Preserved Number of Entorhinal Cortex Layer II Neurons in Aged Macaque Monkeys

Gazzaley, A.H; Thakker, M.M; Hof, P.R; Morrison, J.H

doi:10.1016/s0197-4580(97)00112-7

Cited by 122Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Preserved Number of Entorhinal Cortex Layer II Neurons in Aged Macaque Monkeys

Gazzaley, A.H, Thakker, M.M, Hof, P.R, Morrison, J.H·1997·Neurobiology of Aging

DOI 10.1016/s0197-4580(97)00112-7

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Abstract

The perforant path, which consists of the projection from the layer II neurons of the entorhinal cortex to the outer molecular layer of the dentate gyrus, is a critical circuit involved in learning and memory formation. Accordingly, disturbances in this circuit may contribute to age-related cognitive deficits. In a previous study, we demonstrated a decrease in N-methyl-D-aspartate receptor subunit 1 immunofluorescence intensity in the outer molecular layer of aged macaque monkeys. In this study, we used the optical fractionator, a stereological method, to determine if a loss of layer II neurons occurred in the same animals in which the N-methyl-D-aspartate receptor subunit 1 alteration was observed. Our results revealed no significant differences in the number of layer II neurons between juvenile, young adult, and aged macaque monkeys. These results suggest that the circuit-specific decrease in N-methyl-D-aspartate receptor subunit 1 reported previously occurs in the absence of structural compromise of the perforant path, and thus may be linked to an age-related change in the physiological properties of this circuit.

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Authors: Gazzaley, A. H., Thakker, M. M., Hof, P. R., & Morrison, J. H.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Morrison, J.H
ORCID: Gazzaley, A.H
Hof, P.R
Morrison, J.H
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1997-09
Volume: 18
Issue: 5
Pages: 549-553
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(97)00112-7
OpenAlex: W2117435281
Cited by: 122
References: 37
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 9
FWCI: 2.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: Foundation for the National Institutes of Health
Dana Foundation
National Institute on Aging (AG 05138, P50AG005138, AG-06647)
National Institute of Mental Health (MH/DA 52154)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: entorhinal cortex, perforant path, dentate gyrus, NMDA receptor 1, aging, macaque, age-related cognitive decline, stereology, neuron number
MeSH terms: Aging, Animals, Image Processing, Computer-Assisted, Macaca mulatta, Neurons, Receptors, N-Methyl-D-Aspartate, Entorhinal Cortex

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Preserved Number of Entorhinal Cortex Layer II Neurons in Aged Macaque Monkeys

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