PREVENTION OF DISUSE MUSCLE ATROPHY BY MEANS OF ELECTRICAL STIMULATION: MAINTENANCE OF PROTEIN SYNTHESIS
Abstract
The effect of percutaneous electrical stimulation in preventing immobilisation-induced muscle atrophy was determined from measurements of quadriceps mass, composition, and rate of protein synthesis in seven men who had a fracture of one tibia immobilised in a long-leg cast for 6 weeks. These features were compared with those of fourteen men with similar injuries who did not use an electrical stimulator. In men who did not use the stimulator, quadriceps cross-sectional area (CSA) at midthigh, measured by ultrasonography, fell by a mean (SD) 17 (10)% and the rate of muscle protein synthesis was 23 (10)% lower on the immobilised than on the control side (0.037 [0.016] vs 0.048 [0.02]%/h). In contrast, in those who used the stimulator, quadriceps CSA (55.5 [7.3]) cm2 control leg, 50.9 [9.0] cm2 immobilised leg) and the rate of muscle protein synthesis (0.053 [0.009] %/h control leg, 0.059 [0.012] %/h immobilised leg) were similar on the two sides. The results suggest that brief periods of low-voltage percutaneous electrical stimulation will reduce quadriceps atrophy secondary to knee immobilisation, and that the mechanism includes prevention of the fall in muscle protein synthesis that usually occurs on immobilisation.
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Muscle electrical stimulation may be an effective therapy to help alleviate muscle loss in individuals who cannot tolerate exercise or very high protein/amino acid supplementation.
“In these situations, muscle electrical stimulation may be an effective therapy to help alleviate muscle loss.186e188”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [186]
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- Authors
- Gibson, J. N. A., Smith, K., & Rennie, M. J.
- Affiliations
- University of Edinburgh (GB)
- University of Dundee (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1988-10
- Volume
- 332
- Issue
- 8614
- Pages
- 767-770
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1967174207
- Cited by
- 270
- References
- 29
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 8 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 14 · 2019: 12 · 2018: 10 · 2017: 16 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 15
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Keywords
- disuse atrophy, percutaneous electrical stimulation, muscle protein synthesis, immobilization, quadriceps, tibial fractures, long leg cast, cross-sectional area
- MeSH terms
- Adolescent, Adult, Electric Stimulation Therapy, Evaluation Studies as Topic, Humans, Immobilization, Male, Middle Aged, Muscle Contraction, Muscle Proteins, Muscular Atrophy, Self Care, Tibial Fractures, Time Factors
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