The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function
Abstract
The Ts65Dn mouse is segmentally trisomic for a part of mouse chromosome 16 and is a genetic model for Down syndrome and Alzheimer's disease. Although many studies have examined the learning and memory processes in Ts65Dn mice, it has yet to be determined if Ts65Dn mice are specifically impaired in learning tasks that require an intact hippocampus. Context discrimination learning is dependent on the dorsal hippocampus in mice. In this task, mice learn to discriminate two similar contexts, one of which is associated with foot shock. In the current study, Ts65Dn mice learned almost identically to what has been reported for mice with dorsal hippocampal lesions, while controls behaved similarly to sham lesioned mice. Therefore, Ts65Dn mice have learning deficits in a hippocampal dependent task that may be related to the loss of cholinergic input to the hippocampus, which occurs after 6 months of age.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Mouse models have provided additional insights into the developmental progression of DS, elucidating specific defects in neurogenesis, neuronal differentiation, and impaired synaptic plasticity and learning (Chakrabarti et al., 2007, 2010; Hyde et al., 2001; Kleschevnikov et al., 2004; Siarey et al., 1997, 1999; Tyler and Haydar, 2013; Wang et al., 2013).”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Hyde et al., 2001
Citations
Cites
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Hippocampus, space, and memory
Olton, D. S., Becker, J. T., & Handelmann, G. E. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00062713 · Cited by 2,018
On the role of the hippocampus in learning and memory in the rat.
Jarrard, L. E. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)90664-4 · Cited by 1,125
A mouse model for Down syndrome exhibits learning and behaviour deficits
Reeves, R. H., Irving, N. G., Moran, T. H., Wohn, A., Kitt, C., Sisodia, S. S., Schmidt, C., Bronson, R. T., & Davisson, M. T. (1995) · Nature Genetics · doi:10.1038/ng1095-177 · Cited by 913
Pittler, S. J., & Baehr, W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8322 · Cited by 562
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome
Holtzman, D. M., Santucci, D., Kilbridge, J., Chua-Couzens, J., Fontana, D. J., Daniels, S. E., Johnson, R. M., Chen, K., Sun, Y., Carlson, E., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13333 · Cited by 448
The dorsal hippocampus is essential for context discrimination but not for contextual conditioning.
Frankland, P. W., Cestari, V., Filipkowski, R. K., McDonald, R. J., & Silva, A. J. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.4.863 · Cited by 410
(1990) · PubMed · Cited by 351
(1993) · PubMed · Cited by 301
Granholm, A., Sanders, L., & Crnic, L. S. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7289 · Cited by 237
Self-citationA behavioral assessment of Ts65Dn mice: a putative Down syndrome model
Escorihuela, R. M., Fernández‐Teruel, A., Vallina, I. F., Baamonde, C., Lumbreras, M., Dierssen, M., Tobeña, A., & Flórez, J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12052-6 · Cited by 234
Hippocampus: cognitive map or working memory?
Nadel, L., & MacDonald, L. (1980) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(80)90430-6 · Cited by 224
Altered long-term potentiation in the young and old Ts65Dn mouse, a model for down syndrome
Siarey, R. J., Stoll, J., Rapoport, S. I., & Galdzicki, Z. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00157-3 · Cited by 222
Hippocampal function required for nonspatial working memory
Olton, D. S., & Feustle, W. A. (1981) · Experimental Brain Research · doi:10.1007/bf00238896 · Cited by 207
Schwegler, H., Crusio, W. E., & Brust, I. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90139-u · Cited by 200
Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
Siarey, R. J., Carlson, E. J., Epstein, C. J., Balbo, A., Rapoport, S. I., & Galdzicki, Z. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00083-0 · Cited by 184
Sago, H., Carlson, E. J., Smith, D., Rubin, E. M., Crnic, L. S., Huang, T., & Epstein, C. J. (2000) · Pediatric Research · doi:10.1203/00006450-200011000-00009 · Cited by 172
Self-citationMotor dysfunction in a mouse model for Down syndrome
Costa, A. C. S., WALSH, K., & Davisson, M. T. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00178-x · Cited by 164
Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of down syndrome.
Insausti, A. M., Megı́as, M., Crespo, D., Cruz-Orive, L. M., Dierssen, M., Vallina, T. F., Insausti, R., & Flórez, J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00641-7 · Cited by 149
Gerlai, R. T. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00144-7 · Cited by 142
Cho, Y. H., Friedman, E., & Silva, A. J. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00054-0 · Cited by 140
Spatial memory deficits in segmental trisomic Ts65Dn mice
Demas, G. E., Nelson, R. J., Krueger, B. K., & Yarowsky, P. (1996) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)81111-4 · Cited by 126
Radial-arm maze behavior by rats with dorsal hippocampal lesions: Effects of cuing.
Winocur, G. (1982) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077882 · Cited by 117
Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome
Dierssen, M., Vallina, I. F., Baamonde, C., Calatayud, S. G., Lumbreras, M., & Flórez, J. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01173-0 · Cited by 101
Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice
Demas, G. E., Nelson, R. J., Krueger, B. K., & Yarowsky, P. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00116-2 · Cited by 101
Klein, S. L., Kriegsfeld, L. J., Hairston, J. E., Rau, V., Nelson, R. J., & Yarowsky, P. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(96)00218-1 · Cited by 56
Davisson, M. T., & Costa, A. C. S. (1999) · Springer eBooks · doi:10.1007/978-1-4615-4887-4_13 · Cited by 55
Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model
Dierssen, M., Vallina, I. F., Baamonde, C., Lumbreras, M., Martínez‐Cué, C., Calatayud, S. G., & Flórez, J. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(96)00071-5 · Cited by 53
A study of behavioral and sensorial bases of radial maze learning in mice
Roullet, P., Lassalle, J. M., & Jegat, R. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)90926-9 · Cited by 47
Roullet, P., & Lassalle, J. M. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80141-x · Cited by 43
Working memory theory of hippocampal function needs qualification
Leis, T., Pallage, V., Toniolo, G., & Will, B. E. (1984) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(84)90994-4 · Cited by 43
Mouse Molecular Cytogenetic Resource: 157 BACs Link the Chromosomal and Genetic MapsPreprint
Korenberg, J. R., Chen, X.-N., Devon, K. L., Noya, D., Oster‐Granite, M. L., & Birren, B. W. (1999) · Genome Research · doi:10.1101/gr.9.5.514 · Cited by 42
Supplementary report: Shock intensity and unconditioned responding in a shuttle box.
Trabasso, T. R., & Thompson, R. W. (1962) · Journal of Experimental Psychology · doi:10.1037/h0046946 · Cited by 28
Ammassari‐Teule, M., & Marsanich, B. D. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(96)00001-7 · Cited by 16
Research works printed but not linked: 1
- Crnic, 1998, Ts65Dn model of Down syndrome (DS): radial maze learning and contextual conditioning, Soc. Neurosci., 24, 1199
Cited by
Sorted by citations
Roizen, N., & Patterson, D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12987-x · Cited by 1,386
Kleschevnikov, A. M., Belichenko, P. V., Villar, A. J., Epstein, C. J., Malenka, R. C., & Mobley, W. C. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1766-04.2004 · Cited by 459
Cooper, J. D., Salehi, A., Delcroix, J.-D., Howe, C. L., Belichenko, P. V., Chua-Couzens, J., Kilbridge, J. F., Carlson, E. J., Epstein, C. J., & Mobley, W. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181219298 · Cited by 336
Down syndrome and the complexity of genome dosage imbalance
Antonarakis, S. E. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.154 · Cited by 314
Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome
Belichenko, P. V., Masliah, E., Kleschevnikov, A. M., Villar, A. J., Epstein, C. J., Salehi, A., & Mobley, W. C. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20337 · Cited by 297
Metadata
- Authors
- Hyde, L. A., Frisone, D. F., & Crnic, L. S.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Hyde, Lynn A
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 118
- Issue
- 1
- Pages
- 53-60
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1987268303
- Cited by
- 108
- References
- 36
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 9
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32ag005866-02)
- National Institute on Aging (AG05866)
- National Institute of Mental Health (MH 15442, T32MH015442)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-04024, P30HD004024, HD17449, P01HD017449)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Ts65Dn mouse model, Down syndrome, hippocampus, dorsal hippocampus, hippocampus-dependent learning, Alzheimer's disease, trisomy, learning deficits
- MeSH terms
- Age Factors, Animals, Discrimination Learning, Disease Models, Animal, Down Syndrome, Fear, Genotype, Hippocampus, Male, Mice, Neurologic Mutants, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
