Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders
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J. Neurochem. (2010) 112, 1099–1114. Among multiple structural and functional brain changes, aging is accompanied by an increase of inflammatory signaling in the nervous system as well as a dysfunction of the immune system elsewhere. Although the long‐held view that aging involves neurocognitive impairment is now dismissed, aging is a major risk factor for neurodegenerative diseases such as Alzheimer`s disease, Parkinson`s disease and Huntington’s disease, among others. There are many age‐related changes affecting the brain, contributing both to certain declining in function and increased frailty, which could singly and collectively affect neuronal viability and vulnerability. Among those changes, both inflammatory responses in aged brains and the altered regulation of toll like receptors, which appears to be relevant for understanding susceptibility to neurodegenerative processes, are linked to pathogenic mechanisms of several diseases. Here, we review how aging and pro‐inflammatory environment could modulate microglial phenotype and its reactivity and contribute to the genesis of neurodegenerative processes. Data support our idea that age‐related microglial cell changes, by inducing cytotoxicity in contrast to neuroprotection, could contribute to the onset of neurodegenerative changes. This view can have important implications for the development of new therapeutic approaches.
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Immunosenescence and inflammaging can both contribute to neuroinflammation, resulting in impaired neuronal function and the accumulation of brain tissue damage.
“Immunosenescence and inflammaging can both contribute to neuroinflammation, resulting in impaired neuronal function and the accumulation of brain tissue damage.137,138”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [138]
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Inflammation and aging: signaling pathways and intervention therapies
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Self-citationThe outdoor air pollution and brain health workshop
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Age- and location-related changes in microglial function
Ritzel, R. M., Patel, A. R., Pan, S., Crapser, J., Hammond, M., Jellison, E., & McCullough, L. D. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.016 · Cited by 134 · see citing works
Alzheimer’s Disease, Inflammation, and the Role of Antioxidants
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Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice
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A2E accumulation influences retinal microglial activation and complement regulation
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Self-citationThe killifish visual system as an in vivo model to study brain aging and rejuvenation
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The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases
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Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy
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- Authors
- Von Bernhardi, R., Tichauer, J. E., & Eugenín, J.
- Affiliations
- Pontificia Universidad Católica de Chile (CL)
- Universidad de Santiago de Chile (CL)
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2010-02-02
- Volume
- 112
- Issue
- 5
- Pages
- 1099-1114
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2027368264
- Cited by
- 258
- References
- 203
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 16 · 2023: 14 · 2022: 13 · 2021: 21 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 13 · 2016: 15 · 2015: 16 · 2014: 10 · 2013: 22 · 2012: 23
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- microglia, brain aging, neuroinflammation, neurodegenerative diseases, Toll-like receptors, microglial phenotype, Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection, cytotoxicity, neurodegeneration
- MeSH terms
- Aging, Animals, Brain, Disease Models, Animal, Humans, Iron, Gene Expression, Cytokines, Microglia, Oxidative Stress, Neurodegenerative Diseases
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