Engineering brain-derived neurotrophic factor mRNA delivery for the treatment of Alzheimer’s disease
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PBAE NPs with BDNF mRNA encapsulated improved synaptic markers and behavioral outcomes in APP/PS1 double transgenic AD model mice.
“(iii) improved synaptic markers and behavioral outcomes in APP/PS1 double transgenic AD model mice.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [103]
PBAE NPs with BDNF mRNA encapsulated increased BDNF expression, confirmed by translation of BDNF mRNA into protein in 293T cells and astrocytes and by functional release and neuronal activation in a transwell co-culture model.
“Results demonstrated: (i) an increase in BDNF expression, confirmed by translation of the BDNF mRNA into protein in 293T cells and astrocytes and by functional release and neuronal activation in a transwell co-culture model;”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [103]
Astrocyte-derived BDNF effectively protects neurons from Aβ-induced toxicity, restoring both cell viability and neuron proliferation in an in vitro transwell co-culture model.
“(ii) astrocyte-derived BDNF effectively protects neurons from Aβ-induced toxicity, restoring both cell viability and neuron proliferation in an in vitro transwell co-culture model;”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [103]
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- Authors
- Li, H., Cao, Y., Ye, J., Yang, Z., Chen, Q., Liu, X., Zhang, B., Qiao, J., Tang, Q., Yang, H., Li, J., Shi, Z., & Mao, Y.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- ShanghaiTech University (CN)
- University of Edinburgh (GB)
- Fudan University (CN)
- Shanghai Chest Hospital (CN)
- Corresponding author
- Shi, Zhifeng
- Mao, Ying
- Venue
- Chemical Engineering Journal
- Publisher
- Elsevier BV
- Published
- 2023-06
- Volume
- 466
- Pages
- 143152
- ISSN
- 1385-8947 (ISSN-L)
- OpenAlex
- W4366748085
- Cited by
- 32
- References
- 55
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 11 · 2023: 3
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemical Engineering Journal (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- brain-derived neurotrophic factor, Alzheimer's disease, mRNA delivery, poly(β-amino ester), sustained protein release, memory enhancement, seizures, neurodegenerative disease treatment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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