Sustained Visual Attention Performance-Associated Prefrontal Neuronal Activity: Evidence for Cholinergic Modulation
Open accessAbstract
Cortical cholinergic inputs are hypothesized to mediate attentional functions. The present experiment was designed to determine the single unit activity of neurons within the medial prefrontal cortex (mPFC) of rats performing a sustained visual attention task. Demands on attentional performance were varied by the presentation of a visual distractor. The contribution of cholinergic afferents of the mPFC to performance-associated unit activity within this area was determined by recording neuronal activity before and after unilateral cholinergic deafferentation using intracortical infusion of the immunotoxin 192 IgG-saporin. Presentation of the visual distractor resulted in a decrease in the detection of brief, unpredictable visual signals. As predicted, the unilateral loss of cholinergic inputs within the recording area of the mPFC did not affect sustained attentional performance. Cholinergic deafferentation, however, resulted in a decrease in the overall firing rate of medial prefrontal neurons and a substantial reduction in the proportion of neurons whose firing patterns correlated with specific aspects of behavioral performance. Furthermore, cholinergic deafferentation attenuated the frequency and amplitude of increased mPFC neuronal firing rates that were associated with the presentation of the visual distractor. The main findings from this experiment suggest that cholinergic inputs to the mPFC strongly influence spontaneous and behaviorally correlated single unit activity and mediate increases in neuronal activity associated with enhanced demands for attentional processing, all of which may be fundamental aspects in the maintenance of attentional performance.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prefrontal muscarinic recruitment of efferent circuitry may mediate top-down effects to combat performance decay from time-on-task and distractors.
“Such prefrontal, muscarinic recruitment of efferent circuitry may mediate top-down effects in order to, for example, combat performance decay as a result of time-on-task and other performance challenges, such as distractors (Gill et al, 2000; Kozak et al, 2006; Sarter et al, 2006).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Gill et al, 2000
Distractor stimuli in the sustained attention task should not evoke cholinergic transients.
“In contrast, distractor stimuli in the sustained attention task should not evoke cholinergic transients (Himmelheber et al, 2000; Gill et al, 2000; Howe et al, unpublished results).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Gill et al, 2000
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501 · see citing works
Bowman, P. W. (1963) · AIBS Bulletin · doi:10.2307/1292957 · Cited by 3,654 · see citing works
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541 · see citing works
CENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348 · see citing works
The mechanism of excitation by acetylcholine in the cerebral cortex
Krnjević, K., Pumain, R., & Renaud, L. P. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009467 · Cited by 708 · see citing works
Do Rats Have Prefrontal Cortex? The Rose-Woolsey-Akert Program Reconsidered
Preuss, T. M. (1995) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1995.7.1.1 · Cited by 666 · see citing works
Cognitive functions of cortical acetylcholine: toward a unifying hypothesis
Sarter, M. F., & Bruno, J. P. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00009-4 · Cited by 662 · see citing works
Self-citationDissociating executive functions of the prefrontal cortex.
Robbins, T. W. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0131 · Cited by 574 · see citing works
McNaughton, B. L., O'Keefe, J. M., & Barnes, C. A. (1983) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(83)90097-3 · Cited by 571 · see citing works
Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.
McCormick, D. A., & Prince, D. A. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016112 · Cited by 499 · see citing works
Uylings, H. B. M., & van Eden, C. G. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)62675-8 · Cited by 454 · see citing works
Cholinergic Switching Within Neocortical Inhibitory Networks
Xiang, Z., Huguenard, J. R., & Prince, D. A. (1998) · Science · doi:10.1126/science.281.5379.985 · Cited by 438 · see citing works
McGaughy, J., Kaiser, T., & Sarter, M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.2.247 · Cited by 435 · cited 5× · see citing works
“…demonstrated that the selective loss of corticopetal cholinergic projections is sufficient to produce impairments in attention (Chiba et al., 1995, 1999; Bucci et al., 1998), especially in sustained (McGaughy et al., 1996; McGaughy and Sarter, 1998) and divided attention (Turchi and Sarter, 1997).”
BackgroundMethodResultInfluentialSelf-citationMcGaughy, J. A., Kaiser, T. E., & Sarter, M. F. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.2.247 · Cited by 435 · see citing works
Self-citationArousal systems and attentional processes
Robbins, T. W. (1997) · Biological Psychology · doi:10.1016/s0301-0511(96)05222-2 · Cited by 430 · see citing works
Tago, H., Kimura, H., & Maeda, T. (1986) · Journal of Histochemistry & Cytochemistry · doi:10.1177/34.11.2430009 · Cited by 429 · see citing works
Muir, J. L., Everitt, B. J., & Robbins, T. W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02313.1994 · Cited by 421 · see citing works
Diamond, A. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb48900.x · Cited by 377 · see citing works
McGaughy, J. A., & Sarter, M. F. (1995) · Psychopharmacology · doi:10.1007/bf02246109 · Cited by 348 · see citing works
Self-citationTorres, E. M., Perry, T., Blokland, A., Wilkinson, L. S., Wiley, R. G., Lappi, D. A., & Dunnett, S. B. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90010-8 · Cited by 329 · see citing works
Schoenbaum, G. M., & Eichenbaum, H. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.2.733 · Cited by 329 · see citing works
Robbins, T. W., Everitt, B. J., Marston, H. M., Wilkinson, J., Jones, G. H., & Page, K. J. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80143-3 · Cited by 321 · see citing works
Jung, M. W., Qin, Y. F., McNaughton, B. L., & Barnes, C. A. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.5.437 · Cited by 306 · see citing works
Muir, J. L., Dunnett, S. B., Robbins, T. W., & Everitt, B. J. (1992) · Experimental Brain Research · doi:10.1007/bf00229886 · Cited by 280 · see citing works
Chiba, A., Bucci, D., Holland, P., & Gallagher, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07315.1995 · Cited by 257 · see citing works
The Basal Forebrain Corticopetal System Revisited
Záborszky, L., Pang, K. C. H., Somogyi, J., Nádasdy, Z., & Kalló, I. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09276.x · Cited by 242 · see citing works
Bucci, D. J., Holland, P. C., & Gallagher, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08038.1998 · Cited by 205 · see citing works
Muir, J. L., Page, K. J., Sirinathsinghji, D. J. S., Robbins, T. W., & Everitt, B. J. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90128-d · Cited by 199 · see citing works
Smythe, J. W., Colom, L. V., & Bland, B. H. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80203-9 · Cited by 182 · see citing works
Chapter 10 The prefrontal cortex and its relation to behavior
Fuster, J. M. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63053-8 · Cited by 180 · see citing works
Turchi, J. N., & Sarter, M. F. (1997) · Cognitive Brain Research · doi:10.1016/s0926-6410(97)00027-x · Cited by 165 · see citing works
Self-citationCognitive functions of the basal forebrain cholinergic system in monkeys: memory or attention?
Voytko, M. L. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00143-3 · Cited by 160 · see citing works
Sarter, M., & Bruno, J. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01289-2 · Cited by 159 · see citing works
Self-citationMcGaughy, J., & Sarter, M. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1519 · Cited by 147 · see citing works
Self-citationMcGaughy, J. A., & Sarter, M. F. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.6.1519 · Cited by 143 · see citing works
Self-citationCholinergic mechanisms in the rat somatosensory cerebral cortex
Stone, T. W. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009951 · Cited by 139 · see citing works
Mechanisms controlling neuronal plasticity in somatosensory cortex
Dykes, R. W. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-75-5-535 · Cited by 135 · see citing works
Holst, M., Kelly, J. B., & Powley, T. L. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970428)381:1 · Cited by 124 · see citing works
Frontal units of the monkey coding the associative significance of visual and auditory stimuli
Watanabe, M. (1992) · Experimental Brain Research · doi:10.1007/bf00228241 · Cited by 123 · see citing works
Sarter, M. F., Bruno, J. P., & Turchi, J. N. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09277.x · Cited by 110 · see citing works
Self-citationWaite, J. J., Wardlow, M. L., Chen, A. C., Lappi, D. A., Wiley, R. G., & Thal, L. J. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90379-4 · Cited by 103 · see citing works
Mandel, R. J., Gage, F. H., & Thal, L. J. (1989) · Behavioural Brain Research · doi:10.1016/0166-4328(89)90004-1 · Cited by 91 · see citing works
Holley, L. A., Wiley, R. G., Lappi, D. A., & Sarter, M. F. (1994) · Brain Research · doi:10.1016/0006-8993(94)91274-2 · Cited by 85 · see citing works
Self-citationSelective removal of cholinergic neurons in the basal forebrain alters cued target detection
Chiba, A. A., Bushnell, P. J., Oshiro, W. M., & Gallagher, M. (1999) · NeuroReport · doi:10.1097/00001756-199909290-00044 · Cited by 83 · see citing works
Chang, J.-Y., Zhang, L., Janak, P. H., & Woodward, D. J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00012-7 · Cited by 83 · see citing works
The Issue of Memory in the Study of Prefrontal Function
Goldman‐Rakic, P. S. (1994) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-85007-3_7 · Cited by 79 · see citing works
Searching for spatial unit firing in the prelimbic area of the rat medial prefrontal cortex
Poucet, B. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)00144-1 · Cited by 75 · see citing works
Himmelheber, A. M., Sarter, M., & Bruno, J. P. (1997) · Cognitive Brain Research · doi:10.1016/s0926-6410(97)00014-1 · Cited by 68 · see citing works
Self-citationACETYLCHOLINE AND THE SYNAPTIC TRANSMISSION OF SPECIFIC IMPULSES TO THE VISUAL CORTEX
Spehlmann, R., Daniels, J. C., & Smathers, C. C. (1971) · Brain · doi:10.1093/brain/94.1.125 · Cited by 63 · see citing works
Chapter 15 Behavioral electrophysiology of the prefrontal cortex of the primate
Fuster, J. M. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)62687-4 · Cited by 62 · see citing works
Sarter, M. F., Bruno, J. P., Givens, B. S., Moore, H. M., McGaughy, J. A., & McMahon, K. (1996) · Cognitive Brain Research · doi:10.1016/0926-6410(96)00018-3 · Cited by 55 · see citing works
Self-citationModulation of cognitive processes by transsynaptic activation of the basal forebrain
Givens, B. S., & Sarter, M. F. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)00146-5 · Cited by 52 · see citing works
Self-citationEffects of acetylcholine on single cortical somatosensory neurons in the unanesthetized rat
Bassant, M. H., Baleyte, J.-M., & Lamour, Y. A. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90232-s · Cited by 39 · see citing works
Cognitive and Motivational Operations in Primate Prefrontal Neurons
Watanabe, M. (1998) · Reviews in the Neurosciences · doi:10.1515/revneuro.1998.9.4.225 · Cited by 38 · see citing works
Prefrontal neurones sensitive to increased visual attention in the monkey
Lecas, J.-C. (1995) · Neuroreport · doi:10.1097/00001756-199512000-00073 · Cited by 22 · see citing works
Prefrontal neurones sensitive to increased visual attention in the monkey
Lecas, J.-C. (1995) · Neuroreport · doi:10.1097/00001756-199512290-00073 · Cited by 17 · see citing works
Sukhov, R. R., Cayouette, M. H., Radeke, M. J., Feinstein, S. C., Blumberg, D., Rosenthal, A., Price, D. L., & Koliatsos, V. E. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970630)383:2 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329 · see citing works
The cognitive neuroscience of sustained attention: where top-down meets bottom-up.
Sarter, M., Givens, B., & Bruno, J. P. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00044-3 · Cited by 1,194 · see citing works
Self-citationVigilance, alertness, or sustained attention: physiological basis and measurement
Oken, B. S., Salinsky, M. C., & Elsas, S. M. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.01.017 · Cited by 887 · see citing works
Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733 · see citing works
Self-citationSarter, M., Hasselmo, M. E., Bruno, J. P., & Givens, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.006 · Cited by 667 · see citing works
Self-citationPrefrontal Acetylcholine Release Controls Cue Detection on Multiple Timescales
Parikh, V., Kozak, R., Martinez, V., & Sarter, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.025 · Cited by 623 · see citing works
Self-citationMore attention must be paid: The neurobiology of attentional effort
Sarter, M., Gehring, W. J., & Kozak, R. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.002 · Cited by 552 · see citing works
Self-citationMillan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 549 · see citing works
Hasselmo, M. E., & McGaughy, J. (2004) · Progress in Brain Research · doi:10.1016/s0079-6123(03)45015-2 · Cited by 525 · see citing works
Choline transporters, cholinergic transmission and cognition
Sarter, M. F., & Parikh, V. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1588 · Cited by 400 · see citing works
Self-citationBouret, S., & Sara, S. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03526.x · Cited by 371 · see citing works
Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350 · see citing works
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology
Schmitz, T. W., Spreng, R. N., Initiative, T. A. D. N., Weiner, M. W., Aisen, P. S. S., Petersen, R. C., Jack, C. R., Jagust, W. J., Trojanowki, J. Q., Toga, A. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms13249 · Cited by 335 · see citing works
McGaughy, J., Dalley, J. W., Morrison, C. H., Everitt, B. J., & Robbins, T. W. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01905.2002 · Cited by 311 · see citing works
Attentional functions of cortical cholinergic inputs: What does it mean for learning and memory?
Sarter, M. F., Bruno, J. P., & Givens, B. S. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00070-4 · Cited by 278 · see citing works
Self-citationNeurosystems: brain rhythms and cognitive processing
Cannon, J. J., McCarthy, M. M., Lee, S., Lee, J. H., Börgers, C., Whittington, M. A., & Kopell, N. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12453 · Cited by 221 · see citing works
Cognitive sequelae of head injury: involvement of basal forebrain and associated structures
Salmond, C. H. (2004) · Brain · doi:10.1093/brain/awh352 · Cited by 194 · see citing works
Cortical cholinergic signaling controls the detection of cues
Gritton, H. J., Howe, W. M., Mallory, C. S., Hetrick, V. L., Berke, J. D., & Sarter, M. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516134113 · Cited by 191 · see citing works
Self-citationThe involvement of the orbitofrontal cortex in learning under changing task contingencies.
Kim, J., & Ragozzino, M. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.10.003 · Cited by 206 · see citing works
Pratt, W. E., & Mizumori, S. J. Y. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00204-2 · Cited by 179 · see citing works
Bentley, P., Masud Husain, B., & Dolan, R. J. (2004) · Neuron · doi:10.1016/s0896-6273(04)00145-x · Cited by 179 · see citing works
Cholinergic Mediation of Attention
Parikh, V., & Sarter, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.021 · Cited by 171 · see citing works
Self-citationCholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging
Bentley, P., Driver, J., & Dolan, R. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.06.002 · Cited by 173 · see citing works
McGaughy, J. A., Everitt, B. J., Robbins, T. W., & Sarter, M. F. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00262-x · Cited by 161 · see citing works
Self-citationDynamic network connectivity: a new form of neuroplasticity
Arnsten, A. F. T., Paspalas, C. D., Gamo, N. J., Yang, Y., & Wang, M. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.05.003 · Cited by 160 · see citing works
Cholinergic enhancement modulates neural correlates of selective attention and emotional processing
Bentley, P., Vuilleumier, P. O., Thiel, C. M., Driver, J., & Dolan, R. J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00302-1 · Cited by 157 · see citing works
Cortical Cholinergic Transmission and Cortical Information Processing in Schizophrenia
Sarter, M. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi006 · Cited by 153 · see citing works
Self-citationBloem, B., Poorthuis, R. B., & Mansvelder, H. D. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00017 · Cited by 146 · see citing works
Shin, S. S., & Dixon, C. E. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3445 · Cited by 149 · see citing works
Sarter, M. F., & Bruno, J. P. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.011 · Cited by 148 · see citing works
Self-citationAugmented Prefrontal Acetylcholine Release during Challenged Attentional Performance
Kozak, R., Bruno, J. P., & Sarter, M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi079 · Cited by 144 · see citing works
Self-citationEnhanced Control of Attention by Stimulating Mesolimbic-Corticopetal Cholinergic Circuitry
Peters, M. M. M. S., Demeter, E., Lustig, C., Bruno, J., & Sarter, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-11.2011 · Cited by 147 · see citing works
Self-citationPrefrontal cortical modulation of acetylcholine release in posterior parietal cortex
Nelson, C. L., Sarter, M., & Bruno, J. P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.007 · Cited by 128 · see citing works
Self-citationParikh, V., Man, K., Decker, M. W., & Sarter, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5251-07.2008 · Cited by 127 · see citing works
Self-citationnAChR agonist-induced cognition enhancement: Integration of cognitive and neuronal mechanisms
Sarter, M., Parikh, V., & Howe, W. M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.019 · Cited by 123 · see citing works
Self-citationGolmayo, L., Núñez, Á., & Záborszky, L. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00031-9 · Cited by 120 · see citing works
Testa-Silva, G., Loebel, A., Giugliano, M., de Kock, C. P. J., Mansvelder, H. D., & Meredith, R. M. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr224 · Cited by 118 · see citing works
CNTRICS final animal model task selection: Control of attention
Lustig, C., Kozak, R., Sarter, M. F., Young, J. W., & Robbins, T. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.009 · Cited by 117 · see citing works
Self-citationBeane, M., & Marrocco, R. T. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.001 · Cited by 114 · see citing works
Sarter, M. F., & Bruno, J. P. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02004.x · Cited by 113 · see citing works
Self-citationForebrain Cholinergic Signaling: Wired and Phasic, Not Tonic, and Causing Behavior
Sarter, M. F., & Lustig, C. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1305-19.2019 · Cited by 110 · see citing works
Self-citationDemeter, E., Hernández-García, L., Sarter, M. F., & Lustig, C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.026 · Cited by 107 · see citing works
Self-citationRats and humans paying attention: Cross-species task development for translational research.
Demeter, E., Sarter, M. F., & Lustig, C. (2008) · Neuropsychology · doi:10.1037/a0013712 · Cited by 104 · see citing works
Self-citationJackson, M. E., Frost, A. S., & Moghaddam, B. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00499.x · Cited by 139 · see citing works
Lehmann, O., Grottick, A. J., Cassel, J., & Higgins, G. A. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02745.x · Cited by 102 · see citing works
Central blockade of muscarinic cholinergic receptors disrupts affective and attentional set‐shifting
Chen, K. C., Baxter, M. G., & Rodefer, J. S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03548.x · Cited by 97 · see citing works
The Effects of Prelimbic and Infralimbic Lesions on Working Memory for Visual Objects in Rats
Ragozzino, M. E., Detrick, S., & Kesner, R. P. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4003 · Cited by 97 · see citing works
The effects of manipulations of attentional demand on cortical acetylcholine release
Himmelheber, A. M., Sarter, M. F., & Bruno, J. P. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(01)00064-7 · Cited by 94 · see citing works
Self-citationCholinergic enhancement of episodic memory in healthy young adults
Grön, G., Kirstein, M., Thielscher, A., Riepe, M. W., & Spitzer, M. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0043-2 · Cited by 91 · see citing works
Attention – oscillations and neuropharmacology
Deco, G., & Thiele, A. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06833.x · Cited by 85 · see citing works
Arco, A. D., Segovia, G., Canales, J. J., GARRIDO, P., de Blas, M., García‐Verdugo, J. M., & Mora, F. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0565-8 · Cited by 85 · see citing works
Sarter, M. F., Lustig, C., & Taylor, S. F. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.001 · Cited by 82 · see citing works
Self-citationThe neuroscience of cognitive-motivational styles: Sign- and goal-trackers as animal models.
Sarter, M. F., & Phillips, K. B. (2018) · Behavioral Neuroscience · doi:10.1037/bne0000226 · Cited by 83 · see citing works
Self-citationGain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex
Zhang, Z., & Arsenault, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.086066 · Cited by 82 · see citing works
Kucinski, A. J., Paolone, G., Bradshaw, M., Albin, R. L., & Sarter, M. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2545-13.2013 · Cited by 81 · see citing works
Self-citationCarr, D. B., & Surmeier, D. J. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00828.2006 · Cited by 81 · see citing works
Unique Contributions of Distinct Cholinergic Projections to Motor Cortical Plasticity and Learning
Conner, J. M., Kulczycki, M., & Tuszynski, M. H. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq022 · Cited by 79 · see citing works
Boosting visual cortex function and plasticity with acetylcholine to enhance visual perception
Kang, J. I., Huppé‐Gourgues, F., & Vaucher, E. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00172 · Cited by 77 · see citing works
Leveraging the cortical cholinergic system to enhance attention
Demeter, E., & Sarter, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.060 · Cited by 75 · see citing works
Self-citationBurk, J. A., & Sarter, M. F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00233-0 · Cited by 75 · see citing works
Self-citationAitta‐aho, T., Hay, Y. A., Phillips, B. U., Saksida, L. M., Bussey, T. J., Paulsen, O., & Apergis‐Schoute, J. (2018) · Current Biology · doi:10.1016/j.cub.2018.06.064 · Cited by 73 · see citing works
Turchi, J. N., & Sarter, M. F. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.01347.x · Cited by 72 · see citing works
Self-citationNewman, L. A., & McGaughy, J. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5112-07.2008 · Cited by 71 · see citing works
Maddux, J.-M., Kerfoot, E. C., Chatterjee, S., & Holland, P. C. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.1.63 · Cited by 67 · see citing works
Kolisnyk, B., Al‐Onaizi, M., Hirata, P. H. F., Guzmán, M. S., Nikolova, S., Barbash, S., Soreq, H., Bartha, R., Prado, M. A. M., & Prado, V. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1933-13.2013 · Cited by 67 · see citing works
Apparsundaram, S., Martínez, V., Parikh, V., Kozak, R., & Sarter, M. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0205-05.2005 · Cited by 66 · see citing works
Self-citationBerry, A. S., Demeter, E., Sabhapathy, S., English, B. A., Blakely, R., Sarter, M. F., & Lustig, C. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00607 · Cited by 66 · see citing works
Self-citationSylvester, C. M., Krout, K. E., & Loewy, A. D. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00361-5 · Cited by 64 · see citing works
Zhang (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00021 · Cited by 61 · see citing works
Osman, N. I., Baghdoyan, H. A., & Lydic, R. (2005) · Anesthesiology · doi:10.1097/00000542-200510000-00016 · Cited by 62 · see citing works
Vale-Martı́nez, A., Baxter, M. G., & Eichenbaum, H. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02153.x · Cited by 58 · see citing works
Laplante, F., Morin, Y., Quirion, R., & Vaucher, E. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.059 · Cited by 58 · see citing works
Thiele, A., Herrero, J. L., Distler, C., & Hoffmann, K. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0554-12.2012 · Cited by 57 · see citing works
Turchi, J. N., & Sarter, M. F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00089-6 · Cited by 56 · see citing works
Self-citationPrenatal Ethanol Exposure Leads to Attention Deficits in Both Male and Female Rats
Wang, R., Martin, C. D., Lei, A. L., Hausknecht, K. A., Ishiwari, K., Richards, J. B., Haj‐Dahmane, S., & Shen, R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00012 · Cited by 54 · see citing works
Interactions between aging and cortical cholinergic deafferentation on attention⋆
Burk, J. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00315-3 · Cited by 54 · see citing works
Impact of brain networks involved in vigilance on processing irrelevant visual motion
Breckel, T. P. K., Gießing, C., & Thiel, C. M. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.025 · Cited by 53 · see citing works
Cholinergic optimization of cue‐evoked parietal activity during challenged attentional performance
Broussard, J. I., Karelina, K., Sarter, M. F., & Givens, B. S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06713.x · Cited by 53 · see citing works
Self-citationPoorthuis, R. B., & Mansvelder, H. D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.003 · Cited by 48 · see citing works
Physiological responses of 5-month-old infants to smiling and blank faces
Bazhenova, O. V., Stroganova, T. A., Doussard-Roosevelt, J. A., Posikera, I. N., & Porges, S. W. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2006.08.008 · Cited by 47 · see citing works
CNTRICS Final Biomarker Selection: Control of Attention
Luck, S. J., Ford, J. M., Sarter, M. F., & Lustig, C. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr065 · Cited by 48 · see citing works
Self-citationBerry, A. S., Blakely, R., Sarter, M. F., & Lustig, C. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.12.036 · Cited by 47 · see citing works
Self-citationVandesquille, M., Baudonnat, M., Decorte, L., Louis, C., Lestage, P. J., & Béracochéa, D. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.10.006 · Cited by 46 · see citing works
Sarter, M. F., Lustig, C., Blakely, R., & Cherian, A. K. (2016) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2016.07.001 · Cited by 46 · see citing works
Self-citationThe Monitoring and Control of Task Sequences in Human and Non-Human Primates
Desrochers, T. M., Burk, D. C., Badre, D., & Sheinberg, D. L. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00185 · Cited by 47 · see citing works
Cholinergic enhancement of functional networks in older adults with mild cognitive impairment
Pa, J., Berry, A. S., Compagnone, M., Boccanfuso, J. B., Greenhouse, I., Rubens, M. T., Johnson, J. K., & Gazzaley, A. H. (2013) · Annals of Neurology · doi:10.1002/ana.23874 · Cited by 45 · see citing works
Posterior Parietal Cortex: An Interface between Attention and Learning?
Bucci, D. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.07.004 · Cited by 50 · see citing works
Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex
Stancampiano, R., Carta, M., Cocco, S., Curreli, R., Rossetti, Z. L., & Fadda, F. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.078 · Cited by 45 · see citing works
Fernández, P. J., Campoy, G., Santos, J. M. G., Antequera, M. M., García-Sevilla, J., Castillo, A., Antúnez, C., & Fuentes, L. J. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000327165 · Cited by 44 · see citing works
Kim, K., Müller, M. L. T. M., Bohnen, N. I., Sarter, M. F., & Lustig, C. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.006 · Cited by 46 · see citing works
Self-citationBrowne, R. O., BenMoyal‐Segal, L., Zumsteg, D., David, Y., Kofman, O., Berger, A., Soreq, H., & Friedman, A. (2006) · The FASEB Journal · doi:10.1096/fj.05-5576fje · Cited by 43 · see citing works
Lopes Aguiar, C., Romcy-Pereira, R. N., Escorsim Szawka, R., Galvis-Alonso, O. Y., Anselmo-Franci, J. A., & Pereira Leite, J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.040 · Cited by 42 · see citing works
Siegel, J. A., Craytor, M. J., & Raber, J. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833e7e44 · Cited by 42 · see citing works
Sarter, M., Martinez, V., & Kozak, R. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1216-6 · Cited by 41 · see citing works
Self-citationBroussard, J. I., Sarter, M. F., & Givens, B. S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.030 · Cited by 40 · see citing works
Self-citationKljakic, O., Janíčková, H., Prado, V. F., & Prado, M. A. M. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14003 · Cited by 39 · see citing works
Cognitive Performances of Cholinergically Depleted Rats Following Chronic Donepezil Administration
Cutuli, D., Foti, F., Mandolesi, L., Bartolo, P. D., Gelfo, F., Federico, F., & Petrosini, L. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1040 · Cited by 39 · see citing works
Lateralized Attentional Functions of Cortical Cholinergic Inputs.
Martínez, V., & Sarter, M. F. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.5.984 · Cited by 38 · see citing works
Self-citationTime-dependent alterations of cholinergic markers after experimental traumatic brain injury
Donat, C. K., Schuhmann, M. U., Voigt, C., Nieber, K., Deuther‐Conrad, W., & Brust, P. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.059 · Cited by 37 · see citing works
Bensadoun, J., Brooks, S. P., & Dunnett, S. B. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1751-0 · Cited by 37 · see citing works
- Authors
- Gill, T. M., Sarter, M., & Givens, B.
- Affiliations
- The Ohio State University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-06-15
- Volume
- 20
- Issue
- 12
- Pages
- 4745-4757
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6772472
- OpenAlex
- W1775539225
- Cited by
- 228
- References
- 55
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 7 · 2012: 5
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH-19936, T32MH019936)
- National Institute of Neurological Disorders and Stroke (NS37026, R01NS037026)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sustained visual attention, medial prefrontal cortex, cholinergic modulation, cholinergic deafferentation, single-unit activity, visual distractors, attentional demands, neuronal firing rate, rats
- MeSH terms
- Saporins, Afferent Pathways, Animals, Antibodies, Monoclonal, Immunotoxins, Attention, Conditioning, Operant, Male, Neurons, N-Glycosyl Hydrolases, Reward, Visual Perception, Prefrontal Cortex, Cholinergic Agents, Rats, Long-Evans, Rats, Ribosome Inactivating Proteins, Type 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
