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Cited by 383Intensive Care Unit Cognitive DisordersSpaceflight effects on biologyMuscle Physiology and Disorders

The impact of extended bed rest on the musculoskeletal system in the critical care environment

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Parry, Selina M., Puthucheary, Zudin A.·2015·Extreme Physiology & Medicine
DOI 10.1186/s13728-015-0036-7PMC PMC4600281
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Abstract

Prolonged immobility is harmful with rapid reductions in muscle mass, bone mineral density and impairment in other body systems evident within the first week of bed rest which is further exacerbated in individuals with critical illness. Our understanding of the aetiology and secondary consequences of prolonged immobilization in the critically ill is improving with recent and ongoing research to establish the cause, effect, and best treatment options. This review aims to describe the current literature on bed rest models for examining immobilization-induced changes in the musculoskeletal system and pathophysiology of immobilisation in critical illness including examination of intracellular signalling processes involved. Finally, the review examines the current barriers to early activity and mobilization and potential rehabilitation strategies, which are being, investigated which may reverse the effects of prolonged bed rest. Addressing the deleterious effects of immobilization is a major step in treatment and prevention of the public health issue, that is, critical illness survivorship.

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  • Recent findings clustered periods of disuse into three subsections: acute periods of 1-10 days, the mid-term interval of 11 days up to 1 mo, and long-term periods >1 mo.

    “Thereby, recent findings clustered the periods of disuse in three subsections: acute periods of 1–10 days, the mid-term interval of 11 days up to 1 mo and long-term periods >1 mo (11).”

    From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [11]

    The Background section on intracellular signalling describes early and late stages of muscle dysfunction after critical illness, not three periods of disuse. Searches for the stated 1–10-day, 11-day-to-one-month, and over-one-month boundaries found no such classification in our copy. (LLM, conf=0.75)

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Cited by

Sorted by citations

Authors
Parry, S. M., & Puthucheary, Z. A.
Affiliations
  • The University of Melbourne (AU)
  • National University Health System (SG)
Corresponding author
Parry, Selina M.
ORCID
Venue
Extreme Physiology & Medicine
Publisher
Springer Science and Business Media LLC
Published
2015-10-09
Volume
4
Issue
1
Pages
16-16
ISSN
2046-7648 (ISSN-L)
DOI
10.1186/s13728-015-0036-7
PMC
PMC4600281
OpenAlex
W1958567138
Cited by
383
References
7
Citations by year
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FWCI
2.15
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Extreme Physiology & Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
  • UCL Discovery (University College London) (submittedVersion)
  • Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
prolonged bed rest, immobilization, critical illness, musculoskeletal system, muscle mass loss, bone mineral density, critical illness polyneuropathy, critical illness myopathy, intracellular signaling, early mobilization, rehabilitation

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