Cited by 999Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 301 of the 301 references it cites were found in a registry or an index.

Nucleus accumbens shell and core dopamine: differential role in behavior and addiction

Di Chiara, Gaetano·2002·Behavioural Brain Research

DOI 10.1016/s0166-4328(02)00286-3

Open this paper in CoChat — free account

Abstract

Drug addiction can be conceptualized as a disturbance of behavior motivated by drug-conditioned incentives. This abnormality has been explained by Incentive-Sensitization and Allostatic-Counteradaptive theories as the result of non-associative mechanisms acting at the stage of the expression of incentive motivation and responding for drug reinforcement. Each one of these theories, however, does not account per se for two basic properties of the motivational disturbance of drug addiction: (1). focussing on drug- at the expenses of non-drug-incentives; (2). virtual irreversibility. To account for the above aspects we have proposed an associative learning hypothesis. According to this hypothesis the basic disturbance of drug addiction takes place at the stage of acquisition of motivation and in particular of Pavlovian incentive learning. Drugs share with non-drug rewards the property of stimulating dopamine (DA) transmission in the nucleus accumbens shell but this effect does not undergo habituation upon repeated drug exposure, as instead is the case of non-drug rewards. Repetitive, non-decremental stimulation of DA transmission by drugs in the nucleus accumbens septi (NAc) shell abnormally strengthens stimulus-drug associations. Thus, stimuli contingent upon drug reward acquire powerful incentive properties after a relatively limited number of predictive associations with the drug and become particularly resistant to extinction. Non-contingent occurrence of drug-conditioned incentive cues or contexts strongly facilitates and eventually reinstates drug self-administration. Repeated drug exposure also induces a process of sensitization of drug-induced stimulation of DA transmission in the NAc core. The precise significance of this adaptive change for the mechanism of drug addiction is unclear given the complexity and uncertainties surrounding the role of NAc core DA in responding but might be more directly related to instrumental performance.

Integrity signals

Registry

Crossref · 10.1016/s0166-4328(02)00286-3

Cites

301 of 301 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Psychology as the behaviorist views it
Watson, J. B. (1913) · Psychological Review · doi:10.1037/h0074428 · Cited by 3,230
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Handbook of Psychopharmacology
Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0933-8 · Cited by 2,756
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331
Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.
Kalivas, P., & Stewart, J. (1991) · Brain research. Brain research reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,087

Show all 300 references

Research works printed but not linked: 1

Himmelsbach, 1943, Morphine, with reference to physical dependence, Fed. Proc., 2, 201

Sorted by citations

Items 201–300 of 999

Food Addiction and Obesity: Evidence from Bench to Bedside
Liu, Y., von Deneen, K. M., Kobeissy, F. H., & Gold, M. S. (2010) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2010.10400686 · Cited by 84
Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine‐induced locomotor activity, reward and CREB phosphorylation
Karasinska, J. M., George, S. R., Cheng, R., & O’Dowd, B. F. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04353.x · Cited by 83
Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation
Addolorato, G., Leggio, L., Hopf, F. W., Diana, M., & Bonci, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.216 · Cited by 86
Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring
Bubeníková‐Valešová, V., Kačer, P., Syslová, K., Rambousek, L., Janovsky, M., Schutová, B., Hrubá, L., & Šlamberová, R. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.06.012 · Cited by 82
Cue Reactivity in the Ventral Striatum Characterizes Heavy Cannabis Use, Whereas Reactivity in the Dorsal Striatum Mediates Dependent Use
Zhou, X., Zimmermann, K., Xin, F., Zhao, W., Derckx, R. T., Sassmannshausen, A., Scheele, D., Hurlemann, R., Weber, B., Kendrick, K. M., et al. (2019) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.04.006 · Cited by 77
Gene expression differences in mice divergently selected for methamphetamine sensitivity
Palmer, A. A., Verbitsky, M., Suresh, R., Kamens, H. M., Reed, C. L., Li, N., Burkhart‐Kasch, S., McKinnon, C. S., Belknap, J. K., Gilliam, T. C., et al. (2005) · Mammalian Genome · doi:10.1007/s00335-004-2451-8 · Cited by 81
Adolescent Development of Forebrain Stimulant Responsiveness: Insights from Animal Studies
LESLIE, F. M., LOUGHLIN, S. E., WANG, R., PEREZ, L., LOTFIPOUR, S., & BELLUZZIA, J. D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.018 · Cited by 81
Neural Substrates and Circuits of Drug AddictionPreprint
Feltenstein, M. W., See, R. E., & Fuchs, R. A. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039628 · Cited by 92
Current Concepts on the Physiopathological Relevance of Dopaminergic Receptors
Ledonne, A., & Mercuri, N. B. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00027 · Cited by 86
The role of dopamine in conditioning and latent inhibition: What, when, where and how?
Young, A. M. J., Moran, P. M., & Joseph, M. H. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.02.004 · Cited by 79
Chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring of the striatum
Taylor, S. B., Anglin, J. M., Paode, P. R., Riggert, A. G., Olive, M. F., & Conrad, C. D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.029 · Cited by 78
Corticotropin-releasing factor in the nucleus accumbens shell induces swim depression, anxiety, and anhedonia along with changes in local dopamine/acetylcholine balance
Chen, Y.-W., Rada, P. V., Bützler, B. P., LEIBOWITZ, S. F., & Hoebel, B. G. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.009 · Cited by 78
Genotrim™, a DNA-customized nutrigenomic product, targets genetic factors of obesity: Hypothesizing a dopamine–glucose correlation demonstrating reward deficiency syndrome (RDS)
Blum, K., Chen, T. J. H., Meshkin, B., Downs, B. W., Gordon, C. A., Blum, S. H., Mangucci, J. F., Braverman, E. R., Arcuri, V., Deutsch, R., et al. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.08.041 · Cited by 78
Reduced grey matter in the posterior insula as a structural vulnerability or diathesis to addiction
Gardini, S., & Venneri, A. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.021 · Cited by 82
Neurogenetics of Dopaminergic Receptor Supersensitivity in Activation of Brain Reward Circuitry and Relapse: Proposing “Deprivation-Amplification Relapse Therapy” (DART)
Blum, K., Chen, T. J. H., Downs, B. W., Bowirrat, A., Waite, R. L., Braverman, E. R., Madigan, M. A., Oscar‐Berman, M., DiNubile, N. A., Stice, E. M., et al. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.11.2087 · Cited by 82
Behavioral sensitization to Δ9‐tetrahydrocannabinol and cross‐sensitization with morphine: differential changes in accumbal shell and core dopamine transmission
Cadoni, C., Valentini, V., & Chiara, G. D. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05503.x · Cited by 77
The Lack of A2A Adenosine Receptors Diminishes the Reinforcing Efficacy of Cocaine
Sòria, G., Castañé, A., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300876 · Cited by 75
The uncertainty processing theory of motivation
Anselme, P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.020 · Cited by 77
Oxytocin in the nucleus accumbens core reduces reinstatement of methamphetamine‐seeking behaviour in rats
Baracz, S. J., Everett, N. A., McGregor, I. S., & Cornish, J. L. (2014) · Addiction Biology · doi:10.1111/adb.12198 · Cited by 75
“Wanting,” “liking,” and their relation to consciousness.
Anselme, P., & Robinson, M. J. F. (2015) · Journal of Experimental Psychology Animal Learning and Cognition · doi:10.1037/xan0000090 · Cited by 82
Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats
Gál, K., & Gyertyán, I. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.05.011 · Cited by 74
Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC
Sòria, G., Castañé, A., Berrendero, F., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03682.x · Cited by 74
New perspectives on adolescent motivated behavior: Attention and conditioning
Ernst, M., Daniele, T., & Frantz, K. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.013 · Cited by 73
Glycogen synthase kinase 3β in the nucleus accumbens core is critical for methamphetamine‐induced behavioral sensitization
Xu, C., Wang, J., Wu, P., Xue, Y.-X., Zhu, W., Li, Q., Zhai, H., Shi, J., & Lü, L. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07281.x · Cited by 73
A differential activation of dopamine output in the shell and core of the nucleus accumbens is associated with the motor responses to addictive drugs: a brain dialysis study in Roman high- and low-avoidance rats
Lecca, D., Piras, G., Driscoll, P., Giorgi, O., & Corda, M. G. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.11.011 · Cited by 73
The nucleus accumbens in reward and aversion processing: insights and implications
Xu, Y., Lin, Y., Yu, M., & Zhou, K. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1420028 · Cited by 86
Sex-dependent effects of periadolescent exposure to the cannabinoid agonist CP-55,940 on morphine self-administration behaviour and the endogenous opioid system
Fernández, J. M. B., Fernández, B., Higuera‐Matas, A., Miguéns, M., Viveros, M., Garcı́a-Lecumberri, C., & Ambrosio, E. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.01.006 · Cited by 72
Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression
Calipari, E. S., Ferris, M. J., Salahpour, A., Caron, M. G., & Jones, S. R. (2013) · Nature Communications · doi:10.1038/ncomms3720 · Cited by 72
Neuropeptides and Neurotransmitters That Modulate Thalamo‐Cortical Pathways Relevant to Migraine Headache
Noseda, R., Borsook, D., & Burstein, R. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13083 · Cited by 74
Differential impact of pavlovian drug conditioned stimuli on in vivo dopamine transmission in the rat accumbens shell and core and in the prefrontal cortex
Bassareo, V., Luca, M. A. D., & Chiara, G. D. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0560-7 · Cited by 71
GSK-3β activity and hyperdopamine-dependent behaviors
Li, Y., & Gao, W. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.08.001 · Cited by 72
Computational models of reinforcement learning: the role of dopamine as a reward signal
Samson, R. D., Frank, M. J., & Fellous, J. (2010) · Cognitive Neurodynamics · doi:10.1007/s11571-010-9109-x · Cited by 75
Dopamine responsiveness to drugs of abuse: A shell‐core investigation in the nucleus accumbens of the mouse
Zocchi, A., Girlanda, E., Varnier, G., Sartori, I., Zanetti, L., Wildish, G. A., Lennon, M. G., Mugnaini, M., & Heidbreder, C. A. (2003) · Synapse · doi:10.1002/syn.10271 · Cited by 71
The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine‐induced dopamine elevations in the nucleus accumbens shell in rats
Scherma, M., Justinová, Z., Zanettini, C., Panlilio, L. V., Mascia, P., Fadda, P., Fratta, W., Makriyannis, A., Vadivel, S. K., Gamaleddin, I., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01467.x · Cited by 74
Blockade of dopamine D3 receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: Similar actions of D1 receptor agonists, but not of D2 antagonists
Loiseau, F., & Millan, M. J. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.07.012 · Cited by 72
The Role of Nucleus Accumbens Core/Shell in Sleep-Wake Regulation and their Involvement in Modafinil-Induced Arousal
Qiu, M., Liu, W., Qu, W., Urade, Y., Lu, J., & Huang, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045471 · Cited by 71
Effect of amphetamine, cocaine and depolarization by high potassium on extracellular dopamine in the nucleus accumbens shell of SHR rats. An in vivo microdyalisis study
Carboni, E., Silvagni, A., Valentini, V., & Chiara, G. D. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.008 · Cited by 70
Alcohol Preference Influences the Subthalamic Nucleus Control on Motivation for Alcohol in Rats
Lardeux, S., & Baunez, C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301432 · Cited by 70
GABAB Receptor Activation in the Ventral Tegmental Area Inhibits the Acquisition and Expression of Opiate-Induced Motor Sensitization
Leite‐Morris, K. A., Fukudome, E. Y., Shoeb, M. H., & Kaplan, G. B. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.058412 · Cited by 70
ORIGINAL RESEARCH—BASIC SCIENCE: Acute and Repeated Flibanserin Administration in Female Rats Modulates Monoamines Differentially Across Brain Areas: A Microdialysis Study
Allers, K. A., Dremencov, E., Ceci, A., Flik, G., Ferger, B., Cremers, T. I. F. H., Ittrich, C., & Sommer, B. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01763.x · Cited by 70
The central serotonin2Breceptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity
Auclair, A. L., Cathala, A., Sarrazin, F., Depoortère, R., Piazza, P. V., Newman‐Tancredi, A., & Spampinato, U. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06848.x · Cited by 69
Contrast enhancement: a physiological effect of striatal dopamine?
Nicola, S. M., Hopf, F. W., & Hjelmstad, G. O. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0929-z · Cited by 68
Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
Gould, T. J., & Leach, P. T. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.004 · Cited by 72
Evaluation of electrochemical methods for tonic dopamine detection in vivo
Rusheen, A. E., Gee, T. A., Jang, D. P., Blaha, C. D., Bennet, K. E., Lee, K. H., Heien, M. L., & Oh, Y. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116049 · Cited by 67
Role of nitrergic system in behavioral and neurotoxic effects of amphetamine analogs
Itzhak, Y., & Ali, S. F. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.08.004 · Cited by 67
Distinct resting-state brain activities in heroin-dependent individuals
Zhang, Y., Tian, J., Yuan, K., Liu, P., Zhuo, L., Qin, W., Zhao, L., Liu, J., von Deneen, K. M., Klahr, N. J., et al. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.054 · Cited by 68
Nicotine place preference in a biased conditioned place preference design
Brielmaier, J. M., McDonald, C. G., & Smith, R. F. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.11.005 · Cited by 67
Dopamine D1-like receptor activation depolarizes medium spiny neurons of the mouse nucleus accumbens by inhibiting inwardly rectifying K+ currents through a cAMP-dependent protein kinase A-independent mechanism
Podda, M. V., Riccardi, E., D’Ascenzo, M., Azzena, G. B., & Grassi, C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.075 · Cited by 66
The roles of the nucleus accumbens core, dorsomedial striatum, and dorsolateral striatum in learning: Performance and extinction of Pavlovian fear-conditioned responses and instrumental avoidance responses
Wendler, E., Gaspar, J. C. C., Ferreira, T. L., Barbiero, J. K., Andreatini, R., Vital, M. A. B. F., Blaha, C. D., Winn, P., & Da Cunha, C. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.009 · Cited by 65
Divergent effects of D2/3 receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats
Moreno, M., Economidou, D., Mar, A. C., López-Granero, C., Caprioli, D., Theobald, D. E. H., Fernando, A. B. P., Newman, A. H., Robbins, T. W., & Dalley, J. W. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3010-3 · Cited by 63
Central GLP-1 receptors: Novel molecular targets for cocaine use disorder
Hernandez, N. S., & Schmidt, H. D. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.03.026 · Cited by 66
Opioids in the Hypothalamic Paraventricular Nucleus Stimulate Ethanol Intake
Barson, J. R., Carr, A., Soun, J. E., Sobhani, N. C., Rada, P. V., LEIBOWITZ, S. F., & Hoebel, B. G. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01084.x · Cited by 64
Overconsumption of dietary fat and alcohol: Mechanisms involving lipids and hypothalamic peptides
LEIBOWITZ, S. F. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.03.018 · Cited by 64
Neurotensin in reward processes
Torruella-Suárez, M. L., & McElligott, Z. A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108005 · Cited by 63
Prostaglandin E2Acts on EP1Receptor and Amplifies Both Dopamine D1and D2Receptor Signaling in the Striatum
Kitaoka, S., Furuyashiki, T., Nishi, A., Shuto, T., Koyasu, S., Matsuoka, T., Miyasaka, M., Greengard, P., & Narumiya, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3257-07.2007 · Cited by 63
Neurobiological Bases of Individual Differences in Emotional and Stress Responsiveness
Kabbaj, M. (2004) · Archives of Neurology · doi:10.1001/archneur.61.7.1009 · Cited by 63
A scale-free systems theory of motivation and addiction
Chambers, R. A., Bickel, W. K., & Potenza, M. N. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.005 · Cited by 63
Dopamine efflux in nucleus accumbens shell and core in response to appetitive classical conditioning
Cheng, J., de Bruin, J. P. C., & Feenstra, M. G. P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02849.x · Cited by 63
Abnormal patterns of displacement activities: A review and reinterpretation
Anselme, P. (2008) · Behavioural Processes · doi:10.1016/j.beproc.2008.05.001 · Cited by 58
Voluntary Ethanol Intake Predicts κ-Opioid Receptor Supersensitivity and Regionally Distinct Dopaminergic Adaptations in Macaques
Siciliano, C. A., Calipari, E. S., Carlson, V. C. C., Helms, C. M., Lovinger, D. M., Grant, K. A., & Jones, S. R. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4820-14.2015 · Cited by 62
Methoxetamine, a ketamine derivative, produced conditioned place preference and was self-administered by rats: Evidence of its abuse potential
Botanas, C. J., de la Peña, J. B., Peña, I. J. D., Tampus, R., Yoon, R., Kim, H. J., Lee, Y. S., Jang, C., & Cheong, J. H. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.007 · Cited by 61
Cognitive neuroenhancement: false assumptions in the ethical debate
Heinz, A., Kipke, R., Heimann, H., & Wiesing, U. (2012) · Journal of Medical Ethics · doi:10.1136/medethics-2011-100041 · Cited by 63
Circuit selectivity in drug versus natural reward seeking behaviors
Nall, R. W., Heinsbroek, J. A., Nentwig, T. B., Kalivas, P. W., & Bobadilla, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15297 · Cited by 64
A rodent “self-report” measure of methamphetamine craving? Rat ultrasonic vocalizations during methamphetamine self-administration, extinction, and reinstatement
Mahler, S. V., Moorman, D. E., Feltenstein, M. W., Cox, B. M., Ogburn, K. B., Bachar, M., McGonigal, J. T., Ghee, S. M., & See, R. E. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.023 · Cited by 61
Latent inhibition is disrupted by nucleus accumbens shell lesion but is abnormally persistent following entire nucleus accumbens lesion: The neural site controlling the expression and disruption of the stimulus preexposure effect
Gal, G., Schiller, D., & Weiner, I. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.019 · Cited by 61
Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist
Justinová, Z., Ferré, S., Redhi, G. H., Mascia, P., Stroik, J., Quarta, D., Yaşar, S., Müller, C. E., Franco, R., & Goldberg, S. R. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00258.x · Cited by 58
Is ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol
Quertemont, É., & Tambour, S. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.01.001 · Cited by 59
Behavioral effects of psychostimulants in mutant mice with cell-type specific deletion of CB2 cannabinoid receptors in dopamine neurons
Canseco-Alba, A., Schanz, N., Sanabria, B., Zhao, J., Lin, Z., Liu, Q., & Onaivi, E. S. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.043 · Cited by 62
Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans
Malik, S., Jacobs, M., Cho, S.-S., Boileau, I., Blumberger, D., Heilig, M., Wilson, A., Daskalakis, Z. J., Strafella, A. P., Zangen, A., et al. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9800-1 · Cited by 58
Classic and non‐classic psychedelics for substance use disorder: A review of their historic, past and current research
Mendes, F. R., Costa, C. D. S., Wiltenburg, V. D., Morales-Lima, G., Fernandes, J. A. B., & Filev, R. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100025 · Cited by 67
Altered Gene Expression and Spine Density in Nucleus Accumbens of Adolescent and Adult Male Mice Exposed to Emotional and Physical Stress
Warren, B. L., Sial, O. K., Parise, L. F., Greenwood, M. A., Brewer, J. S., Rozofsky, J. P., Parise, E. M., & Bolaños‐Guzmán, C. A. (2014) · Developmental Neuroscience · doi:10.1159/000362875 · Cited by 64
Cannabinoid modulation of limbic forebrain noradrenergic circuitry
Carvalho, A. F., Mackie, K., & Bockstaele, E. J. V. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07054.x · Cited by 58
Framework for sex differences in adolescent neurobiology: A focus on cannabinoids
Viveros, M., Marco, E. M., López‐Gallardo, M., García‐Segura, L. M., & Wagner, E. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.005 · Cited by 59
Eating dependence and weight gain; no human evidence for a ‘sugar-addiction’ model of overweight
Markus, C. R., Rogers, P. J., Brouns, F. J. P. H., & Schepers, R. (2017) · Appetite · doi:10.1016/j.appet.2017.03.024 · Cited by 58
Caffeine and accumbens shell dopamine
Luca, M. A. D., Bassareo, V., Bauer, A., & Chiara, G. D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04754.x · Cited by 56
Neurophysiology of Reward-Guided Behavior: Correlates Related to Predictions, Value, Motivation, Errors, Attention, and Action
Bissonette, G. B., & Roesch, M. R. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_382 · Cited by 68
Reward deficiency syndrome in obesity: A preliminary cross-sectional trial with a genotrim variant
Blum, K., Chen, T. J. H., Meshkin, B., Downs, B. W., Gordon, C. A., Blum, S. H., Mengucci, J. F., Braverman, E. R., Arcuri, V., Varshavskiy, M., et al. (2006) · Advances in Therapy · doi:10.1007/bf02850224 · Cited by 57
Effect of 3,4-methylendioxymethamphetamine (MDMA, “ecstasy”) on dopamine transmission in the nucleus accumbens shell and core
Cadoni, C., Solinas, M., Pisanu, A., Zernig, G., Acquas, E., & Chiara, G. D. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.002 · Cited by 51
Food Reward-Induced Neurotransmitter Changes in Cognitive Brain Regions
Fallon, S. M., Shearman, E., Sershen, H. W., & Lajtha, Á. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9343-8 · Cited by 56
Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission
Lintas, A., Chi, N., Lauzon, N. M., Bishop, S. F., Sun, N., Tan, H., & Laviolette, S. R. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07943.x · Cited by 55
The role of nucleus accumbens and dorsolateral striatal D2 receptors in active avoidance conditioning
Boschen, S. L., Lovato, E. C. W., Winn, P., & Cunha, C. D. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.05.002 · Cited by 54
Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids
Rodrigues, A. J., Leão, P., Pêgo, J. M., Cardona, D., Carvalho, M. M., de Oliveira, M. M., Costa, B. M., Carvalho, A. F., Morgado, P. F., Araújo, D., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.126 · Cited by 57
Diverging frequency-modulated 50-kHz vocalization, locomotor activity and conditioned place preference effects in rats given repeated amphetamine treatment
Taracha, E., Kaniuga, E., Chrapusta, S. J., Maciejak, P., Śliwa, L., Hamed, A., & Krząścik, P. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.04.008 · Cited by 55
Drug addiction: An affective-cognitive disorder in need of a cure
Fattore, L., & Diana, M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.006 · Cited by 58
Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens
Lee, K. M., Coelho, M. A., McGregor, H. A., Solton, N. R., Cohen, M., & Szumlinski, K. K. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00265 · Cited by 53
PRECLINICAL STUDY: FULL ARTICLE: Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence
Spiga, S., Lintas, A., Migliore, M., & Diana, M. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00218.x · Cited by 53
Ethanol‐Induced Extracellular Signal Regulated Kinase: Role of Dopamine D1 Receptors
Ibba, F., Vinci, S., Spiga, S., Peana, A. T., Assaretti, A., Spina, L., Longoni, R., & Acquas, E. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00907.x · Cited by 53
Prenatal ethanol exposure stimulates neurogenesis in hypothalamic and limbic peptide systems: Possible mechanism for offspring ethanol overconsumption
Chang, G., Karatayev, O., Liang, S., Barson, J. R., & LEIBOWITZ, S. F. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.066 · Cited by 53
Inhibition of 5α‐Reduced Steroid Biosynthesis Impedes Acquisition of Ethanol Drinking in Male C57BL/6J Mice
Ford, M. M., Yoneyama, N., Strong, M. N., Fretwell, A. M., Tanchuck, M. A., & Finn, D. A. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00718.x · Cited by 53
From Disordered Eating to Addiction: The “Food Drug” in Bulimia Nervosa
Umberg, E. N., Shader, R. I., Hsu, L. K. G., & Greenblatt, D. J. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318252464f · Cited by 52
Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity
Jenson, D., Yang, K., Acevedo-Rodriguez, A., Levine, A., Broussard, J. I., Tang, J., & Dani, J. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.029 · Cited by 52
Effect of Ginkgo Biloba Extract on Lipopolysaccharide-induced Anhedonic Depressive-like Behavior in Male Rats
Yeh, K.-Y., Shou, S.-S., Lin, Y.-X., Chen, C.-C., Chiang, C.-Y., & Yeh, C.-Y. (2014) · Phytotherapy Research · doi:10.1002/ptr.5247 · Cited by 52
Levodopa treatment and dendritic spine pathology
Nishijima, H., Ueno, T., Funamizu, Y., Ueno, S., & Tomiyama, M. (2017) · Movement Disorders · doi:10.1002/mds.27172 · Cited by 52
The reality of “food porn”: Larger brain responses to food‐related cues than to erotic images predict cue‐induced eating
Versace, F., Frank, D. W., Stevens, E. M., Deweese, M. M., Guindani, M., & Schembre, S. M. (2018) · Psychophysiology · doi:10.1111/psyp.13309 · Cited by 69
The Dopamine System in Mediating Alcohol Effects in Humans
Charlet, K., Beck, A., & Heinz, A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28720-6_130 · Cited by 53
Differential effects of intravenous R,S‐(±)‐3,4‐methylenedioxymethamphetamine (MDMA, Ecstasy) and its S(+)‐ and R(−)‐enantiomers on dopamine transmission and extracellular signal regulated kinase phosphorylation (pERK) in the rat nucleus accumbens shell and core
Acquas, E., Pisanu, A., Spiga, S., Plumitallo, A., Zernig, G., & Chiara, G. D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04451.x · Cited by 53
Dopamine in disturbances of food and drug motivated behavior: A case of homology?
Chiara, G. D. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.06.020 · Cited by 52
Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice
Mereu, M., Tronci, V., Chun, L. E., Thomas, A. M., Green, J. L., Katz, J. L., & Tanda, G. (2013) · Addiction Biology · doi:10.1111/adb.12080 · Cited by 52
Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses
Lovato, E. C. W., Boschen, S. L., Miyoshi, E., Bortolanza, M., dos Santos, L. M., Frank, M. J., Brandão, M. L., Winn, P., & Cunha, C. D. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2384-3 · Cited by 50
Endocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell
Luca, M. A. D., Valentini, V., Bimpisidis, Z., Cacciapaglia, F., Caboni, P., & Chiara, G. D. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00140 · Cited by 51

Authors: Di Chiara, G.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2002-12
Volume: 137
Issue: 1-2
Pages: 75-114
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/s0166-4328(02)00286-3
OpenAlex: W1980890656
Cited by: 996
References: 300
Citations by year: 2026: 17 · 2025: 28 · 2024: 30 · 2023: 24 · 2022: 33 · 2021: 30 · 2020: 30 · 2019: 40 · 2018: 40 · 2017: 39 · 2016: 45 · 2015: 56 · 2014: 49 · 2013: 54 · 2012: 54
FWCI: 3.92
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: nucleus accumbens shell, nucleus accumbens core, dopamine, drug addiction, incentive sensitization, self-administration, reinstatement, extinction, habituation
MeSH terms: Animals, Appetitive Behavior, Brain Mapping, Conditioning, Classical, Dopamine, Humans, Motivation, Neural Pathways, Synaptic Transmission, Nucleus Accumbens, Behavior, Addictive, Prefrontal Cortex, Substance-Related Disorders, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nucleus accumbens shell and core dopamine: differential role in behavior and addiction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks