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Cited by 1,360Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

The DOI matches its Crossref record; 179 of the 181 references it cites were found in a registry or an index.

Polycystic ovary syndrome

Norman, Robert J, Dewailly, Didier, Legro, Richard S, Hickey, Theresa E·2007·The Lancet
DOI 10.1016/s0140-6736(07)61345-2
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Abstract

Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects about one in 15 women worldwide. The major endocrine disruption is excessive androgen secretion or activity, and a large proportion of women also have abnormal insulin activity. Many body systems are affected in polycystic ovary syndrome, resulting in several health complications, including menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome. Women with this disorder have an established increased risk of developing type 2 diabetes and a still debated increased risk of cardiovascular disease. The diagnostic traits of polycystic ovary syndrome are hyperandrogenism, chronic anovulation, and polycystic ovaries, after exclusion of other conditions that cause these same features. A conclusive definition of the disorder and the importance of the three diagnostic criteria relative to each other remain controversial. The cause of polycystic ovary syndrome is unknown, but studies suggest a strong genetic component that is affected by gestational environment, lifestyle factors, or both.

Overview

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Crossref · 10.1016/s0140-6736(07)61345-2

Cites

179 of 179 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 5

  1. Azziz, 2006, Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess Society guideline, J Clin Endocrinol Metab, 91, 4237, 10.1210/jc.2006-0178 · DOI · Paper page
  2. Legro, 1999, Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women, J Clin Endocrinol Metab, 84, 165
  3. Legro, 2006, Pregnancy in polycystic ovary syndrome (PPCOS) baseline characteristics: effect of race and ethnicity on the PCOS phenotype, J Soc Gynecol Investig, 13, 268a
  4. van Vloten, 2002, The effect of 2 combined oral contraceptives containing either drospirenone or cyproterone acetate on acne and seborrhea, Cutis, 69, 2
  5. Hughes, 2000, Gonadotrophin-releasing hormone analogue as an adjunct to gonadotropin therapy for clomiphene-resistant polycystic ovarian syndrome, Cochrane Database Syst Rev, 2

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Metadata

Authors
Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E.
Affiliations
  • The University of Adelaide (AU)
  • Centre Hospitalier Universitaire de Lille (FR)
  • Pennsylvania State University (US)
Corresponding author
Hickey, Theresa E
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
2007-08
Volume
370
Issue
9588
Pages
685-697
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(07)61345-2
OpenAlex
W2499178053
Cited by
1,360
References
181
Citations by year
2026: 43 · 2025: 61 · 2024: 100 · 2023: 100 · 2022: 101 · 2021: 105 · 2020: 94 · 2019: 86 · 2018: 86 · 2017: 74 · 2016: 78 · 2015: 70 · 2014: 62 · 2013: 52 · 2012: 60
FWCI
6.99
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, hyperandrogenism, insulin resistance, menstrual disorders, infertility, hirsutism, acne, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, diagnostic criteria, chronic anovulation, polycystic ovary, genetic susceptibility, lifestyle factors

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