Patterns of impaired verbal, spatial, and object working memory after thalamic lesions
Abstract
Working memory processes in six individuals with isolated thalamic lesions were assessed. Participants were given a verbal, spatial, and object n-back task, each at three levels of task load (1-back, 2-back, and 3-back). Relative to a control group, the patients were impaired on the verbal and spatial n-back tasks, and possibly on the object n-back task as well. None of the patients showed impaired short-term memory as measured by digit span. Group differences on trials measuring matching, sequencing, and inhibitory abilities were consistent with other reports suggesting that thalamic lesions may impair the operation of executive processes.
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The amygdala, thalamus, striatum, and corpus callosum have been implicated in performance on the N-Back previously.
“These regions have been implicated in performance on the N‐Back previously (Dahlin, Neely, Larsson, Bäckman, & Nyberg, 2008; Kubat‐Silman, Dagenbach, & Absher, 2002; Schaefer et al., 2006; Takeuchi et al., 2010; Zou, Hong, Wang, Gao, & Yang, 2011).”
From Brain structure, working memory and response inhibition in childhood leukemia survivors (2017) · cites this paper as Kubat-Silman et al., 2002
Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · see citing works
Baddeley, A. D., & Hitch, G. (1974) · Psychology of Learning and Motivation · doi:10.1016/s0079-7421(08)60452-1 · Cited by 9,860 · see citing works
Individual differences in working memory and reading
Daneman, M., & Carpenter, P. A. (1980) · Journal of Verbal Learning and Verbal Behavior · doi:10.1016/s0022-5371(80)90312-6 · Cited by 6,336 · see citing works
Working memory, short-term memory, and general fluid intelligence: A latent-variable approach.
Engle, R. W., Tuholski, S. W., Laughlin, J. E., & Conway, A. R. A. (1999) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.128.3.309 · Cited by 3,078 · see citing works
Is working memory capacity task dependent?
Turner, M. L., & Engle, R. W. (1989) · Journal of Memory and Language · doi:10.1016/0749-596x(89)90040-5 · Cited by 2,299 · see citing works
Kane, M. J., & Engle, R. W. (2002) · Psychonomic Bulletin & Review · doi:10.3758/bf03196323 · Cited by 2,229 · see citing works
Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man
Petrides, M., & Milner, B. A. (1982) · Neuropsychologia · doi:10.1016/0028-3932(82)90100-2 · Cited by 1,272 · see citing works
Miyake, A., Friedman, N. P., Rettinger, D. A., Shah, P., & Hegarty, M. (2001) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.130.4.621 · Cited by 1,139 · see citing works
Miyake, A., Friedman, N. P., Rettinger, D. A., Shah, P., & Hegarty, M. (2001) · Journal of Experimental Psychology General · doi:10.1037//0096-3445.130.4.621 · Cited by 1,137 · see citing works
Dissociating Verbal and Spatial Working Memory Using PET
Smith, E. E., Jonides, J., & Koeppe, R. A. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.1.11 · Cited by 962 · see citing works
Shah, P., & Miyake, A. (1996) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.125.1.4 · Cited by 913 · see citing works
Petrides, M., Alivisatos, B., Meyer, E., & Evans, A. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.878 · Cited by 897 · see citing works
Callicott, J. H. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.1.20 · Cited by 771 · see citing works
Memory updating in working memory: The role of the central executive
Morris, N., & Jones, D. M. (1990) · British Journal of Psychology · doi:10.1111/j.2044-8295.1990.tb02349.x · Cited by 739 · see citing works
Verbal Working Memory Load Affects Regional Brain Activation as Measured by PET
Jonides, J., Schumacher, E. H., Smith, E. E., Lauber, E. J., Awh, E., Minoshima, S., & Koeppe, R. A. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.4.462 · Cited by 715 · see citing works
The quantitative study of shape and pattern perception.
Attneave, F., & Arnoult, M. D. (1956) · Psychological Bulletin · doi:10.1037/h0044049 · Cited by 651 · see citing works
Architecture of the Prefrontal Cortex and the Central Executive
Goldman, P. S. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb38132.x · Cited by 640 · see citing works
Spatial versus Object Working Memory: PET Investigations
Smith, E. E., Jonides, J. J., Koeppe, R. A., Awh, E., Schumacher, E. H., & Minoshima, S. (1995) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1995.7.3.337 · Cited by 512 · see citing works
Temporal processing in the basal ganglia.
Harrington, D. L., Haaland, K. Y., & Hermanowitz, N. (1998) · Neuropsychology · doi:10.1037//0894-4105.12.1.3 · Cited by 483 · see citing works
Imaging Cognition: An Empirical Review of PET Studies with Normal Subjects
Cabeza, R. E. L., & Nyberg, L. H. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.1.1 · Cited by 450 · see citing works
Neuropsychology of infarctions in the thalamus: a review
van der Werf, Y. D., Witter, M. P., Uylings, H. B. M., & Jolles, J. (2000) · Neuropsychologia · doi:10.1016/s0028-3932(99)00104-9 · Cited by 353 · see citing works
Mechanisms of Cognitive Development
(2001) · Psychology Press eBooks · doi:10.4324/9781410600646 · Cited by 342 · see citing works
Regional brain activity during working memory tasks
Salmon, É., der Linden, M. V., Collette, F., Delfiore, G., Maquet, P., Degueldre, C., Luxen, A., & Franck, G. (1996) · Brain · doi:10.1093/brain/119.5.1617 · Cited by 329 · see citing works
Structure and Functions of the Human Prefrontal Cortex
Grafman, J. H., Holyoak, K. J., & Boller, F. (1996) · Medical Entomology and Zoology · Cited by 308 · see citing works
Thalamic mediodorsal nucleus and memory: A critical evaluation of studies in animals and man
Markowitsch, H. J. (1982) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(82)90046-x · Cited by 283 · see citing works
PET Evidence for an Amodal Verbal Working Memory System
Schumacher, E. H., Lauber, E. J., Awh, E., Jonides, J. J., Smith, E. E., & Koeppe, R. A. (1996) · NeuroImage · doi:10.1006/nimg.1996.0009 · Cited by 262 · see citing works
Nonhemorrhagic infarction of the thalamus
Graff‐Radford, N. R., Eslinger, P. J., Damásio, A. R., & Yamada, T. (1984) · Neurology · doi:10.1212/wnl.34.1.14 · Cited by 202 · see citing works
Memory systems of the brain : animal and human cognitive processes
Weinberger, N. M., McGaugh, J. L., & LYNCH, G. S. (1985) · Medical Entomology and Zoology · Cited by 193 · see citing works
On Some Functions of the Human Prefrontal Cortexa
Damásio, A. R. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb38142.x · Cited by 186 · see citing works
Selection of actions in the basal ganglia–thalamocortical circuits: review and model
Kropotov, J. D., & Etlinger, S. C. (1999) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(98)00051-8 · Cited by 144 · see citing works
Clarke, S., ASSAL, G., Bogousslavsky, J., Regli, F., Townsend, D. W., Leenders, K. L., & Blecic, S. A. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.1.27 · Cited by 138 · see citing works
Amnesia in a patient with bilateral lesions to the thalamus
Winocur, G., Oxbury, S., ROBERTS, R. C., Agnetti, V., & Davis, C. (1984) · Neuropsychologia · doi:10.1016/0028-3932(84)90056-3 · Cited by 137 · see citing works
The neuropsychology of paramedian thalamic infarction
Stuss, D. T., Guberman, A. H., Nelson, R., & Larochelle, S. (1988) · Brain and Cognition · doi:10.1016/0278-2626(88)90059-0 · Cited by 135 · see citing works
Human Rehearsal Processes and the Frontal Lobes: PET Evidence
Awh, E., Smith, E. E., & Jonides, J. J. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb38134.x · Cited by 125 · see citing works
Hegarty, M., Shah, P., & Miyake, A. (2000) · Memory & Cognition · doi:10.3758/bf03198553 · Cited by 99 · see citing works
Fedio, P., & Buren, J. M. V. (1975) · Brain and Language · doi:10.1016/s0093-934x(75)80056-3 · Cited by 90 · see citing works
On the Role of Thalamic Pathology in Diencephalic Amnesia
Mair, R. G. (1994) · Reviews in the Neurosciences · doi:10.1515/revneuro.1994.5.2.105 · Cited by 85 · see citing works
Basal ganglia involvement in memory-guided movement sequencing
Menon, V., Anagnoson, R., Glover, G. H., & Pfefferbaum, A. (2000) · Neuroreport · doi:10.1097/00001756-200011090-00048 · Cited by 67 · see citing works
Selective dorsolateral frontal lobe dysfunction associated with diencephalic amnesia
Pepin, E. P., & Auray-Pepin, L. (1993) · Neurology · doi:10.1212/wnl.43.4.733 · Cited by 57 · see citing works
(2001) · Cited by 49 · see citing works
Krayenbühl, H., Siegfried, J., Kohenof, M., & Yasargil, M. G. (2009) · Confinia Neurologica · doi:10.1159/000104033 · Cited by 36 · see citing works
Human Verbal Working Memory Impairments Associated with Thalamic Damage
Dagenbach, D., Kubat-Silman, A. K., & Absher, J. R. (2001) · International Journal of Neuroscience · doi:10.3109/00207450108986553 · Cited by 23 · see citing works
Self-citationSelective impairment of Porteus maze test performance after right subthalamotomy
Meier, M. J., & Story, J. L. (1967) · Neuropsychologia · doi:10.1016/0028-3932(67)90021-8 · Cited by 19 · see citing works
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Woodward, N. D., & Heckers, S. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.026 · Cited by 264 · see citing works
Budson, A. E., & Price, B. H. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041071 · Cited by 262 · see citing works
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Little, D. M., Kraus, M. F., Joseph, J. W., Geary, E., Susmaras, T. M., Zhou, X. J., Pliskin, N. H., & Gorelick, P. B. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cff5d5 · Cited by 234 · see citing works
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Galvan, A., Hare, T. A., Davidson, M., Spicer, J., Glover, G., & Casey, B. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2431-05.2005 · Cited by 207 · see citing works
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Caeyenberghs, K., Leemans, A., Leunissen, I., Gooijers, J., Michiels, K., Sunaert, S. G., & Swinnen, S. P. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0494-2 · Cited by 172 · see citing works
John A. Groeger, P., Viola, A., June C.Y. Lo, M., Malcolm von Schantz, P., Simon N. Archer, P., & Derk-Jan Dijk, P. (2008) · SLEEP · doi:10.5665/sleep/31.8.1159 · Cited by 160 · see citing works
Gabel, V., Maire, M., Reichert, C. F., Chellappa, S. L., Schmidt, C., Hommes, V., Viola, A. U., & Cajochen, C. (2013) · Chronobiology International · doi:10.3109/07420528.2013.793196 · Cited by 154 · see citing works
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Witte, L. D., Brouns, R., Kavadias, D., Engelborghs, S., Deyn, P. P. D., & Mariën, P. (2010) · Cortex · doi:10.1016/j.cortex.2010.09.002 · Cited by 121 · see citing works
Jennings, J. M., Webster, L. M., Kleykamp, B. A., & Dagenbach, D. (2005) · Aging, Neuropsychology, and Cognition · doi:10.1080/138255890968312 · Cited by 115 · see citing works
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Voets, N., Menke, R., Jbabdi, S., Masud Husain, B., Stacey, R. J., Carpenter, K., & Adcock, J. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv109 · Cited by 28 · see citing works
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- Authors
- Kubat-Silman, A. K., Dagenbach, D., & Absher, J. R.
- Affiliations
- University of North Carolina at Greensboro (US)
- Atrium Health Wake Forest Baptist (US)
- Corresponding author
- Kubat-Silman, Alycia K
- ORCID
- Absher, John R
- Venue
- Brain and Cognition
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 50
- Issue
- 2
- Pages
- 178-193
- ISSN
- 0278-2626 (ISSN-L)
- OpenAlex
- W2071760438
- Cited by
- 39
- References
- 42
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain and Cognition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wisconsin Alumni Research Foundation
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- thalamic lesions, working memory, verbal working memory, spatial working memory, object working memory, n-back task, workload, short-term memory, digit span, executive function, inhibitory control, matching, sequencing
- MeSH terms
- Aged, Aged, 80 and over, Aphasia, Cerebral Infarction, Cognition Disorders, Female, Humans, Male, Memory Disorders, Neuropsychological Tests, Perceptual Disorders, Severity of Illness Index, Space Perception, Thalamus
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