Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis

Feng, Li; Lin, Xiao-Fang; Wan, Zhi-Hua; Hu, Dan; Du, Yu-Kai

doi:10.3109/09513590.2015.1041906

Cited by 50Ovarian function and disordersGestational Diabetes Research and ManagementAssisted Reproductive Technology and Twin Pregnancy

Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis

Feng, Li, Lin, Xiao-Fang, Wan, Zhi-Hua, Hu, Dan, Du, Yu-Kai·2015·Gynecological Endocrinology

DOI 10.3109/09513590.2015.1041906

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Abstract

OBJECTIVE: To evaluate the efficacy of metformin administration throughout pregnancy on pregnancy-related complications in women with polycystic ovary syndrome (PCOS). STUDY DESIGN: MEDLINE and ScienceDirect were searched to retrieve relevant trials. The endpoint was the incidence of complications of pregnancy, gestational diabetes mellitus (GDM), pre-eclampsia (PE), miscarriage and premature birth included. RESULTS: Five studies with 502 PCOS patients with metformin administration throughout pregnancy and 427 controls who used metformin just to get conception were included in our meta-analysis. In study group, a significantly lower change of emerging miscarriage and premature birth was observed, the pooled relative risk (RR) was 0.32 (95% confidence interval (CI): 0.19-0.56) for miscarriage and 0.40 (95%CI: 0.18-0.91) for premature birth. No significant difference was demonstrated in emerging GDM and PE. CONCLUSIONS: Metformin therapy throughout pregnancy can reduce the RR of miscarriage and premature birth incidence in PCOS patients with no serious side effects.

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“Evidence regarding the impact of metformin on the incidence of GDM is controversial [58–61].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [58]

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Authors: Feng, L., Lin, X.-F., Wan, Z.-H., Hu, D., & Du, Y.-K.
Affiliations: Huazhong University of Science and Technology (CN)
ORCID: Hu, Dan
Venue: Gynecological Endocrinology
Publisher: Informa UK Limited
Published: 2015-10-06
Volume: 31
Issue: 11
Pages: 833-839
ISSN: 0951-3590 (ISSN-L)
1473-0766
DOI: 10.3109/09513590.2015.1041906
OpenAlex: W1842453750
Cited by: 50
References: 46
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 4
FWCI: 0.90
Type: journal article
Language: en
Open access: closed
Locations: Gynecological Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords: metformin, polycystic ovary syndrome, pregnancy complications, miscarriage, preterm birth, gestational diabetes mellitus, preeclampsia
MeSH terms: Abortion, Spontaneous, Female, Humans, Hypoglycemic Agents, Metformin, Polycystic Ovary Syndrome, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Incidence, Case-Control Studies, Diabetes, Gestational, Premature Birth

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Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis

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