The DOI matches its Crossref record; 134 of the 136 references it cites were found in a registry or an index.
Environmental risk factors for type 1 diabetes
Open accessAbstract
The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to β cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.
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“Under the GBD's comparative risk assessment framework, we do not currently capture risk factors that have been reported in the literature for type 1 diabetes.93, 94”
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Cites
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,723
Classification and Diagnosis of Diabetes
Fajans, S. S. (1990) · Medical Entomology and Zoology · Cited by 2,356
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921
Patterson, C. C., Dahlquist, G. G., Gyürüs, E., Green, A., & Soltész, G. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60568-7 · Cited by 1,854
(2) Classification and diagnosis of diabetes
American Diabetes Association (2015) · Diabetes Care · doi:10.2337/dc15-s005 · Cited by 1,841
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
Ziegler, A. G., Rewers, M., Simell, O., Simell, T., Lempainen, J., Steck, A., Winkler, C., Ilonen, J., Veijola, R., Knip, M., et al. (2013) · JAMA · doi:10.1001/jama.2013.6285 · Cited by 1,312
Self-citationDiet, gut microbiota and immune responses
Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261
Insel, R. A., Dunne, J. L., Atkinson, M. A., Chiang, J. L., Dabelea, D., Gottlieb, P. A., Greenbaum, C. J., Herold, K. C., Krischer, J. P., Lernmark, Å., et al. (2015) · Diabetes Care · doi:10.2337/dc15-1419 · Cited by 1,216
Self-citationKostic, A. D., Gevers, D., Siljander, H., Vatanen, T., Hyötyläinen, T., Hämäläinen, A., Peet, A., Tillmann, V., Pöhö, P., Mattila, I. M., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.001 · Cited by 1,198
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Vatanen, T., Franzosa, E. A., Schwager, R., Tripathi, S. M., Arthur, T. D., Vehik, K., Lernmark, Å., Hagopian, W., Rewers, M., She, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0620-2 · Cited by 926
Self-citationMolecular mechanisms of ROS production and oxidative stress in diabetes
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Metadata
- Authors
- Rewers, M., & Ludvigsson, J.
- Affiliations
- University of Colorado Anschutz (US)
- Linköping University (SE)
- Corresponding author
- Ludvigsson, Johnny
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 387
- Issue
- 10035
- Pages
- 2340-2348
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC5571740
- OpenAlex
- W2416473596
- Semantic Scholar
- cfb08c15990c940ca28c917c4b6cd3743c3d269c
- Cited by
- 676
- References
- 136
- Citations by year
- 2026: 29 · 2025: 49 · 2024: 75 · 2023: 83 · 2022: 94 · 2021: 84 · 2020: 88 · 2019: 53 · 2018: 69 · 2017: 45 · 2016: 7
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 32493, R01DK032493, R37DK032493)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- type 1 diabetes, environmental risk factors, islet autoimmunity, disease incidence, hybrid peptides, environmental exposure
- MeSH terms
- Animals, Autoantigens, Birth Weight, Breast Feeding, Diabetes Mellitus, Type 1, Diet, Environment, Fatty Acids, Unsaturated, Growth, Humans, Hygiene, Infant, Infant Food, Milk, Risk Factors, RNA, Toxins, Biological, Vaccines, Vitamin D, Autoimmunity, Insulin-Secreting Cells
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