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Cited by 64Circadian rhythm and melatoninSleep and Wakefulness ResearchNeuroscience and Neuropharmacology Research

Suprachiasmatic nucleus projection to the medial prefrontal cortex: a viral transneuronal tracing study

Sylvester, C.M, Krout, K.E, Loewy, A.D·2002·Neuroscience
DOI 10.1016/s0306-4522(02)00361-5
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Abstract

The viral transneuronal labeling method was used to examine whether the suprachiasmatic nucleus (SCN) is linked by multisynaptic connections to the medial prefrontal cortex of the rat. In separate experiments, pseudorabies virus (PRV) was injected into one of the three different cytoarchitectonic regions that comprise the medial prefrontal cortex: infralimbic (Brodmann area 25), prelimbic (Brodmann area 32), and cingulate (Brodmann area 24) cortical areas. After 4-days survival, extensive SCN transneuronal labeling was found following infralimbic cortex (ILC) injections, but almost none occurred when the PRV injections were centered in the prelimbic or cingulate areas. In the ILC cases, transneuronal labeling was localized mainly in the dorsomedial SCN, although a moderate number of labeled neurons were found in the ventrolateral SCN. About 13% of the infected neurons were vasopressin immunoreactive and 4% were vasoactive intestinal polypeptide-positive. Another set of experiments was performed in which the paraventricular thalamic nucleus (PVT) was destroyed 2 weeks prior to making PRV injections into the ILC. Almost no SCN transneuronal labeling occurred in these animals, suggesting that the SCN projection to the ILC is dependent on a relay in the PVT. We propose that the SCN sends timing signals, via its relay in the PVT, to the ILC. This pathway may modulate higher-level brain functions, such as attention, mood, or working memory. Assuming that a homologous circuit exists in humans, we speculate that neurochemical changes affecting this pathway may account for some of the symptoms associated with clinical depression and attention-deficit/hyperactivity disorder.

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  • The pulvinar receives a direct retinal projection and provides an indirect link between the suprachiasmatic nucleus and the prefrontal cortex.

    “It receives a direct retinal projection, and provides an indirect link between the suprachiasmatic nucleus and the prefrontal cortex [41].”

    From Dawn simulation light impacts on different cognitive domains under sleep restriction (2015) · cites this paper as [41]

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Authors
Sylvester, C. M., Krout, K. E., & Loewy, A. D.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Loewy, A.D
ORCID
Sylvester, C.M
Venue
Neuroscience
Publisher
Elsevier BV
Published
2002-11
Volume
114
Issue
4
Pages
1071-1080
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/s0306-4522(02)00361-5
OpenAlex
W1974822318
Cited by
64
References
60
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL25449)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
suprachiasmatic nucleus, medial prefrontal cortex, infralimbic cortex, prelimbic cortex, cingulate cortex, paraventricular thalamus, pseudorabies virus, transneuronal tracing, vasopressin, vasoactive intestinal peptide, circadian timing, depression, attention deficit hyperactivity disorder
MeSH terms
Affect, Animals, Attention, Circadian Rhythm, Depression, Female, Neural Pathways, Suprachiasmatic Nucleus, Rats, Sprague-Dawley, Prefrontal Cortex, Pseudorabies Vaccines, Rats

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