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New evidence for neurotransmitter influences on brain development
Abstract
The early appearance of monoamine systems in the developing mammalian CNS suggests that they play a role in neural development. We review data from two model systems that provide compelling new evidence of this role. In one model system-in utero exposure to cocaine-specific and robust alterations are seen in dopamine-rich areas of the cerebral cortex, such as the anterior cingulate cortex: D1 receptor-G protein coupling is greatly reduced, the GABAergic system is altered and pyramidal dendrites undergo excessive growth. In a second model system-a transgenic mouse line in which the gene that encodes monoamine oxidase A (MAOA) is disrupted, resulting in excessively high 5-HT levels-barrels fail to form in the developing somatosensory cortex. Both models reveal the effects of very early manipulation of monoamines on forebrain development, and the long-term anomalies that persist into adulthood.
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“Specific genes (e.g., 5-HTTLPR; (112, 113)) influencing neuromaturation have known associations with self-injurious behaviors (114, 115).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [113]
Citations
Cites
(2005) · Choice Reviews Online · doi:10.5860/choice.43-0626 · Cited by 4,726
Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
Psychopharmacology: The Third Generation of Progress.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530
Neuronal migration, with special reference to developing human brain: a review
Sidman, R. L., & RAKIC, P. T. (1973) · Brain Research · doi:10.1016/0006-8993(73)90617-3 · Cited by 1,260
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Lipsitt, L. P., & Rovee‐Collier, C. (1981) · Ablex Publishing Corp. eBooks · Cited by 1,146
Moore, R. Y., & Bloom, F. E. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.000553 · Cited by 1,118
Research works printed but not linked: 13
- Olsen, 1995, Neurotoxicology, 16, 159
- Spear, 1995, Vol. 9, 55
- Seidler, 1992, J. Pharmacol. Exp. Ther., 263, 413
- Battaglia, 1995, NIDA Res. Monogr. Ser., 158, 115
- Lidow, 1994, Soc. Neurosci. Abstr., 20, 596
- Murphy, 1995, Lab. Anim. Sci., 45, 163
- Breslin, N.A. and Weinberger, D.R. (1991) in Fetal Neural Development and Adult Schizophrenia (Mednick, S.A. et al., eds), pp. pp. 199–215, Cambridge University Press
- Wang, 1997, Exp. Brain Res., 112, 359
- Murphy, E.H. et al. Exp. Brain Res. (in press)
- Wang, 1995, J. Pharmacol. Exp. Ther., 273, 492
- Grayson, 1941, Soc. Neurosci. Abstr., 22
- Wang, 1996, Brain Res., 715, 221, 10.1016/0006-8993(96)00012-1 · DOI
- Goldberg, 1989, Dev. Biol., 141, 438
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Rodrigues, W. D. S., Oliveira-Silva, P., Faria‐Melibeu, A. D. C., Campello‐Costa, P., & Serfaty, C. A. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.047 · Cited by 3
Chapter 4.9 Methodological issues in the assessment of behavioral development in laboratory mice
Wainwright, P. E. (1999) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(99)80055-8 · Cited by 3
Shumsky, J. S., Wu, Y., Murphy, E. H., Nissanov, J., & Grayson, D. R. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09758.x · Cited by 3
Segawa, M., & Nomura, Y. (1998) · Advances in behavioral biology · doi:10.1007/978-1-4615-5337-3_51 · Cited by 3
Endocannabinoids and Dopamine-Related Functions in the CNS
de Miguel, R., Ramos, J. A., Cebeira, M., Hernández, M., & Fernández‐Ruíz, J. (2005) · CRC Press eBooks · doi:10.1201/9781420023640.ch11 · Cited by 3
Horackova, H., Musilova, I. K., Abad, C., Karahoda, R., Váchalová, V., Portillo, R., Viñas-Noguera, M., Anandam, K. Y., Heblik, D., Cífková, E., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118680 · Cited by 3
Palacios-Avendaño, N., Rojas, P. S., Alarcón-Mardones, M., & Fiedler, J. L. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1800447 · Cited by 4
Arterial spin labeling perfusion magnetic resonance imaging in developmental neuroscience
Wang, J.-J., Rao, H., & Detre, J. A. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511757402.026 · Cited by 2
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Carcoba, L. M., SANTIAGO, M., Moss, D. E., & Cabeza, R. D. J. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.09.008 · Cited by 2
Maternidad, infancia y drogas: implicaciones clínicas
Botella, H. C. (2004) · Adicciones · doi:10.20882/adicciones.395 · Cited by 2
Developmental roles for the serotonin transporter
Persico, A. M. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511729935.004 · Cited by 3
Wainwright, P. E., & Martin, D. (2005) · Cited by 2
Ishizuka, T., Ozawa, A., Katsuura, M., Nomura, S., & Satoh, Y. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12993 · Cited by 2
Suter, B., & Bhide, P. G. (2006) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195183139.003.0002 · Cited by 2
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Pavone, L. M., Mithbaokar, P., Mastellone, V., Muto, R. L., Spina, A., Maharajan, V., PAINO, G., & Avallone, L. (2008) · Veterinary Research Communications · doi:10.1007/s11259-008-9109-z · Cited by 2
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Homer, R. (2003) · International Joint Conference on Neural Networks (IJCNN) · doi:10.1109/ijcnn.1999.831464 · Cited by 1
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Nakamura, K., & Hasegawa, H. (2009) · The Open Neuroscience Journal · doi:10.2174/1874082000903010035 · Cited by 1
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Pryweller, J. R. (2006) · Vanderbilt Undergraduate Research Journal · doi:10.15695/vurj.v2i0.2751 · Cited by 1
Erdem, M., Kara, K., & Karaman, D. (2013) · Cited by 1
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Urbach‐Ross, D., & Thiruchelvam, M. J. (2010) · doi:10.1002/9780470917060.ch13 · Cited by 1
Reynell, C. (2013) · UCL Discovery (University College London) · Cited by 1
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Ahmari, S. E., Alter, M. D., & Hen, R. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00834-2 · Cited by 1
Feng, P. (2004) · Lung biology in health and disease · doi:10.1201/b14100-8 · Cited by 1
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Stoyanova, I. I., le Feber, J., Wiertz, R. W. F., & Rutten, W. L. C. (2009) · University of Twente Research Information
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Scherer, E. B. D. S. (2010) · Americanae (AECID Library)
Proteome changes associated with developmental defects following perinatally acquired brain damage
Kaindl, A. M. (2009) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-16753
Clark, D. L., Boutros, N. N., & Mendez, M. F. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543661.004
Bayer, L. E. (2008) · eCommons (Cornell University)
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Daniel, J. J. (2011) · UC Research Repository (University of Canterbury) · doi:10.26021/7388
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Arain, F. M. (2010)
Mierzewska, H., Szczepanik, E., & Sykut‐Cegielska, J. (2007)
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Vanhatalo, S., & Soinila, S. O. (1999) · Nutritional Neuroscience · doi:10.1080/1028415x.1999.11747294
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Gressèns, P., Sfaello, I., & Evrard, P. (2006) · CRC Press eBooks · doi:10.1201/b14101-33
Price, J. S. (2010) · OhioLink ETD Center (Ohio Library and Information Network)
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Segawa, M. (1999) · Springer eBooks · doi:10.1007/978-4-431-68373-5_104
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Lavdas, A. Α. (1997) · OpenGrey (Institut de l'Information Scientifique et Technique)
Ramkissoon, A. (2012) · TSpace (University of Toronto)
Santis, M. D. (2018) · Research Online (University of Wollongong)
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Monti, S. F. (2019) · Digital Commons-DePaul (DePaul University)
Байрамов, А. А., Proshin, S. N., Gavrilov, N., Losev, N. A., & Сапронов, Н. С. (2010) · Medical academic journal · doi:10.17816/maj10131-38
Shi, Y., van Rhijn, J.-R., Bormann, M., Mossink, B., Frega, M., Recaioglu, H., Hakobjan, M., Gunnewiek, T. M. K., Schoenmaker, C., Palmer, E. E., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.28.359224
Lamberink, H. J. (2021) · Utrecht University Repository (Utrecht University) · doi:10.33540/431
Alkaloid avoidance in poison frog tadpolesPreprint
Sanchez, E., Ramirez, T., & O’Connell, L. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.12.476122
Clark, D. L., Boutros, N. N., & Mendez, M. F. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511776915.005
Bajjalieh, S., & Yao, J. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13371155.14742090
Role of Dietary Polyunsaturated Fatty Acids in Brain and Cognitive Function
Martin, D., & Wainwright, P. E. (2005) · Nutrition, brain, and behavior./Nutrition, brain and behavior · doi:10.1201/9780203564554.ch11
Cezar, L. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2022.tde-20012023-112002
Prenatal Cocaine Exposure as a Risk Factor for Later Developmental Outcomes
Stanwood, G. D., & Levitt, P. R. (2001) · JAMA · doi:10.1001/jama.286.1.45-c
Yang, X., Agartz, I., Andreassen, O. A., Bachman, P., Baeza, I., Bartholomeusz, C., Borgwardt, S., Choi, S., Colibazzi, T., Cooper, R. E., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03586-4
Singh, K. P., & Dubey, A. (2026) · Neurotoxicity Research · doi:10.1007/s12640-026-00820-3
Craig, A. M., Clemens, K. J., & Leigh, S. (2026) · Clinical Science · doi:10.1042/cs20250049
Metadata
- Authors
- Levitt, P., Harvey, J. A., Friedman, E., Simansky, K., & Murphy, E. H.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 20
- Issue
- 6
- Pages
- 269-274
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2167345246
- Cited by
- 362
- References
- 86
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 11 · 2012: 11
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01da006871-04)
- National Institute on Drug Abuse (P01DA06871)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- monoaminergic systems, brain development, dopamine, dopamine D1 receptor, G protein coupling, GABAergic system, anterior cingulate cortex, monoamine oxidase A, serotonin, somatosensory cortex, transgenic mice, forebrain development, developmental neurotoxicity
- MeSH terms
- Animals, Brain, Cocaine, Female, Mice, Transgenic, Pregnancy, Prenatal Exposure Delayed Effects, Neurotransmitter Agents, Mice
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