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Cited by 136Retinal Diseases and TreatmentsRetinal Imaging and AnalysisDementia and Cognitive Impairment Research

Risk factors for age‐related maculopathy in a 14‐year follow‐up study: the Copenhagen City Eye Study

Buch, Helena, Vinding, Troels, La Cour, Morten, Jensen, Gorm B., Prause, Jan U., Nielsen, Niels V.·2005·Acta Ophthalmologica Scandinavica
DOI 10.1111/j.1600-0420.2005.00492.x
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Abstract

Abstract.: Purpose: To examine the association between potential risk factors and the 14‐year incidence of age‐related maculopathy (ARM). Design: Population‐based cohort study. Participants: At baseline, 946 volunteers participated in the study during 1986−88. These subjects were between 60 and 80 years of age and lived in the Østerbro district of Copenhagen. Excluding participants who had died since baseline, 359 subjects (97.3% of survivors) were re‐examined 14 years later, during 2000−2002. A total of 31.8% (301/946) of the original material was included in the risk factor analyses. Methods: Participants underwent an ophthalmological examination at Rigshos‐pitalet, the National University Hospital of Copenhagen. Similar standardized protocols for physical examination were used at the baseline and follow‐up examinations. Age‐related maculopathy lesions were determined by the same grader grading colour fundus photographs from both examinations using a modification of the Wisconsin Age‐related Maculopathy Grading System protocol. Results: Of the 359 participants, 94 had incident early ARM and 52 had incident late ARM at follow‐up in either eye. In logistic regression, the risk factors for early ARM or worse were as follows: cataract (odds ratio [OR] 2.8, 95% confidence interval [CI] 1.2–6.2); family history of ARM (OR 4.5, 95% CI 1.3–15.5), and alcohol consumption > 250 g/week (OR 4.6, 95% CI 1.1–19.2). High levels of apolipoprotein B (> 100 mg/l) decreased the risk of development of early ARM or worse (OR 0.4, 95% CI 0.2–0.8), while high levels of apolipoprotein A1 (≥ 150 mg/l) increased the risk of late ARM (OR 2.5, 95% CI 1.2–5.3). Advanced age at baseline was also associated with the incidence of late ARM (OR 2.0, 95% CI 1.4–2.9). Conclusions: These findings indicate a direct correlation between age, cataract, family history, alcohol consumption, the apolipoproteins A1 and B and the 14‐year incidence of ARM.

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  • The systematic review included 18 prospective and cross-sectional studies and 8 case control studies, contributing 94,058 patients and 3,178 late AMD cases.

    “In total, data from 18 prospective, cross-sectional studies and 8 case control studies [12,24-26,28,30,31,33-47,49-54,57-73] were included in the final analysis, contributing a sample of some 94,058 patients (ranging from 261 to 22,071) including 3,178 (ranging from 8 to 776) late AMD cases.”

    From Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis (2010) · cites this paper as [33]

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Authors
Buch, H., Vinding, T., La Cour, M., Jensen, G. B., Prause, J. U., & Nielsen, N. V.
Affiliations
  • Copenhagen University Hospital (DK)
  • Rigshospitalet (DK)
  • Bispebjerg Hospital (DK)
Corresponding author
Buch, Helena
ORCID
Jensen, Gorm B.
Venue
Acta Ophthalmologica Scandinavica
Publisher
Wiley
Published
2005-07-19
Volume
83
Issue
4
Pages
409-418
ISSN
  • 1395-3907 (ISSN-L)
  • 1600-0420
DOI
10.1111/j.1600-0420.2005.00492.x
OpenAlex
W1520662388
Cited by
136
References
90
Citations by year
2026: 3 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 4 · 2012: 12
FWCI
7.64
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Ophthalmologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • Velux Stiftung
  • Ögonfonden
  • Danish Eye Research Foundation
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
age-related maculopathy, risk factors, cataract, family history (medicine), alcohol consumption, apolipoprotein B, apolipoprotein A-I, old age, incidence, older adults, serum lipids, cardiovascular risk
MeSH terms
Aged, Aged, 80 and over, Denmark, Female, Follow-Up Studies, Humans, Macular Degeneration, Male, Middle Aged, Risk Factors, Incidence, Odds Ratio, Age Distribution, Sex Distribution

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