silva-de-Sa, M. F., & Bettiol, H. (2010) · Human Reproduction · doi:10.1093/humrep/deq162 · Cited by 114
Excessive Ovarian Production of Nerve Growth Factor Facilitates Development of Cystic Ovarian Morphology in Mice and Is a Feature of Polycystic Ovarian Syndrome in Humans
Dissen, G. A., Garcia‐Rudaz, C., Paredes, A., Mayer, C. A., Mayerhofer, A., & Ojeda, S. R. (2009) · Endocrinology · doi:10.1210/en.2008-1575 · Cited by 114
The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome
Khorshidi, M., Moini, A., Alipoor, E., Rezvan, N., Gorgani‐Firuzjaee, S., Yaseri, M., & Hosseinzadeh‐Attar, M. J. (2018) · Phytotherapy Research · doi:10.1002/ptr.6166 · Cited by 112
Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
Cao, Y., Li, Z., Jiang, W., Yan, L., & Kuang, H. (2019) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0511-x · Cited by 116
Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters
Heffernan, A. L., Cunningham, T. K., Drage, D. S., Aylward, L. L., Thompson, K., Vijayasarathy, S., Mueller, J. F., Atkin, S. L., & Sathyapalan, T. (2018) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2018.07.009 · Cited by 110
Elevated levels of oxidized low-density lipoprotein and of catalase activity in follicular fluid of obese women
Bausenwein, J., Serke, H., Eberle, K., Hirrlinger, J., Jogschies, P., Hmeidan, F. A., Blumenauer, V., & Spanel‐Borowski, K. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap078 · Cited by 110
Metabolic disturbances in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis
Zhu, S., Zhang, B., Jiang, X., Li, Z., Zhao, S., Cui, L., & Chen, Z.-J. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.09.013 · Cited by 109
Polycystic ovary syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from a meta-analysis
Li, Y., Li, Y., Ng, E. H. Y., Stener‐Victorin, E., Hou, L., Wu, T., Han, F., & Wu, X. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.072 · Cited by 110
PCOS and Depression: Common Links and Potential Targets
Kolhe, J. V., Chhipa, A. S., Butani, S., Chavda, V. K., & Patel, S. S. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00765-2 · Cited by 126
Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis
Pan, J., Tan, Y., Wang, F., Hou, N.-N., Xiang, Y., Zhang, J., Liu, Y., Qu, F., Meng, Q., Xu, J., et al. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0442-y · Cited by 109
The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Guan, Y., Wang, D., Bu, H., Zhao, T., & Wang, H. (2020) · International Journal of Endocrinology · doi:10.1155/2020/5150684 · Cited by 109
Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
Dewailly, D., Barbotin, A., Dumont, A., Catteau-Jonard, S., & Robin, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00641 · Cited by 118
Self-citation
Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome
de Medeiros, S. F., Rodgers, R. J., & Norman, R. J. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab004 · Cited by 107
Self-citation
Anti-Mullerian hormone concentrations in androgen-suppressed women with polycystic ovary syndrome
Carlsen, S. M., Vanky, E., & Fleming, R. (2009) · Human Reproduction · doi:10.1093/humrep/dep074 · Cited by 102
Prevalence of Polycystic Ovary Syndrome Phenotypes Using Updated Criteria for Polycystic Ovarian Morphology: An Assessment of Over 100 Consecutive Women Self-reporting Features of Polycystic Ovary Syndrome
Clark, N. M., Podolski, A. J., Brooks, E. D., Chizen, D. R., Pierson, R. A., Lehotay, D. C., & Lujan, M. E. (2014) · Reproductive Sciences · doi:10.1177/1933719114522525 · Cited by 103
Interleukin-6 Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Peng, Z., Sun, Y., Lv, X., Zhang, H., Liu, C., & Dai, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148531 · Cited by 102
Apolipoprotein A-I and B levels, dyslipidemia and metabolic syndrome in south-west Chinese women with PCOS
Zhang, J., Fan, P., Liu, H., Bai, H., Wang, Y., & Zhang, F. (2012) · Human Reproduction · doi:10.1093/humrep/des191 · Cited by 98
The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial
Sohaei, S., Amani, R., Tarrahi, M. J., & Ghasemi-Tehrani, H. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102201 · Cited by 100
Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause
de Melo, A. S., Dias, S. V., Cavalli, R. D. C., Cardoso, V. C., Bettiol, H., Barbieri, M. A., Ferriani, R. A., & Vieira, C. S. (2015) · Reproduction · doi:10.1530/rep-14-0499 · Cited by 99
Comparative assessment of five serum antimüllerian hormone assays for the diagnosis of polycystic ovary syndrome
Pigny, P., Gorisse, E., Ghulam, A., Robin, G., Catteau-Jonard, S., Duhamel, A., & Dewailly, D. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.12.023 · Cited by 98
Self-citation
Ovarian angiogenesis in polycystic ovary syndrome
Pietro, M. D., Pascuali, N., Parborell, F., & Abramovich, D. (2018) · Reproduction · doi:10.1530/rep-17-0597 · Cited by 98
Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review
Guo, J., Shao, J., Yang, Y., Niu, X., Liao, J., Zhao, Q. S., Wang, D., Li, S., & Hu, J. (2021) · Reproductive Sciences · doi:10.1007/s43032-020-00430-0 · Cited by 101
Influence of steroid hormones on ventricular repolarization
Salem, J., Alexandre, J., Bachelot, A., & Funck‐Brentano, C. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.005 · Cited by 97
A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome
Mejia, R. B., Summers, K. M., Kresowik, J. D., & Voorhis, B. J. V. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.11.030 · Cited by 103
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice
Yun, C., Yan, S., Liao, B., Ding, Y., Qi, X., Zhao, M., Wang, K., Zhuo, Y., Nie, Q., Ye, C., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01041-8 · Cited by 103
Female Gonadal Function before and after Treatment of Acromegaly
Grynberg, M., Salenave, S., Young, J., & Chanson, P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2815 · Cited by 96
Lifestyle intervention and anti-obesity therapies in the polycystic ovary syndrome: impact on metabolism and fertility
Panidis, D., Tziomalos, K., Papadakis, E., Vosnakis, C., Chatzis, P., & Katsikis, I. (2013) · Endocrine · doi:10.1007/s12020-013-9971-5 · Cited by 93
Serum metabolomics study of polycystic ovary syndrome based on UPLC-QTOF-MS coupled with a pattern recognition approach
Dong, F., Deng, D., Chen, H., Cheng, W., Li, Q., Luo, R., & Ding, S. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8670-x · Cited by 92
Pharmacologic therapy to induce weight loss in women who have obesity/overweight with polycystic ovary syndrome: a systematic review and network meta‐analysis
Wang, F., Wu, Y. T., Zhu, Y. ‐., Ding, T., Batterham, R. L., Qu, F., & Hardiman, P. (2018) · Obesity Reviews · doi:10.1111/obr.12720 · Cited by 96
Association between circadian rhythm disruption and polycystic ovary syndrome
Wang, F., Xie, N., Wu, Y., Zhang, Q., Zhu, Y., Dai, M., Zhou, J., Pan, J., Tang, M., Cheng, Q., et al. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.08.1425 · Cited by 91
Comparison between effects of myo-inositol and d-chiro-inositol on ovarian function and metabolic factors in women with PCOS
Pizzo, A., Laganà, A. S., & Barbaro, L. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.860120 · Cited by 90
The Effect of Liraglutide on Weight Loss in Women with Polycystic Ovary Syndrome: An Observational Study
Rasmussen, C. B., & Lindenberg, S. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00140 · Cited by 90
Linkage of regulators of TGF‐β activity in the fetal ovary to polycystic ovary syndrome
Hatzirodos, N., Bayne, R. A. L., Irving‐Rodgers, H. F., Hummitzsch, K., Sabatier, L., Lee, S. S., Bonner, W. M., Gibson, M. A., Rainey, W. E., Carr, B. R., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-181099 · Cited by 90
Effect of body mass index on in vitro fertilization outcomes in women with polycystic ovary syndrome
Bailey, A. P., Hawkins, L. K., Missmer, S. A., Correia, K. F. B., & Yanushpolsky, E. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.03.035 · Cited by 90
Inositol’s and other nutraceuticals’ synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state-of-the-art and future perspectives
Paul, C. I., Laganà, A. S., Maniglio, P., Triolo, O., & Brady, D. M. (2016) · Gynecological Endocrinology · doi:10.3109/09513590.2016.1144741 · Cited by 88
Long Noncoding RNAs: Potential Regulators Involved in the Pathogenesis of Polycystic Ovary Syndrome
Liu, Y., Li, Y., Feng, S., Ye, D.-S., Chen, X., Zhou, X., & Chen, S. (2017) · Endocrinology · doi:10.1210/en.2017-00605 · Cited by 89
Impaired receptivity and decidualization in DHEA-induced PCOS mice
Li, S., Song, Z., Song, M., Qin, J., Zhao, M.-L., & Yang, Z. (2016) · Scientific Reports · doi:10.1038/srep38134 · Cited by 88
Anti-Müllerian hormone (AMH): Regulator and marker of ovarian function
van Houten, E. L. A. F., Themmen, A. P. N., & Visser, J. A. (2010) · Annales d Endocrinologie · doi:10.1016/j.ando.2010.02.016 · Cited by 88
Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome
Echiburú, B., Pérez‐Bravo, F., Galgani, J. E., Sandoval, D., Saldías, C., Crisosto, N., Maliqueo, M. A., & Sir‐Petermann, T. (2017) · Steroids · doi:10.1016/j.steroids.2017.12.009 · Cited by 88
The effect of weight loss on anti-Mullerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment
Thomson, R. L., Buckley, J. D., Moran, L., Noakes, M., Clifton, P. M., Norman, R. J., & Brinkworth, G. D. (2009) · Human Reproduction · doi:10.1093/humrep/dep101 · Cited by 87
Self-citation
Bone Turnover Is Suppressed in Insulin Resistance, Independent of Adiposity
Tonks, K., White, C. P., J. Center, Samocha-Bonet, D., & Greenfield, J. (2017) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2016-3282 · Cited by 80
Polycystic ovaries at ultrasound: normal variant or silent polycystic ovary syndrome?
Catteau-Jonard, S., Bancquart, J., Poncelet, É., Lefebvre‐Maunoury, C., Robin, G., & Dewailly, D. (2012) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.11202 · Cited by 86
Self-citation
The physiological basis of complementary and alternative medicines for polycystic ovary syndrome
Raja-Khan, N. T., Stener‐Victorin, E., Wu, X., & Legro, R. S. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00667.2010 · Cited by 88
Self-citation
It's Not Planned, But Is It Okay? The Acceptability of Unplanned Pregnancy Among Young People
Gómez, A. M., Arteaga, S., Ingraham, N., Arcara, J., & Villaseñor, E. (2018) · Women s Health Issues · doi:10.1016/j.whi.2018.07.001 · Cited by 85
Burden of polycystic ovary syndrome in the Middle East and North Africa region, 1990–2019
Asghari, K. M., Nejadghaderi, S. A., Alizadeh, M., Sanaie, S., Sullman, M. J. M., Kolahi, A., Avery, J., & Safiri, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-11006-0 · Cited by 85
Antimüllerian hormone levels decrease in female-to-male transsexuals using testosterone as cross-sex therapy
Caanen, M. R., Soleman, R. S., Kuijper, E. A. M., Kreukels, B. P. C., Roo, C. D., Tilleman, K., Sutter, P. D., van Trotsenburg, M. A. A., Broekmans, F. J., & Lambalk, C. B. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.02.003 · Cited by 87
Thyroid-stimulating hormone is associated with insulin resistance independently of body mass index and age in women with polycystic ovary syndrome
Mueller, A., Schöfl, C., Dittrich, R., Cupisti, S., Oppelt, P. G., Schild, R., Beckmann, M. W., & Häberle, L. (2009) · Human Reproduction · doi:10.1093/humrep/dep285 · Cited by 86
The role of IGF1 in the in vivo production of bovine embryos from superovulated donors
Velazquez, M. A., Zaraza, J., Oropeza, A., WEBB, R., & Niemann, H. (2008) · Reproduction · doi:10.1530/rep-08-0362 · Cited by 85
Adiponectin Deficiency Leads to Female Subfertility and Ovarian Dysfunctions in Mice
Cheng, L., Shi, H., Jin, Y. J., Li, X., Pan, J., Lai, Y., Lin, Y., Jin, Y., Roy, G., Zhao, A. Z., et al. (2016) · Endocrinology · doi:10.1210/en.2015-2080 · Cited by 84
Identification of epigenetic interactions between microRNA and DNA methylation associated with polycystic ovarian syndrome
Mao, Z., Li, T., Zhao, H., Qin, Y., Wang, X., & Kang, Y. (2020) · Journal of Human Genetics · doi:10.1038/s10038-020-0819-6 · Cited by 89
Effect of lifestyle modifications on anthropometric, clinical, and biochemical parameters in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis
Abdolahian, S., Tehrani, F. R., Amiri, M., Ghodsi, D., Yarandi, R. B., Jafari, M., Majd, H. A., & Nahidi, F. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-00552-1 · Cited by 95
Polycystic ovary syndrome and circulating inflammatory markers
Zangeneh, F. Z., Naghizadeh, M., & Masoumi, M. (2017) · International Journal of Reproductive BioMedicine · doi:10.29252/ijrm.15.6.375 · Cited by 77
Use of the serum anti-Müllerian hormone assay as a surrogate for polycystic ovarian morphology: impact on diagnosis and phenotypic classification of polycystic ovary syndrome
Fraissinet, A., Robin, G., Pigny, P., Lefebvre, T., Catteau-Jonard, S., & Dewailly, D. (2017) · Human Reproduction · doi:10.1093/humrep/dex239 · Cited by 84
Self-citation
How should postmenopausal androgen excess be evaluated?
Rothman, M. S., & Wierman, M. E. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04040.x · Cited by 81
Effects of Electro-Acupuncture on Ovarian P450arom, P450c17α and mRNA Expression Induced by Letrozole in PCOS Rats
Sun, J., Jin, C., Wu, H., Zhao, J., Cui, Y., Liu, H., Wu, L., Shi, Y., & Zhu, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079382 · Cited by 81
Intense electroacupuncture normalizes insulin sensitivity, increases muscle GLUT4 content, and improves lipid profile in a rat model of polycystic ovary syndrome
Johansson, J., Feng, Y., Shao, R., Lönn, M., Billig, H., & Stener‐Victorin, E. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00323.2010 · Cited by 81
Adiponectin and the Control of Female Reproductive Functions
Palin, M., Bordignon, V., & Murphy, B. D. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-398313-8.00010-5 · Cited by 83
Guizhi Fuling Wan, Chinese Herbal Medicine, Ameliorates Insulin Sensitivity in PCOS Model Rats With Insulin Resistance via Remodeling Intestinal Homeostasis
Zhu, Y., Li, Y., Liu, M., Hu, X., & Zhu, H. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00575 · Cited by 80
Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance
Georgopoulos, N. A., Saltamavros, A. D., Vervita, V., Karkoulias, K., Adonakis, G., Decavalas, G., Kourounis, G., Markou, K. B., & Kyriazopoulou, V. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.04.067 · Cited by 80
Metabolic Phenotype in the Brothers of Women with Polycystic Ovary Syndrome
Sam, S., Coviello, A. D., Sung, Y., Legro, R. S., & Dunaif, A. E. (2008) · Diabetes Care · doi:10.2337/dc07-2190 · Cited by 82
Self-citation
A case–control observational study of insulin resistance and metabolic syndrome among the four phenotypes of polycystic ovary syndrome based on Rotterdam criteria
Jamil, A. S., Alalaf, S., Al-Tawil, N. G., & Al‐Shawaf, T. (2015) · Reproductive Health · doi:10.1186/1742-4755-12-7 · Cited by 86
Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis
Peng, Q., Chen, X., Liang, X., Ouyang, J., Wang, Q., Ren, S., Xie, H., Wang, C., Sun, Y., Wu, X., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1070264 · Cited by 79
The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome
Liu, D., Gao, X., Pan, X., Zhou, T., Zhu, C., Li, F., Fan, J., Targher, G., & Zhao, J. (2023) · BMC Medicine · doi:10.1186/s12916-023-02775-0 · Cited by 83
Ovarian Hypertension: Polycystic Ovary Syndrome
Bentley–Lewis, R., Seely, E. W., & Dunaif, A. E. (2011) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2011.01.009 · Cited by 83
Association between Polycystic Ovary Syndrome, Oral Microbiota and Systemic Antibody Responses
Akcalı, A., Bostancı, N., Özçaka, Ö., Ceyhan, B. Ö., Gümüş, P., Buduneli, N., & Belibasakis, G. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108074 · Cited by 78
Effects of Mixed of a Ketogenic Diet in Overweight and Obese Women with Polycystic Ovary Syndrome
Cincione, R. I., Losavio, F., Ciolli, F., Valenzano, A., Cibelli, G., Messina, G., & Polito, R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182312490 · Cited by 77
Acupuncture and physical exercise for affective symptoms and health-related quality of life in polycystic ovary syndrome: secondary analysis from a randomized controlled trial
Stener‐Victorin, E., Holm, G., Janson, P. O., Gustafson, D., & Wærn, M. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-131 · Cited by 77
Maternal and neonatal outcomes in pregnant women with PCOS: comparison of different diagnostic definitions
Kollmann, M., Klaritsch, P., Martins, W. P., Guenther, F., Schneider, V., Herzog, S. A., Craciunas, L., Lang, U. E., Obermayer-Pietsch, B. M., Lerchbaum, E., et al. (2015) · Human Reproduction · doi:10.1093/humrep/dev187 · Cited by 79
Cardiovascular risk in women with polycystic ovary syndrome
Giallauria, F., Orio, F., Palomba, S., Lombardi, G., Colao, A., & Vigorito, C. (2008) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e32830b58d4 · Cited by 76
Artificial intelligence for medicine: Progress, challenges, and perspectives
Huang, T., Xu, H., Wang, H., Huang, H., Xu, Y., Li, B., Hong, S., Feng, G., Kui, S., Liu, G., et al. (2023) · The Innovation Medicine · doi:10.59717/j.xinn-med.2023.100030 · Cited by 77
Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D
Ngo, D. T. M., Chan, W. P. A., Rajendran, S., Heresztyn, T., Amarasekera, A. T., Sverdlov, A. L., O’Loughlin, P. D., Morris, H. A., Chirkov, Y. Y., Norman, R. J., et al. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.06.005 · Cited by 73
Self-citation
The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial
Vizza, L., Smith, C. A., Swaraj, S., Agho, K., & Cheema, B. S. (2016) · BMC Sports Science, Medicine and Rehabilitation · doi:10.1186/s13102-016-0039-8 · Cited by 74
Vitamin D and Polycystic Ovary Syndrome: a Narrative Review
Yang, M., Cheng, D., Yin, T., & Yang, J. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00369-2 · Cited by 74
The gut microbial composition in polycystic ovary syndrome with insulin resistance: findings from a normal‐weight population
He, F., & Li, Y. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00799-9 · Cited by 77
Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms
Shpakov, A. O. (2021) · Pharmaceuticals · doi:10.3390/ph14010042 · Cited by 83
Sleep Duration, Exercise, Shift Work and Polycystic Ovarian Syndrome-Related Outcomes in a Healthy Population: A Cross-Sectional Study
Lim, A. J. R., Huang, Z., Chua, S. E., Kramer, M. S., & Yong, E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167048 · Cited by 73
Identification of potential metabolic biomarkers of polycystic ovary syndrome in follicular fluid by SWATH mass spectrometry
Sun, Z., Chang, H., Wang, A., Song, J., Zhang, X., Guo, J., Leung, P. C. K., & Lian, F. (2019) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0490-y · Cited by 74
Effects of lifestyle modification in polycystic ovary syndrome compared to metformin only or metformin addition: A systematic review and meta-analysis
Kim, C. H., Chon, S. J., & Lee, S. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-64776-w · Cited by 76
Ovarian ferroptosis induced by androgen is involved in pathogenesis of PCOS
Li, X., Lin, Y., Cheng, X.-Y., Yao, G., Yao, J., Hu, S., Zhu, Q., Wang, Y., Ding, Y., Lu, Y., et al. (2024) · Human Reproduction Open · doi:10.1093/hropen/hoae013 · Cited by 72
RETRACTED ARTICLE: Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with d-Chiro-Inositol
Laganà, A. S., Barbaro, L., & Pizzo, A. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3552-6 · Cited by 70
Retracted
The impact of oral contraceptives and metformin on anti-Müllerian hormone serum levels in women with polycystic ovary syndrome and biochemical hyperandrogenemia
Panidis, D., Georgopoulos, N. A., Piouka, A., Katsikis, I., Saltamavros, A. D., Decavalas, G., & Diamanti‐Kandarakis, E. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.507283 · Cited by 71
Association of ethnicity, Fitzpatrick skin type, and hirsutism: A retrospective cross-sectional study of women with polycystic ovarian syndrome
Afifi, L., Saeed, L., Pasch, L. A., Huddleston, H. G., Cedars, M. I., Zane, L. T., & Shinkai, K. (2017) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2017.01.006 · Cited by 70
Associations between polycystic ovary syndrome and adverse obstetric and neonatal outcomes: a population study of 9.1 million births
Mills, G., Badeghiesh, A. M., Suarthana, E., Baghlaf, H. A., & Dahan, M. H. (2020) · Human Reproduction · doi:10.1093/humrep/deaa144 · Cited by 75
Exercise for the treatment and management of overweight women with polycystic ovary syndrome: a review of the literature
Thomson, R. L., Buckley, J. D., & Brinkworth, G. D. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00758.x · Cited by 70
Elevated serum levels of anti‐Müllerian hormone can be introduced as a new diagnostic marker for polycystic ovary syndrome
Şahmay, S., Atakul, N., Mathyk, B. A., AYDIN, Y. M., İmamoğlu, M., & Seyisoğlu, H. (2013) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.12247 · Cited by 70
Assessment of hirsutism among Korean women: results of a randomly selected sample of women seeking pre-employment physical check-up
Kim, J. J., Chae, S. J., Choi, Y. M., Hwang, S.-S., Hwang, K. R., Kim, S. M., Yoon, S. H., & Moon, S. Y. (2010) · Human Reproduction · doi:10.1093/humrep/deq303 · Cited by 70
Polycystic Ovary Syndrome and Weight Management
Moran, L., Lombard, C. B., Lim, S. S., Noakes, M., & Teede, H. J. (2010) · Women s Health · doi:10.2217/whe.09.89 · Cited by 70
Role of vitamin E and D3 supplementation in Intra-Cytoplasmic Sperm Injection outcomes of women with polycystic ovarian syndrome: A double blinded randomized placebo-controlled trial
Fatemi, F., Mohammadzadeh, A., Sadeghi, M. R., Akhondi, M. M., Mohammadmoradi, S., Kamali, K., Lackpour, N., Jouhari, S., Zafardoust, S., Mokhtar, S., et al. (2017) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2017.01.002 · Cited by 70
Polycystic Ovary-Like Abnormalities (PCO-L) in Women with Functional Hypothalamic Amenorrhea
Robin, G., Gallo, C., Catteau-Jonard, S., Maunoury-Lefebvre, C., Pigny, P., Duhamel, A., & Dewailly, D. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1836 · Cited by 69
Self-citation

Authors: Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E.
Affiliations: The University of Adelaide (AU)
Centre Hospitalier Universitaire de Lille (FR)
Pennsylvania State University (US)
Corresponding author: Hickey, Theresa E
ORCID: Norman, Robert J
Dewailly, Didier
Legro, Richard S
Hickey, Theresa E
Venue: The Lancet
Publisher: Elsevier BV
Published: 2007-08
Volume: 370
Issue: 9588
Pages: 685-697
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(07)61345-2
OpenAlex: W2499178053
Cited by: 1,360
References: 181
Citations by year: 2026: 43 · 2025: 61 · 2024: 100 · 2023: 100 · 2022: 101 · 2021: 105 · 2020: 94 · 2019: 86 · 2018: 86 · 2017: 74 · 2016: 78 · 2015: 70 · 2014: 62 · 2013: 52 · 2012: 60
FWCI: 6.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: polycystic ovary syndrome, hyperandrogenism, insulin resistance, menstrual disorders, infertility, hirsutism, acne, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, diagnostic criteria, chronic anovulation, polycystic ovary, genetic susceptibility, lifestyle factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polycystic ovary syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks