Cited by 1,360Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

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Polycystic ovary syndrome

Norman, Robert J, Dewailly, Didier, Legro, Richard S, Hickey, Theresa E·2007·The Lancet

DOI 10.1016/s0140-6736(07)61345-2

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Abstract

Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects about one in 15 women worldwide. The major endocrine disruption is excessive androgen secretion or activity, and a large proportion of women also have abnormal insulin activity. Many body systems are affected in polycystic ovary syndrome, resulting in several health complications, including menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome. Women with this disorder have an established increased risk of developing type 2 diabetes and a still debated increased risk of cardiovascular disease. The diagnostic traits of polycystic ovary syndrome are hyperandrogenism, chronic anovulation, and polycystic ovaries, after exclusion of other conditions that cause these same features. A conclusive definition of the disorder and the importance of the three diagnostic criteria relative to each other remain controversial. The cause of polycystic ovary syndrome is unknown, but studies suggest a strong genetic component that is affected by gestational environment, lifestyle factors, or both.

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Authors: Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E.
Affiliations: The University of Adelaide (AU)
Centre Hospitalier Universitaire de Lille (FR)
Pennsylvania State University (US)
Corresponding author: Hickey, Theresa E
ORCID: Norman, Robert J
Dewailly, Didier
Legro, Richard S
Hickey, Theresa E
Venue: The Lancet
Publisher: Elsevier BV
Published: 2007-08
Volume: 370
Issue: 9588
Pages: 685-697
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(07)61345-2
OpenAlex: W2499178053
Cited by: 1,360
References: 181
Citations by year: 2026: 43 · 2025: 61 · 2024: 100 · 2023: 100 · 2022: 101 · 2021: 105 · 2020: 94 · 2019: 86 · 2018: 86 · 2017: 74 · 2016: 78 · 2015: 70 · 2014: 62 · 2013: 52 · 2012: 60
FWCI: 6.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: polycystic ovary syndrome, hyperandrogenism, insulin resistance, menstrual disorders, infertility, hirsutism, acne, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, diagnostic criteria, chronic anovulation, polycystic ovary, genetic susceptibility, lifestyle factors

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