Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety
Abstract
According to "The Neuropsychology of Anxiety" [Gray, J.A., 1982, The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, Oxford University Press, Oxford; Gray, J.A., McNaughton, N., 2000, The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, 2nd ed., Oxford University Press, Oxford], anxiolytic drugs of all types act on a behavioural inhibition system, the most important neural component of which is the septo-hippocampal system. Anxiolytics affect septo-hippocampal function by impairing the subcortical control of hippocampal "theta" activity - the principle response of the septo-hippocampal system to arousal. Our recent experiments show that there are multiple systems controlling theta activity and that anxiolytics act on several, but not all, of these systems. This pattern of results implies that there are many different types of arousal, only some of which appear to contribute to the generation of anxiety in normal subjects and to the etiology of pathological anxiety.
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McNaughton and Gray suggest this mechanism within their model of a behavioral inhibition system.
“McNaughton and Gray (2000) suggest this mechanism within their model of a behavioral inhibition system.”
From Extension of the Transdiagnostic Model to Focus on Intolerance of Uncertainty: A Review of the Literature and Implications for Treatment (2014) · cites this paper as McNaughton and Gray (2000)
When a discrepancy is noted, the comparator system may halt the current program in an attempt to resolve the mismatch and alter the individual's actions.
“When a discrepancy is noted, the comparator system may halt the current program in an attempt to resolve the mismatch and alter the individual’s actions.”
From Extension of the Transdiagnostic Model to Focus on Intolerance of Uncertainty: A Review of the Literature and Implications for Treatment (2014) · cites this paper as McNaughton and Gray, 2000
The comparator system compares what is perceived (actual events) to what is desired (expected events).
“they outline a “comparator of inputs” which compares what is perceived (actual events) to what is desired (expected events).”
From Extension of the Transdiagnostic Model to Focus on Intolerance of Uncertainty: A Review of the Literature and Implications for Treatment (2014) · cites this paper as McNaughton and Gray, 2000
Decreases in theta power in the vHIP occur after anxiolytic drug administration.
“with decreases in theta power in the vHIP occurring after anxiolytic drug administration (19)”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [19]
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- Authors
- McNaughton, N., & Gray, J. A.
- Affiliations
- University of Otago (NZ)
- Maudsley Hospital (GB)
- Corresponding author
- McNaughton, Neil
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 61
- Issue
- 3
- Pages
- 161-176
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2056637988
- Cited by
- 553
- References
- 43
- Citations by year
- 2026: 23 · 2025: 32 · 2024: 22 · 2023: 24 · 2022: 33 · 2021: 37 · 2020: 24 · 2019: 17 · 2018: 28 · 2017: 20 · 2016: 25 · 2015: 25 · 2014: 26 · 2013: 34 · 2012: 13
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anxiolytics, behavioral inhibition system, septo-hippocampal system, hippocampal theta activity, arousal, anxiety
- MeSH terms
- Amygdala, Animals, Anxiety Disorders, Arousal, Feedback, Hippocampus, Humans, Neural Inhibition, Neural Pathways, Septum Pellucidum, Theta Rhythm, Anti-Anxiety Agents
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