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Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
Abstract
Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to be a neurotoxin in tissue culture and in vivo studies and is elevated in ventricular fluid in AD. We report here an increase in mean free HNE in multiple brain regions in AD compared with age-matched control subjects. These increases reached statistical significance in the amygdala and hippocampus and parahippocampal gyrus, regions showing the most pronounced histopathological alterations in AD. This study, in conjunction with cell culture studies, suggests that HNE may be an important substance in the pathogenesis of neuron degeneration in AD.
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“A previous study has shown that a product of lipid peroxidation is increased in brain of patients with AD [55].”
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Metadata
- Authors
- Markesbery, W. R., & Lovell, M. A.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Markesbery, W.R
- ORCID
- Lovell, M.A
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 19
- Issue
- 1
- Pages
- 33-36
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1994151063
- Cited by
- 680
- References
- 39
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 12 · 2023: 21 · 2022: 16 · 2021: 19 · 2020: 16 · 2019: 21 · 2018: 13 · 2017: 25 · 2016: 29 · 2015: 29 · 2014: 19 · 2013: 21 · 2012: 32
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P50AG005144, 5 P50 AG05144, P01AG005119, 1-P01-AG 05119)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- lipid peroxidation, Alzheimer's disease, oxidative stress, amygdala, hippocampus, parahippocampal gyrus, neuron degeneration, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Aldehydes, Alzheimer Disease, Amygdala, Brain Chemistry, Female, Hippocampus, Humans, Male, Lipid Peroxidation, Cysteine Proteinase Inhibitors, Oxidative Stress
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