The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Microglia-specific localisation of a novel calcium binding protein, Iba1
Abstract
Recently it has been shown that mRNA of Iba1 (ionized calcium binding adaptor molecule 1), which was a novel calcium binding protein cDNA-cloned by our group, is specifically expressed in microglia in cultures of rat brain cells [Imai et al. Biophys. Biochem. Res. Commun., 224 (1996) 855-862]. In the present study, immunocytochemical and immunohistochemical examinations demonstrated that Iba1 protein is expressed in microglia alone both in cultured brain cells and in the brain, respectively. In a mixed cell culture of embryonic rat brain, immunocytochemically positive for Iba1 protein were the microglia but it was not detectable in neurons, astroglia, or oligodendroglia. Immunohistochemical staining of adult rat brain sections showed Iba1 protein to be specifically localised in ramified microglia. In addition, immunohistochemical staining and immunoblot analysis of activated microglia in the facial nucleus after facial nerve axotomy shows that expression of Iba1 protein was upregulated and peaked at 7 days. These results indicated that localisation of Iba1 protein is restricted to microglia both in vitro and in vivo, and that Iba1 protein plays a role in regulating the function of microglia, especially in the activated microglia.
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In the citing paper
“Since its first description in 1998 [3], IBA1 has been the most widely used marker for the immunohistochemical analysis of microglia.”
From Beyond Activation: Characterizing Microglial Functional Phenotypes (2021) · cites this paper as [3]
In the citing paper
“In contrast, the studies using cell counting for Iba1, which is expressed by all microglia,58, 77 assess the absolute number of microglia in the samples.”
From Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review (2018) · cites this paper as [58]
In the citing paper
“Iba1 is a pan-microglial marker whose expression increases with microglial activation,58, 77”
From Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review (2018) · cites this paper as [58]
In the citing paper
“Iba1 is a microglia specific marker, which expression increases with microglia activation and macrophage transformation [30]”
From APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice (2017) · cites this paper as [30]
In the citing paper
“In AD mice, sustained microglial depletion with CSF1R inhibitor reduced plaque development.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [32]
In the citing paper
“These markers have been extensively used to label or define microglia in various systems 24.”
From Efficient derivation of microglia-like cells from human pluripotent stem cells (2016) · cites this paper as [24]
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
Maddon, P. J., Dalgleish, A. G., McDougal, J. S., Clapham, P. R., Weiss, R. A., & Axel, R. (1986) · Cell · doi:10.1016/0092-8674(86)90590-8 · Cited by 2,003
Dijkstra, C. D., Döpp, E. A., Joling, P., & Kraal, G. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2463-8_50 · Cited by 1,598
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466
Activation of microglial cells by β-amyloid protein and interferon-γ
Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314
Functional plasticity of microglia: A review
Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1988) · Glia · doi:10.1002/glia.440010502 · Cited by 937
Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90215-5 · Cited by 902
Research works printed but not linked: 2
- del Rio-Hortega, 1919, El tercer elemento de los centros nerviosos: I. La microglia en estados normal; II. Intervencio de la microglia en los processos patologicas; III. Naturaleza probable de la microglia, Bol. Soc. Espanola Biol., 9, 69
- Dolman, C.L., Microglia, in: R.L. Davis, D.M. Robertson (Eds.), Textbook of Neuropathology, Microglia, Williams and Wilkins, Baltimore, 1985, pp. 117–137.
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Items 901–999 of 999
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Leiter, I., Bascuñana, P., Bengel, F. M., Bankstahl, J. P., & Bankstahl, M. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104510 · Cited by 16
Sánchez-Alavez, M., Nguyen, W., Mori, S., Wills, D. N., Otero, D. C., Aguirre, C., Singh, M., Ehlers, C. L., & Conti, B. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14209 · Cited by 14
Dysregulation of trophic factors contributes to diabetic retinopathy in the Ins2Akita mouse
Araújo, R. S., Silva, M. S., Santos, D. F., & Silva, G. A. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108027 · Cited by 15
Hofmann, G., Hasser, E. M., & Kline, D. D. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00019.2021 · Cited by 15
Sommakia, S., Rickus, J. L., & Otto, K. J. (2014) · Frontiers in Neuroengineering · doi:10.3389/fneng.2014.00041 · Cited by 15
Leung, J. W.-H., Lau, B. W.-M., Chan, V. S. F., Lau, C.-S., & So, K. (2016) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-160638 · Cited by 15
Potter, E. G., Cheng, Y., Knight, J. B., Gordish‐Dressman, H., & Natale, J. E. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0056.r1 · Cited by 15
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Biggs, J. E., Lu, V. B., Kim, H. J., Lai, A. Y., Todd, K. G., Ballanyi, K., Colmers, W. F., & Smith, P. A. (2012) · Neuromethods · doi:10.1007/978-1-62703-020-5_14 · Cited by 15
Nelson, J. C., Greengrove, E., Nwachukwu, K. N., Grifasi, I. R., & Marshall, S. A. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2004094 · Cited by 14
Xie, Y., Wu, Z., Sun, L., Zhou, L., Xiao, L., Wang, H., & Wang, G. (2022) · Neuroreport · doi:10.1097/wnr.0000000000001779 · Cited by 14
Peripheral and central neuroplasticity in a mouse model of endometriosis
Castro, J., Maddern, J., Erickson, A., Harrington, A. M., & Brierley, S. M. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15843 · Cited by 14
Wala, S. J., Sajankila, N., Ragan, M. V., Duff, A. F., Wickham, J., Volpe, S. G., Wang, Y., Conces, M. R., Dumbauld, Z., Purayil, N., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-44676-5 · Cited by 14
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Cao, Z., Min, X., Xie, X., Huang, M., Liu, Y., Sun, W., Xu, G., He, M., He, K., Li, Y., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2320383121 · Cited by 14
Yu, H., Shen, B., Han, R., Zhang, Y., Xu, S., Zhang, Y., Guo, Y., Huang, P., Huang, S., & Zhong, Y. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00343-4 · Cited by 15
Marinho, T. D. S., Fabiano, M. M., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149225 · Cited by 17
Chen, J., Dai, X., Li, X., Tang, Y.-X., Xu, X.-W., & Li, J. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156114 · Cited by 16
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Rahim, R. S., Meedeniya, A. C. B., & Crane, D. I. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.034 · Cited by 14
Berdasco, C., Pinto, A., Calabró, V., Arenas, D., Cangelosi, A., Geoghegan, P. A., Evelson, P., & Goldstein, J. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0509-x · Cited by 14
Tan, Z., Lei, Z., Zhang, Z., Zhang, H., Shu, K., Hu, F., & Lei, T. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4725-5 · Cited by 14
Kan, Z., Wang, Y., Chen, Q., Tang, X., Thompson, H. J., Huang, J., Zhang, J., Gao, F., Shen, Y., & Wan, X. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100626 · Cited by 15
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Melzi, S., Morel, A., Scoté-Blachon, C., Liblau, R., Dauvilliers, Y. A., & Peyron, C. (2021) · Brain Pathology · doi:10.1111/bpa.13027 · Cited by 14
Ferrara, N. C., Trask, S., Yan, L., Padival, M., Helmstetter, F. J., & Rosenkranz, J. A. (2022) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2022.107626 · Cited by 13
Liu, M., Eguchi, N., Yamasaki, Y., Urade, Y., Hattori, N., & Urabe, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.027 · Cited by 14
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McCabe, J. T., Moratz, C. M., Liu, Y., Burton, E. E., Morgan, A., Budinich, C. S., Lowe, D., Rosenberger, J. G., Chen, H., Liu, J., et al. (2014) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2013.11.023 · Cited by 14
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Claes, C., Daele, J. V. D., & Verfaillie, C. M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.019 · Cited by 13
Nakajima, K., Tanaka, T., Masubuchi, Y., Ito, Y., Kikuchi, S. S., Woo, G., Yoshida, T., & Shibutani, M. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9981-4 · Cited by 14
Self-citationActivation of hippocampal microglia in a murine model of cancer-induced pain
Miladinovic, T., Sharma, M., Phan, A., Geres, H., Ungard, R. G., Linher‐Melville, K., & Singh, G. (2019) · Journal of Pain Research · doi:10.2147/jpr.s191860 · Cited by 14
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Massengill, M. T., Ash, N. F., Young, B. M., Ildefonso, C. J., & Lewin, A. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-73749-y · Cited by 13
Mortensen, D., Thoefner, M. S., Agerholm, J. S., Slumstrup, L., Jensen, T. S., Bjerrum, O. J., Berendt, M., & Nyengaard, J. R. (2022) · Pain · doi:10.1097/j.pain.0000000000002630 · Cited by 13
Iida, T., Yanai, K., & Yoshikawa, T. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_322 · Cited by 13
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Vu, A. P., Lam, D., Denney, C., Lee, K. V., Plemel, J. R., & Jackson, J. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15966 · Cited by 14
Lao, Y., Li, Z., Bai, Y., Li, W., Wang, J., Wang, Y., Li, Q., & Dong, Z. (2023) · Pain Research and Management · doi:10.1155/2023/2061632 · Cited by 13
Shen, J., Gong, L., Sun, Y., Lin, J., Hu, W., Wei, J., Miao, X., Gao, T., Suo, J., Xu, J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109649 · Cited by 14
McGregor, R., Wu, M.-F., Thannickal, T. C., Li, S., & Siegel, J. M. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00278-2 · Cited by 13
Bok, S., Wang, T., Lee, C.-J., Jeon, S.-U., Kim, Y.-E., Kim, J., Hong, B.-J., Yoon, C. J., Kim, S., Lee, S., et al. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.003303 · Cited by 13
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Sun, C., Liu, Y., Liu, Y., Zhao, M., Zhai, J., Hao, P., Wang, Y., & Ji, Y. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.05.016 · Cited by 13
Carmona‐Abellán, M., Martínez-Valbuena, I., Marcilla, I., DiCaudo, C., Gil, I., Núñez, J., & Luquín, M. R. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04686-x · Cited by 13
Calsbeek, J. J., González, E. A., Bruun, D. A., Guignet, M. A., Copping, N. A., Dawson, M. E., Yu, A. J., MacMahon, J. A., Saito, N. H., Harvey, D. J., et al. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.09.001 · Cited by 13
Ebert, T., Heinz, D. E., Almeida-Corrêa, S., Cruz, R., Dethloff, F., Štark, T., Bajaj, T., Maurel, O. M., Ribeiro, F. M., Calcagnini, S., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.731603 · Cited by 14
Chamas, L., Seugnet, I., Poirier, R., Clerget-Froidevaux, M.-S., & Enderlin, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911938 · Cited by 16
Yanai, S., Tago, T., Toyohara, J., Arasaki, T., & Endo, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1031637 · Cited by 14
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Hassler, L., Wysocki, J. A., Ahrendsen, J. T., Ye, M., Gelarden, I. A., Nicolaescu, V. I., Τοματσίδου, Α., Gula, H., Cianfarini, C. L., Khurram, N., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202301969 · Cited by 14
Xue, Q., Yang, C., Hoffman, P. M., & Streit, W. J. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.089 · Cited by 13
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Ghatak, A., & Combs, C. K. (2014) · MethodsX · doi:10.1016/j.mex.2014.10.007 · Cited by 13
Nakajima, K., Graeber, M. B., Sonoda, M., Tohyama, Y., Kohsaka, S., & Kurihara, T. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20882 · Cited by 13
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Yu, A. C., Neil‐Sztramko, S., & Quandt, J. A. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.03.018 · Cited by 13
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Fehrenbach, M. K., Tjwa, M., Bechmann, I., & Krueger, M. (2018) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2018.03.004 · Cited by 14
Angelim, M. K. S. C., Maia, L. M. S. D. S., Mouffle, C., Ginhoux, F., Low, D., dos Santos, Â. A., Makhoul, J., Corronc, H. L., Mangin, J., & Legendre, P. (2018) · Glia · doi:10.1002/glia.23499 · Cited by 15
Iemolo, A., Montilla‐Perez, P., Lai, I., Meng, Y., Nolan, S. L., Wen, J., Rusu, I., Dulcis, D., & Telese, F. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24886 · Cited by 15
Ceccarelli, I., Fiengo, P., Remelli, R., Miragliotta, V., Rossini, L., Biotti, I., Cappelli, A., Petricca, L., Rosa, S. L., Caricasole, A., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.11.019 · Cited by 14
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dos Santos, B. L., dos Santos, C. C., Soares, J. R. P., da Silva, K. C., de Oliveira, J. V. R., Pereira, G. S., de Araújo, F. M., Costa, M. D. F. D., David, J. M., da Silva, V. D. A., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051410 · Cited by 12
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Otuyemi, B. A., Jackson, T., Ma, R., Monteiro, A. R., Seifi, M., & Swinny, J. D. (2023) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102233 · Cited by 12
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Yin, Q., Chen, G., Mu, D., Yang, Y., Hao, J., Lin, B., Zhou, D., Hou, Y., & Li, N. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107335 · Cited by 12
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Hamada, S., Hirashima, H., Imaeda, M., Okamoto, Y., Hamaguchi‐Hamada, K., & Kurumata‐Shigeto, M. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000017 · Cited by 12
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Al‐Shammari, A. R., Bhardwaj, S. K., Musaelyan, K., Srivastava, L. K., & Szele, F. G. (2018) · Schizophrenia · doi:10.1038/s41537-018-0057-5 · Cited by 12
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Wang, H., Devadoss, D., Nair, M., Chand, H. S., & Lakshmana, M. K. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.954071 · Cited by 12
Rava, A., Rosa, P. L., Palladino, G., Dragotto, J., Totaro, A., Tiberi, J., Canterini, S., Oddi, S., & Fiorenza, M. T. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30909 · Cited by 13
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Jehmlich, U., Ritzer, J., Grosche, J., Härtig, W., & Liebert, U. G. (2013) · Journal of NeuroVirology · doi:10.1007/s13365-013-0199-1 · Cited by 12
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Ghosh, C., Westcott, R., O’Connor, C., Williams, S., Liu, X., Hossain, M. K., Nemeth, M., & Najm, I. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02624-2 · Cited by 11
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Dadario, N. B., Boyett, D. M., Teasley, D. E., Chabot, P. J., Winans, N. J., Argenziano, M., Sperring, C. P., Canoll, P., & Bruce, J. N. (2024) · Cancers · doi:10.3390/cancers16193283 · Cited by 12
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Tsuda, N., Tohmi, M., Mizuno, M., & Nawa, H. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.007 · Cited by 11
Liu, M., Eguchi, N., Yamasaki, Y., Urade, Y., Hattori, N., & Urabe, T. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.018 · Cited by 11
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Metadata
- Authors
- Ito, D., Imai, Y., Ohsawa, K., Nakajima, K., Fukuuchi, Y., & Kohsaka, S.
- Affiliations
- Keio University (JP)
- National Institute of Neuroscience (JP)
- Corresponding author
- Kohsaka, Shinichi
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 57
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W2053176712
- Cited by
- 1,476
- References
- 35
- Citations by year
- 2026: 56 · 2025: 82 · 2024: 77 · 2023: 88 · 2022: 92 · 2021: 95 · 2020: 85 · 2019: 103 · 2018: 82 · 2017: 78 · 2016: 70 · 2015: 52 · 2014: 78 · 2013: 55 · 2012: 57
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Iba1, calcium-binding proteins, microglia, microglial activation, facial nerve axotomy, facial nucleus, ramified microglia, rat brain
- MeSH terms
- Animals, Brain, Calcium-Binding Proteins, Cells, Cultured, Facial Nerve, Fluorescent Antibody Technique, Microfilament Proteins, Motor Neurons, Rats, Wistar, Microglia, Axotomy, Rats
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