CoChat
Sign Up
Cited by 144Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 117 of the 118 references it cites were found in a registry or an index.

Cholecystokinin-immunopositive basket and Schaffer collateral-associated interneurones target different domains of pyramidal cells in the CA1 area of the rat hippocampus

Cope, D.W, Maccaferri, G, Márton, L.F, Roberts, J.D.B, Cobden, P.M, Somogyi, P·2002·Neuroscience
DOI 10.1016/s0306-4522(01)00440-7
Open this paper in CoChat — free account

Abstract

Two types of GABAergic interneurone are known to express cholecystokinin-related peptides in the isocortex: basket cells, which preferentially innervate the somata and proximal dendrites of pyramidal cells; and double bouquet cells, which innervate distal dendrites and dendritic spines. In the hippocampus, cholecystokinin immunoreactivity has only been reported in basket cells. However, at least eight distinct GABAergic interneurone types terminate in the dendritic domain of CA1 pyramidal cells, some of them with as yet undetermined neurochemical characteristics. In order to establish whether more than one population of cholecystokinin-expressing interneurone exist in the hippocampus, we have performed whole-cell current clamp recordings from interneurones located in the stratum radiatum of the hippocampal CA1 region of developing rats. Recorded neurones were filled with biocytin to reveal their axonal targets, and were tested for the presence of pro-cholecystokinin immunoreactivity. The results show that two populations of cholecystokinin-immunoreactive interneurones exist in the CA1 area (n=15 positive cells). Cholecystokinin-positive basket cells (53%) preferentially innervate stratum pyramidale and adjacent strata oriens and radiatum. A second population of cholecystokinin-positive cells, previously described as Schaffer collateral-associated interneurones [Vida et al. (1998) J. Physiol. 506, 755-773], have axons that ramify almost exclusively in strata radiatum and oriens, overlapping with the Schaffer collateral/commissural pathway originating from CA3 pyramidal cells. Two of seven of the Schaffer collateral-associated cells were also immunopositive for calbindin. Soma position and orientation in stratum radiatum, the number and orientation of dendrites, and the passive and active membrane properties of the two cell populations are only slightly different. In addition, in stratum radiatum and its border with lacunosum of perfusion-fixed hippocampi, 31.6+/-3.8% (adult) or 26.8+/-2.9% (postnatal day 17-20) of cholecystokinin-positive cells were also immunoreactive for calbindin. Therefore, at least two populations of pro-cholecystokinin-immunopositive interneurones, basket and Schaffer collateral-associated cells, exist in the CA1 area of the hippocampus, and are probably homologous to cholecystokinin-immunopositive basket and double bouquet cells in the isocortex. It is not known if the GABAergic terminals of double bouquet cells are co-aligned with specific glutamatergic inputs. However, in the hippocampal CA1 area, it is clear that the terminals of Schaffer collateral-associated cells are co-stratified with the glutamatergic input from the CA3 area, with as yet unknown functional consequences. The division of the postsynaptic neuronal surface by two classes of GABAergic cell expressing cholecystokinin in both the hippocampus and isocortex provides further evidence for the uniform synaptic organisation of the cerebral cortex.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0306-4522(01)00440-7

Cites

117 of 117 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 118 references

Research works printed but not linked: 3

  1. Pawelzik, 2000, Autapses modulate discharge characteristics in hippocampal interneurones, J. Physiol., 526, 60
  2. Ramon y Cajal, 1893, Estructura del asta de ammon y fascia dentata, Anal. Soc. Espan. Hist. Nat., 22, 53
  3. Ramon y Cajal, 1899, Estudios sobre la corteza cerebral humana, Cort. Vis. Rev. Trim. Microgr., 4, 1

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Cope, D. W., Maccaferri, G., Márton, L. F., Roberts, J. D. B., Cobden, P. M., & Somogyi, P.
Affiliations
University of Oxford (GB)
Corresponding author
Cope, D.W
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2002-01
Volume
109
Issue
1
Pages
63-80
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/s0306-4522(01)00440-7
OpenAlex
W2168534653
Cited by
144
References
118
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 6
FWCI
3.49
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
basket cells, GABAergic interneurons, CA1 pyramidal neurons, dendritic innervation, calbindin, hippocampus development, stratum radiatum, membrane properties, postnatal development, rat hippocampus
MeSH terms
Action Potentials, Aging, Animals, Animals, Newborn, Axons, Cholecystokinin, gamma-Aminobutyric Acid, Hippocampus, Immunohistochemistry, Interneurons, Lysine, Male, Neural Inhibition, Synaptic Transmission, Organ Culture Techniques, Rats, Wistar, Pyramidal Cells, Rats, Calbindins, S100 Calcium Binding Protein G

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review