In vitro inhibition of the replication of haemorrhagic septicaemia virus (VHSV) and African swine fever virus (ASFV) by extracts from marine microalgae
Open accessAbstract
We have screened for in vitro inhibition of viral replication with extracts from the following marine microalgae: Porphyridium cruentum, Phaeodactylum tricornutum, Tetraselmis suecica, Chlorella autotrophica, Dunaliella tertiolecta, Dunaliella bardawil, Isochrysis galbana, Isochrysis galbana var Tiso, Ellipsoidon sp. and Tetraselmis tetrathele. We have used as viral models two enveloped viruses of significant economic importance, the viral hemorrhagic septicemia virus (VHSV) of salmonid fish and the African swine fever virus (ASFV). The aqueous extracts from P. cruentum, C. autotrophica and Ellipsoidon sp., produced a significant inhibition of the in vitro replication of both viruses in a dose-dependent manner. That this inhibition could be due to sulfated polysaccharides was suggested because the same pattern of viral inhibition was obtained by using exocellular extracts from microalgae enriched in these compounds and/or dextran sulfate of high molecular weight. However, the inhibition of viral replication did not correlate with the percentage of sulfatation of the exocellular polysaccharides. Extracts from marine microalgae may have prophylactic utility against fish and mammalian viral diseases.
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- Authors
- Fabregas, J., Garcı́a, D., Fernandez-Alonso, M., Rocha, A. I., Gómez-Puertas, P., Escribano, J. M., Otero, A., & Coll, J. M.
- Affiliations
- Universidade de Santiago de Compostela (ES)
- Centro de Investigación en Sanidad Animal (ES)
- Corresponding author
- Coll, J.M.
- Venue
- Antiviral Research
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 44
- Issue
- 1
- Pages
- 67-73
- ISSN
- 0166-3542 (ISSN-L)
- OpenAlex
- W2037625831
- Cited by
- 144
- References
- 27
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 7 · 2023: 14 · 2022: 11 · 2021: 16 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 10 · 2012: 3
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Antiviral Research (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Keywords
- African swine fever virus, antiviral activity, viral replication inhibition, sulfated polysaccharides, dextran sulfate, Porphyridium cruentum, swine viral disease, prophylaxis
- MeSH terms
- African Swine Fever Virus, Animals, Antiviral Agents, Rhabdoviridae, Tumor Cells, Cultured, Virus Replication, Eukaryota
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