Cited by 1,476Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Microglia-specific localisation of a novel calcium binding protein, Iba1

Ito, Daisuke, Imai, Yoshinori, Ohsawa, Keiko, Nakajima, Kazuyuki, Fukuuchi, Yasuo, Kohsaka, Shinichi·1998·Molecular Brain Research

DOI 10.1016/s0169-328x(98)00040-0

Open this paper in CoChat — free account

Abstract

Recently it has been shown that mRNA of Iba1 (ionized calcium binding adaptor molecule 1), which was a novel calcium binding protein cDNA-cloned by our group, is specifically expressed in microglia in cultures of rat brain cells [Imai et al. Biophys. Biochem. Res. Commun., 224 (1996) 855-862]. In the present study, immunocytochemical and immunohistochemical examinations demonstrated that Iba1 protein is expressed in microglia alone both in cultured brain cells and in the brain, respectively. In a mixed cell culture of embryonic rat brain, immunocytochemically positive for Iba1 protein were the microglia but it was not detectable in neurons, astroglia, or oligodendroglia. Immunohistochemical staining of adult rat brain sections showed Iba1 protein to be specifically localised in ramified microglia. In addition, immunohistochemical staining and immunoblot analysis of activated microglia in the facial nucleus after facial nerve axotomy shows that expression of Iba1 protein was upregulated and peaked at 7 days. These results indicated that localisation of Iba1 protein is restricted to microglia both in vitro and in vivo, and that Iba1 protein plays a role in regulating the function of microglia, especially in the activated microglia.

Integrity signals

Registry

Crossref · 10.1016/s0169-328x(98)00040-0

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
Maddon, P. J., Dalgleish, A. G., McDougal, J. S., Clapham, P. R., Weiss, R. A., & Axel, R. (1986) · Cell · doi:10.1016/0092-8674(86)90590-8 · Cited by 2,003
The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3
Dijkstra, C. D., Döpp, E. A., Joling, P., & Kraal, G. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2463-8_50 · Cited by 1,598
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466
Activation of microglial cells by β-amyloid protein and interferon-γ
Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314
Functional plasticity of microglia: A review
Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1988) · Glia · doi:10.1002/glia.440010502 · Cited by 937
Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90215-5 · Cited by 902

Show all 35 references

Research works printed but not linked: 2

del Rio-Hortega, 1919, El tercer elemento de los centros nerviosos: I. La microglia en estados normal; II. Intervencio de la microglia en los processos patologicas; III. Naturaleza probable de la microglia, Bol. Soc. Espanola Biol., 9, 69
Dolman, C.L., Microglia, in: R.L. Davis, D.M. Robertson (Eds.), Textbook of Neuropathology, Microglia, Williams and Wilkins, Baltimore, 1985, pp. 117–137.

Sorted by citations

Items 501–600 of 999

Accumulation of chondroitin sulfate proteoglycans in the microenvironment of spinal motor neurons in amyotrophic lateral sclerosis transgenic rats
Mizuno, H., Warita, H., Aoki, M., & Itoyama, Y. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21702 · Cited by 44
Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus
Ma, J., Choi, B., Chung, C., Min, S. S., Jeon, W. K., & Han, J. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-33 · Cited by 42
Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially
Kang, W., Ju, C., Joo, J., Lee, J., Shon, Y., & Park, S. (2022) · Nature Communications · doi:10.1038/s41467-022-35540-7 · Cited by 44
Microglia are Involved in Pruritus Induced by DNFB via the CX3CR1/p38 MAPK Pathway
Zhang, Y., Yan, J., Hu, R., Sun, Y., Ma, Y., Chen, Z., & Jiang, H. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373929 · Cited by 42
Patterns of cell death in the perinatal mouse forebrain
Mosley, M., Shah, C. R., Morse, K. A., Miloro, S. A., Holmes, M. M., Ahern, T. H., & Forger, N. G. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24041 · Cited by 44
CD74-immunoreactive activated M1 microglia are shown late in the gerbil hippocampal CA1 region following transient cerebral ischemia
Hwang, I. K., Park, J. H., Lee, T.-K., Kim, D. W., Yoo, K., Ahn, J. H., Kim, Y. H., Cho, J. H., Kim, Y., Won, M., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6525 · Cited by 43
Molecular insights into the mechanisms of M-cell differentiation and transcytosis in the mucosa-associated lymphoid tissues
Kimura, S. (2017) · Anatomical Science International · doi:10.1007/s12565-017-0418-6 · Cited by 48
Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival
Bien-Möller, S., Balz, E., Herzog, S., Plantera, L., Vogelgesang, S., Weitmann, K., Seifert, C., Fink, M. A., Marx, S., Bialke, A., et al. (2018) · Stem Cells International · doi:10.1155/2018/9628289 · Cited by 43
Microglial Mincle receptor in the PVN contributes to sympathetic hyperactivity in acute myocardial infarction rat
Wang, Y., Yin, J., Wang, C., Hu, H., Li, X., Xue, M., Liu, J., Cheng, W., Wang, Y., Li, Y., et al. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13890 · Cited by 43
Age‐dependent release of high‐mobility group box protein‐1 and cellular neuroinflammation after traumatic brain injury in mice
Webster, K. M., Sun, M., Crack, P. J., O'Brien, T. J., Shultz, S. R., & Semple, B. D. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24589 · Cited by 44
Fungicide Residues Exposure and β-amyloid Aggregation in a Mouse Model of Alzheimer’s Disease
Lafon, P., Wang, Y., Arango-Lievano, M., Torrent, J., Salvador-Prince, L., Mansuy, M., Mestre‐Francés, N., Givalois, L., Liu, J., Mercader, J. V., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp5550 · Cited by 43
Expression of CD200 by macrophage-like cells in ischemic core of rat brain after transient middle cerebral artery occlusion
Matsumoto, H., Kumon, Y., Watanabe, H., Ohnishi, T., Takahashi, H., Imai, Y., & Tanaka, J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.027 · Cited by 43
Self-citation
Glial Expression of Interleukin-18 and its Receptor After Excitotoxic Damage in the Mouse Hippocampus
Jeon, G. S., Park, S. K., Park, S. W., Kim, D. W., Chung, C. K., & Cho, S. S. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9434-6 · Cited by 43
Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma
Chiu, K., Yeung, S., So, K., & Chang, R. C. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.110 · Cited by 43
Eicosapentaenoic Acid Prevents Memory Impairment After Ischemia by Inhibiting Inflammatory Response and Oxidative Damage
Okabe, N., Nakamura, T., Toyoshima, T., Miyamoto, O., Feng, L., & Itano, T. (2010) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2009.11.016 · Cited by 43
Modulating cell signalling in vivo with magnetic nanotransducers
Romero, G., Park, J., Koehler, F., Pralle, A., & Anikeeva, P. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00170-2 · Cited by 46
Development of Cerebral Gray and White Matter Injury and Cerebral Inflammation over Time after Inflammatory Perinatal Asphyxia
Bonestroo, H. J. C., Heijnen, C. J., Groenendaal, F., van Bel, F., & Nijboer, C. H. A. (2015) · Developmental Neuroscience · doi:10.1159/000368770 · Cited by 42
Structure-Based Drug Discovery for Prion Disease Using a Novel Binding Simulation
Ishibashi, D., Nakagaki, T., Ishikawa, T., Atarashi, R., Watanabe, K., Cruz, F. A., Hamada, T., & Nishida, N. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.06.010 · Cited by 42
An emerging role for microglia in stress‐effects on memory
Sanguino‐Gómez, J., Buurstede, J. C., Abiega, O., Fitzsimons, C. P., Lucassen, P. J., Eggen, B. J. L., Lesuis, S. L., Meijer, O. C., & Krugers, H. J. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15188 · Cited by 43
Microglial/macrophage cells in mammalian olfactory nerve fascicles
Smithson, L. J., & Kawaja, M. D. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22254 · Cited by 42
Intra‐neural administration of fractalkine attenuates neuropathic pain‐related behaviour
Holmes, F. E., Arnott, N., Vanderplank, P. A., Kerr, N. C. H., Longbrake, E. E., Popovich, P. G., Imai, T., Combadière, C., Murphy, P. M., & Wynick, D. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05419.x · Cited by 41
Dual Role of Fcγ Receptor in Transient Focal Cerebral Ischemia in Mice
Komine‐Kobayashi, M., Chou, N., Mochizuki, H., Nakao, A., Mizuno, Y., & Urabe, T. (2004) · Stroke · doi:10.1161/01.str.0000120321.30916.8e · Cited by 42
Proliferative Vitreoretinopathy in the Swine–A New Model
Umazume, K., Barak, Y., McDonald, K., Liu, L., Kaplan, H. J., & Tamiya, S. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9768 · Cited by 42
Homeostatic state of microglia in a rat model of chronic sleep restriction
Hall, S., Deurveilher, S., Robertson, G. S., & Semba, K. (2020) · SLEEP · doi:10.1093/sleep/zsaa108 · Cited by 40
Aminoguanidine inhibits caspase‐3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia
Dingman, A., Lee, S., Derugin, N., Wendland, M. F., & Vexler, Z. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03672.x · Cited by 41
Differential neurogenic potential of progenitor cells in dentate gyrus and CA1 sector of the postischemic adult monkey hippocampus
Tonchev, A. B., & Yamashima, T. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.11.022 · Cited by 42
Calretinin interneuron density in the caudate nucleus is lower in autism spectrum disorder
Adorján, I., Ahmed, B., Feher, V., Torso, M., Krug, K., Esiri, M. M., Chance, S. A., & Szele, F. G. (2017) · Brain · doi:10.1093/brain/awx131 · Cited by 41
Allograft Inflammatory Factor 1 as an Immunohistochemical Marker for Macrophages in Multiple Tissues and Laboratory Animal Species
Donovan, K. M., Leidinger, M., McQuillen, L. P., Goeken, J. A., Hogan, C. M., Harwani, S. C., Flaherty, H. A., & Meyerholz, D. K. (2018) · Comparative Medicine · doi:10.30802/aalas-cm-18-000017 · Cited by 41
Age Influences Microglial Activation After Cuprizone-Induced Demyelination
Klein, B., Mrowetz, H., Barker, C. M., Lange, S., Rivera, F. J., & Aigner, L. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00278 · Cited by 44
The Novel DA–CH3 Dual Incretin Restores Endoplasmic Reticulum Stress and Autophagy Impairments to Attenuate Alzheimer-Like Pathology and Cognitive Decrements in the APP SWE /PS1 ΔE9 Mouse Model
Panagaki, T., Gengler, S., & Hölscher, C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180584 · Cited by 42
Silencing the Cytoskeleton Protein Iba1 (Ionized Calcium Binding Adapter Protein 1) Interferes with BV2 Microglia Functioning
Gheorghe, R., Deftu, A., Filippi, A., Grosu, A. V., Bica-Popi, M., Chiritoiu‐Butnaru, M., Chirițoiu, G. N., Munteanu, C. V. A., Silvestro, L., & Ristoiu, V. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00790-w · Cited by 41
Combined 1-Deoxynojirimycin and Ibuprofen Treatment Decreases Microglial Activation, Phagocytosis and Dopaminergic Degeneration in MPTP-Treated Mice
Costa, T., Fernández‐Villalba, E., Izura, V., Lucas-Ochoa, A.-M., Menezes-Filho, N. J., Santana, R., de Oliveira, M., Araújo, F., Estrada, C. M., Silva, V., et al. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09925-8 · Cited by 41
Chemo-Protective Potential of Cerium Oxide Nanoparticles against Fipronil-Induced Oxidative Stress, Apoptosis, Inflammation and Reproductive Dysfunction in Male White Albino Rats
Saleh, H. M., Nassar, A. M. K., Noreldin, A. E., Samak, D. H., Elshony, N., Wasef, L., Elewa, Y. H. A., Hassan, S. M. A., Saati, A. A., Hetta, ‏. F., et al. (2020) · Molecules · doi:10.3390/molecules25153479 · Cited by 41
Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review
Xu, Y., & Chen, F. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s273446 · Cited by 45
Microglia as therapeutic targets after neurological injury: strategy for cell therapy
Scott, M. C., Bedi, S. S., Olson, S. D., Sears, C. M., & Cox, C. S. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1934447 · Cited by 43
Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge
Xu, Y., Nygård, M., Kristensson, K., & Bentivoglio, M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.006 · Cited by 42
Rapid isolation and culture of primary microglia from adult mouse spinal cord
Yip, P. K., Kaan, T. K. Y., Fenesan, D., & Malcangio, M. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.07.002 · Cited by 41
An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles
Smith, N. M., Gachulincová, I., Ho, D., Bailey, C. S. L., Bartlett, C. A., Nörret, M., Murphy, J., Buckley, A. G., Rigby, P. J., House, M. J., et al. (2016) · Scientific Reports · doi:10.1038/srep22595 · Cited by 41
Age-related decline of myelin proteins is highly correlated with activation of astrocytes and microglia in the rat CNS
Xie, F., Zhang, J.-C., Han, F., & Chen, J. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1486 · Cited by 40
Neuroinflammation as a neurotoxic mechanism in alcoholism: Commentary on “Increased MCP-1 and microglia in various regions of human alcoholic brain”
Sullivan, E. V., & Zahr, N. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.05.016 · Cited by 40
Treadmill Exercise Improves Motor Function by Suppressing Purkinje Cell Loss in Parkinson Disease Rats
Lee, J. M., Kim, T.-W., Park, S.-S., Han, J., Shin, M., Lim, B., Kim, S., Baek, S., Cho, Y. S., & Kim, K. H. (2018) · International Neurourology Journal · doi:10.5213/inj.1836226.113 · Cited by 40
A Comparative Biology of Microglia Across Species
Sharma, K. P., Bisht, K., & Eyo, U. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.652748 · Cited by 46
PSMC5 Regulates Microglial Polarization and Activation in LPS-Induced Cognitive Deficits and Motor Impairments by Interacting with TLR4
Bi, W., Bao, K., Zhou, X., Deng, Y., Li, X., Zhang, J., Lan, X., Zhao, J., Lu, D., Xu, Y., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02904-9 · Cited by 36
Adenosine triphosphate‐induced photoreceptor death and retinal remodeling in rats
Vessey, K. A., Greferath, U., Aplin, F. P., Jobling, A. I., Phipps, J. A., Ho, T., de Iongh, R. U., & Fletcher, E. L. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23558 · Cited by 39
Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity
Ativie, F., Komorowska‐Müller, J. A., Beins, E. C., Albayram, Ö., Zimmer, T. S., Zimmer, A., Tejera, D., Heneka, M. T., & Bilkei‐Gorzó, A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00295 · Cited by 42
Loss of ferritin‐positive microglia relates to increased iron, RNA oxidation, and dystrophic microglia in the brains of aged male marmosets
Rodríguez-Callejas, J. D., Cuervo-Zanatta, D., Rosas‐Arellano, A., Fonta, C., Fuchs, E., & Perez‐Cruz, C. (2019) · American Journal of Primatology · doi:10.1002/ajp.22956 · Cited by 39
mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury
Wen, Y., Zhang, J., Kapupara, K., & Tsai, R. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0298-z · Cited by 38
Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology
Tisdall, M. D., Ohm, D. T., Lobrovich, R., Das, S. R., Mizsei, G., Prabhakaran, K., Ittyerah, R., Lim, S., McMillan, C. T., Wolk, D. A., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102913 · Cited by 41
Neuropathogenesis of influenza virus infectionin mice
Mori, I., & Kimura, Y. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01403-4 · Cited by 39
Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury
Iwai, H., Ataka, K., Suzuki, H., Dhar, A., Kuramoto, E., Yamanaka, A., & Goto, T. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02283-z · Cited by 37
Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death
Yamada, H., Kase, Y., Okano, Y., Kim, D., Goto, M., Takahashi, S., Okano, H., & Toda, M. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-022-00236-4 · Cited by 38
Locomotor impairment and cerebrocortical oxidative stress in portal vein ligated rats in vivo
Brück, J., Görg, B., Bidmon, H. J., Zemtsova, I., Qvartskhava, N., Keitel, V., KIRCHEIS, G., & Häussinger, D. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.06.035 · Cited by 38
Spatiotemporal pattern of rod degeneration in the S334ter-line-3 rat model of retinitis pigmentosa
Zhu, C. L., Ji, Y., Lee, E.-J., & Grzywacz, N. M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1522-5 · Cited by 38
Gender-specific brain regional variation of neurons, endogenous estrogen, neuroinflammation and glial cells during rotenone-induced mouse model of Parkinson’s disease
Mitra, S., Chakrabarti, N., Dutta, S., Ray, S., Bhattacharya, P., Sinha, P., & Bhattacharyya, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.052 · Cited by 36
Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration
Papageorgiou, I. E., Fetani, A. F., Lewen, A., Heinemann, U., & Kann, O. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0802-0 · Cited by 37
Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice
Chen, K., Harris, L., Lim, J. W. C., Harvey, T. J., Piper, M., Gronostajski, R. M., Richards, L. J., & Bunt, J. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24206 · Cited by 38
Looking for a Treatment for the Early Stage of Alzheimer’s Disease: Preclinical Evidence with Co-Ultramicronized Palmitoylethanolamide and Luteolin
Facchinetti, R., Valenza, M., Bronzuoli, M. R., Menegoni, G., Ratano, P., Steardo, L., Campolongo, P., & Scuderi, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113802 · Cited by 38
Ionized Calcium Binding Adaptor Molecule 1 (IBA1)
Zhang, X., Wang, L., Ziober, A. F., Zhang, P. J., & Bagg, A. (2020) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqaa209 · Cited by 38
Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury
Mandwie, M., Piper, J., Gorrie, C. A., Keay, K. A., Musumeci, G., Al‐Badri, G., & Castorina, A. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.317982 · Cited by 38
Age-Related Changes in Ionized Calcium-Binding Adapter Molecule 1 Immunoreactivity and Protein Level in the Gerbil Hippocampal CA1 Region
Choi, J. H., Lee, C. H., Hwang, I. K., Won, M. H., Seong, J. K., Yoon, Y. S., Lee, H. S., & Lee, I. S. (2007) · Journal of Veterinary Medical Science · doi:10.1292/jvms.69.1131 · Cited by 39
Exercise protects against chronic restraint stress-induced oxidative stress in the cortex and hippocampus
Gerecke, K. M., Kolobova, A., Allen, S., & Fawer, J. L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.027 · Cited by 37
Strain-dependent brain defects in mouse models of primary ciliary dyskinesia with mutations in Pcdp1 and Spef2
Finn, R., Evans, C. C., & Lee, L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.029 · Cited by 37
Up-regulation of neurofilament light chains is associated with diminished immunoreactivities for MAP2 and tau after ischemic stroke in rodents and in a human case
Härtig, W., Krueger, M., Hofmann, S., Preißler, H., Märkel, M., Frydrychowicz, C., Mueller, W. C., Bechmann, I., & Michalski, D. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.09.004 · Cited by 37
Autophagy gene FIP200 in neural progenitors non–cell autonomously controls differentiation by regulating microglia
Wang, C., Yeo, S. K., Haas, M. A., & Guan, J. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201609093 · Cited by 40
Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny
Beaudry‐Richard, A., Nadeau‐Vallée, M., Prairie, É., Maurice, N., Heckel, É., Nezhady, M. A. M., Pundir, S., Madaan, A., Boudreault, A., Hou, X., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30087-4 · Cited by 37
Chronic unpredictable stress influenced the behavioral but not the neurodegenerative impact of paraquat
Rudyk, C., Dwyer, Z., McNeill, J., Salmaso, N., Farmer, K., Prowse, N. A., & Hayley, S. P. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100179 · Cited by 39
Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia
Toyama, T., Hoshi, T., Noguchi, T., Saito, Y., Matsuzawa, A., Naganuma, A., & Hwang, G. (2021) · Scientific Reports · doi:10.1038/s41598-021-89210-7 · Cited by 37
Expression of CD200 in alternative activation of microglia following an excitotoxic lesion in the mouse hippocampus
Yi, M., Zhang, E., Kang, J. W., Shin, Y. N., Byun, J. Y., Oh, S., Seo, J. H., Lee, Y., & Kim, D. W. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.053 · Cited by 36
Stromal cell-derived factor 1α decreases β-amyloid deposition in Alzheimer's disease mouse model
Wang, Q., Xu, Y., Chen, J., Qin, Y., Liu, M., Liu, Y., Xie, M.-J., Yu, Z., Zhu, Z., & Wang, W. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.011 · Cited by 39
Methamphetamine sensitization attenuates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus
Buchanan, J. B., Sparkman, N. L., & Johnson, R. W. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.12.008 · Cited by 37
Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume
Höfling, C., Kulesskaya, N., Jaako, K., Peltonen, I., Männistö, P. T., Nurmi, A., Vartiainen, N. E., Morawski, M., Zharkovsky, A., Võikar, V., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.02.015 · Cited by 38
Neurodegeneration and Glial Response after Acute Striatal Stroke: Histological Basis for Neuroprotective Studies
Lima, R. R., Santana, L. N. S., Fernandes, R. M., do Nascimento, E. M., de Oliveira, A. C. A., Fernandes, L. M. P., dos Santos, E. M. N., Tavares, P. A. N., Santos, I. R., Santos, A. G., et al. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3173564 · Cited by 37
Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels
Köhler, C., Ebert, U., Baumann, K., & Schröder, H. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.04.009 · Cited by 37
Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain
Hultman, K., Cortés‐Canteli, M., Bounoutas, A., Richards, A. T., Strickland, S., & Norris, E. H. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12553 · Cited by 36
Rapid Changes in Synaptic Strength After Mild Traumatic Brain Injury
Witkowski, E. D., Gao, Y. Z., Gavsyuk, A. F., Maor, I., DeWalt, G. J., Eldred, W. D., Mizrahi, A., & Davison, I. G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00166 · Cited by 38
The Role of Microglia during West Nile Virus Infection of the Central Nervous System
Stonedahl, S., Clarke, P., & Tyler, K. L. (2020) · Vaccines · doi:10.3390/vaccines8030485 · Cited by 37
Chronic Anatabine Treatment Reduces Alzheimer’s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD
Verma, M., Beaulieu‐Abdelahad, D., Ait‐Ghezala, G., Li, R., Crawford, F., MULLAN, M. J., & Paris, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128224 · Cited by 36
Disease Progression After Bone Marrow Transplantation in a Model of Multiple Sclerosis Is Associated With Chronic Microglial and Glial Progenitor Response
Cassiani‐Ingoni, R., Muraro, P. A., Magnus, T., Reichert-Scrivner, S. A., Schmidt, J., Huh, J., Quandt, J. A., Bratincsák, A., Shahar, T., Eusebi, F., et al. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318093f3ef · Cited by 36
Glial expression of the 90‐kDa heat shock protein (HSP90) and the 94‐kDa glucose‐regulated protein (GRP94) following an excitotoxic lesion in the mouse hippocampus
Jeon, G. S., Park, S. W., Kim, D. W., Seo, J. H., Cho, J., Lim, S. Y., Kim, S. D., & Cho, S. S. (2004) · Glia · doi:10.1002/glia.20075 · Cited by 36
Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus
Yuan, W., Deren, K. E., McAllister, J. P., Holland, S. K., Lindquist, D. M., Cancelliere, A., Mason, M., Shereen, A. D., Hertzler, D. A., Altaye, M., et al. (2010) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-7-19 · Cited by 38
Iba1 expressing microglia in the dorsal root ganglia become activated following peripheral nerve injury in rats.
Patro, N., Nagayach, A., & Patro, I. K. (2010) · PubMed · Cited by 36
A neurotoxic regimen of methamphetamine exacerbates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus
Buchanan, J. B., Sparkman, N. L., & Johnson, R. W. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-82 · Cited by 35
Mapping of Cbln1‐like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons
Peng, W. J., Smeyne, R. J., Bao, D., Parris, J., & Morgan, J. I. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05913.x · Cited by 36
Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine
Franceschini, A., Nair, A., Bele, T., van den Maagdenberg, A. M. J. M., Nistri, A., & Fabbretti, E. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-143 · Cited by 35
Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration
Doig, R. O., Bartlett, C. A., Maghzal, G. J., Lam, M. A., Archer, M. A., Stocker, R., & Fitzgerald, M. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.06.007 · Cited by 35
Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury
Chen, X., Chen, X., Huang, X., Qin, C., Fang, Y., Liu, Y., Zhang, G., Pan, D., Wang, W., & Xie, M. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9118-1 · Cited by 35
Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures
de Araújo, F. M., Ferreira, R. S., Souza, C. D. S., dos Santos, C. C., Rodrigues, T. L. R. S., Silva, J. H. C. E., Gasparotto, J., Gelain, D. P., El-Bachá, R. D. S., Costa, M. D. F. D., et al. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.03.009 · Cited by 35
Cerebroprotection by progesterone following ischemic stroke: Multiple effects and role of the neural progesterone receptors
Zhu, X., Fréchou, M., Schumacher, M., & Guennoun, R. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.07.014 · Cited by 35
The role of DNA methylation and hydroxymethylation in immunosenescence
Johnson, N. D., & Conneely, K. N. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.011 · Cited by 35
Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer’s Disease
Polis, B., Gurevich, V., Assa, M., & Samson, A. O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184616 · Cited by 34
Neuroprotective effect of ketamine against TNF‐α‐induced necroptosis in hippocampal neurons
Wang, L., Deng, B., Yan, P., Wu, H., Li, C., Zhu, H., Du, J., & Hou, L. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16426 · Cited by 37
Rare contacts between synapses and microglial processes containing high levels of Iba1 and actin - a postembedding immunogold study in the healthy rat brain
Sogn, C. J., Puchades, M. A., & Gundersen, V. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12213 · Cited by 35
Major histocompatability complex class I expression and glial reaction influence spinal motoneuron synaptic plasticity during the course of experimental autoimmune encephalomyelitis
Freria, C. M., Zanon, R. G., dos Santos, L. M. B., & de Oliveira, A. L. R. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22259 · Cited by 35
Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion
Sargin, D., Hassouna, I. A., Sperling, S., Sirén, A., & Ehrenreich, H. (2008) · Glia · doi:10.1002/glia.20797 · Cited by 36
Monitoring in vivo function of cortical microglia
Brawek, B., & Garaschuk, O. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.02.011 · Cited by 35
APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice
Pankiewicz, J. E., Baquero-Buitrago, J., Sanchez, S., Lopez-Contreras, J., Kim, J., Sullivan, P. M., Holtzman, D. M., & Sadowski, M. J. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0156-1 · Cited by 34
“Iba1 is a calcium-binding protein specifically expressed by microglia and macrophages and its expression increases with microglia activation [30].”
Background
Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour
Ratsika, A., Codagnone, M. G., Bastiaanssen, T. F. S., Sardá, F. A. H., Lynch, C. M. K., Ventura‐Silva, A. P., Rosell‐Cardona, C., Caputi, V., Stanton, C., Fülling, C., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.020 · Cited by 36
Adenosine A2A Receptor Signaling in the Immunopathogenesis of Experimental Autoimmune Encephalomyelitis
Rajasundaram, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00402 · Cited by 37
S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit
Liu, C., Zhang, C., Lo, S. Q., Ang, S. T., Chew, K. C. M., Yu, D., Chai, B. H., Tan, B. C. Y., Tsang, F., Tai, Y. K., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3262-17.2018 · Cited by 34
Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury
Bader, M., Li, Y., Lecca, D., Rubovitch, V., Tweedie, D., Glotfelty, E. J., Rachmany, L., Kim, H. K., Choi, H., Hoffer, B. J., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.11.023 · Cited by 34

Authors: Ito, D., Imai, Y., Ohsawa, K., Nakajima, K., Fukuuchi, Y., & Kohsaka, S.
Affiliations: Keio University (JP)
National Institute of Neuroscience (JP)
Corresponding author: Kohsaka, Shinichi
ORCID: Ito, Daisuke
Nakajima, Kazuyuki
Kohsaka, Shinichi
Venue: Molecular Brain Research
Publisher: Elsevier BV
Published: 1998-06
Volume: 57
Issue: 1
Pages: 1-9
ISSN: 0169-328X (ISSN-L)
DOI: 10.1016/s0169-328x(98)00040-0
OpenAlex: W2053176712
Cited by: 1,476
References: 35
Citations by year: 2026: 56 · 2025: 82 · 2024: 77 · 2023: 88 · 2022: 92 · 2021: 95 · 2020: 85 · 2019: 103 · 2018: 82 · 2017: 78 · 2016: 70 · 2015: 52 · 2014: 78 · 2013: 55 · 2012: 57
FWCI: 5.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Molecular Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Iba1, calcium-binding proteins, microglia, microglial activation, facial nerve axotomy, facial nucleus, ramified microglia, rat brain
MeSH terms: Animals, Brain, Calcium-Binding Proteins, Cells, Cultured, Facial Nerve, Fluorescent Antibody Technique, Microfilament Proteins, Motor Neurons, Rats, Wistar, Microglia, Axotomy, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microglia-specific localisation of a novel calcium binding protein, Iba1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks