Microglia-specific localisation of a novel calcium binding protein, Iba1

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

Maddon, P. J., Dalgleish, A. G., McDougal, J. S., Clapham, P. R., Weiss, R. A., & Axel, R. (1986) · Cell · doi:10.1016/0092-8674(86)90590-8 · Cited by 2,003

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

Dijkstra, C. D., Döpp, E. A., Joling, P., & Kraal, G. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2463-8_50 · Cited by 1,598

Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466

Activation of microglial cells by β-amyloid protein and interferon-γ

Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314

Functional plasticity of microglia: A review

Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1988) · Glia · doi:10.1002/glia.440010502 · Cited by 937

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90215-5 · Cited by 902

CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain

Bulloch, K., Miller, M. M., Toth, J. G., Milner, T. A., Gottfried‐Blackmore, A., Waters, E. M., Kaunzner, U. W., Liu, K., Lindquist, R. L., Nussenzweig, M. C., et al. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21668 · Cited by 215

Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma.

Naskar, R., Wissing, M., & Thanos, S. (2002) · PubMed · Cited by 209

Microglia/macrophages promote glioma progression

Zhai, H., Heppner, F. L., & Tsirka, S. E. (2010) · Glia · doi:10.1002/glia.21117 · Cited by 209

Rapid Response of Identified Resident Endoneurial Macrophages to Nerve Injury

Mueller, M., Wacker, K., Ringelstein, E. B., Hickey, W. F., Imai, Y., & Kiefer, R. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63070-2 · Cited by 208

Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma

Inman, D. M., & Horner, P. J. (2007) · Glia · doi:10.1002/glia.20516 · Cited by 205

Sodium Butyrate Abolishes Lipopolysaccharide-Induced Depression-like Behaviors and Hippocampal Microglial Activation in Mice

Yamawaki, Y., Yoshioka, N., Nozaki, K., Ito, H., Oda, K., Harada, K., Shirawachi, S., Asano, S., Aizawa, H., Yamawaki, S., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2017.12.004 · Cited by 204

An Adverse Role for Matrix Metalloproteinase 12 after Spinal Cord Injury in Mice

Wells, J. E. A., Rice, T. K., Nuttall, R. K., Edwards, D. R., Zekki, H., Rivest, S., & Yong, V. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10107.2003 · Cited by 203

Microglial Activation in the Visual Pathway in Experimental Glaucoma: Spatiotemporal Characterization and Correlation with Axonal Injury

Ebneter, A., Casson, R. J., Wood, J. P. M., & Chidlow, G. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5284 · Cited by 198

Time course and distribution of inflammatory and neurodegenerative events suggest structural bases for the pathogenesis of experimental autoimmune encephalomyelitis

Brown, D. A., & Sawchenko, P. E. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21307 · Cited by 200

The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer’s Disease

Habtemariam, S. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/2680409 · Cited by 195

Central Nervous System-Initiated Inflammation and Neurotrophism in Trauma: IL-1β Is Required for the Production of Ciliary Neurotrophic Factor

Herx, L. M., Rivest, S., & Yong, V. W. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.2232 · Cited by 190

Adolescent binge alcohol exposure induces long-lasting partial activation of microglia

McClain, J. A., Morris, S. A. V., Deeny, M. A., Marshall, S. A., Hayes, D. M., Kiser, Z. M., & Nixon, K. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.006 · Cited by 199

Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?

Eichler, F. S., Ren, J., Cossoy, M., Rietsch, A. M., Nagpal, S., Moser, A. B., Frosch, M. P., & Ransohoff, R. M. (2008) · Annals of Neurology · doi:10.1002/ana.21391 · Cited by 178

Invasion of Hematopoietic Cells into the Brain of Amyloid Precursor Protein Transgenic Mice

Stalder, A. K., Ermini, F., Bondolfi, L., Krenger, W., Burbach, G. J., Deller, T., Coomaraswamy, J., Staufenbiel, M., Landmann, R. M., & Jucker, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2545-05.2005 · Cited by 185

Amyloid-Peptide Vaccinations Reduce β-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer’s Transgenic Mice

Liu, B., Rasool, S., Yang, Z., Glabe, C. G., Schreiber, S. S., Ge, J., & Tan, Z. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090159 · Cited by 182

Zika Virus Targeting in the Developing Brain

van den Pol, A. N., Mao, G., Yang, Y., Ornaghi, S., & Davis, J. N. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3124-16.2017 · Cited by 178

Characterization of Stanniocalcin 2, a Novel Target of the Mammalian Unfolded Protein Response with Cytoprotective Properties

Ito, D., Walker, J. R., Thompson, C. S., Moroz, I., Lin, W., Veselits, M., Hakim, A. M., Fienberg, A. A., & Thinakaran, G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9456-9469.2004 · Cited by 179

Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis

Stephenson, D. T., O'Neill, S. M., Narayan, S., Tiwari, A., Arnold, E., Samaroo, H. D., Du, F., Ring, R. H., Campbell, B., Pletcher, M., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-7 · Cited by 180

Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10.

van Marle, G., Henry, S., Todoruk, T., Sullivan, A., Silva, C., Rourke, S., Holden, J., McArthur, J. C., Gill, M., & Power, C. (2004) · Virology · doi:10.1016/j.virol.2004.08.024 · Cited by 184

Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse

Schuster, D. J., Dykstra, J. A., Riedl, M. S., Kitto, K. F., Belur, L. R., McIvor, R. S., Elde, R. P., Fairbanks, C. A., & Vulchanova, L. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00042 · Cited by 161

Morphologic Features and Glial Activation in Rat Oxaliplatin-Dependent Neuropathic Pain

Mannelli, L. D. C., Pacini, A., Bonaccini, L., Zanardelli, M., Mello, T., & Ghelardini, C. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.08.002 · Cited by 175

The NAD‐dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

Pais, T. F., Szegő, É. M., Marques, O., Miller‐Fleming, L., Antas, P., Guerreiro, P. S., de Oliveira, R. M., Kasapoğlu, B., & Outeiro, T. F. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.200 · Cited by 177

Inflammatory changes parallel the early stages of Alzheimer disease

Parachikova, A., Agadjanyan, M. G., Cribbs, D. H., Blurton-Jones, M., Perreau, V., Rogers, J., Beach, T. G., & Cotman, C. W. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.014 · Cited by 203

Distribution and differentiation of microglia in the human encephalon during the first two trimesters of gestation

Monier, A., Evrard, P., Gressèns, P., & Verney, C. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21123 · Cited by 169

Glial role in oxaliplatin-induced neuropathic pain

Mannelli, L. D. C., Pacini, A., Micheli, L., Tani, A., Zanardelli, M., & Ghelardini, C. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.06.016 · Cited by 175

Activation of dorsal horn microglia contributes to diabetes‐induced tactile allodynia via extracellular signal‐regulated protein kinase signaling

Tsuda, M., Ueno, H., Kataoka, A., Tozaki‐Saitoh, H., & Inoue, K. (2008) · Glia · doi:10.1002/glia.20623 · Cited by 170

Macrophage/Microglia-specific Protein Iba1 Enhances Membrane Ruffling and Rac Activation via Phospholipase C-γ-dependent Pathway

Kanazawa, H., Ohsawa, K., Sasaki, Y., Kohsaka, S., & Imai, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109218200 · Cited by 174

Intestinal pathology and gut microbiota alterations in a methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

Lai, F., Jiang, R., Xie, W., Liu, X., Tang, Y., Xiao, H., Gao, J., Jia, Y., & Bai, Q. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2620-x · Cited by 169

A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease

Serrano-Pozo, A., Gómez-Isla, T., Growdon, J. H., Frosch, M. P., & Hyman, B. T. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.02.031 · Cited by 169

Effect of Lipopolysaccharide on the Morphology and Integrin Immunoreactivity of Ramified Microglia in the Mouse Brain and in Cell Culture

Kloss, C. U. A., Bohatschek, M., Kreutzberg, G. W., & Raivich, G. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7575 · Cited by 169

Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy

Chen, M., Hong, C., Yue, T., Li, H., Duan, R., Hu, W., Cao, J., Wang, Z., Chen, C., Hu, X., et al. (2020) · Theranostics · doi:10.7150/thno.47408 · Cited by 168

Functional recovery in aging mice after experimental stroke

Manwani, B., Liu, F., Xu, Y., Persky, R., Li, J., & McCullough, L. D. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.015 · Cited by 166

Spinal Cord Injury Elicits Expression of Keratan Sulfate Proteoglycans by Macrophages, Reactive Microglia, and Oligodendrocyte Progenitors

Jones, L. L., & Tuszynski, M. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04611.2002 · Cited by 166

Nonrenewal of Neurons in the Cerebral Neocortex of Adult Macaque Monkeys

Koketsu, D., Mikami, A., Miyamoto, Y., & Hisatsune, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00937.2003 · Cited by 160

Methamphetamine neurotoxicity, microglia, and neuroinflammation

Shaerzadeh, F., Streit, W. J., Heysieattalab, S., & Khoshbouei, H. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1385-0 · Cited by 159

Hematopoietic cells maintain hematopoietic fates upon entering the brain

Massengale, M., Wagers, A. J., Vogel, H. S., & Weissman, I. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050030 · Cited by 159

An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization

Weaver, A., DaSilva, A. G., Nuttall, R. K., Edwards, D. R., Shapiro, S. D., Rivest, S., & Yong, V. W. (2005) · The FASEB Journal · doi:10.1096/fj.04-2030fje · Cited by 158

Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease

Barron, A. M., García‐Segura, L. M., Caruso, D., Jayaraman, A., Lee, J.-W., Melcangi, R. C., & Pike, C. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1350-13.2013 · Cited by 159

Cellular and Molecular Characterization of Microglia: A Unique Immune Cell Population

Sousa, C., Biber, K. P. H., & Michelucci, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00198 · Cited by 159

Progranulin expression in the developing and adult murine brain

Petkau, T. L., Neal, S. J., Orban, P. C., MacDonald, J. L., Hill, A. M., Lu, G., Feldman, H. H., Mackenzie, I. R. A., & Leavitt, B. R. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22430 · Cited by 152

Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model

Aryanpour, R., Pasbakhsh, P., Zibara, K., Namjoo, Z., Boroujeni, F. B., Shahbeigi, S., Kashani, I. R., Beyer, C., & Zendedel, A. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.08.007 · Cited by 156

Loss of Neurons from Laminas I-III of the Spinal Dorsal Horn Is Not Required for Development of Tactile Allodynia in the Spared Nerve Injury Model of Neuropathic Pain

Polgár, E., Hughes, D. I., Arham, A. Z., & Todd, A. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1490-05.2005 · Cited by 161

Postischemic Brain Infiltration of Leukocyte Subpopulations Differs among Murine Permanent and Transient Focal Cerebral Ischemia Models

Zhou, W., Liesz, A., Bauer, H., Sommer, C., Lahrmann, B., Valous, N. A., Grabe, N., & Veltkamp, R. C. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00614.x · Cited by 150

Brain Microglia and Microglial Markers

Korzhevsky, D. E., & Kirik, O. V. (2016) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-016-0231-z · Cited by 148

A systematic review on the neuroprotective perspectives of beta‐caryophyllene

Machado, K. D. C., Islam, M. T., Ali, E. S., Rouf, R., Uddin, S. J., Dev, S., Shilpi, J. A., Shill, M. C., Reza, H. M., Das, A. K., et al. (2018) · Phytotherapy Research · doi:10.1002/ptr.6199 · Cited by 152

Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s disease

Gomez-Nicola, D., & Boche, D. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0126-1 · Cited by 147

A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease

Simmons, D. A., Belichenko, N. P., Yang, T., Condon, C., Monbureau, M., Shamloo, M., Jing, D., Massa, S. M., & Longo, F. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1310-13.2013 · Cited by 145

Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke

Lee, Y., Lee, S., Choi, S. S., Yeo, H.-G., Chang, K., & Lee, H. J. (2014) · BioMed Research International · doi:10.1155/2014/297241 · Cited by 149

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

Wu, Y., Du, S., Johnson, J. L., Tung, H.-Y., Landers, C. T., Liu, Y., Seman, B. G., Wheeler, R. T., Costa-Mattioli, M., Kheradmand, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07991-4 · Cited by 143

Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells via inhibiting hyperglycemia‐mediated ERK1/2–NF‐κB signaling pathway

Zhang, T., Ouyang, H., Mei, X., Lü, B., Yu, Z., Chen, K., Wang, Z., & Ji, L. (2019) · The FASEB Journal · doi:10.1096/fj.201802614rrr · Cited by 145

Statin Therapy Inhibits Remyelination in the Central Nervous System

Miron, V. E., Zehntner, S. P., Kuhlmann, T., Ludwin, S. K., Owens, T., Kennedy, T. E., Bedell, B. J., & Antel, J. P. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080947 · Cited by 141

Caspase-11 Mediates Inflammatory Dopaminergic Cell Death in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson's Disease

Furuya, T., Hayakawa, H., YAMADA, M., Yoshimi, K., Hisahara, S., Miura, M., Mizuno, Y., & Mochizuki, H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3309-03.2004 · Cited by 140

Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination

Binder, M. D., Cate, H. S., Prieto, A. L., Kemper, D., Butzkueven, H., Gresle, M. M., Cipriani, T., Jokubaitis, V. G., Carmeliet, P., & Kilpatrick, T. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1180-08.2008 · Cited by 138

Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy

Castro, B. A., Flanigan, P. M., Jahangiri, A., Hoffman, D. B., Chen, W. C., Kuang, R., Lay, M. D. D., Yagnik, G., Wagner, J. R., Mascharak, S., et al. (2017) · Oncogene · doi:10.1038/onc.2017.1 · Cited by 138

Siglec‐H is a microglia‐specific marker that discriminates microglia from CNS‐associated macrophages and CNS‐infiltrating monocytes

Konishi, H., Kobayashi, M., Kunisawa, T., Imai, K., Sayo, A., MALISSEN, B., Crocker, P. R., Sato, K., & Kiyama, H. (2017) · Glia · doi:10.1002/glia.23204 · Cited by 141

Estradiol Is Required for a Proper Immune Response to Bacterial and Viral Pathogens in the Female Brain

Soucy, G., Boivin, G., Labrie, F., & Rivest, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6391 · Cited by 138

Microglia and Brain Plasticity in Acute Psychosis and Schizophrenia Illness Course: A Meta-Review

Picker, L. D., Morrens, M., Chance, S. A., & Boche, D. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00238 · Cited by 138

The allograft inflammatory factor‐1 family of proteins

Deininger, M. H., Meyermann, R., & Schluesener, H. J. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02430-4 · Cited by 140

Activation of Presynaptic P2X7-Like Receptors Depresses Mossy Fiber–CA3 Synaptic Transmission through p38 Mitogen-Activated Protein Kinase

Armstrong, J. N., Brust, T., Lewis, R. G., & MacVicar, B. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05938.2002 · Cited by 136

Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice.

Schroeter, M., Zickler, P., Denhardt, D., Hartung, H., & Jander, S. (2006) · Brain : a journal of neurology · doi:10.1093/brain/awl094 · Cited by 141

TNF-α-Induced Optic Nerve Degeneration and Nuclear Factor-κB p65

Kitaoka, Y., Kitaoka, Y., Kwong, J. M. K., Ross‐Cisneros, F. N., Wang, J., Tsai, R., Sadun, A. A., & Lam, T. T. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0299 · Cited by 135

Phenotypic clustering: a novel method for microglial morphology analysis

Verdonk, F., Roux, P., Flamant, P., Fiette, L., Bozza, F. A., Simard, S., Lemaire, M., Plaud, B., Shorte, S. L., Sharshar, T., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0614-7 · Cited by 142

Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages

Lehmann, M. L., Cooper, H. A., Maric, D., & Herkenham, M. A. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0672-x · Cited by 138

Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model

Horstmann, L., Schmid, H., Heinen, A. P., Kurschus, F. C., Dick, H. B., & Joachim, S. C. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-120 · Cited by 133

Combined Immunosuppressive Agents or CD4 Antibodies Prolong Survival of Human Neural Stem Cell Grafts and Improve Disease Outcomes in Amyotrophic Lateral Sclerosis Transgenic Mice

Yan, J., Xu, L., Welsh, A. M., Chen, D., Hazel, T. G., Johe, K. K., & Koliatsos, V. E. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0518 · Cited by 133

Enhanced Insight into the Autoimmune Component of Glaucoma: IgG Autoantibody Accumulation and Pro-Inflammatory Conditions in Human Glaucomatous Retina

Gramlich, O. W., Gehrke-Beck, S., Hohenstein-Blaul, N. V. T. U., Boehm, N., Ziegler, A., Vetter, J. M., Pfeiffer, N., & Grus, F. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057557 · Cited by 132

Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation

Alexander, J., DeVries, A. C., Kigerl, K. A., Dahlman, J. M., & Popovich, P. G. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.001 · Cited by 135

Induction of Brain-Derived Neurotrophic Factor in Plaque-Associated Glial Cells of Aged APP23 Transgenic Mice

Burbach, G. J., Hellweg, R., Haas, C. A., Del Turco, D., Deicke, U., Abramowski, D., Jucker, M., Staufenbiel, M., & Deller, T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5599-03.2004 · Cited by 132

Neurofibromatosis-1 Heterozygosity Increases Microglia in a Spatially and Temporally Restricted Pattern Relevant to Mouse Optic Glioma Formation and Growth

Simmons, G. W., Pong, W. W., Emnett, R. J., White, C. R., Gianino, S. M., Rodriguez, F. J., & Gutmann, D. H. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182032d37 · Cited by 130

Age-related changes in neuroactive steroid levels in 3xTg-AD mice

Caruso, D., Barron, A. M., Brown, M. A., Abbiati, F., Carrero, P., Pike, C. J., García‐Segura, L. M., & Melcangi, R. C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.10.007 · Cited by 135

Lauroyl-gemcitabine-loaded lipid nanocapsule hydrogel for the treatment of glioblastoma

Bastiancich, C., Vanvarenberg, K., Učakar, B., Pitorre, M., Bastiat, G., Lagarce, F., Véronique Préat, A., & Danhier, F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.054 · Cited by 129

SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia

Olajide, O. A., Iwuanyanwu, V. U., Adegbola, O. D., & Al‐Hindawi, A. A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02593-6 · Cited by 124

Macrophage-Derived Tumor Necrosis Factor α, an Early Developmental Signal for Motoneuron Death

Sedel, F., Béchade, C., Vyas, S., & Triller, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4464-03.2004 · Cited by 128

Manganese Taken Up into the CNS via the Olfactory Pathway in Rats Affects Astrocytes

Henriksson, J. (2000) · Toxicological Sciences · doi:10.1093/toxsci/55.2.392 · Cited by 128

Curcumin-releasing mechanically adaptive intracortical implants improve the proximal neuronal density and blood–brain barrier stability

Potter, K. A., Jorfi, M., Householder, K. T., Foster, E. J., Weder, C., & Capadona, J. R. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.01.018 · Cited by 127

DIFFERENTIATION OF TRANSPLANTED BONE MARROW CELLS IN THE ADULT MOUSE BRAIN1

Nakano, K., Migita, M., Mochizuki, H., & Shimada, T. (2001) · Transplantation · doi:10.1097/00007890-200106270-00006 · Cited by 125

Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1 β Axis in Microglia

Sui, D.-M., Xie, Q., Yi, W.-J., Gupta, S., Yu, X.-Y., Li, J.-B., Wang, J., Wang, J.-F., & Deng, X.-M. (2016) · Mediators of Inflammation · doi:10.1155/2016/1045657 · Cited by 124

Bifidobacteria shape host neural circuits during postnatal development by promoting synapse formation and microglial function

Luk, B., Engevik, M. A., Ganesh, B. P., Lackey, E. P., Lin, T., Balderas, M. A., Major, A. M., Runge, J. K., Luna, R. A., Sillitoe, R. V., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64173-3 · Cited by 128

Possibility for neurogenesis in substantia nigra of parkinsonian brain

Yoshimi, K., Ren, Y., Seki, T., Yamada, M., 大泉, 英., Onodera, M., Saito, Y., Murayama, S., Okano, H., Mizuno, Y., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20506 · Cited by 123

The relationship between the morphological subtypes of microglia and Alzheimer’s disease neuropathology

Paasila, P. J., Davies, D., Kril, J. J., Goldsbury, C. S., & Sutherland, G. T. (2019) · Brain Pathology · doi:10.1111/bpa.12717 · Cited by 120

Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

Laffer, B., Bauer, D., Wasmuth, S., Busch, M., Jalilvand, T. V., Thanos, S., Meyer zu Hörste, G., Loser, K., Langmann, T., Heiligenhaus, A., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00430 · Cited by 120

Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism

Patel, A., Tsilioni, I., Leeman, S. E., & Theoharides, T. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604992113 · Cited by 123

Allograft inflammatory factor-1/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis

Köhler, C. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0474-7 · Cited by 120

Slit and glypican‐1 mRNAs are coexpressed in the reactive astrocytes of the injured adult brain

Hagino, S., Iseki, K., Mori, T., Zhang, Y., Hikake, T., Yokoya, S., Takeuchi, M., Hasimoto, H., Kikuchi, S., & Wanaka, A. (2003) · Glia · doi:10.1002/glia.10207 · Cited by 125

Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples

Prokop, S., Miller, K. R., Labra, S. R., Pitkin, R. M., Hoxha, K., Narasimhan, S., Changolkar, L., Rosenbloom, A., Lee, V. M.-Y., & Trojanowski, J. Q. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02048-2 · Cited by 119

Genetic targeting of microglia

Wieghofer, P., Knobeloch, K., & Prinz, M. (2014) · Glia · doi:10.1002/glia.22727 · Cited by 118

Microglial morphometric analysis: so many options, so little consistency

Reddaway, J., Richardson, P., Bevan, R. J., Stoneman, J., & Palombo, M. (2023) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2023.1211188 · Cited by 131

Interleukin-1 and the Interleukin-1 Type 1 Receptor are Essential for the Progressive Neurodegeneration that Ensues Subsequent to a Mild Hypoxic/Ischemic Injury

Basu, A., Lazović, J., Krady, J. K., Mauger, D. T., Rothstein, R. P., Smith, M. B. H., & Levison, S. W. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600002 · Cited by 118

NADPH oxidase is involved in post-ischemic brain inflammation

Chen, H., Kim, G. S., Okami, N., Narasimhan, P., & Chan, P. H. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.027 · Cited by 117

Characterization of retinal function and glial cell response in a mouse model of oxygen‐induced retinopathy

Vessey, K. A., Wilkinson‐Berka, J. L., & Fletcher, E. L. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22530 · Cited by 116

Differences of Migratory Behavior between Direct Progeny of Apical Progenitors and Basal Progenitors in the Developing Cerebral Cortex

Tabata, H., Kanatani, S., & Nakajima, K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn227 · Cited by 116

Prior Binge Ethanol Exposure Potentiates the Microglial Response in a Model of Alcohol-Induced Neurodegeneration

Marshall, S. A., Geil, C., & Nixon, K. (2016) · Brain Sciences · doi:10.3390/brainsci6020016 · Cited by 119

Near-infrared light-triggered NO release for spinal cord injury repair

Jiang, Y., Fu, P., Liu, Y., Wang, C., Zhao, P., Chu, X., Jiang, X., Yang, W., Wu, Y., Ya, W., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc3513 · Cited by 115

Regulation of podosome formation, microglial migration and invasion by Ca2+-signaling molecules expressed in podosomes

Siddiqui, T. A., Lively, S. S., Vincent, C. E., & Schlichter, L. C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-250 · Cited by 115

Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease

Chang, R., Knox, J., Chang, J. H., Derbedrossian, A., Vasilevko, V., Cribbs, D. H., Boado, R. J., Pardridge, W. M., & Sumbria, R. K. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00200 · Cited by 116

Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy

López, F. M., Nakajima, K., Honda, S., & Kohsaka, S. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00022-x · Cited by 113

Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge

Parrott, J. M., Redus, L., & O’Connor, J. C. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0590-y · Cited by 112

Systemic LPS Injection Leads to Granulocyte Influx into Normal and Injured Brain: Effects of ICAM-1 Deficiency

Bohatschek, M., Werner, A., & Raivich, G. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7764 · Cited by 112

Associative image analysis: A method for automated quantification of 3D multi-parameter images of brain tissue

Bjornsson, C. S., Lin, G., Al‐Kofahi, Y., Narayanaswamy, A., Smith, K. L., Shain, W. G., & Roysam, B. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.12.024 · Cited by 111

Cold-inducible RNA-binding Protein Mediates Neuroinflammation in Cerebral Ischemia

Zhou, M., Yang, W.-L., Ji, Y.-X., Qiang, X., & Wang, P. (2014) · Biochimica et Biophysica Acta · doi:10.1016/j.bbagen.2014.02.027 · Cited by 108

Calcium-Binding Protein Iba-1/AIF-1 in Rat Brain Cells

Kirik, O. V., Sukhorukova, E. G., & Korzhevsky, D. E. (2011) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-011-9391-z · Cited by 9

Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, After Transient Focal Cerebral Ischemia In Rat Brain

DaisukeIto, KortaroTanaka, ShigeakiSuzuki, TomohisaDembo, & YasuoFukuuchi (2001) · Stroke

UC Davis - Immunohistochemistry IBA1 v1Preprint

Rutkowsky, J. M. (2019) · doi:10.17504/protocols.io.y7pfzmn

UC Davis - Immunohistochemistry IBA1 v2Preprint

Rutkowsky, J. (2019) · doi:10.17504/protocols.io.56pg9dn

Intranuclear Accumulation of Iba-1 Protein in Microgliocytes in the Human Brain

Korzhevsky, D. E., Kirik, O. V., Alekseeva, O. S., Sukhorukova, E. G., & Syrtsova, M. A. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0417-z · Cited by 4