Cancer Protective Action of Polysaccharide, Derived from Red Microalga Porphyridium Cruentum—A Biological Background
Abstract
The cell wall sulfated polysaccharide of the red microalga Porphyridium cruentum (Rhodophyta) (PcrPSH) exhibited strong antitumor activity against Graffi myeloid tumor in hamsters both in vitro and in vivo. When tested in vivo, depending on the concentration and the way of application, this polysaccharide decreased transplantability in all experimental groups till 20 days of observation and mortality rate. The tumor growth was retarded and the mean survival time was prolonged with 10 - 16 days. Applied in in vitro experiments the PcrPSH increased both—spreading and phagocytic ability of peritoneal macrophages from healthy and Graffi tumor bearing hamsters in a dose—dependent manner. Primary Graffi tumor cell culture, cultivated in the presence of PcrPSH showed significant decrease of cell viability, determined by MTT test, while in cells derived from bone marrow it was increased at the same conditions of cultivation and concentration of polysaccharide. Primary Graffi tumor cell culture, treated with PcrPSH showed the appearance of a characteristic DNA ladder on agarose gel electrophoresis, which is a biochemical hallmark of apoptosis. The manifested anticancer activity of PcrPSH could be associated with its immunostimulating action as well as with direct cytotoxic properties. Based on these results, we could suggest that the tested algal PcrPSH is a promising candidate as an antitumor agent. Further studies will be done to clarify the mechanisms of a biological action of PcrPSH.
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Cancer preventive action of the oligosaccharide derived from the microalga P. cruentum was reported.
“Cancer preventive action of the oligosaccharide derived from the microalga P. cruentum was reported [123].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [123]
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- Authors
- Gardeva, E., Toshkova, R., Minkova, K., & Gigova, L.
- Affiliations
- Bulgarian Academy of Sciences (BG)
- Corresponding author
- Gardeva, E.
- ORCID
- Toshkova, R.
- Venue
- Biotechnology & Biotechnological Equipment
- Publisher
- Informa UK Limited
- Published
- 2009-01
- Volume
- 23
- Issue
- sup1
- Pages
- 783-787
- ISSN
- 1310-2818 (ISSN-L)
- 1314-3530
- OpenAlex
- W2045348116
- Cited by
- 76
- References
- 21
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 15 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology & Biotechnological Equipment (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- Porphyridium cruentum, sulfated polysaccharides, red microalgae, anticancer activity, hamster tumor model, peritoneal macrophages, phagocytosis, apoptosis, immunostimulation, cytotoxicity, algal polysaccharides, anticancer agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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