Cited by 999Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 301 of the 301 references it cites were found in a registry or an index.

Nucleus accumbens shell and core dopamine: differential role in behavior and addiction

Di Chiara, Gaetano·2002·Behavioural Brain Research

DOI 10.1016/s0166-4328(02)00286-3

Open this paper in CoChat — free account

Abstract

Drug addiction can be conceptualized as a disturbance of behavior motivated by drug-conditioned incentives. This abnormality has been explained by Incentive-Sensitization and Allostatic-Counteradaptive theories as the result of non-associative mechanisms acting at the stage of the expression of incentive motivation and responding for drug reinforcement. Each one of these theories, however, does not account per se for two basic properties of the motivational disturbance of drug addiction: (1). focussing on drug- at the expenses of non-drug-incentives; (2). virtual irreversibility. To account for the above aspects we have proposed an associative learning hypothesis. According to this hypothesis the basic disturbance of drug addiction takes place at the stage of acquisition of motivation and in particular of Pavlovian incentive learning. Drugs share with non-drug rewards the property of stimulating dopamine (DA) transmission in the nucleus accumbens shell but this effect does not undergo habituation upon repeated drug exposure, as instead is the case of non-drug rewards. Repetitive, non-decremental stimulation of DA transmission by drugs in the nucleus accumbens septi (NAc) shell abnormally strengthens stimulus-drug associations. Thus, stimuli contingent upon drug reward acquire powerful incentive properties after a relatively limited number of predictive associations with the drug and become particularly resistant to extinction. Non-contingent occurrence of drug-conditioned incentive cues or contexts strongly facilitates and eventually reinstates drug self-administration. Repeated drug exposure also induces a process of sensitization of drug-induced stimulation of DA transmission in the NAc core. The precise significance of this adaptive change for the mechanism of drug addiction is unclear given the complexity and uncertainties surrounding the role of NAc core DA in responding but might be more directly related to instrumental performance.

Integrity signals

Registry

Crossref · 10.1016/s0166-4328(02)00286-3

Cites

301 of 301 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Psychology as the behaviorist views it
Watson, J. B. (1913) · Psychological Review · doi:10.1037/h0074428 · Cited by 3,230
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Handbook of Psychopharmacology
Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0933-8 · Cited by 2,756
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331
Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.
Kalivas, P., & Stewart, J. (1991) · Brain research. Brain research reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,087

Show all 300 references

Research works printed but not linked: 1

Himmelsbach, 1943, Morphine, with reference to physical dependence, Fed. Proc., 2, 201

Sorted by citations

Items 401–500 of 999

Separate Populations of Neurons in Ventral Striatum Encode Value and Motivation
Bissonette, G. B., Burton, A. C., Gentry, R. N., Goldstein, B. L., Hearn, T., Barnett, B. R., Kashtelyan, V., & Roesch, M. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064673 · Cited by 39
Exposure to Kynurenic Acid during Adolescence Increases Sign-Tracking and Impairs Long-Term Potentiation in Adulthood
DeAngeli, N. E., Todd, T. P., Chang, S. E., Yeh, H. H., Yeh, P. W. L., & Bucci, D. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00451 · Cited by 35
Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats
Gao, J., Li, Y., Zhu, N., Brimijoin, S., & Sui, N. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112466181 · Cited by 35
Cocaine‐induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: A meta‐analysis
Frank, S. T., Krumm, B., & Spanagel, R. (2008) · Synapse · doi:10.1002/syn.20489 · Cited by 35
Escalation of food-maintained responding and sensitivity to the locomotor stimulant effects of cocaine in mice
Goeders, J. E., Murnane, K. S., Banks, M. L., & Fantegrossi, W. E. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.008 · Cited by 35
NMDA and dopamine D1 receptors within NAc-shell regulate IEG proteins expression in reward circuit during cocaine memory reconsolidation
Li, Y., Ge, S., Li, N., Chen, L., Zhang, S., Wang, J., Wu, H., Wang, X., & Wang, X. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.063 · Cited by 35
Experimental Investigations on Dopamine Transmission Can Provide Clues on the Mechanism of the Therapeutic Effect of Amphetamine and Methylphenidate in ADHD
Carboni, E., & Silvagni, A. (2004) · Neural Plasticity · doi:10.1155/np.2004.77 · Cited by 35
Chronic Smoking and Alcoholism Change Expression of Selective Genes in the Human Prefrontal Cortex
Flatscher‐Bader, T., & Wilce, P. A. (2006) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00106.x · Cited by 34
Microsurgical and Fiber Tract Anatomy of the Nucleus Accumbens
Baydın, S. Ş., Yağmurlu, K., Tanrıöver, N., Güngör, A., & Rhoton, A. L. (2015) · Operative Neurosurgery · doi:10.1227/neu.0000000000001133 · Cited by 38
Obesity and addiction: can a complication of surgery help us understand the connection?
Ivezaj, V., Stoeckel, L. E., Avena, N. M., Benoit, S. C., Conason, A., Davis, J. F., Gearhardt, A. N., Goldman, R. L., Mitchell, J. E., Ochner, C. N., et al. (2017) · Obesity Reviews · doi:10.1111/obr.12542 · Cited by 34
Resistance exercise decreases heroin self-administration and alters gene expression in the nucleus accumbens of heroin-exposed rats
Smith, M. A., Fronk, G. E., Abel, J. M., Lacy, R. T., Bills, S. E., & Lynch, W. J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4840-9 · Cited by 34
The effect of exposure to drugs on the processing of natural rewards
Anselme, P. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.002 · Cited by 35
The Role of Mesoaccumbens Dopamine in Nicotine Dependence
Balfour, D. J. K. (2015) · Current topics in behavioral neurosciences · doi:10.1007/978-3-319-13482-6_3 · Cited by 36
A systematic microdialysis study of dopamine transmission in the accumbens shell/core and prefrontal cortex after acute antipsychotics
Tanda, G., Valentini, V., De Luca, M. A., Perra, V., Serra, G. P., & Di Chiara, G. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3780-2 · Cited by 33
Alcohol: A stimulant activating brain stress responsive systems with persistent neuroadaptation
Zhou, Y., & Kreek, M. J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.044 · Cited by 34
Attenuation of cocaine seeking in rats via enhancement of infralimbic cortical activity using stable step-function opsins
Ewald, V. A. M., Corte, B. J. D., Gupta, S. C., Lillis, K. V., Narayanan, N. S., Wemmie, J. A., & LaLumiere, R. T. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4964-y · Cited by 34
Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards
Godino, A., Salery, M., Cuttoli, R. D.-D., Estill, M. S., Holt, L. M., Futamura, R., Browne, C. J., Mews, P., Hamilton, P. J., Neve, R. L., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.02.013 · Cited by 29
Dopamine dynamics associated with, and resulting from, schedule-induced alcohol self-administration: analyses in dopamine transporter knockout mice
Mittleman, G., Call, S. B., Cockroft, J. L., Goldowitz, D., Matthews, D. B., & Blaha, C. D. (2011) · Alcohol · doi:10.1016/j.alcohol.2010.12.006 · Cited by 33
Impairment of acquisition of intravenous cocaine self-administration by RNA-interference of dopamine D1-receptors in the nucleus accumbens shell
Pisanu, A., Lecca, D., Valentini, V., Bahí, A., Dreyer, J., Cacciapaglia, F., Scifo, A., Piras, G., Cadoni, C., & Chiara, G. D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.018 · Cited by 32
Dopamine, Reward, and Frontostriatal Circuitry in Impulse Control Disorders in Parkinson's Disease: Insights from Functional Imaging
Ray, N. J., & Strafella, A. P. (2010) · Clinical EEG and Neuroscience · doi:10.1177/155005941004100208 · Cited by 34
Inactivation of PKMζ in the NAc Shell Abolished Cocaine-Conditioned Reward
Shabashov, D., Shohami, E., & Yaka, R. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9671-7 · Cited by 33
Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens
Šustková-Fišerová, M., Jerabek, P., Havlickova, T., Syslová, K., & Kačer, P. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4119-3 · Cited by 33
In Situ Live-Cell Nucleus Fluorescence Labeling with Bioinspired Fluorescent Probes
Ding, P., Wang, H., Song, B., Ji, X., Su, Y., & He, Y. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04427 · Cited by 33
Individual differences in dopamine efflux in nucleus accumbens shell and core during instrumental learningPreprint
Cheng, J., & Feenstra, M. G. P. (2006) · Learning & Memory · doi:10.1101/lm.1806 · Cited by 34
Pharmacological and genetic interventions in serotonin (5-HT)2C receptors to alter drug abuse and dependence processes
Filip, M., Spampinato, U., McCreary, A. C., & Przegaliński, E. (2012) · Brain Research · doi:10.1016/j.brainres.2012.03.035 · Cited by 32
Dopamine D2-Like Receptor in the Nucleus Accumbens Is Involved in the Antinociceptive Effect of Nitrous Oxide
Koyanagi, S., Himukashi, S., Mukaida, K., Shichino, T., & Fukuda, K. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318172b15b · Cited by 32
γ-Hydroxybutyric acid (GHB) and the mesoaccumbens reward circuit: Evidence for GABAB receptor-mediated effects
Pistis, M., Muntoni, A. L., Pillolla, G., Perra, S., Cignarella, G., Melis, M., & Gessa, G. L. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.021 · Cited by 32
Nucleus accumbens shell and core dopamine responsiveness to sucrose in rats: role of response contingency and discriminative/conditioned cues
Bassareo, V., Cucca, F., Musio, P., Lecca, D., Frau, R., & Chiara, G. D. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12839 · Cited by 36
GABAB receptors within the ventral tegmental area are involved in the expression and acquisition of morphine-induced place preference in morphine-sensitized rats
Sahraei, H., Etemadi, L., Rostami, P., Pourmotabbed, A., Zarrindast, M., Shams, J., Ghoshooni, H., Noroozzadeh, A., Esfandiari, B., & Salimi, S. H. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.08.015 · Cited by 31
The role of metabotropic glutamate receptors in addiction: Evidence from preclinical models
Duncan, J. R., & Lawrence, A. J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.015 · Cited by 33
Effects of nucleus accumbens core and shell lesions on autoshaped lever-pressing
Chang, S. E., & Holland, P. C. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.07.046 · Cited by 31
Reward, emotion and consumer choice: from neuroeconomics to neurophilosophy
Foxall, G. R. (2008) · Journal of Consumer Behaviour · doi:10.1002/cb.258 · Cited by 31
Organization of Prefrontal-Striatal Connections
Groenewegen, H. J., & Uylings, H. B. M. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00020-2 · Cited by 31
The mesolimbic dopaminergic response to novel palatable food consumption increases dopamine‐D1 receptor‐mediated signalling with complex modifications of the DARPP‐32 phosphorylation pattern
Rauggi, R., Scheggi, S., Cassanelli, A., Montis, M. G. D., Tagliamonte, A., & Gambarana, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02920.x · Cited by 31
Withania somnifera prevents acquisition and expression of morphine-elicited conditioned place preference
Ruiu, S., Longoni, R., Spina, L., Orrù, A., Cottiglia, F., Collu, M., Kasture, S. B., & Acquas, E. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32835f3d15 · Cited by 31
Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens
Aharon, I., Becerraa, L., Chabris, C. F., & Borsooka, D. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.054 · Cited by 31
Social anxiety, acute social stress, and reward parameters interact to predict risky decision-making among adolescents
Richards, J., Patel, N., Daniele, T., MacPherson, L., Lejuez, C. W., & Monique Ernst, D. (2014) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2014.10.001 · Cited by 30
Chronic opiate treatment enhances both cocaine-reinforced and cocaine-seeking behaviors following opiate withdrawal
He, S., & Grasing, K. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.02.010 · Cited by 30
Accumbal dopamine and serotonin activity throughout acquisition and expression of place conditioning: correlative relationships with preference and aversion
Weitemier, A. Z., & Murphy, N. P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06652.x · Cited by 30
Development of conditioned place preference induced by intra-accumbens infusion of amphetamine is attenuated by co-infusion of dopamine D1 and D2 receptor antagonists
Liao, R. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.01.009 · Cited by 32
Targeted intervention: Computational approaches to elucidate and predict relapse in alcoholism
Heinz, A., Deserno, L., Zimmermann, U. S., Smolka, M. N., Beck, A., & Schlagenhauf, F. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.07.055 · Cited by 29
Alterations in Rat Accumbens Endocannabinoid and GABA Content during Fentanyl Treatment: The Role of Ghrelin
Šustková-Fišerová, M., Charalambous, C., Havlickova, T., Lapka, M., Jerabek, P., Puskina, N., & Syslová, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112486 · Cited by 29
Comparing phasic dopamine dynamics in the striatum, nucleus accumbens, amygdala, and medial prefrontal cortex
Holloway, Z. R., Freels, T. G., Comstock, J. F., Nolen, H. G., Sable, H. J. K., & Lester, D. B. (2018) · Synapse · doi:10.1002/syn.22074 · Cited by 33
Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction
Thibeault, K. C., Kutlu, M. G., Sanders, C. M., & Calipari, E. S. (2018) · Brain Research · doi:10.1016/j.brainres.2018.12.024 · Cited by 28
Interactions of benzodiazepines with heroin: Respiratory depression, temperature effects, and behavior
Afzal, A., & Kiyatkin, E. A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107677 · Cited by 29
Covid-19 interface with drug misuse and substance use disorders
Cisneros, I. E., & Cunningham, K. A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108766 · Cited by 30
Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a κ-opioid has no antagonistic effect on μ-opioid-induced increases in serotonin efflux
Tao, R., Ma, Z., Thakkar, M. M., McCarley, R. W., & Auerbach, S. B. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.011 · Cited by 29
Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism
Graves, S. M., Clark, M. J., Traynor, J. R., Hu, X., & Napier, T. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.001 · Cited by 29
Repeated amphetamine administration induces Fos in prefrontal cortical neurons that project to the lateral hypothalamus but not the nucleus accumbens or basolateral amygdala
Morshedi, M. M., & Meredith, G. E. (2007) · Psychopharmacology · doi:10.1007/s00213-007-1021-7 · Cited by 28
Pre‐existing differences and diet‐induced alterations in striatal dopamine systems of obesity‐prone rats
Vollbrecht, P. J., Mabrouk, O. S., Nelson, A. D., Kennedy, R. T., & Ferrario, C. R. (2016) · Obesity · doi:10.1002/oby.21411 · Cited by 29
Parsing Glucose Entry into the Brain: Novel Findings Obtained with Enzyme-Based Glucose Biosensors
Kiyatkin, E. A., & Wakabayashi, K. T. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5002304 · Cited by 28
c-Fos induction in mesotelencephalic dopamine pathway projection targets and dorsal striatum following oral intake of sugars and fats in rats
Cruz, J. A. D. D., Coke, T., Karagiorgis, T., Sampson, C., Icaza-Cukali, D., Kest, K., Ranaldi, R., & Bodnar, R. J. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.11.002 · Cited by 28
Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression
Eipper-Mains, J. E., Eipper, B. A., & Mains, R. E. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00109 · Cited by 28
Deep Brain Stimulation for Obesity
Ho, A. L., Sussman, E. S., Zhang, M., Pendharkar, A. V., Azagury, D. E., Bohon, C., & Halpern, C. H. (2015) · Cureus · doi:10.7759/cureus.259 · Cited by 28
Morphine-induced sensitization in mice: changes in locomotor activity by prior scheduled exposure to GABAA receptor agents
Zarrindast, M., Heidari-Darvishani, A., Rezayof, A., Fathi-Azarbaijani, F., Jafari‐Sabet, M., & Moghaddam, A. H. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282186baa · Cited by 28
Effects of ethanol exposure and withdrawal on dendritic morphology and spine density in the nucleus accumbens core and shell
Peterson, V. L., McCool, B. A., & Hamilton, D. A. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.036 · Cited by 29
Latent inhibition of conditioned taste aversion is not disrupted, but can be enhanced, by selective nucleus accumbens shell lesions in rats
Pothuizen, H. H. J., Jongen‐Rêlo, A. L., Feldon, J., & Yee, B. K. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.032 · Cited by 28
Three-dimensional organization of dendrites and local axon collaterals of shell and core medium-sized spiny projection neurons of the rat nucleus accumbens
van Dongen, Y. C., Mailly, P., Thierry, A. M., Groenewegen, H. J., & Deniau, J. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0173-5 · Cited by 28
Neurokinin3receptor antagonism attenuates cocaine's behavioural activating effects yet potentiates its dopamine‐enhancing action in the nucleus accumbens core
Jocham, G., Lezoch, K., Müller, C. P., KARTTEKE, E., Huston, J. P., & Silva, M. A. D. S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05041.x · Cited by 28
Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning
Engel, L., Wolff, A. R., Blake, M., Collins, V. L., Sinha, S., & Saunders, B. T. (2024) · Current Biology · doi:10.1016/j.cub.2024.05.069 · Cited by 30
Involvement of Dopamine D1/D5 and D2 Receptors in Context-Dependent Extinction Learning and Memory Reinstatement
André, M., & Manahan-Vaughan, D. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00372 · Cited by 30
Anti-anhedonic activity of long-term lithium treatment in rats exposed to repeated unavoidable stress
Marchese, G., Scheggi, S., Secci, M. E., Montis, M. G. D., & Gambarana, C. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001654 · Cited by 26
Atypical Protein Kinase C Is a Novel Mediator of Dopamine-Enhanced Firing in Nucleus Accumbens Neurons
Hopf, F. W., Mailliard, W. S., Gonzalez, G. F., Diamond, I., & Bonci, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3099-04.2005 · Cited by 27
Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency
Motahari, A. A., Sahraei, H., & Meftahi, G. H. (2016) · Basic and Clinical Neuroscience Journal · doi:10.15412/j.bcn.03070401 · Cited by 27
On Mourning and Recovery: Integrating Stages of Grief and Change Toward a Neuroscience-Based Model of Attachment Adaptation in Addiction Treatment
Chambers, R. A., & Wallingford, S. C. (2017) · Psychodynamic Psychiatry · doi:10.1521/pdps.2017.45.4.451 · Cited by 29
Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2
Zheng, F., Zheng, G., Deaciuc, A. G., Zhan, C., Dwoskin, L. P., & Crooks, P. A. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.02.013 · Cited by 27
Effects of Methamphetamine and Lobeline on Vesicular Monoamine and Dopamine Transporter-Mediated Dopamine Release in a Cotransfected Model System
Wilhelm, C., Johnson, R. A., Lysko, P. G., Eshleman, A. J., & Janowsky, A. J. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.067314 · Cited by 27
The impact of drugs of abuse on executive function: characterizing long-term changes in neural correlates following chronic drug exposure and withdrawal in ratsPreprint
Brockett, A. T., Pribut, H. J., Vázquez, D., & Roesch, M. R. (2018) · Learning & Memory · doi:10.1101/lm.047001.117 · Cited by 28
Glucocorticoid receptor-regulated enhancers play a central role in the gene regulatory networks underlying drug addiction
Duttke, S. H., Montilla-Perez, P., Chang, M. W., Li, H., Chen, H., Carrette, L. L. G., Guglielmo, G. D., George, O., Palmer, A. A., Benner, C., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.858427 · Cited by 26
Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol
Quintanilla, M. E., Bustamante, D., Tampier, L., Israel, Y., & Herrera-Marschitz, M. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.06.038 · Cited by 26
Methylxanthines and Drug Dependence: A Focus on Interactions with Substances of Abuse
Morelli, M., & Simola, N. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_20 · Cited by 26
Inhibition of actin polymerization in the NAc shell inhibits morphine-induced CPP by disrupting its reconsolidation
Li, G., Wang, Y., Yan, M., Xu, Y., Song, X., Li, Q., Zhang, J., Ma, H., & Wu, Y. (2015) · Scientific Reports · doi:10.1038/srep16283 · Cited by 26
Mitochondria-Related Nuclear Gene Expression in the Nucleus Accumbens and Blood Mitochondrial Copy Number After Developmental Fentanyl Exposure in Adolescent Male and Female C57BL/6 Mice
Calarco, C. A., Fox, M. E., Terheyden, S. V., Turner, M. D., Alipio, J. B., Chandra, R., & Lobo, M. K. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.737389 · Cited by 27
Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors
Gil-Lievana, E., Ramírez-Mejía, G., Urrego-Morales, O., Luis-Islas, J., Gutiérrez, R., & Bermúdez‐Rattoni, F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.823220 · Cited by 28
Smoking in Context
Corsi, D. J., Chow, C. K., Lear, S. A., Subramanian, S. V., Teo, K. K., & Boyle, M. H. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.08.023 · Cited by 26
Psychobiological Theories of Smoking and Smoking Motivation
Lujic, C., Reuter, M., & Netter, P. (2005) · European Psychologist · doi:10.1027/1016-9040.10.1.1 · Cited by 30
Electrophysiological evidence of mediolateral functional dichotomy in the rat accumbens during cocaine self‐administration: tonic firing patterns
Fabbricatore, A. T., Ghitza, U. E., Prokopenko, V. F., & West, M. O. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07033.x · Cited by 26
Why Adolescents Are at Risk of Misusing Alcohol and Gambling
Noël, X. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt161 · Cited by 28
Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats
Lewis, C. R., Bastle, R. M., Manning, T. B., Himes, S. M., Fennig, P., Conrad, P. R., Colwell, J., Pagni, B. A., Hess, L. A., Matekel, C. G., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.96 · Cited by 26
Neuroadaptations of Cdk5 in Cholinergic Interneurons of the Nucleus Accumbens and Prefrontal Cortex of Inbred Alcohol‐preferring Rats Following Voluntary Alcohol Drinking
Camp, M., Mayfield, R. D., McCracken, M. L., McCracken, L. M., & Alcantara, A. A. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00160.x · Cited by 26
Individual differences in the behavioral effects of nicotine: A review of the preclinical animal literature
Falco, A. M., & Bevins, R. A. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.09.017 · Cited by 25
Role of dopamine D1receptors in caffeine‐mediated ERK phosphorylation in the rat brain
Acquas, E., Vinci, S., Ibba, F., Spiga, S., Luca, M. A. D., & Chiara, G. D. (2009) · Synapse · doi:10.1002/syn.20732 · Cited by 25
Blunted striatal responses to favorite-food cues in smokers
Jastreboff, A. M., Sinha, R., Lacadie, C., Balodis, I. M., Sherwin, R., & Potenza, M. N. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.09.006 · Cited by 24
Protracted motivational dopamine-related deficits following adolescence sugar overconsumption
Naneix, F., Darlot, F., Smedt, V. D., Pape, J., Coutureau, É., & Cador, M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.021 · Cited by 25
Sensitization-based risk for substance abuse in vulnerable individuals with ADHD: Review and re-examination of evidence
Ivanov, I., Bjork, J. M., Blair, J., & Newcorn, J. H. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104575 · Cited by 26
Simultaneous prenatal ethanol and nicotine exposure affect ethanol consumption, ethanol preference and oxytocin receptor binding in adolescent and adult rats
Williams, S. K., Cox, E., McMurray, M. S., Fay, E., Jarrett, T. M., Walker, C. H., Overstreet, D. H., & Johns, J. M. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.06.001 · Cited by 25
Nicotine sensitization of monkey striatal dopamine release
Domino, E. F., & Tsukada, H. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.02.011 · Cited by 25
The MEK inhibitor SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study
Longoni, R., Spina, L., Vinci, S., & Acquas, E. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2192-9 · Cited by 25
Nicotine produces chronic behavioral sensitization with changes in accumbal neurotransmission and increased sensitivity to re‐exposure
Morud, J., Adermark, L., Pérez-Alcázar, M., Ericson, M., & Söderpalm, B. (2015) · Addiction Biology · doi:10.1111/adb.12219 · Cited by 25
Differential-reinforcement-of-low-rate-schedule performance and nicotine administration: a systematic investigation of dose, dose-regimen, and schedule requirement
Kirshenbaum, A. P., Brown, S. J., Hughes, D. M., & Doughty, A. H. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328315ecbb · Cited by 25
Descending projections from the nucleus accumbens shell suppress activity of taste-responsive neurons in the hamster parabrachial nuclei
Li, C.-S., Chung, S., Lu, D.-P., & Cho, Y. K. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00121.2012 · Cited by 24
Amphetamine- and cocaine-induced conditioned place preference and concomitant psychomotor sensitization in mice with genetically inactivated melanin-concentrating hormone MCH1 receptor
Tyhon, A., Lakaye, B., Adamantidis, A., & Tirelli, E. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.09.027 · Cited by 24
Three dimensional anatomy of the human nucleus accumbens
Neto, L. L., Neto, D., Oliveira, E., Martins, H., Mourato, M. B., Correia, F., Campos, A. R., & Gonçalves-Ferreira, A. (2013) · Acta Neurochirurgica · doi:10.1007/s00701-013-1820-z · Cited by 27
Voluntary Alcohol Drinking Enhances Proopiomelanocortin Gene Expression in Nucleus Accumbens Shell and Hypothalamus of S ardinian Alcohol‐Preferring Rats
Zhou, Y., Colombo, G., Niikura, K., Carai, M. A. M., Femenía, T., García‐Gutiérrez, M. S., Manzanares, J., Ho, A., Gessa, G. L., & Kreek, M. J. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01867.x · Cited by 24
Decrease of GSK 3β phosphorylation in the rat nucleus accumbens core enhances cocaine‐induced hyper‐locomotor activity
Kim, W. Y., Jang, J. K., Lee, J. W., Jang, H., & Kim, J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12222 · Cited by 24
Influence of morphine sensitization on the responsiveness of mesolimbic and mesocortical dopamine transmission to appetitive and aversive gustatory stimuli
Luca, M. A. D., Bimpisidis, Z., Bassareo, V., & Chiara, G. D. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2220-9 · Cited by 23
Sardinian alcohol-preferring rats show low 5-HT extraneuronal levels in the mPFC and no habituation in monoaminergic response to repeated ethanol consumption in the NAcS
Montis, M. G. D., Grappi, S., Gambarana, C., Leggio, B., Nanni, G., Scheggi, S., & Tagliamonte, A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.043 · Cited by 24
Ascorbate deficiency decreases dopamine release in gulo–/– and APP/PSEN1 mice
Consoli, D. C., Brady, L. J., Bowman, A. B., Calipari, E. S., & Harrison, F. E. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15151 · Cited by 23
Transcranial direct current stimulation of the prefrontal cortex reduces cigarette craving in not motivated to quit smokers: A randomized, sham-controlled study
Perri, R. L., & Perrotta, D. (2021) · Addictive Behaviors · doi:10.1016/j.addbeh.2021.106956 · Cited by 23
Enriched environment attenuates nicotine self-administration and induces changes in ΔFosB expression in the rat prefrontal cortex and nucleus accumbens
Venebra-Muñoz, A., Corona-Morales, A. A., Santiago-Garcı́a, J., Melgarejo-Gutiérrez, M. A., Caba, M., & García‐García, F. (2014) · Neuroreport · doi:10.1097/wnr.0000000000000157 · Cited by 23

Authors: Di Chiara, G.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2002-12
Volume: 137
Issue: 1-2
Pages: 75-114
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/s0166-4328(02)00286-3
OpenAlex: W1980890656
Cited by: 996
References: 300
Citations by year: 2026: 17 · 2025: 28 · 2024: 30 · 2023: 24 · 2022: 33 · 2021: 30 · 2020: 30 · 2019: 40 · 2018: 40 · 2017: 39 · 2016: 45 · 2015: 56 · 2014: 49 · 2013: 54 · 2012: 54
FWCI: 3.92
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: nucleus accumbens shell, nucleus accumbens core, dopamine, drug addiction, incentive sensitization, self-administration, reinstatement, extinction, habituation
MeSH terms: Animals, Appetitive Behavior, Brain Mapping, Conditioning, Classical, Dopamine, Humans, Motivation, Neural Pathways, Synaptic Transmission, Nucleus Accumbens, Behavior, Addictive, Prefrontal Cortex, Substance-Related Disorders, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nucleus accumbens shell and core dopamine: differential role in behavior and addiction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks