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Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey

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Bowley, Michael P., Cabral, Howard, Rosene, Douglas L., Peters, Alan·2010·Journal of Comparative Neurology

Abstract

Aging is accompanied by deficits in cognitive function, which may be related to the vulnerability of myelinated nerve fibers to the normal process of aging. Loss of nerve fibers, together with age‐related alterations in myelin sheath structure, may result in the inefficient and poorly coordinated conduction of neuronal signals. Until now, the ultrastructural analysis of cerebral white matter fiber tracts associated with frontal lobe areas critical in cognitive processing has been limited. In this study we analyzed the morphology and area number density of myelinated nerve fibers in the cingulate bundle and genu of the corpus callosum in behaviorally assessed young, middle aged, and old rhesus monkeys ( Macaca mulatta ). In both structures, normal aging results in a 20% decrease in the number of myelinated nerve fibers per unit area, while remaining nerve fibers exhibit an increasing frequency of degenerative changes in their myelin sheaths throughout middle and old age. Concomitantly, myelination continues in older monkeys, suggesting ongoing, albeit inadequate, reparative processes. Despite similar patterns of degeneration in both fiber tracts, only the age‐related changes in the cingulate bundle correlate with declining cognitive function, underscoring its role as a critical corticocortical pathway linking the medial prefrontal, cingulate, and parahippocampal cortices in processes of working memory, recognition memory, and other higher cognitive faculties. These results further demonstrate the important role myelinated nerve fiber degeneration plays in the pathogenesis of age‐related cognitive decline. J. Comp. Neurol. 518:3046–3064, 2010. © 2010 Wiley‐Liss, Inc.

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Authors
Bowley, M. P., Cabral, H., Rosene, D. L., & Peters, A.
Affiliations
Boston University (US)
Corresponding author
Bowley, Michael P.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
2010-06
Volume
518
Issue
15
Pages
3046-3064
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
OpenAlex
W2028923096
Cited by
162
References
78
Citations by year
2026: 9 · 2025: 16 · 2024: 14 · 2023: 17 · 2022: 9 · 2021: 17 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 12 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 8
FWCI
6.44
Type
journal article
Language
en
Open access
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (P01AG000001, RF1AG043640)
  • National Center for Research Resources (P51RR000165)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
aging, myelinated axons, corpus callosum, myelin degeneration, white matter, rhesus monkeys, age-related cognitive decline, myelination, cortico-cortical pathways, frontal lobe, ultrastructure
MeSH terms
Aging, Animals, Axons, Behavior, Animal, Cell Count, Cognition, Cognition Disorders, Corpus Callosum, Data Interpretation, Statistical, Female, Gyrus Cinguli, Immunohistochemistry, Macaca mulatta, Male, Microscopy, Electron, Myelin Sheath, Nerve Degeneration, Nerve Fibers, Myelinated, Ranvier's Nodes

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