The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Translating developmental time across mammalian species
Abstract
Conservation of the order in which events occur in developing mammalian brains permits use of regression theory to model the timing of neural development. Following a small adjustment to account for a systematic variability in primate cortical and limbic systems, the model is used to generate a 95-event/nine-species matrix that predicts aspects of neurogenesis and axonal outgrowth in the brains of developing mice, hamsters, rats, spiny mice, rabbits, ferrets, cats, monkeys, and humans. Although data are compiled from species in which the timing of birth and the rate of maturation vary widely, the model proves statistically accurate, with practical implications for improving estimation of milestones of neural development, particularly for humans. Using the three-factor model (species, neural events, and primate adjustments), we produce predictions for the timing of 493 neural occurrences in developing mammalian brains that either have not yet been, or cannot be, empirically derived. We also relate the timing of neural events across the nine species in the form of a reference table calibrated to the development of laboratory rats. This 'translation' table will assist in attempts to equate the neurodevelopmental literature across species with either large or small differences in gestation and maturation, and also permit studies done in a variety of mammals to be applied to better understand human development. The comparative data indicate that humans, although conventionally considered an altricial species, are neurally advanced at birth relative to the other species studied.
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“As this developmental stage in the mouse CNS corresponds to the second prenatal trimester in humans (Clancy et al., 2001), it is of limited clinical relevance.”
From Recombinant Human Myelin-Associated Glycoprotein Promoter Drives Selective AAV-Mediated Transgene Expression in Oligodendrocytes (2016) · cites this paper as Clancy et al., 2001
In the citing paper
“Since the rodent brain is less mature at birth than the human brain, it has been suggested that brain maturation occurring in the early postnatal period in the rat is analogous to maturational changes that occur in humans in late gestation (Clancy et al., 2001).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Clancy et al., 2001
In the citing paper
“development of the limbic region and cortex on postnatal day (PND) 10 in the rat equates to that of a human fetus in the second to third trimester (Clancy et al., 2001).”
From The effects of early life stress on reward processing (2018) · cites this paper as Clancy et al., 2001
In the citing paper
“development of the human brain is protracted compared to other species (Clancy et al., 2001; Miller et al, 2012; Semple et al., 2013), so despite having a more “mature” brain at birth compared to rats, vulnerability to insult remains.”
From The effects of early life stress on reward processing (2018) · cites this paper as Clancy et al., 2001
Citations
Cites
The Theory of Island Biogeography
MacArthur, R. H., & Wilson, E. O. (2001) · Princeton University Press eBooks · doi:10.1515/9781400881376 · Cited by 13,298
Construct validity in psychological tests.
Cronbach, L. J., & Meehl, P. E. (1955) · Psychological Bulletin · doi:10.1037/h0040957 · Cited by 11,195
Applied Linear Statistical Models
Ziegel, E. R., Neter, J., Wasserman, W., & Kutner, M. (1992) · Technometrics · doi:10.2307/1269588 · Cited by 9,906
Statistical learning by 8-month-old infants
Saffran, J. R., Aslin, R. N., & Newport, E. L. (1996) · Science · doi:10.1126/science.274.5294.1926 · Cited by 5,659
A precursor of language acquisition in young infants
Mehler, J., Jusczyk, P. W., Dehaene‐Lambertz, G., Halsted, N., Bertoncini, J., & Amiel‐Tison, C. (1988) · Cognition · doi:10.1016/0010-0277(88)90035-2 · Cited by 1,577
Newborn Infants Imitate Adult Facial Gestures
Meltzoff, A. N., & Moore, M. (1983) · Child Development · doi:10.1111/j.1467-8624.1983.tb00496.x · Cited by 1,339
Newborn infants imitate adult facial gestures
Meltzoff, A. N., & Moore, M. K. (1983) · Child Development · doi:10.2307/1130058 · Cited by 1,307
Linked Regularities in the Development and Evolution of Mammalian Brains
Finlay, B. L., & Darlington, R. B. (1995) · Science · doi:10.1126/science.7777856 · Cited by 1,217
Self-citationRakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex
Rakic, P., Bourgeois, J.-P., Eckenhoff, M. F., Zecevic, N., & Goldman-Rakic, P. S. (1986) · Science · doi:10.1126/science.3952506 · Cited by 1,133 · cited 1×
“One neural event was also excluded, a surge in the production of synapses in the developing brain which begins just before birth in primates (Rakic et al., 1986; Zecevic and Rakic, 1991; Missler et al., 1993a,b; Bourgeois et al., 1994; Granger et al., 1995; Huttenlocher and Dabholkar, 1997) or eye…”
BackgroundDarlington, R. B. (1990) · Cited by 986
Self-citationBayer, S. A. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901900107 · Cited by 913
Bayer, S. A., Altman, J., Russo, R. J., & Zhang, X. (1993) · PubMed · Cited by 912
Synaptogenesis in the Prefrontal Cortex of Rhesus Monkeys
Bourgeois, J.-P., Goldman-Rakic, P. S., & Rakic, P. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.1.78 · Cited by 687
Development of the corpus callosum and cavum septi in man
RAKIC, P. T., & Yakovlev, P. I. (1968) · The Journal of Comparative Neurology · doi:10.1002/cne.901320103 · Cited by 640
Caviness, V. S. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90141-9 · Cited by 639
The formation and maturation of synapses in the visual cortex of the rat. II. Quantitative analysis
Blue, M. E., & Parnavelas, J. G. (1983) · Journal of Neurocytology · doi:10.1007/bf01181531 · Cited by 506
Kostović, I., & RAKIC, P. T. (1980) · Journal of Neurocytology · doi:10.1007/bf01205159 · Cited by 499
Heterochrony: The Evolution of Ontogeny
McKinney, M. L., & McNamara, K. J. (1991) · Medical Entomology and Zoology · Cited by 451
McKinney, M. L., & McNamara, K. J. (1991) · Springer eBooks · doi:10.1007/978-1-4757-0773-1 · Cited by 441
Normal and abnormal development of the human nervous system
Lemire, R. J., & etc. (1975) · Medical Entomology and Zoology · Cited by 422
The role of immaturity in human development.
Bjorklund, D. F. (1997) · Psychological Bulletin · doi:10.1037/0033-2909.122.2.153 · Cited by 358
Neurogenesis of the cat's primary visual cortex
Luskin, M. B., & Shatz, C. J. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902420409 · Cited by 344
The time of origin of neurons in the hippocampal region of the rhesus monkey
RAKIC, P. T., & Nowakowski, R. S. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901960109 · Cited by 305
Neurochemical architecture of the human striatum
Holt, D. J., Graybiel, A. M., & Saper, C. B. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970721)384:1 · Cited by 297
Development of layer I and the subplate in the rat neocortex
Bayer, S. A., & Altman, J. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90062-w · Cited by 239
Towards a Developmental Cognitive Science
Meltzoff, A. N. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb48889.x · Cited by 229
RAKIC, P. T. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901760103 · Cited by 219
The formation and maturation of synapses in the visual cortex of the rat. I. Qualitative analysis
Blue, M. E., & Parnavelas, J. G. (1983) · Journal of Neurocytology · doi:10.1007/bf01181526 · Cited by 206
Early Language Development And Its Neural Correlates
Bates, E. A., Thal, D. J., Finlay, B. L., & Clancy, B. (1992) · Cited by 195
Self-citationThe development of the human amygdala during early embryonic life
Humphrey, T. (1968) · Journal of Comparative Neurology · doi:10.1002/cne.901320108 · Cited by 160
Levitt, P. R., & RAKIC, P. T. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90095-5 · Cited by 145
Synaptogenesis in Monkey Somatosensory Cortex
Zečević, N., & RAKIC, P. T. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.6.510 · Cited by 122
Dreher, B., & Robinson, S. R. (2008) · Brain Behavior and Evolution · doi:10.1159/000116602 · Cited by 106
Dual Fate of Subplate Neurons in a Rodent
Woo, T., Beale, J. M., & Finlay, B. L. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.5.433 · Cited by 105
Self-citationPatterns of Vertebrate Neurogenesis and the Paths of Vertebrate Evolution
Finlay, B. L., Hersman, M. N., & Darlington, R. B. (1998) · Brain Behavior and Evolution · doi:10.1159/000006566 · Cited by 101
Self-citationInfants' Discrimination of the Duration of a Rapid Spectrum Change in Nonspeech Signals
Jusczyk, P. W., Pisoni, D. B., Reed, M. A., Fernald, A. E., & Myers, M. G. (1983) · Science · doi:10.1126/science.6623067 · Cited by 93
Robinson, S. R., & Dreher, B. (2008) · Brain Behavior and Evolution · doi:10.1159/000115306 · Cited by 88
Human fetal hippocampal development: II. The neuronal cytoskeleton
Arnold, S. E., & Trojanowski, J. Q. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960401)367:2 · Cited by 87
Bayer, S. A., & Altman, J. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902650106 · Cited by 85
Missler, M., Wolff, A., Merker, H., & Wolff, J. R. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903330105 · Cited by 85
The course of human events: predicting the timing of primate neural development
Clancy, B., Darlington, R. B., & Finlay, B. L. (2000) · Developmental Science · doi:10.1111/1467-7687.00100 · Cited by 74
Self-citationGranger, B., Tekaia, F., Sourd, A. L., RAKIC, P. T., & Bourgeois, J. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903600212 · Cited by 67
Development of Enzymes of Energy Metabolism in the Neonatal Mammalian Brain
Clark, J. B., Bates, T. E., Cullingford, T. E., & Land, J. M. (1994) · Developmental Neuroscience · doi:10.1159/000111333 · Cited by 63
Development of the Perception of Invariants: Substance and Shape
Gibson, E. J., Owsley, C. J., Walker, A. S., & Megaw-Nyce, J. (1979) · Perception · doi:10.1068/p080609 · Cited by 61
Missler, M., Eins, S., Merker, H., Rothe, H., & Wolff, J. R. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903330104 · Cited by 59
Ontogenesis of the laminar structure in areas 17 and 18 of the human visual cortex
Zilles, K., Werners, R., B�sching, U., & Schleicher, A. (1986) · Anatomy and Embryology · doi:10.1007/bf00698784 · Cited by 51
Ashwell, K. W. S., Waite, P. M. E., & Marotte, L. R. (2008) · Brain Behavior and Evolution · doi:10.1159/000113225 · Cited by 44
Early development of the human thalamus: Golgi and Nissl study
Mojsilović, J., & Zečević, N. (1991) · Early Human Development · doi:10.1016/0378-3782(91)90033-y · Cited by 43
The development of the human internal capsule and lentiform nucleus.
Hewitt, W. (1961) · PubMed · Cited by 29
Prenatal neurogenesis in the telencephalon of the precocial mouse Acomys cahirinus
Brunjes, P. C., Korol, D. L., & Stern, K. G. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90801-x · Cited by 28
Shea, B. T. (1993) · International Journal of Primatology · doi:10.1007/bf02192192 · Cited by 27
Detection of Elasticity as an Invariant Property of Objects by Young Infants
Walker, A. S., Owsley, C. J., Megaw-Nyce, J., Gibson, E. J., & Bahrick, L. E. (1980) · Perception · doi:10.1068/p090713 · Cited by 24
Effects of temperature on sleep in the developing rat
Morrissette, R. N., & Heller, H. C. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.4.r1087 · Cited by 19
Quantitative analysis of synaptogenesis in the cerebral cortex of the cat suprasylvian gyrus
Benhamida, C. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90074-8 · Cited by 7
Huttenlocher (1997) · doi:10.1002/(sici)1096-9861(19971020)387:2
Nakagawa (1999) · doi:10.1002/(sici)1096-9861(19990830)411:3
Self-citation
Research works printed but not linked: 1
- Clancy, 1999, Translating time across species: what is that in rat days?, Soc. Neurosci. Abstr., 25, 503
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Stiles, J., & Jernigan, T. L. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9148-4 · Cited by 2,009
Gene expression across mammalian organ development
Cardoso-Moreira, M., Halbert, J., Valloton, D., Velten, B., Chen, C., Shao, Y., Liechti, A., Ascenção, K., Rummel, C., Ovchinnikova, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1338-5 · Cited by 838
Modeling transformations of neurodevelopmental sequences across mammalian species
Workman, A. D., Charvet, C. J., Clancy, B., Darlington, R. B., & Finlay, B. L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5746-12.2013 · Cited by 833
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Clancy, B., Finlay, B. L., Darlington, R. B., & Anand, K. J. S. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.01.014 · Cited by 812
Self-citationEarly motor activity drives spindle bursts in the developing somatosensory cortex
Khazipov, R., Sirota, A., Leinekugel, X., Holmes, G. L., Ben‐Ari, Y., & Buzsáki, G. (2004) · Nature · doi:10.1038/nature03132 · Cited by 634
Metadata
- Authors
- Clancy, B., Darlington, R. B., & Finlay, B. L.
- Affiliations
- Cornell University (US)
- Corresponding author
- Finlay, B.L
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 105
- Issue
- 1
- Pages
- 7-17
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2155471406
- Cited by
- 1,221
- References
- 57
- Citations by year
- 2026: 27 · 2025: 41 · 2024: 32 · 2023: 41 · 2022: 48 · 2021: 76 · 2020: 74 · 2019: 69 · 2018: 55 · 2017: 57 · 2016: 62 · 2015: 69 · 2014: 59 · 2013: 69 · 2012: 60
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention (T32 MN 19389)
- U.S. Public Health Service (R01 19245)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
- Keywords
- developmental milestones, regression theory, comparative neuroanatomy, neurogenesis, axon growth, human brain development, altriciality, species comparison
- MeSH terms
- Aging, Animals, Brain, Cell Differentiation, Cell Division, Humans, Mammals, Models, Neurological, Phylogeny, Reproducibility of Results, Statistical Distributions, Body Patterning
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