Alcohol consumption and the 5-year incidence of age-related maculopathy
Abstract
Objective This study evaluated alcohol consumption as a risk factor for incidence of age-related maculopathy (ARM).Design Persons aged 43 to 86 years in 1988 in Beaver Dam, Wisconsin, were examined from 1988 through 1990 and 1993 through 1995, n = 3684. The presence and severity of ARM at both examinations were determined from gradings of stereoscopic fundus photographs using the Wisconsin Age-related Maculopathy Classification System. Alcohol consumption was determined by self-report.Results Men drinking at least 78 g/week of alcohol from beer had a higher 5-year age-adjusted incidence of early ARM (10.6%) than did men who did not drink beer (6.9%), but the test for trend was only borderline significant (P = 0.08). However, incidence of soft indistinct drusen (P = 0.01), increased drusen area (P < 0.01), and confluent drusen (P = 0.02) are all associated with beer drinking in men. Increased retinal pigment and retinal pigment epithelial depigmentation are not associated with beer drinking in men or women nor are any lesions associated with total alcohol consumption or consumption from liquor or wine in either men or women.Conclusions Except for an association of beer drinking with retinal drusen in men, consumption of alcoholic beverages is not likely to be an important risk factor for incidence of ARM.
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Additional environmental factors that may influence AMD pathogenesis include sunlight exposure, alcohol use, and infection of bacterial pathogens, particularly Chlamydia pneumoniae.
“Additional environmental factors that may influence AMD pathogenesis include sunlight exposure (33, 35, 85), alcohol use (23, 24, 114), and infection of bacterial pathogens (particularly Chlamydia pneumoniae) (11, 76, 81).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [114]
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- Authors
- Moss, S. E., Klein, R., Klein, B. E. K., Jensen, S. C., & Meuer, S. M.
- Affiliations
- University of Wisconsin–Madison (US)
- ORCID
- Meuer, Stacy M
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 105
- Issue
- 5
- Pages
- 789-794
- ISSN
- 0161-6420 (ISSN-L)
- OpenAlex
- W2181480652
- Cited by
- 49
- References
- 35
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2013: 2 · 2012: 2
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY O6594, U10EY006594)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- age-related maculopathy, alcohol consumption, beer drinking, retinal drusen, risk factors, incidence, sex differences
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alcohol Drinking, Female, Humans, Macular Degeneration, Male, Middle Aged, Prospective Studies, Risk Factors, Wisconsin, Retinal Drusen, Incidence, Disease Progression
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