Cited by 108Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsConnexins and lens biology

Cell adhesion and matricellular support by astrocytes of the tripartite synapse

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Hillen, Anne E.J., Burbach, J. Peter H., Hol, Elly M.·2018·Progress in Neurobiology

Abstract

Astrocytes contribute to the formation, function, and plasticity of synapses. Their processes enwrap the neuronal components of the tripartite synapse, and due to this close interaction they are perfectly positioned to modulate neuronal communication. The interaction between astrocytes and synapses is facilitated by cell adhesion molecules and matricellular proteins, which have been implicated in the formation and functioning of tripartite synapses. The importance of such neuron-astrocyte integration at the synapse is underscored by the emerging role of astrocyte dysfunction in synaptic pathologies such as autism and schizophrenia. Here we review astrocyte-expressed cell adhesion molecules and matricellular molecules that play a role in integration of neurons and astrocytes within the tripartite synapse.

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Authors
Hillen, A. E. J., Burbach, J. P. H., & Hol, E. M.
Affiliations
  • University Medical Center Utrecht (NL)
  • Netherlands Institute for Neuroscience (NL)
Corresponding author
Hol, Elly M.
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2018-06
Volume
165-167
Pages
66-86
ISSN
0301-0082 (ISSN-L)
OpenAlex
W2790000715
Cited by
108
References
375
Citations by year
2026: 7 · 2025: 16 · 2024: 11 · 2023: 17 · 2022: 14 · 2021: 13 · 2020: 19 · 2019: 6 · 2018: 5
FWCI
1.39
Type
journal article
Language
en
Open access
Locations
  • Progress in Neurobiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Pure Amsterdam UMC (submittedVersion, other-oa)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion, other-oa)
Funders
  • Autism Speaks (115300)
  • European Federation of Pharmaceutical Industries and Associations
  • European Commission (2007–2013, 115300)
  • Hersenstichting
  • Internationale Stichting Alzheimer Onderzoek (08504, 12509)
  • Innovative Medicines Initiative (115300)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Keywords
astrocytes, tripartite synapse, adhesion molecules, matricellular proteins, astrocyte-neuron interaction, synaptogenesis, synaptic plasticity, astrocyte dysfunction, autism spectrum disorder, schizophrenia
MeSH terms
Animals, Astrocytes, Extracellular Matrix, Humans, Membrane Proteins, Synaptic Transmission, Neurons, Synapses, Cell Adhesion Molecules

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