The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study
Open accessAbstract
Background Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the Framingham cohort over 50 years.Methods We investigated trends in incidence, prevalence, and risk factors for atrial fibrillation and its association with stroke and mortality after onset in 9511 participants enrolled in the Framingham Heart Study between 1958 and 2007. We analysed trends within 10 year groups (1958-67, 1968-77, 1978-87, 1988-97, and 1998-2007), stratified by sex.Findings During 50 years of observation (202,417 person-years), 1544 cases of new-onset atrial fibrillation occurred (of whom 723 [47%] were women). Between 1958-67 and 1998-2007, age-adjusted prevalence of atrial fibrillation quadrupled from 20·4 to 96·2 cases per 1000 person-years in men and from 13·7 to 49·4 cases per 1000 person-years in women; age-adjusted incidence increased from 3·7 to 13·4 new cases per 1000 person-years in men and from 2·5 to 8·6 new cases per 1000 person-years in women (ptrend<0·0001 for all comparisons). For atrial fibrillation diagnosed by electrocardiograph (ECG) during routine Framingham examinations, age-adjusted prevalence per 1000 person-years increased (12·6 in 1958-67 to 25·7 in 1998-2007 in men, ptrend=0·0007; 8·1 to 11·8 in women, ptrend=0·009). However, age-adjusted incidence of atrial fibrillation by Framingham Heart Study ECGs did not change significantly with time. Although the prevalence of most risk factors changed over time, their associated hazards for atrial fibrillation changed little. Multivariable-adjusted proportional hazards models revealed a 74% (95% CI 50-86%) decrease in stroke (hazards ratio [HR] 3·77, 95% CI 1·98-7·20 in 1958-1967 compared with 1998-2007; ptrend=0·0001) and a 25% (95% CI -3-46%) decrease in mortality (HR 1·34, 95% CI 0·97-1·86 in 1958-1967 compared with 1998-2007; ptrend=0·003) in 20 years following atrial fibrillation onset.Interpretation Trends of increased incidence and prevalence of atrial fibrillation in the community were probably partly due to enhanced surveillance. Measures are needed to enhance early detection of atrial fibrillation, through increased awareness coupled with targeted screening programmes and risk factor-specific prevention.Funding NIH, NHLBI, NINDS, Deutsche Forschungsgemeinschaft.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Similarly to incidence, age-adjusted prevalence of AF has been reported to be lower in women than in men in North America and Europe (Figure 2) (Supplementary Tables S3 and S4).”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [5]
Experimental — accuracy not yet measuredIn the citing paper
“Hypertension (treated) vs. none 19 HR 1.32 (95% CI 1.08-1.60)”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [19]
In the citing paper
“Heart failure vs. none 19 HR 1.43 (95% CI 0.85-2.40)”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [19]
In the citing paper
“Older age 19 50-59 years 60-69 years 70-79 years 80-89 years HR: 1.00 (reference) 4.98 (95% CI 3.49-7.10) 7.35 (95% CI 5.28-10.2) 9.33 (95% CI 6.68-13.0)”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [19]
In the citing paper
“Obesity 19, 208 none (BMI < 25 kg/m²) overweight (BMI 25-30 kg/m²) obese (BMI ≥ 31 kg/m²) HR: 1.00 (reference) 1.13 (95% CI 0.87-1.46)1.37 (95% CI 1.05-1.78)”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [19]
In the citing paper
“Myocardial infarction vs. none 19 HR 1.46 (95% CI 1.07-1.98)”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [19]
In the citing paper
“Diabetes mellitus vs. none 19 HR 1.25 (95% CI 0.98-1.60)”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [19]
In the citing paper
“In North American and European populations, the age-adjusted incidence of AF has been estimated to be 1.5 to 2 times higher in men than in women (Supplementary Tables S1 and S2).”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [5]
In the citing paper
“Elevated body mass index, hypertension, diabetes mellitus, coronary heart disease, valvular heart disease, and heart failure (HF) constitute major risk factors for AF, but the prevalence of these risk factors vary between women and men.3–5”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [5]
In the citing paper
“Women with AF have higher prevalence of hypertension and valvular heart disease and lower prevalence of coronary heart disease than men with AF.5,11,34”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [5]
In the citing paper
“However, in studies from North America,5 Europe,34,35 and Australia,11 women with AF are, on average, older than men.”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [5]
In the citing paper
“In particular, body mass index has increased significantly (Figure 3).5”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Regression Analysis of Count Data
Cameron, A. C., & Trivedi, P. K. (2013) · doi:10.1017/cbo9781139013567 · Cited by 6,640
Go, A. S., Hylek, E. M., Phillips, K. A., Chang, Y., Henault, L. E., Selby, J. V., & Singer, D. E. (2001) · JAMA · doi:10.1001/jama.285.18.2370 · Cited by 6,205
Burden of valvular heart diseases: a population-based study
Nkomo, V. T., Gardin, J. M., Skelton, T. N., Gottdiener, J. S., Scott, C. G., & Enriquez-Sarano, M. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69208-8 · Cited by 4,881
Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
Benjamin, E. J., Wolf, P. A., D’Agostino, R. B., Silbershatz, H., Kannel, W. B., & Levy, D. (1998) · Circulation · doi:10.1161/01.cir.98.10.946 · Cited by 4,575
Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study
Chugh, S. S., Havmoeller, R., Narayanan, K., Singh, D., Rienstra, M., Benjamin, E. J., Gillum, R. F., Kim, Y.-H., McAnulty, J. H., Zheng, Z.-J., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.005119 · Cited by 4,506
Self-citationExplaining the decrease in U.S. deaths from coronary disease, 1980–2000
Ford, E. S., Ajani, U. A., Croft, J. B., Critchley, J. A., Labarthe, D. R., Kottke, T. E., Giles, W. H., & Capewell, S. (2007) · New England Journal of Medicine · doi:10.1056/nejmsa053935 · Cited by 2,757
Benjamin, E. J. (1994) · JAMA · doi:10.1001/jama.1994.03510350050036 · Cited by 2,613
Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., Seward, J. B., & Tsang, T. S. M. (2006) · Circulation · doi:10.1161/circulationaha.105.595140 · Cited by 2,564
US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008
Egan, B. M. (2010) · JAMA · doi:10.1001/jama.2010.650 · Cited by 2,197
Long-term trends in the incidence of and survival with heart failure
Levy, D., Kenchaiah, S., Larson, M. G., Benjamin, E. J., Kupka, M. J., Ho, K. K. L., Murabito, J. M., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020265 · Cited by 2,152
Self-citation
Cited by
Sorted by citations
Items 301–400 of 1,000
Atrial fibrillation: villain or bystander in vascular brain injury
Freedman, B., Kamel, H., Gelder, I. C. V., & Schnabel, R. B. (2020) · European Heart Journal Supplements · doi:10.1093/eurheartj/suaa166 · Cited by 33
Orkaby, A. R., Kornej, J., Lubitz, S. A., McManus, D. D., Travison, T. G., Sherer, J. A., Trinquart, L., Murabito, J. M., Benjamin, E. J., & Preis, S. R. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.018557 · Cited by 33
Vora, A. M., Kapoor, A., Nair, M., Lokhandwala, Y. Y., Narsimhan, C., Ravikishore, A. G., Dwivedi, S. K., Namboodiri, N., Hygriv, R., Saxena, A., et al. (2016) · Indian Heart Journal · doi:10.1016/j.ihj.2016.06.006 · Cited by 33
Antoun, I., Abdelrazik, A., Eldesouky, M., Li, X., Layton, G. R., Zakkar, M., Somani, R., & Ng, G. A. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1596574 · Cited by 38
Kany, S., Reißmann, B., Metzner, A., Kirchhof, P. F., Darbar, D., & Schnabel, R. B. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab153 · Cited by 32
Atrial Fibrillation and Cancer Patients: Mechanisms and Management
Madnick, D. L., & Fradley, M. G. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01769-3 · Cited by 32
Carmo, J., Ferreira, J., Costa, F. M., Carmo, P., Cavaco, D., Carvalho, M. S., Morgado, F. B., Adragão, P., & Mendes, M. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.06.004 · Cited by 32
Glucagon-Like Peptide 1 Receptor Agonists: A Medication for Obesity Management
Taha, M. B., Yahya, T., Satish, P., Laird, R., Agatston, A. S., Cainzos-Achirica, M., Patel, K. V., & Nasir, K. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01041-7 · Cited by 31
Oltman, C. G., Kim, T. P., Lee, J. W. Y., Lupu, J. D., Zhu, R., & Moussa, I. D. (2024) · JACC: Advances · doi:10.1016/j.jacadv.2024.101330 · Cited by 31
Ferroptosis in cardiovascular diseases: role and mechanism
Zhang, Q., Luo, Y., Peng, L., Rong, X., Liu, Y., Li, J., & Luo, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01169-2 · Cited by 33
Silbernagel, G., Spirk, D., Hager, A., Baumgärtner, I., & Kucher, N. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003776 · Cited by 31
Becattini, C., Dentali, F., Camporese, G., Sembolini, A., Rancan, E., Tonello, C., Manina, G., Jose, S. P., & Agnelli, G. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.02.004 · Cited by 31
Lifestyle management to prevent and treat atrial fibrillation
Gallagher, C., Hendriks, J. M. L., Mahajan, R., Middeldorp, M. E., Elliott, A. D., Pathak, R. K., Sanders, P., & Lau, D. H. (2016) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2016.1179581 · Cited by 29
Global burden of atrial fibrillation/flutter: Trends from 1990 to 2019 and projections until 2044
Ma, Q., Zhu, J., Zheng, P., Zhang, J., Xia, X., Zhao, Y., Cheng, Q., & Zhang, N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24052 · Cited by 30
Risk prediction of atrial fibrillation in the community combining biomarkers and genetics
Börschel, C. S., Ohlrogge, A. H., Geelhoed, B., Niiranen, T., Havulinna, A. S., Palosaari, T., Jousilahti, P., Rienstra, M., van der Harst, P., Blankenberg, S., et al. (2020) · EP Europace · doi:10.1093/europace/euaa334 · Cited by 31
Park, C. S., Han, K., Choi, E., Kim, D. H., Lee, H., Lee, S., & Oh, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-84307-5 · Cited by 31
Temporal trends in the burden of heart failure
Chan, D., Kerr, A., & Doughty, R. N. (2021) · Internal Medicine Journal · doi:10.1111/imj.15253 · Cited by 32
National Trends in the Burden of Atrial Fibrillation During Hospital Admissions for Heart Failure
Reinhardt, S. W., Chouairi, F. K., Miller, P. E., Clark, K. A. A., Kay, B., Fuery, M. A., Guha, A., Freeman, J. V., Ahmad, T., Desai, N. R., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019412 · Cited by 30
Atrial fibrillation and heart failure: A contemporary review of current management approaches
Lee, J. Z., & Cha, Y. (2021) · Heart Rhythm O2 · doi:10.1016/j.hroo.2021.11.006 · Cited by 30
van der Burgh, A. C., Geurts, S., Ikram, M. A., Hoorn, E. J., Kavousi, M., & Chaker, L. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.025303 · Cited by 30
Chamberlain, A. M., Brown, R. D., Alonso, Á., Gersh, B. J., Killian, J. M., Weston, S. A., & Roger, V. L. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003408 · Cited by 29
Tran, K., Majka, J., Sanghai, S., Sardana, M., Lessard, D., Milstone, Z. J., Tanrıverdi, K., Freedman, J. E., Fitzgibbons, T. P., & McManus, D. D. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00115 · Cited by 30
Zhang, X., Wei, M., Shang, L., Lu, Y., Zhang, L., Li, Y., Zhang, J., Xing, Q., Tu-Erhong, Z. K., Tang, B., et al. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01392-7 · Cited by 29
Liu, J., Jin, X., Chen, W., Wang, L., Feng, Z.-Y., & Huang, J. (2023) · Maturitas · doi:10.1016/j.maturitas.2023.107784 · Cited by 26
Masuda, M., Matsuda, Y., Uematsu, H., Sugino, A., Ooka, H., Kudo, S., Fujii, S., Asai, M., Iida, O., Okamoto, S., et al. (2023) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2023.07.001 · Cited by 29
Jortveit, J., Pripp, A. H., Langørgen, J., & Halvorsen, S. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319841940 · Cited by 28
Yang, S., Kwak, S., Kwon, S., Lee, H., Lee, H., Park, J., Lee, S., Kim, H., Han, K., Kim, Y.-J., et al. (2019) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.119.007428 · Cited by 28
Endothelial dysfunction and vascular maladaptation in atrial fibrillation
Qin, S., Boidin, M., Buckley, B. J. R., Lip, G. Y. H., & Thijssen, D. H. J. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13477 · Cited by 28
Lee, J. H., Kim, Y., Park, H., Kim, C., Cho, S., & Kim, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10235497 · Cited by 28
The Tromsø study 1974–2016: 40 years of cardiovascular research
Njølstad, I., Mathiesen, E. B., Schirmer, H., & Thelle, D. S. (2016) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2016.1239837 · Cited by 28
Sundbøll, J., Horváth–Puhó, E., Adelborg, K., Ording, A. G., Schmidt, M., Bøtker, H. E., & Sørensen, H. T. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.04.081 · Cited by 28
Is Vagal Response During Left Atrial Ganglionated Plexi Stimulation a Normal Phenomenon?
Iso, K., Okumura, Y., Watanabe, I., Nagashima, K., Takahashi, K., Arai, M., Watanabe, R., Wakamatsu, Y., Otsuka, N., Yagyu, S., et al. (2019) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.118.007281 · Cited by 28
Intravenous Flecainide for Emergency Department Management of Acute Atrial Fibrillation
Markey, G., Salter, N., & Ryan, J. M. (2017) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2017.11.016 · Cited by 27
Yang, P., Ryu, S., Kim, D., Jang, E., Yu, H. T., Kim, T., Hwang, J., Joung, B., & Lip, G. Y. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-25111-6 · Cited by 27
Relationship between QRS duration and incident atrial fibrillation
Aeschbacher, S., O’Neal, W. T., Krisai, P., Loehr, L. R., Chen, L. Y., Alonso, Á., Soliman, E. Z., & Conen, D. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.03.050 · Cited by 27
Ghazi, L., Bennett, A., Petrov, M. E. R., Howard, V. J., Safford, M. M., Soliman, E. Z., & Glasser, S. P. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7320 · Cited by 26
Thongprayoon, C., Chokesuwattanaskul, R., Bathini, T., Khoury, N. J., Sharma, K., Ungprasert, P., Prasitlumkum, N., Aeddula, N. R., Watthanasuntorn, K., Salim, S. A., et al. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100370 · Cited by 28
Calleja, M. A. R., Miquélez, A. A., Díez‐Manglano, J., Gullón, A., Pose, A., Formiga, F., Mostaza, J. M., Cepeda, J. M., & Suárez, C. (2019) · Revista Clínica Española · doi:10.1016/j.rce.2019.04.001 · Cited by 29
Ruan, B., Yu, Z., Yang, S., Xu, K., Ren, J., Yao, J., Wu, N., Yu, C., Deng, M., Xie, T., et al. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4150-9 · Cited by 27
Maurer, T., Schlüter, M., & Kück, K. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2020.08.041 · Cited by 28
Prognostic significance of natriuretic peptide levels in atrial fibrillation without heart failure
Hamatani, Y., Iguchi, M., Ueno, K., Aono, Y., Esato, M., Tsuji, H., Wada, H., Hasegawa, K., Ogawa, H., Abe, M., et al. (2020) · Heart · doi:10.1136/heartjnl-2020-317735 · Cited by 27
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castellà, M., Dan, G., Dilaveris, P., et al. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.10.022 · Cited by 34
Schnabel, R. B., Witt, H., Walker, J., Ludwig, M., Geelhoed, B., Kossack, N., Schild, M., Miller, R. E., & Kirchhof, P. F. (2022) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcac013 · Cited by 28
Relationship Between Periodontitis and Atrial Fibrosis in Atrial Fibrillation
Miyauchi, S., Nishi, H., Ouhara, K., Tokuyama, T., Okubo, Y., Okamura, S., Miyamoto, S., Oguri, N., Uotani, Y., Takasaki, T., et al. (2022) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2022.08.018 · Cited by 27
Paquissi, F. C. (2016) · Journal of Biomarkers · doi:10.1155/2016/8160393 · Cited by 28
O’Neal, W. T., Kamel, H., Judd, S. E., Safford, M. M., Vaccarino, V., Howard, V. J., Howard, G., & Soliman, E. Z. (2017) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2017.06.007 · Cited by 27
Association between ambient air pollution and hospitalization caused by atrial fibrillation.
Saifipour, A., Azhari, A., Pourmoghaddas, A., Hosseini, S. M., Jafari‐Koshki, T., Rahimi, M., Nasri, A., Shishehforoush, M., Lahijanzadeh, A., Sadeghian, B., et al. (2019) · PubMed Central · doi:10.22122/arya.v15i3.1843 · Cited by 27
O’Connor, K. P., Hathidara, M. Y., Danala, G., Xu, C., McCoy, T. M., Sidorov, E. V., Zheng, B., Bohnstedt, B. N., & Ray, B. S. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.11.127 · Cited by 27
Increased plasma corin levels in patients with atrial fibrillation
Chen, F., Xia, Y., Liu, Y., Zhang, Y., Song, W., Yang, Z. H., Gao, L., Jin, Y., Li, S., Jiang, Y., et al. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.05.017 · Cited by 27
Bernáth-Nagy, D., Kalinyaprak, M. S., Giannitsis, E., Ábrahám, P., Leuschner, F., Frey, N., & Krohn, J. B. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1425159 · Cited by 30
Niiranen, T., Schnabel, R. B., Schutte, A. E., Biton, Y., Boriani, G., Buckley, C. M., Cameron, A. C., Damasceno, A. A. M., Diederichsen, S. Z., Doehner, W., et al. (2025) · Circulation · doi:10.1161/circulationaha.124.071047 · Cited by 29
Calleja, M. A. R., Miquélez, A. A., Díez‐Manglano, J., Gullón, A., Pose, A., Formiga, F., Mostaza, J. M., Cepeda, J. M., & Suárez, C. (2019) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2019.04.002 · Cited by 28
Atrial Fibrillation Genetics Update: Toward Clinical Implementation
Kalstø, S. M., Siland, J. E., Rienstra, M., & Christophersen, I. E. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00127 · Cited by 28
Guttman, M. A., Tao, S., Fink, S., Tunin, R., Schmidt, E. J., Herzka, D. A., Halperin, H. R., & Kolandaivelu, A. (2019) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28001 · Cited by 26
Fan, G., & Jin, W. (2020) · Kardiologia Polska · doi:10.33963/kp.15339 · Cited by 26
Cartledge, R. G., Suwalski, G., Witkowska, A., Gottlieb, G., Cioci, A., Chidiac, G., Ilsin, B., Merrill, B., & Suwalski, P. (2021) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivab334 · Cited by 26
Verhaert, D. V. M., Linz, D., Chaldoupi, S., Westra, S. W., den Uijl, D. W., Philippens, S., Kerperien, M., Habibi, Z., Vorstermans, B. J. G. H., ter Bekke, R. M. A., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.879139 · Cited by 26
Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis
Wang, X., Song, J., Yuan, Y., Li, L., Abu-Taha, I., Heijman, J., Sun, L. T., Dobrev, S., Kamler, M., Xie, L., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.322213 · Cited by 31
Twenty-year trends in cardiovascular risk among men and women in the United States
Kim, J. K., Ailshire, J., & Crimmins, E. M. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-0932-y · Cited by 26
Luo, J., Li, Z., Qin, X., Zhang, X., Liu, X., Zhang, W., Xu, W., Liu, B., Wei, Y., & the NOAFCAMI‐SH Registry Investigators (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3726 · Cited by 25
The Role of Immune Cells Driving Electropathology and Atrial Fibrillation
Huang, M., Huiskes, F. G., de Groot, N. M. S., & Brundel, B. J. J. M. (2024) · Cells · doi:10.3390/cells13040311 · Cited by 31
Zhu, W., Guo, L., & Hong, K. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.07.220 · Cited by 25
Right Ventricular Structure and Function Are Associated With Incident Atrial Fibrillation
Chatterjee, N. A., Shah, R. V., Murthy, V. L., Praestgaard, A. H., Shah, S. J., Ventetuolo, C. E., Barr, R. G., Kronmal, R. A., Lima, J. A. C., Bluemke, D. A., et al. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.116.004738 · Cited by 25
Camen, S., Ojeda, F., Niiranen, T., Gianfagna, F., Vishram‐Nielsen, J. K. K., Costanzo, S., Söderberg, S., Vartiainen, E. A., Donati, M. B., Løchen, M., et al. (2019) · EP Europace · doi:10.1093/europace/euz312 · Cited by 27
Olimpieri, P. P., Lenarda, A. D., Mammarella, F., Gozzo, L., Cirilli, A., Cuomo, M., Gulizia, M. M., Colivicchi, F., Murri, G., Gabrielli, D., et al. (2020) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2019.100465 · Cited by 25
Very Low Prevalence and Incidence of Atrial Fibrillation among Bolivian Forager-Farmers
Rowan, C. J., Eskander, M., Seabright, E., Rodriguez, D. E., Linares, E. C., Gutierrez, R. Q., Adrian, J. C., Cummings, D. K., Beheim, B., Tolstrup, K., et al. (2021) · Annals of Global Health · doi:10.5334/aogh.3252 · Cited by 24
New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation
Kornej, J., Hanger, V. A., Trinquart, L., Ko, D., Preis, S. R., Benjamin, E. J., & Lin, H. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab073 · Cited by 26
Heitmann, K. A., Løchen, M., Stylidis, M., Hopstock, L. A., Schirmer, H., & Morseth, B. (2022) · Open Heart · doi:10.1136/openhrt-2021-001823 · Cited by 25
Sex-Specific Considerations in Drug and Device Therapy of Cardiac Arrhythmias
Amuthan, R., & Curtis, A. B. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.11.066 · Cited by 25
Optimal Rhythm Control Strategy in Patients With Atrial Fibrillation
Kim, D., Yang, P., & Joung, B. (2022) · Korean Circulation Journal · doi:10.4070/kcj.2022.0078 · Cited by 25
Trohman, R. G., Huang, H. D., & Sharma, P. S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1060030 · Cited by 29
O’Neal, W. T., Efird, J. T., Judd, S. E., McClure, L. A., Howard, V. J., Howard, G., & Soliman, E. Z. (2016) · Clinical Cardiology · doi:10.1002/clc.22501 · Cited by 25
The Future of Arrhythmias and Electrophysiology
Albert, C. M., & Stevenson, W. G. (2016) · Circulation · doi:10.1161/circulationaha.116.023519 · Cited by 25
Vinter, N., Christesen, A. M. S., Mortensen, L. S., Urbonavičienė, G., Lindholt, J. S., Johnsen, S. P., & Frost, L. (2017) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jex201 · Cited by 25
Hu, W., & Lin, C. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.007 · Cited by 25
Lee, Y., Park, H.-C., Shin, J., Lim, Y., Shin, J., & Park, J. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.10.070 · Cited by 25
Bose, A., O’Neal, W. T., Wu, C., McClure, L. A., Judd, S. E., Howard, V. J., Howard, G., & Soliman, E. Z. (2019) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2019.01.056 · Cited by 25
Corona, G., Rastrelli, G., Sparano, C., Carinci, V., Casella, G., Vignozzi, L., Sforza, A., & Maggi, M. (2024) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2024.2337741 · Cited by 26
Evertz, R., Reinders, M., Houck, C., Cate, T. T., Duijnhouwer, A., Beukema, R., Westra, S., Vernooy, K., & de Groot, N. D. (2020) · Open Heart · doi:10.1136/openhrt-2020-001298 · Cited by 20
Diabesity in Elderly Cardiovascular Disease Patients: Mechanisms and Regulators
García‐Vega, D., González‐Juanatey, J. R., & Eirás, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147886 · Cited by 26
Racial, ethnic, and sex disparities in atrial fibrillation management: rate and rhythm control
Gomez, S. E., Fazal, M., Nunes, J. C., Shah, S., Perino, A. C., Narayan, S. M., Tamirisa, K. P., Han, J. K., Rodriguez, F., & Baykaner, T. (2022) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-022-01383-x · Cited by 24
Mitacchione, G., Schiavone, M., Gasperetti, A., Arabia, G., Tundo, F., Breitenstein, A., Montemerlo, E., Monaco, C., Gulletta, S., Palmisano, P., et al. (2023) · Heart Rhythm · doi:10.1016/j.hrthm.2023.07.061 · Cited by 24
Atrial Fibrillation and Cardiovascular Outcomes in the Elderly
O’Neal, W. T., Salahuddin, T., Broughton, S. T., & Soliman, E. Z. (2016) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12907 · Cited by 24
H2S inhibits atrial fibrillation-induced atrial fibrosis through miR-133a/CTGF axis
Su, H., Su, H., Liu, C., Hu, H.-J., Zhao, J., Zou, T., & Tang, Y. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155557 · Cited by 23
Determinants of Prolonged Length of Hospital Stay of Patients with Atrial Fibrillation
Vîjan, A. E., Daha, I. C., Delcea, C., & Dan, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163715 · Cited by 23
Pecha, S., Ismaili, D., Geelhoed, B., Knaut, M., Reichenspurner, H. C., Eschenhagen, T., Schnabel, R. B., Christ, T., & Ravens, U. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.01.006 · Cited by 22
End-to-end risk prediction of atrial fibrillation from the 12-Lead ECG by deep neural networks
Habineza, T., Ribeiro, A. H., Gedon, D., Behar, J. A., Ribeiro, A. H., & Schön, T. B. (2023) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2023.09.011 · Cited by 23
New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models
Sharma, A. K., Singh, S., Bhat, M., Gill, K., Zaid, M., Kumar, S., Shakya, A., Tantray, J., Jose, D., Gupta, R., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-41942-4 · Cited by 24
Stærk, L., Wang, B., Lunetta, K. L., Helm, R. H., Ko, D., Sherer, J. A., Ellinor, P. T., Lubitz, S. A., McManus, D. D., Vasan, R. S., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006541 · Cited by 23
Atrial fibrillation self-management: a mobile telephone app scoping review and content analysis
Pearsons, A., Hanson, C. L., Gallagher, R. D., O’Carroll, R. E., Khonsari, S., Hanley, J., Strachan, F. E., Mills, N. L., Quinn, T. J., McKinstry, B., et al. (2020) · European Journal of Cardiovascular Nursing · doi:10.1093/eurjcn/zvaa014 · Cited by 22
A Contact-Aided Asymmetric Steerable Catheter for Atrial Fibrillation Ablation
Gao, A., Liu, H., Zou, Y., Wang, Z., Liang, M., & Wang, Z. (2017) · IEEE Robotics and Automation Letters · doi:10.1109/lra.2017.2676351 · Cited by 23
Early Rhythm Control in Patients With Incident Atrial Fibrillation Who Had a Prior Stroke
Lee, S., Choi, E., Lee, S., Han, K., Oh, S., & Lip, G. Y. H. (2023) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2022.11.021 · Cited by 23
Pana, T. A., Mamas, M. A., Wareham, N. J., Khaw, K., Dawson, D. K., & Myint, P. K. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad283 · Cited by 22
Photoplethysmography based atrial fibrillation detection: a continually growing field
Ding, C., Xiao, R., Wang, W., Holdsworth, E., & Hu, X. (2024) · Physiological Measurement · doi:10.1088/1361-6579/ad37ee · Cited by 29
Fabritz, L., Chua, W., Cardoso, V. R., Al-Taie, C., Borof, K., Suling, A. I., Krause, L., Kany, S., Magnussen, C., Wegscheider, K., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae067 · Cited by 24
A gender perspective on diet, microbiome, and sex hormone interplay in cardiovascular disease
Jovanović, N. D., Zach, V., Crocini, C., Bahr, L. S., Forslund, S. K., & Franz, K. (2024) · Acta Physiologica · doi:10.1111/apha.14228 · Cited by 26
Ahmad, O., Farooqi, H. A., Ahmed, I., Jamil, A., Nabi, R., Ullah, I., Khan, A. W., Ahmed, R., Alam, M., Cortese, B., et al. (2024) · Clinical Cardiology · doi:10.1002/clc.70058 · Cited by 22
Yang, Y., Han, X., Chen, Y., Gao, L., Yin, X., Li, H., Qiu, J., Wang, Y., Zhou, Y., & Xia, Y. (2017) · Clinical Cardiology · doi:10.1002/clc.22771 · Cited by 21
Free thyroxine within the normal reference range predicts risk of atrial fibrillation
Anderson, J. L., Jacobs, V., May, H. T., Bair, T. L., Benowitz, B. A., Lappe, D. L., Muhlestein, J. B., Knowlton, K. U., & Bunch, T. J. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14183 · Cited by 22
Goulart, A. C., Olmos, R. D., Santos, I. S., da Silva, G. T., Alencar, A. P., Thomas, G. N., Lip, G. Y. H., Lotufo, P. A., & Benseñor, I. M. (2021) · International Journal of Stroke · doi:10.1177/1747493021995592 · Cited by 22
Metadata
- Authors
- Schnabel, R. B., Yin, X., Gona, P., Larson, M. G., Beiser, A. S., McManus, D. D., Newton-Cheh, C., Lubitz, S. A., Magnani, J. W., Ellinor, P. T., Seshadri, S., Wolf, P. A., Vasan, R. S., Benjamin, E. J., & Levy, D.
- Affiliations
- Framingham Heart Study (US)
- Boston University (US)
- University of Massachusetts Chan Medical School (US)
- Harvard University (US)
- Broad Institute (US)
- Corresponding author
- Schnabel, Renate B
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 386
- Issue
- 9989
- Pages
- 154-162
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC4553037
- OpenAlex
- W1924098982
- Cited by
- 1,746
- References
- 32
- Citations by year
- 2026: 126 · 2025: 209 · 2024: 253 · 2023: 192 · 2022: 198 · 2021: 155 · 2020: 145 · 2019: 141 · 2018: 120 · 2017: 110 · 2016: 76 · 2015: 20
- FWCI
- 79.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- NIH/NHLBI (contract N01-HC-25195, grant 1K23HL114724)
- NIH (grants 1RC1HL101056, HL102214, and AG028321, grant 2R01HL092577, grants 1U01HL105268-01 and KL2RR031981)
- Fondation Leducq (14CVD01) and NIH grants (1R01HL092577, 1RC1HL101056, 1R01HL102214, 1R01AG028321, R01HL104156, and 1K24HL105780)
- American Heart Association Established Investigator Award (13EIA14220013)
- Deutsche Forschungsgemeinschaft (German Research Foundation) Emmy Noether Program (SCHN 1149/3-2)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- atrial fibrillation, prevalence trends, incidence trends, sex differences, risk factors, stroke, mortality, Framingham Heart Study, electrocardiogram screening, atrial fibrillation screening, atrial fibrillation prevention, cardiovascular disease prevention, long-term cohort follow-up
- MeSH terms
- Aged, Aged, 80 and over, Atrial Fibrillation, Electrocardiography, Female, Humans, Male, Middle Aged, Mortality, Risk Factors, United States, Cohort Studies, Incidence, Prevalence, Age Distribution, Sex Distribution, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
