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Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
Abstract
Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to be a neurotoxin in tissue culture and in vivo studies and is elevated in ventricular fluid in AD. We report here an increase in mean free HNE in multiple brain regions in AD compared with age-matched control subjects. These increases reached statistical significance in the amygdala and hippocampus and parahippocampal gyrus, regions showing the most pronounced histopathological alterations in AD. This study, in conjunction with cell culture studies, suggests that HNE may be an important substance in the pathogenesis of neuron degeneration in AD.
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“A previous study has shown that a product of lipid peroxidation is increased in brain of patients with AD [55].”
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383
Self-citationThe Clinical Diagnosis of Alzheimer's Disease
Wade, J. P. H., Mirsen, T. R., Hachinski, V. C., Fisman, M., Lau, C. S., & Merskey, H. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520130016010 · Cited by 1,416
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.
Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296
Self-citationOxidative damage to mitochondrial DNA is increased in Alzheimer’s disease
Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037
Sayre, L., Zelasko, D. A., Harris, P. L. R., Perry, G., Salomon, R. G., & Smith, M. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052092.x · Cited by 1,032
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Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185
Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357
Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus
Tangvarasittichai, S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.456 · Cited by 1,284
Antioxidants and Prevention of Chronic Disease
Willcox, J. K., Ash, S. L., & Catignani, G. L. (2004) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490468489 · Cited by 1,200
Oxidative stress and Alzheimer disease
Christen, Y. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.621s · Cited by 1,176
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide
Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114
Stadtman, E. R., & Levine, R. L. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06187.x · Cited by 1,037
Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 1,013
Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855
Impaired Proteasome Function in Alzheimer's Disease
Keller, J. N., Hanni, K. B., & Markesbery, W. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750436.x · Cited by 848
Self-citationOxidative stress in brain agingImplications for therapeutics of neurodegenerative diseases
Floyd, R. A., & Hensley, K. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00019-2 · Cited by 837
Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases
Collin, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102407 · Cited by 852
Oxidative Alterations in Alzheimer's Disease
Markesbery, W. R., & Carney, J. M. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00215.x · Cited by 789
Self-citationAllan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786
Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity
Varadarajan, S., Yatin, S., Aksenova, M., & Butterfield, D. A. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4274 · Cited by 735
Allanbutterfield, D., Castegna, A., Lauderback, C. M., & Drake, J. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00340-2 · Cited by 715
Laguerre, M., Lecomte, J., & Villeneuve, P. (2007) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.05.002 · Cited by 706
Park, M. W., Cha, H. W., Kim, J., Kim, J. H., Yang, H., Yoon, S., Boonpraman, N., Yi, S. S., Yoo, I. D., & Moon, J.-S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101947 · Cited by 683
Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview
Mariani, E., Polidori, M. C., Cherubini, A., & Mecocci, P. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.04.023 · Cited by 691
Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory
Massaad, C. A., & Klann, E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3208 · Cited by 635
The redox chemistry of the Alzheimer's disease amyloid β peptide
Smith, D. G., Cappai, R., & Barnham, K. J. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.02.002 · Cited by 608
Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564
Oxidative stress in neurodegenerative diseases.
Chen, X., Guo, C., & Kong, J. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.05.009 · Cited by 608
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Antioxidants and human diseases
Rajendran, P., Nandakumar, N., Rengarajan, T., Palaniswami, R., Edwinoliver, N. G., Uppalapati, L., Gopas, J., & Nishigaki, I. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.06.004 · Cited by 553
Butterfield, D. A., Swomley, A. M., & Sultana, R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5027 · Cited by 526
Kański, J., Aksenova, M. V., Stoyanova, A., & Butterfield, D. A. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00215-7 · Cited by 502
Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease
Kaur, D., Sharma, V., & Deshmukh, R. R. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00580-x · Cited by 503
Lauderback, C. M., Hackett, J. M., Huang, F. F., Keller, J. N., Szweda, L. I., Markesbery, W. R., & Butterfield, D. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00451.x · Cited by 464
Self-citationOxidative stress in Alzheimer disease
Gella, A., & Durany, N. (2009) · Cell Adhesion & Migration · doi:10.4161/cam.3.1.7402 · Cited by 459
Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease
Wang, J., Xiong, S., Xie, C., Markesbery, W. R., & Lovell, M. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03053.x · Cited by 452
Self-citationPathological aspects of lipid peroxidation
Nègre‐Salvayre, A., Augè, N., Ayala, V., Başağa, H., Boada, J., Brenke, R., Chapple, S. J., Cohen, G., Fehér, J., Grune, T., et al. (2010) · Free Radical Research · doi:10.3109/10715762.2010.498478 · Cited by 465
Montine, T. J., Neely, M. D., Quinn, J. F., Beal, M. F., Markesbery, W. R., Roberts, L. J., & Morrow, J. D. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00807-9 · Cited by 451
Self-citationAcrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures
Lovell, M. A., Xie, C., & Markesbery, W. R. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00235-9 · Cited by 449
Self-citationMetal dyshomeostasis and oxidative stress in Alzheimer’s disease
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4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest
Poli, G., Schaur, R. J., Siems, W. G., & Leonarduzzi, G. (2007) · Medicinal Research Reviews · doi:10.1002/med.20117 · Cited by 439
Alzheimer's disease: the two-hit hypothesis
Zhu, X., Raina, A. K., Perry, G. L., & Smith, M. A. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00707-0 · Cited by 431
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Nutritional approaches to combat oxidative stress in Alzheimer’s disease
Butterfield, D. A., Castegna, A., Pocernich, C. B., Drake, J., Scapagnini, G., & Calabrese, V. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00205-x · Cited by 402
Jung, T., Catalgol, B., & Grune, T. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.04.001 · Cited by 401
Williams, T. I., Lynn, B. C., Markesbery, W. R., & Lovell, M. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.004 · Cited by 396
Self-citationSynaptic pathology in Alzheimer's disease: a review of ultrastructural studies
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Oxidative injury in diseases of the central nervous system: focus on alzheimer’s disease
Praticò, D., & Delanty, N. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00547-7 · Cited by 382
Allison, A. C., Cacabelos, R., Lombardi, V. R. M., Álvarez, X. A., & Vigo, C. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00192-0 · Cited by 376
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
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Su, B., Wang, X., Nunomura, A., Moreira, P., Lee, H.-G., Perry, G., Smith, M., & Zhu, X. (2008) · Current Alzheimer Research · doi:10.2174/156720508786898451 · Cited by 344
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Zou, K., Gong, J.-S., Yanagisawa, K., & Michikawa, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04833.2002 · Cited by 305
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Mattson, M. P. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.07.003 · Cited by 311
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Lovell, M. A., Gabbita, S. P., & Markesbery, W. R. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720771.x · Cited by 292
Self-citationOxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases
Gan, L., & Johnson, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.12.011 · Cited by 288
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Giasson, B. I., Ischiropoulos, H., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00804-3 · Cited by 285
Rukhsana Sultana, A., Ravagna, A., Abdul, H. M., Calabrese, V., & Butterfield, D. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02899.x · Cited by 276
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Rukhsana Sultana, A., Marzia Perluigi, A., & Butterfield, D. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2021 · Cited by 261
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Self-citationDecrease in Peptide Methionine Sulfoxide Reductase in Alzheimer's Disease Brain
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Self-citationDi Domenico, F., Tramutola, A., & Butterfield, D. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.490 · Cited by 253
McGrath, L. T. (2001) · QJM · doi:10.1093/qjmed/94.9.485 · Cited by 253
4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications
Parola, M., Bellomo, G., Robino, G., Barrera, G., & Dianzani, M. U. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.3-255 · Cited by 251
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Acosta, C., Anderson, H. D., & Anderson, C. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24075 · Cited by 262
Butterfield, D. A., Reed, T., Perluigi, M., De Marco, C., Coccia, R., Cini, C., & Sultana, R. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.017 · Cited by 246
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Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases
Montine, K. S., Quinn, J. F., Zhang, J., Fessel, J. P., Roberts, L. J., Morrow, J. D., & Montine, T. J. (2003) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2003.10.010 · Cited by 242
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4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product
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Shoeb, M., Ansari, N., Srivastava, S., & Ramana, K. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990181 · Cited by 230
Perluigi, M., Coccia, R., & Butterfield, D. A. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4406 · Cited by 229
Calabrese, V., Rukhsana Sultana, A., Scapagnini, G., Guagliano, E., Sapienza, M. A., Bella, R., Kański, J., Pennisi, G., Mancuso, C., Stella, A. M. G., et al. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1975 · Cited by 227
Sultana, R., Perluigi, M., & Butterfield, D. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0517-0 · Cited by 215
Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease
Rossi, L. C., Mazzitelli, S., Arciello, M., Capo, C. R., & Rotilio, G. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9696-7 · Cited by 223
Hypobaric hypoxia induces oxidative stress in rat brain
Maiti, P., Singh, S. B., Sharma, A. K., Muthuraju, S., Banerjee, P. K., & Ilavazhagan, G. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.06.002 · Cited by 215
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Mancuso, M., Coppedè, F., Migliore, L., Siciliano, G., & Murri, L. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10110 · Cited by 212
Milgram, N. W., Head, E., Zicker, S. C., Ikeda-Douglas, C. J., Murphey, H. L., Muggenburg, B. A., Siwak, C. T., Tapp, D., & Cotman, C. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.014 · Cited by 218
Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease
Bradley, M. A., Markesbery, W. R., & Lovell, M. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.016 · Cited by 193
Self-citation
Metadata
- Authors
- Markesbery, W. R., & Lovell, M. A.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Markesbery, W.R
- ORCID
- Lovell, M.A
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 19
- Issue
- 1
- Pages
- 33-36
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1994151063
- Cited by
- 680
- References
- 39
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 12 · 2023: 21 · 2022: 16 · 2021: 19 · 2020: 16 · 2019: 21 · 2018: 13 · 2017: 25 · 2016: 29 · 2015: 29 · 2014: 19 · 2013: 21 · 2012: 32
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P50AG005144, 5 P50 AG05144, P01AG005119, 1-P01-AG 05119)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- lipid peroxidation, Alzheimer's disease, oxidative stress, amygdala, hippocampus, parahippocampal gyrus, neuron degeneration, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Aldehydes, Alzheimer Disease, Amygdala, Brain Chemistry, Female, Hippocampus, Humans, Male, Lipid Peroxidation, Cysteine Proteinase Inhibitors, Oxidative Stress
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