Untreated depression and tuberculosis treatment outcomes, quality of life and disability, Ethiopia
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OBJECTIVE: To investigate the association between comorbid depression and tuberculosis treatment outcomes, quality of life and disability in Ethiopia. METHODS: The study involved 648 consecutive adults treated for tuberculosis at 14 primary health-care facilities. All were assessed at treatment initiation (i.e. baseline) and after 2 and 6 months. We defined probable depression as a score of 10 or above on the nine-item Patient Health Questionnaire. Data on treatment default, failure and success and on death were obtained from tuberculosis registers. Quality of life was assessed using a visual analogue scale and we calculated disability scores using the World Health Organization's Disability Assessment Scale. Using multivariate Poisson regression analysis, we estimated the association between probable depression at baseline and treatment outcomes and death. RESULTS: < 0.001) at 6 months. CONCLUSION: Untreated depression in people with tuberculosis was associated with worse treatment outcomes, poorer quality of life and greater disability. Health workers should be given the support needed to provide depression care for people with tuberculosis.
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Untreated depression at baseline is independently associated with greater disability, poorer quality of life, TB treatment default and negative TB treatment outcomes.
“Untreated depression at baseline is independently associated with greater disability, poorer quality of life,12,13 TB treatment default12 and negative TB treatment outcomes.14”
From Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review (2021) · cites this paper as [12]
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- Authors
- Ambaw, F., Mayston, R., Hanlon, C., Medhin, G., & Alem, A.
- Affiliations
- Bahir Dar University (ET)
- King's College London (GB)
- Addis Ababa University (ET)
- Corresponding author
- Ambaw, Fentie
- Venue
- Bulletin of the World Health Organization
- Publisher
- WHO Press
- Published
- 2018-02-05
- Volume
- 96
- Issue
- 4
- Pages
- 243-255
- ISSN
- 0042-9686 (ISSN-L)
- PMC
- PMC5872008
- OpenAlex
- W2795341950
- Cited by
- 98
- References
- 46
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 13 · 2023: 7 · 2022: 12 · 2021: 17 · 2020: 14 · 2019: 14 · 2018: 5 · 2017: 1
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Bulletin of the World Health Organization (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Funders
- European Commission
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- depression, tuberculosis, comorbidities, tuberculosis treatment outcomes, treatment default, treatment failure, mortality, quality of life, disability, primary care, Ethiopia
- MeSH terms
- Adolescent, Adult, Antitubercular Agents, Depression, Ethiopia, Female, Persons with Disabilities, Humans, Male, Quality of Life, Tuberculosis, Comorbidity, Treatment Outcome
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