The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function
Abstract
The Ts65Dn mouse is segmentally trisomic for a part of mouse chromosome 16 and is a genetic model for Down syndrome and Alzheimer's disease. Although many studies have examined the learning and memory processes in Ts65Dn mice, it has yet to be determined if Ts65Dn mice are specifically impaired in learning tasks that require an intact hippocampus. Context discrimination learning is dependent on the dorsal hippocampus in mice. In this task, mice learn to discriminate two similar contexts, one of which is associated with foot shock. In the current study, Ts65Dn mice learned almost identically to what has been reported for mice with dorsal hippocampal lesions, while controls behaved similarly to sham lesioned mice. Therefore, Ts65Dn mice have learning deficits in a hippocampal dependent task that may be related to the loss of cholinergic input to the hippocampus, which occurs after 6 months of age.
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“Mouse models have provided additional insights into the developmental progression of DS, elucidating specific defects in neurogenesis, neuronal differentiation, and impaired synaptic plasticity and learning (Chakrabarti et al., 2007, 2010; Hyde et al., 2001; Kleschevnikov et al., 2004; Siarey et al., 1997, 1999; Tyler and Haydar, 2013; Wang et al., 2013).”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Hyde et al., 2001
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Cites
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The dorsal hippocampus is essential for context discrimination but not for contextual conditioning.
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Research works printed but not linked: 1
- Crnic, 1998, Ts65Dn model of Down syndrome (DS): radial maze learning and contextual conditioning, Soc. Neurosci., 24, 1199
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Roizen, N., & Patterson, D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12987-x · Cited by 1,386
Kleschevnikov, A. M., Belichenko, P. V., Villar, A. J., Epstein, C. J., Malenka, R. C., & Mobley, W. C. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1766-04.2004 · Cited by 459
Cooper, J. D., Salehi, A., Delcroix, J.-D., Howe, C. L., Belichenko, P. V., Chua-Couzens, J., Kilbridge, J. F., Carlson, E. J., Epstein, C. J., & Mobley, W. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181219298 · Cited by 336
Down syndrome and the complexity of genome dosage imbalance
Antonarakis, S. E. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.154 · Cited by 314
Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome
Belichenko, P. V., Masliah, E., Kleschevnikov, A. M., Villar, A. J., Epstein, C. J., Salehi, A., & Mobley, W. C. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20337 · Cited by 297
Metadata
- Authors
- Hyde, L. A., Frisone, D. F., & Crnic, L. S.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Hyde, Lynn A
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 118
- Issue
- 1
- Pages
- 53-60
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1987268303
- Cited by
- 108
- References
- 36
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 9
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32ag005866-02)
- National Institute on Aging (AG05866)
- National Institute of Mental Health (MH 15442, T32MH015442)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-04024, P30HD004024, HD17449, P01HD017449)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Ts65Dn mouse model, Down syndrome, hippocampus, dorsal hippocampus, hippocampus-dependent learning, Alzheimer's disease, trisomy, learning deficits
- MeSH terms
- Age Factors, Animals, Discrimination Learning, Disease Models, Animal, Down Syndrome, Fear, Genotype, Hippocampus, Male, Mice, Neurologic Mutants, Mice
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