The DOI matches its Crossref record; 37 of the 39 references it cites were found in a registry or an index.
Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
Abstract
Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to be a neurotoxin in tissue culture and in vivo studies and is elevated in ventricular fluid in AD. We report here an increase in mean free HNE in multiple brain regions in AD compared with age-matched control subjects. These increases reached statistical significance in the amygdala and hippocampus and parahippocampal gyrus, regions showing the most pronounced histopathological alterations in AD. This study, in conjunction with cell culture studies, suggests that HNE may be an important substance in the pathogenesis of neuron degeneration in AD.
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“A previous study has shown that a product of lipid peroxidation is increased in brain of patients with AD [55].”
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Cites
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Self-citationThe Clinical Diagnosis of Alzheimer's Disease
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Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185
Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357
Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus
Tangvarasittichai, S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.456 · Cited by 1,284
Antioxidants and Prevention of Chronic Disease
Willcox, J. K., Ash, S. L., & Catignani, G. L. (2004) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490468489 · Cited by 1,200
Oxidative stress and Alzheimer disease
Christen, Y. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.621s · Cited by 1,176
Metadata
- Authors
- Markesbery, W. R., & Lovell, M. A.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Markesbery, W.R
- ORCID
- Lovell, M.A
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 19
- Issue
- 1
- Pages
- 33-36
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1994151063
- Cited by
- 680
- References
- 39
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 12 · 2023: 21 · 2022: 16 · 2021: 19 · 2020: 16 · 2019: 21 · 2018: 13 · 2017: 25 · 2016: 29 · 2015: 29 · 2014: 19 · 2013: 21 · 2012: 32
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P50AG005144, 5 P50 AG05144, P01AG005119, 1-P01-AG 05119)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- lipid peroxidation, Alzheimer's disease, oxidative stress, amygdala, hippocampus, parahippocampal gyrus, neuron degeneration, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Aldehydes, Alzheimer Disease, Amygdala, Brain Chemistry, Female, Hippocampus, Humans, Male, Lipid Peroxidation, Cysteine Proteinase Inhibitors, Oxidative Stress
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