Cognitive function in diabetes mellitus
Abstract
Diabetes mellitus is characterized by recurrent metabolic abnormalities which postmortem studies suggest might be associated with degenerative changes in the central nervous system. Acute hypoglycemia does indeed lead to cognitive impairment, whereas acute hyperglycemia in the absence of ketoacidosis or hyperosmolarity does not. Insulin-dependent diabetes mellitus is associated with cognitive deficits that tend to be relatively slight, inconsistent between different studies, and unrelated to clinical indicators; they can be ascribed as plausibly to psychogenic factors as to degenerative disease. In contrast, cognitive impairment in noninsulin-dependent diabetes mellitus is more conspicuous in tests of learning and memory, consistently associated with a patient's level of glycemic control, and more plausibly to be ascribed to structural neuropathology. Nevertheless, in both cases the deficits in question are unlikely to interfere significantly with patients' everyday functioning.
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There is a growing literature indicating that individuals with diabetes have impairments in recent memory.
“There is a growing literature indicating that individuals with diabetes have impairments in recent memory (3–6).”
From Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly (2003) · cites this paper as [3]
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- Authors
- Richardson, J. T. E.
- Affiliations
- Brunel University of London (GB)
- Corresponding author
- Richardson, John T.E.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 14
- Issue
- 4
- Pages
- 385-388
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2009662734
- Cited by
- 75
- References
- 60
- Citations by year
- 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Open Research Online - ORO (The Open University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- diabetes mellitus, cognitive impairment, type 1 diabetes, type 2 diabetes, hypoglycemia, hyperglycemia, glycemic control, learning and memory, central nervous system degeneration, neuropathology, psychogenic factors
- MeSH terms
- Cognition Disorders, Diabetes Mellitus, Humans, Diabetes Complications
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