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Cited by 161Mental Health Treatment and AccessTuberculosis Research and EpidemiologyAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Depression, anxiety comorbidity, and disability in tuberculosis and chronic obstructive pulmonary disease patients: applicability of GHQ-12

Orhan Aydin, Ismail, Uluşahin, Aylin·2001·General Hospital Psychiatry
DOI 10.1016/s0163-8343(01)00116-5
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Abstract

Our aim was to study anxiety and/or depression comorbidity and the influence of these comorbid conditions on disability for 3 clinical groups of pulmonary tuberculosis and chronic obstructive pulmonary disease (COPD). We also investigated the applicability of General Health Questionnaire 12 (GHQ12) for these clinical groups as a simple screening test for psychiatric comorbidity. A total of 157 male inpatients were included in the study: 42 with recently diagnosed (RDtb), 39 with defaulted (Dtb), 39 with multidrug resistant tuberculosis (MDRtb) and 38 with COPD. The presence of depression and anxiety was assessed by Composite International Diagnostic Interview (CIDI). Disability was evaluated by Brief Disability Questionnaire. The validity of GHQ12 for the study groups was examined in order to determine a functional cut-off point. Depression and/or anxiety comorbidity was 19% for RDtb, 21.6% for Dtb, 25.6% for MDRtb and 47.3% for COPD. Patients with psychiatric comorbidity had higher disability scores than the group without psychiatric comorbidity. For the tuberculosis group a 3/4 cut-off point of GHQ had 80.7% sensitivity and 87.1% specificity while a 5/6 cut-off point with 83.3% sensitivity and 80% specificity was applicable to the COPD group.

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Crossref · 10.1016/s0163-8343(01)00116-5

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  • In stable COPD, the prevalence of clinical depression ranges between 10% and 42%.

    “In stable COPD, the prevalence of clinical depression ranges between 10% and 42%, while that of anxiety ranges between 10% and 19% (Table 2).6–25”

    From Anxiety and Depression in COPD (2008) · cites this paper as [11]

  • In stable COPD, the prevalence of anxiety ranges between 10% and 19%.

    “In stable COPD, the prevalence of clinical depression ranges between 10% and 42%, while that of anxiety ranges between 10% and 19% (Table 2).6–25”

    From Anxiety and Depression in COPD (2008) · cites this paper as [11]

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Authors
Orhan Aydin, I., & Uluşahin, A.
Affiliations
Hacettepe University (TR)
Corresponding author
Uluşahin, Aylin
Venue
General Hospital Psychiatry
Publisher
Elsevier BV
Published
2001-03
Volume
23
Issue
2
Pages
77-83
ISSN
0163-8343 (ISSN-L)
DOI
10.1016/s0163-8343(01)00116-5
OpenAlex
W2070878359
Cited by
161
References
33
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 11 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 7 · 2012: 10
FWCI
2.74
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • General Hospital Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Environmental Research and Education Foundation
Topics
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
depression, anxiety, psychiatric comorbidity, tuberculosis, chronic obstructive pulmonary disease, disability, GHQ-12, screening validity, multidrug-resistant tuberculosis, treatment default, Composite International Diagnostic Interview
MeSH terms
Adult, Aged, Anxiety, Cross-Sectional Studies, Depression, Humans, Lung Diseases, Obstructive, Male, Mass Screening, Middle Aged, Psychiatric Status Rating Scales, Sensitivity and Specificity, Tuberculosis, Pulmonary, Turkey, Comorbidity

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