Cited by 144Seaweed-derived Bioactive CompoundsAquaculture disease management and microbiotaBacteriophages and microbial interactions

In vitro inhibition of the replication of haemorrhagic septicaemia virus (VHSV) and African swine fever virus (ASFV) by extracts from marine microalgae

Open access
Fabregas, J., Garcı́a, D., Fernandez-Alonso, M., Rocha, A.I., Gómez-Puertas, P., Escribano, J.M., Otero, A., Coll, J.M.·1999·Antiviral Research

Abstract

We have screened for in vitro inhibition of viral replication with extracts from the following marine microalgae: Porphyridium cruentum, Phaeodactylum tricornutum, Tetraselmis suecica, Chlorella autotrophica, Dunaliella tertiolecta, Dunaliella bardawil, Isochrysis galbana, Isochrysis galbana var Tiso, Ellipsoidon sp. and Tetraselmis tetrathele. We have used as viral models two enveloped viruses of significant economic importance, the viral hemorrhagic septicemia virus (VHSV) of salmonid fish and the African swine fever virus (ASFV). The aqueous extracts from P. cruentum, C. autotrophica and Ellipsoidon sp., produced a significant inhibition of the in vitro replication of both viruses in a dose-dependent manner. That this inhibition could be due to sulfated polysaccharides was suggested because the same pattern of viral inhibition was obtained by using exocellular extracts from microalgae enriched in these compounds and/or dextran sulfate of high molecular weight. However, the inhibition of viral replication did not correlate with the percentage of sulfatation of the exocellular polysaccharides. Extracts from marine microalgae may have prophylactic utility against fish and mammalian viral diseases.

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Crossref · 10.1016/s0166-3542(99)00049-2

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Authors
Fabregas, J., Garcı́a, D., Fernandez-Alonso, M., Rocha, A. I., Gómez-Puertas, P., Escribano, J. M., Otero, A., & Coll, J. M.
Affiliations
  • Universidade de Santiago de Compostela (ES)
  • Centro de Investigación en Sanidad Animal (ES)
Corresponding author
Coll, J.M.
Venue
Antiviral Research
Publisher
Elsevier BV
Published
1999-11
Volume
44
Issue
1
Pages
67-73
ISSN
0166-3542 (ISSN-L)
OpenAlex
W2037625831
Cited by
144
References
27
Citations by year
2026: 5 · 2025: 8 · 2024: 7 · 2023: 14 · 2022: 11 · 2021: 16 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 10 · 2012: 3
FWCI
1.46
Type
journal article
Language
en
Open access
Locations
  • Antiviral Research (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
  • Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
Keywords
African swine fever virus, antiviral activity, viral replication inhibition, sulfated polysaccharides, dextran sulfate, Porphyridium cruentum, swine viral disease, prophylaxis
MeSH terms
African Swine Fever Virus, Animals, Antiviral Agents, Rhabdoviridae, Tumor Cells, Cultured, Virus Replication, Eukaryota

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