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Evidence that integrins contribute to multiple stages in the consolidation of long term potentiation in rat hippocampus

Chun, D, Gall, C.M, Bi, X, Lynch, G·2001·Neuroscience
DOI 10.1016/s0306-4522(01)00173-7
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Abstract

Three structurally distinct groups of antagonists were used to test the hypothesis that integrin adhesion receptors play an essential role in consolidating (stabilizing) long term potentiation of the Schaffer collaterals in rat hippocampus. Comparisons were made of percent potentiation at antagonist-treated versus control sites within CA1 stratum radiatum of the same hippocampal slice. Function blocking antibodies against the alpha5 subunit of the fibronectin receptor had no effect on baseline responses or initial potentiation but resulted in a >30% reduction, relative to within-slice control long term potentiation, 45 min later. Larger reductions were recorded in separate experiments continued for 4 h after the induction of potentiation. Alpha(v) and alpha2 subunit antibodies did not reliably affect the stabilization of potentiation. An antagonist peptide with preference for beta1 integrins produced a slowly developing decline of the type seen with alpha5 antibodies. A cyclic peptide antagonist reduced potentiation within 10 min of induction and caused an almost 40% decrease over 45 min. Two disintegrins (snake toxins that potently block integrins) were very effective in preventing the consolidation of long term potentiation: echistatin reduced potentiation by >70%, while triflavin caused approximately 50% decrease. The suppressing effects of echistatin were concentration-dependent, obtained with treatment after induction, and much more rapid than the effects of antibodies.…

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Authors
Chun, D., Gall, C. M., Bi, X., & Lynch, G.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2001-08
Volume
105
Issue
4
Pages
815-829
ISSN
0306-4522
DOI
10.1016/s0306-4522(01)00173-7
Cited by
98
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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