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New evidence for neurotransmitter influences on brain development
Abstract
The early appearance of monoamine systems in the developing mammalian CNS suggests that they play a role in neural development. We review data from two model systems that provide compelling new evidence of this role. In one model system-in utero exposure to cocaine-specific and robust alterations are seen in dopamine-rich areas of the cerebral cortex, such as the anterior cingulate cortex: D1 receptor-G protein coupling is greatly reduced, the GABAergic system is altered and pyramidal dendrites undergo excessive growth. In a second model system-a transgenic mouse line in which the gene that encodes monoamine oxidase A (MAOA) is disrupted, resulting in excessively high 5-HT levels-barrels fail to form in the developing somatosensory cortex. Both models reveal the effects of very early manipulation of monoamines on forebrain development, and the long-term anomalies that persist into adulthood.
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Effects of Psychostimulant Drugs on Developing Brain
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Metadata
- Authors
- Levitt, P., Harvey, J. A., Friedman, E., Simansky, K., & Murphy, E. H.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 20
- Issue
- 6
- Pages
- 269-274
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2167345246
- Cited by
- 362
- References
- 86
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 11 · 2012: 11
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01da006871-04)
- National Institute on Drug Abuse (P01DA06871)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- monoaminergic systems, brain development, dopamine, dopamine D1 receptor, G protein coupling, GABAergic system, anterior cingulate cortex, monoamine oxidase A, serotonin, somatosensory cortex, transgenic mice, forebrain development, developmental neurotoxicity
- MeSH terms
- Animals, Brain, Cocaine, Female, Mice, Transgenic, Pregnancy, Prenatal Exposure Delayed Effects, Neurotransmitter Agents, Mice
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