Cited by 14,070Insurance, Mortality, Demography, Risk ManagementGlobal Health and EpidemiologyHealthcare Systems and Public Health

The DOI matches its Crossref record; 106 of the 110 references it cites were found in a registry or an index; 14 of the 57 sources its claims cite were checked for support.

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.

Open access
Lozano, Rafael, Naghavi, Mohsen, Foreman, Kyle, Lim, Stephen, Shibuya, Kenji, Aboyans, Victor, Abraham, Jerry, Adair, Timothy, Aggarwal, Rakesh, Ahn, Stephanie Y, AlMazroa, Mohammad A, Alvarado, Miriam, Anderson, H Ross, Anderson, Laurie M, Andrews, Kathryn G, Atkinson, Charles, Baddour, Larry M, Barker-Collo, Suzanne, Bartels, David H, Bell, Michelle L, Benjamin, Emelia J, Bennett, Derrick, Bhalla, Kavi, Bikbov, Boris, Abdulhak, Aref Bin, Birbeck, Gretchen, Blyth, Fiona, Bolliger, Ian, Boufous, Soufiane, Bucello, Chiara, Burch, Michael, Burney, Peter, Carapetis, Jonathan, Chen, Honglei, Chou, David, Chugh, Sumeet S, Coffeng, Luc E, Colan, Steven D, Colquhoun, Samantha, Colson, K Ellicott, Condon, John, Connor, Myles D, Cooper, Leslie T, Corriere, Matthew, Cortinovis, Monica, de Vaccaro, Karen Courville, Couser, William, Cowie, Benjamin C, Criqui, Michael H, Cross, Marita, Dabhadkar, Kaustubh C, Dahodwala, Nabila, De Leo, Diego, Degenhardt, Louisa, Delossantos, Allyne, Denenberg, Julie, Des Jarlais, Don C, Dharmaratne, Samath D, Dorsey, E Ray, Driscoll, Tim, Duber, Herbert, Ebel, Beth, Erwin, Patricia J, Espindola, Patricia, Ezzati, Majid, Feigin, Valery, Flaxman, Abraham D, Forouzanfar, Mohammad H, Fowkes, Francis Gerry R, Franklin, Richard, Fransen, Marlene, Freeman, Michael K, Gabriel, Sherine E, Gakidou, Emmanuela, Gaspari, Flavio, Gillum, Richard F, Gonzalez-Medina, Diego, Halasa, Yara A, Haring, Diana, Harrison, James E, Havmoeller, Rasmus, Hay, Roderick J, Hoen, Bruno, Hotez, Peter J, Hoy, Damian, Jacobsen, Kathryn H, James, Spencer L, Jasrasaria, Rashmi, Jayaraman, Sudha, Johns, Nicole, Karthikeyan, Ganesan, Kassebaum, Nicholas, Keren, Andre, Khoo, Jon-Paul, Knowlton, Lisa Marie, Kobusingye, Olive, Koranteng, Adofo, Krishnamurthi, Rita, Lipnick, Michael, Lipshultz, Steven E, Ohno, Summer Lockett, Mabweijano, Jacqueline, MacIntyre, Michael F, Mallinger, Leslie, March, Lyn, Marks, Guy B, Marks, Robin, Matsumori, Akira, Matzopoulos, Richard, Mayosi, Bongani M, McAnulty, John H, McDermott, Mary M, McGrath, John, Memish, Ziad A, Mensah, George A, Merriman, Tony R, Michaud, Catherine, Miller, Matthew, Miller, Ted R, Mock, Charles, Mocumbi, Ana Olga, Mokdad, Ali A, Moran, Andrew, Mulholland, Kim, Nair, M Nathan, Naldi, Luigi, Narayan, K M Venkat, Nasseri, Kiumarss, Norman, Paul, O'Donnell, Martin, Omer, Saad B, Ortblad, Katrina, Osborne, Richard, Ozgediz, Doruk, Pahari, Bishnu, Pandian, Jeyaraj Durai, Rivero, Andrea Panozo, Padilla, Rogelio Perez, Perez-Ruiz, Fernando, Perico, Norberto, Phillips, David, Pierce, Kelsey, Pope, C Arden, Porrini, Esteban, Pourmalek, Farshad, Raju, Murugesan, Ranganathan, Dharani, Rehm, Jürgen T, Rein, David B, Remuzzi, Guiseppe, Rivara, Frederick P, Roberts, Thomas, De León, Felipe Rodriguez, Rosenfeld, Lisa C, Rushton, Lesley, Sacco, Ralph L, Salomon, Joshua A, Sampson, Uchechukwu, Sanman, Ella, Schwebel, David C, Segui-Gomez, Maria, Shepard, Donald S, Singh, David, Singleton, Jessica, Sliwa, Karen, Smith, Emma, Steer, Andrew, Taylor, Jennifer A, Thomas, Bernadette, Tleyjeh, Imad M, Towbin, Jeffrey A, Truelsen, Thomas, Undurraga, Eduardo A, Venketasubramanian, N, Vijayakumar, Lakshmi, Vos, Theo, Wagner, Gregory R, Wang, Mengru, Wang, Wenzhi, Watt, Kerrianne, Weinstock, Martin A, Weintraub, Robert, Wilkinson, James D, Woolf, Anthony D, Wulf, Sarah, Yeh, Pon-Hsiu, Yip, Paul, Zabetian, Azadeh, Zheng, Zhi-Jie, Lopez, Alan D, Murray, Christopher JL·2012·The Lancet

Abstract

Reliable and timely information on the leading causes of death in populations, and how these are changing, is a crucial input into health policy debates. In the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), we aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex. We attempted to identify all available data on causes of death for 187 countries from 1980 to 2010 from vital registration, verbal autopsy, mortality surveillance, censuses, surveys, hospitals, police records, and mortuaries. We assessed data quality for completeness, diagnostic accuracy, missing data, stochastic variations, and probable causes of death. We applied six different modelling strategies to estimate cause-specific mortality trends depending on the strength of the data. For 133 causes and three special aggregates we used the Cause of Death Ensemble model (CODEm) approach, which uses four families of statistical models testing a large set of different models using different permutations of covariates. Model ensembles were developed from these component models. We assessed model performance with rigorous out-of-sample testing of prediction error and the validity of 95% UIs. For 13 causes with low observed numbers of deaths, we developed negative binomial models with plausible covariates. For 27 causes for which death is rare, we modelled the higher level cause in the cause…

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Crossref · 10.1016/s0140-6736(12)61728-0

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106 of 106 references verified0 citation errors · 0 not checkable

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135 Own result · 32 Own method · 27 Own interpretation · 26 No basis given · 21 No full text of the sources · 6 Supported · 6 Partly supported · 4 Sources not found · 1 Not checked yet · accuracy not yet measured

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  • It may state two separate claims as one. 114
  • Probably not a substantial claim. 43
144 of 144
  • The authors state this as an assumption.

    Verbal autopsy cause fractions are representative of the study population.

    “In the absence of evidence on the cause of death pattern in recalled versus not recalled deaths, we have made the simplifying assumption that verbal autopsy cause fractions are representative of the study population; the CHERG analyses of verbal autopsy data make the same assumption.19,20”
  • The authors state this as an assumption.

    A larger sum of deaths across individual causes is more likely to be associated with a higher draw of the all-cause mortality level.

    “We assumed that if the sum of deaths from each individual cause was large, it was more likely to be associated with a higher draw of the all-cause mortality level.”
  • The paper relies on this without support.

    Many diarrhoea pathogens can be cultured from the stool of individuals who do not have diarrhoea.

    “For diarrhoea, many pathogens can be cultured from the stool of individuals without diarrhoea.”
  • The paper relies on this without support.

    Rotavirus remains an important cause of death in many countries.

    “Because rotavirus remains an important cause of death in many countries”
  • The paper relies on this without support.

    In many observational studies, no pathogen is identified in a substantial fraction of cases.

    “In many observational studies, no pathogen is identified in a substantial fraction of cases.”
  • The paper relies on this without support.

    The case-fatality rate for severe respiratory infections varies substantially by pathogen, confounding analysis.

    “the case-fatality rate is likely to vary substantially by pathogen, which confounds the analysis”
  • The paper relies on this without support.

    Most studies show high fractions of neonatal lower respiratory deaths due to RSV.

    “Most studies show high fractions of neonatal lower respiratory deaths due to RSV”
  • The paper relies on this without support.

    Public health priorities everywhere are changing, or soon will be, as large and avoidable causes of disease burden become more common with development.

    “Public health priorities everywhere are changing, or soon will be, as large and avoidable causes of disease burden become more common with development.”
8 of 8

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Research works printed but not linked: 1

  1. 2011, Verbal autopsy: innovations, applications, opportunities—Improving cause of death measurement, Popul Health Metr, 9, 18

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Metadata

Authors
Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., AlMazroa, M. A., Alvarado, M., Anderson, H. R., Anderson, L. M., Andrews, K. G., Atkinson, C., Baddour, L. M., Barker-Collo, S., Bartels, D. H., Bell, M. L., Benjamin, E. J., Bennett, D., Bhalla, K., Bikbov, B., Abdulhak, A. B., Birbeck, G., Blyth, F., Bolliger, I., Boufous, S., Bucello, C., Burch, M., Burney, P., Carapetis, J., Chen, H., Chou, D., Chugh, S. S., Coffeng, L. E., Colan, S. D., Colquhoun, S., Colson, K. E., Condon, J., Connor, M. D., Cooper, L. T., Corriere, M., Cortinovis, M., de Vaccaro, K. C., Couser, W., Cowie, B. C., Criqui, M. H., Cross, M., Dabhadkar, K. C., Dahodwala, N., De Leo, D., Degenhardt, L., Delossantos, A., Denenberg, J., Des Jarlais, D. C., Dharmaratne, S. D., Dorsey, E. R., Driscoll, T., Duber, H., Ebel, B., Erwin, P. J., Espindola, P., Ezzati, M., Feigin, V., Flaxman, A. D., Forouzanfar, M. H., Fowkes, F. G. R., Franklin, R., Fransen, M., Freeman, M. K., Gabriel, S. E., Gakidou, E., Gaspari, F., Gillum, R. F., Gonzalez-Medina, D., Halasa, Y. A., Haring, D., Harrison, J. E., Havmoeller, R., Hay, R. J., Hoen, B., Hotez, P. J., Hoy, D., Jacobsen, K. H., James, S. L., Jasrasaria, R., Jayaraman, S., Johns, N., Karthikeyan, G., Kassebaum, N., Keren, A., Khoo, J.-P., Knowlton, L. M., Kobusingye, O., Koranteng, A., Krishnamurthi, R., Lipnick, M., Lipshultz, S. E., Ohno, S. L., Mabweijano, J., MacIntyre, M. F., Mallinger, L., March, L., Marks, G. B., Marks, R., Matsumori, A., Matzopoulos, R., Mayosi, B. M., McAnulty, J. H., McDermott, M. M., McGrath, J., Memish, Z. A., Mensah, G. A., Merriman, T. R., Michaud, C., Miller, M., Miller, T. R., Mock, C., Mocumbi, A. O., Mokdad, A. A., Moran, A., Mulholland, K., Nair, M. N., Naldi, L., Narayan, K. M. V., Nasseri, K., Norman, P., O'Donnell, M., Omer, S. B., Ortblad, K., Osborne, R., Ozgediz, D., Pahari, B., Pandian, J. D., Rivero, A. P., Padilla, R. P., Perez-Ruiz, F., Perico, N., Phillips, D., Pierce, K., Pope, C. A., Porrini, E., Pourmalek, F., Raju, M., Ranganathan, D., Rehm, J. T., Rein, D. B., Remuzzi, G., Rivara, F. P., Roberts, T., De León, F. R., Rosenfeld, L. C., Rushton, L., Sacco, R. L., Salomon, J. A., Sampson, U., Sanman, E., Schwebel, D. C., Segui-Gomez, M., Shepard, D. S., Singh, D., Singleton, J., Sliwa, K., Smith, E., Steer, A., Taylor, J. A., Thomas, B., Tleyjeh, I. M., Towbin, J. A., Truelsen, T., Undurraga, E. A., Venketasubramanian, N., Vijayakumar, L., Vos, T., Wagner, G. R., Wang, M., Wang, W., Watt, K., Weinstock, M. A., Weintraub, R., Wilkinson, J. D., Woolf, A. D., Wulf, S., Yeh, P.-H., Yip, P., Zabetian, A., Zheng, Z.-J., Lopez, A. D., & Murray, C. J.
Affiliations
  • Institute for Health Metrics and Evaluation (US)
  • Imperial College London (GB)
  • The University of Tokyo (JP)
  • Hôpital Universitaire Dupuytren (FR)
  • The University of Texas at San Antonio (US)
  • Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
  • Ministry of Health (SA)
  • St George's, University of London (GB)
  • University of Washington (US)
  • Mayo Clinic (US)
  • University of Auckland (NZ)
  • Harvard University (US)
  • Yale University (US)
  • Boston University (US)
  • University of Oxford (GB)
  • Russian University of Medicine (RU)
  • Michigan State University (US)
  • The University of Sydney (AU)
  • Great Ormond Street Hospital (GB)
  • The Kids Research Institute Australia (AU)
  • National Institute of Environmental Health Sciences (US)
  • Cedars-Sinai Medical Center (US)
  • Erasmus MC (NL)
  • Menzies School of Health Research (AU)
  • National Health Service Scotland (GB)
  • Loyola University Chicago (US)
  • Wake Forest University (US)
  • Mario Negri Institute for Pharmacological Research (IT)
  • University of California San Diego (US)
  • Emory University (US)
  • University of Pennsylvania (US)
  • National Drug and Alcohol Research Centre (AU)
  • University of Peradeniya (LK)
  • Johns Hopkins University (US)
  • Hospital Maciel (UY)
  • MRC Centre for Environment and Health (GB)
  • Auckland University of Technology (NZ)
  • Royal Life Saving Society - Australia (AU)
  • Howard University (US)
  • Brandeis University (US)
  • Flinders University (AU)
  • King's College London (GB)
  • Centre Hospitalier Universitaire de Besançon (FR)
  • Baylor College of Medicine (US)
  • Monash University (AU)
  • George Mason University (US)
  • Brigham and Women's Hospital (US)
  • All India Institute of Medical Sciences (IN)
  • Hebrew University of Jerusalem (IL)
  • University of South Africa (ZA)
  • Kwame Nkrumah University of Science and Technology (GH)
  • University of California, San Francisco (US)
  • University of Miami (US)
  • The University of Melbourne (AU)
  • Asian Pacific Society of Cardiology (JP)
  • South African Medical Research Council (ZA)
  • University of Cape Town (ZA)
  • Legacy Health (US)
  • Northwestern University (US)
  • The University of Queensland (AU)
  • Alfaisal University (SA)
  • University of Otago (NZ)
  • China Medical Board (US)
  • Pacific Institute For Research and Evaluation (US)
  • Eduardo Mondlane University (MZ)
  • Columbia University (US)
  • London School of Hygiene & Tropical Medicine (GB)
  • Centro Studi GISED (IT)
  • University of Liverpool (GB)
  • The University of Western Australia (AU)
  • Ollscoil na Gaillimhe – University of Galway (IE)
  • Deakin University (AU)
  • B.P. Koirala Institute of Health Sciences (NP)
  • Instituto Nacional de Enfermedades Respiratorias (MX)
  • Brigham Young University (US)
  • Hospital Universitario de Canarias (ES)
  • University of British Columbia (CA)
  • University of Missouri (US)
  • Centre for Addiction and Mental Health (CA)
  • University of Chicago (US)
  • Vanderbilt University (US)
  • University of Alabama at Birmingham (US)
  • Queen's Medical Center (US)
  • Northern Sydney Local Health District (AU)
  • Drexel University (US)
  • King Fahd Medical City (SA)
  • Cincinnati Children's Hospital Medical Center (US)
  • Herlev Hospital (DK)
  • National University of Singapore (SG)
  • National Institute for Occupational Safety and Health (US)
  • Capital Medical University (CN)
  • James Cook University (AU)
  • Brown University (US)
  • Royal Children's Hospital (AU)
  • London School of Economics and Political Science (GB)
  • University of Hong Kong (HK)
Corresponding author
Murray, Christopher JL
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
2012-12
Volume
380
Issue
9859
Pages
2095-2128
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2125065061
Cited by
14,070
References
110
Citations by year
2026: 239 · 2025: 450 · 2024: 639 · 2023: 719 · 2022: 883 · 2021: 1132 · 2020: 1235 · 2019: 1180 · 2018: 1298 · 2017: 1479 · 2016: 1411 · 2015: 1498 · 2014: 1202 · 2013: 665 · 2012: 11
FWCI
2695.23
Type
journal article
Language
en
Open access
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, public-domain)
  • ResearchOnline - JCU (James Cook University) (submittedVersion)
  • Tuwhera (Auckland University of Technology) (submittedVersion, cc-by-nc-nd)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • National University of Singapore (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • HAL (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • Griffith Research Online (submittedVersion)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
  • LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
Funders
  • Bill and Melinda Gates Foundation
  • Robert Wood Johnson Foundation
  • PepsiCo
  • World Health Organization
  • Vanderbilt University
  • Institute for Health Metrics and Evaluation
  • University of New South Wales
  • University of Sydney
  • Vetenskapsrådet
  • H. Lundbeck A/S
  • World Heart Federation
  • Lomonosov Moscow State University
  • National Institutes of Health
  • Centers for Disease Control and Prevention
  • Medical Research Council
  • National Health and Medical Research Council
  • Health Research Council of New Zealand
  • Japan Society for the Promotion of Science (22390130)
  • National Drug and Alcohol Research Centre
  • National Institute on Aging (K23AG034236)
  • National Heart, Lung, and Blood Institute (K08HL089675)
Topics
  • Social Sciences › Demography › Insurance, Mortality, Demography, Risk Management
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Epidemiology
  • Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Keywords
cause-specific mortality, causes of death, global burden of disease, mortality trends, age and sex differences in mortality, cause of death estimation, verbal autopsy, natural history model, uncertainty intervals
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Cause of Death, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Mortality, Sex Factors, Global Health, Young Adult

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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