Cited by 108Down syndrome and intellectual disability researchMemory and Neural MechanismsAlzheimer's disease research and treatments

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Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function

Hyde, Lynn A, Frisone, Deborah F, Crnic, Linda S·2001·Behavioural Brain Research

DOI 10.1016/s0166-4328(00)00313-2

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Abstract

The Ts65Dn mouse is segmentally trisomic for a part of mouse chromosome 16 and is a genetic model for Down syndrome and Alzheimer's disease. Although many studies have examined the learning and memory processes in Ts65Dn mice, it has yet to be determined if Ts65Dn mice are specifically impaired in learning tasks that require an intact hippocampus. Context discrimination learning is dependent on the dorsal hippocampus in mice. In this task, mice learn to discriminate two similar contexts, one of which is associated with foot shock. In the current study, Ts65Dn mice learned almost identically to what has been reported for mice with dorsal hippocampal lesions, while controls behaved similarly to sham lesioned mice. Therefore, Ts65Dn mice have learning deficits in a hippocampal dependent task that may be related to the loss of cholinergic input to the hippocampus, which occurs after 6 months of age.

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Authors: Hyde, L. A., Frisone, D. F., & Crnic, L. S.
Affiliations: University of Colorado Anschutz (US)
Corresponding author: Hyde, Lynn A
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2001-01
Volume: 118
Issue: 1
Pages: 53-60
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/s0166-4328(00)00313-2
OpenAlex: W1987268303
Cited by: 108
References: 36
Citations by year: 2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 9
FWCI: 10.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5f32ag005866-02)
National Institute on Aging (AG05866)
National Institute of Mental Health (MH 15442, T32MH015442)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-04024, P30HD004024, HD17449, P01HD017449)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: Ts65Dn mouse model, Down syndrome, hippocampus, dorsal hippocampus, hippocampus-dependent learning, Alzheimer's disease, trisomy, learning deficits
MeSH terms: Age Factors, Animals, Discrimination Learning, Disease Models, Animal, Down Syndrome, Fear, Genotype, Hippocampus, Male, Mice, Neurologic Mutants, Mice

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Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function

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