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Cited by 138Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

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Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor-LacZ reporter mouse

Gould, B.R, Zingg, H.H·2003·Neuroscience
DOI 10.1016/s0306-4522(03)00283-5
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Abstract

The hypothalamic nonapeptide oxytocin (OT) has an established role as a circulating hormone but can also act as a neurotransmitter and as a neuromodulator by interacting with its central OT receptor (OTR). To understand the role of the OTR in the mouse brain we investigated the expression of the OTR gene at the cellular level. We targeted the lacZ reporter gene to the OTR gene locus downstream of the endogenous OTR regulatory elements. Using lactating mouse mammary gland as a control for OTR promoter directed specificity of lacZ gene expression, X-gal histochemistry on tissue sections confirmed that gene expression was restricted to the myoepithelial cells. We also identified for the first time in mice the expression of the OTR gene in neighbouring adipocytes. Further, investigation in the mouse brain identified numerous nuclei containing neurons expressing the OTR gene. Whilst some of these regions had been described for rat or sheep, the OTR-LacZ reporter mouse enabled the identification of novel sites of central OTR gene expression. These regions include the accessory olfactory bulb, the medial septal nucleus, the posterolateral cortical amygdala nucleus, the posterior aspect of the basomedial amygdala nucleus, the medial part of the supramammillary nucleus, the dorsotuberomammillary nucleus, the medial and lateral entorhinal cortices, as well as specific dorsal tegmental, vestibular, spinal trigeminal, and solitary tract subnuclei. By mapping the distribution of OTR gene…

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  1. Adan, 1995, Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus, Endocrinology, 136, 4022, 10.1210/en.136.9.4022 · DOI · Paper page
  2. Augert, 1988, Insulin and oxytocin effects on phosphoinositide metabolism in adipocytes, J Biol Chem, 263, 3600, 10.1016/S0021-9258(18)68967-7 · DOI
  3. Breton C, Pechoux C, Morel G, Zingg H (1995) Oxytocin receptor messenger ribonucleic acid: characterization, regulation, and cellular localization in the rat pituitary gland endocrinology 136:2928–2963 · DOI
  4. Champagne, 2001, Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors, Proc Natl Acad Sci USA, 98, 12736, 10.1073/pnas.221224598 · DOI · Paper page
  5. Champagne, 2001, Like mother, like daughter, Prog Brain Res, 133, 287, 10.1016/S0079-6123(01)33022-4 · DOI · Paper page
  6. Condes-Lara, 1994, Correlation between oxytocin neuronal sensitivity and oxytocin-binding sites in the amygdala of the rat, Brain Res, 637, 277, 10.1016/0006-8993(94)91245-9 · DOI
  7. Egan, 1990, Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes, Proc Natl Acad Sci USA, 87, 1052, 10.1073/pnas.87.3.1052 · DOI
  8. Freund-Mercier, 1987, Pharmacological characteristics and anatomical distribution of [3H]oxytocin-binding sites in the Wistar rat brain studied by autoradiography, Neuroscience, 20, 599, 10.1016/0306-4522(87)90113-8 · DOI · Paper page
  9. Gimpl, 2001, The oxytocin receptor system, Physiol Rev, 81, 629, 10.1152/physrev.2001.81.2.629 · DOI · Paper page
  10. Grottel, 1999, Bidirectional neurones in the cervical enlargement of the cat spinal cord with axons descending to sacral segments and ascending to the cerebellum and the lateral reticular nucleus, Exp Physiol, 84, 1059, 10.1017/S0958067099018989 · DOI
  11. Insel, 1986, Postpartum increases in brain oxytocin binding, Neuroendocrinology, 44, 515, 10.1159/000124694 · DOI
  12. Insel, 2001, Oxytocin, Prog Brain Res, 133, 59, 10.1016/S0079-6123(01)33005-4 · DOI
  13. Insel, 1997, Central oxytocin and reproductive behaviours, Rev Reprod, 2, 28, 10.1530/ror.0.0020028 · DOI
  14. Insel, 1993, Gonadal steroids have paradoxical effects on brain oxytocin receptors, J Neuroendocrinol, 5, 619, 10.1111/j.1365-2826.1993.tb00531.x · DOI · Paper page
  15. Jurgens, 2002, Neural pathways underlying vocal control, Neurosci Biobehav Rev, 26, 235, 10.1016/S0149-7634(01)00068-9 · DOI
  16. Le Mouellic, 1990, Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse chimeric embryos, Proc Natl Acad Sci USA, 87, 4712, 10.1073/pnas.87.12.4712 · DOI
  17. McCrea, 2001, Current concepts of vestibular nucleus function, Ann NY Acad Sci, 942, 328, 10.1111/j.1749-6632.2001.tb03758.x · DOI
  18. Nishimori, 1996, Oxytocin is required for nursing but is not essential for parturition or reproductive behavior, Proc Natl Acad Sci USA, 93, 11699, 10.1073/pnas.93.21.11699 · DOI · Paper page
  19. Ostrowski, 1998, Oxytocin receptor mRNA expression in rat brain, Psychoneuroendocrinology, 23, 989, 10.1016/S0306-4530(98)00070-5 · DOI
  20. Paban, 1998, The behavioral effect of vasopressin in the ventral hippocampus is antagonized by an oxytocin receptor antagonist, Eur J Pharmacol, 361, 165, 10.1016/S0014-2999(98)00704-3 · DOI
  21. Pettibone, 1990, Identification of functional oxytocin receptors in lactating rat mammary gland in vitro, Eur J Pharmacol, 188, 235, 10.1016/0922-4106(90)90007-K · DOI
  22. Popratiloff, 2001, Hypoglossal and reticular interneurons involved in oro-facial coordination in the rat, J Comp Neurol, 433, 364, 10.1002/cne.1145 · DOI
  23. Rabhi, 1999, Historadioautographic localisation of oxytocin and vasopressin binding sites in the central nervous system of the merione (Meriones shawi), Brain Res Bull, 48, 147, 10.1016/S0361-9230(98)00158-0 · DOI
  24. Sala, 1974, Relationship between ultrastructure and response to oxytocin of the mammary myoepithelium throughout pregnancy and lactation, Biol Reprod, 11, 7, 10.1095/biolreprod11.1.7 · DOI
  25. Sharpe, 2001, Angular velocity and head direction signals recorded from the dorsal tegmental nucleus of gudden in the rat, Behav Neurosci, 115, 517
  26. Shelat, 1998, Adrenal steroid regulation of central angiotensin II receptor subtypes and oxytocin receptors in the rat brain, Brain Res, 807, 135, 10.1016/S0006-8993(98)00794-X · DOI
  27. Soloff, 1989, Vasopressin and oxytocin receptors on plasma membranes from rat mammary gland, Biochem Cell Biol, 67, 152, 10.1139/o89-023 · DOI
  28. Soloff, 1983, Oxytocin receptors in rat involuting mammary gland, Can J Biochem Cell Biol, 61, 631, 10.1139/o83-079 · DOI
  29. Tribollet, 1988, Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography, Brain Res, 442, 105, 10.1016/0006-8993(88)91437-0 · DOI · Paper page
  30. Tribollet, 1992, Oxytocin receptors in the central nervous system, Rev Ann NY Acad Sci, 652, 29, 10.1111/j.1749-6632.1992.tb34343.x · DOI · Paper page
  31. Wang, 1997, Ontogeny of oxytocin and vasopressin receptor binding in the lateral septum in prairie and montane voles, Dev Brain Res, 104, 191, 10.1016/S0165-3806(97)00138-7 · DOI
  32. Whitten, 2002, Neurobehavioral actions of coumestrol and related isoflavonoids in rodents, Neurotoxicol Teratol, 24, 47, 10.1016/S0892-0362(01)00192-1 · DOI
  33. Wilson, 1987, Effects of oxytocin and vasopressin on the preadipocyte 3T3-F442A cell line, Biochem Cell Biol, 65, 211, 10.1139/o87-027 · DOI
  34. Yoshimura, 1993, Localization of oxytocin receptor messenger ribonucleic acid in the rat brain, Endocrinology, 133, 1239, 10.1210/en.133.3.1239 · DOI · Paper page
  35. Yoshimura, 1996, Differential expression of oxytocin receptor mRNA in the developing rat brain, Neurosci Res, 24, 291, 10.1016/0168-0102(95)01003-3 · DOI
  36. Young, 1996, Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition, J Neuroendocrinol, 8, 847, 10.1046/j.1365-2826.1996.05266.x · DOI · Paper page
  37. Zingg HH (2002) Oxytocin. In: Hormones, brain and behavior, vol. 3 (Pfaff D, Arnold AP, Etger AM, Fahrbach SE, Rubin RT, eds), pp 779–803. San Diego: Academic Press · DOI

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Metadata

Authors
Gould, B. R., & Zingg, H. H.
Affiliations
Royal Victoria Hospital (CA)
Corresponding author
Zingg, H.H
Venue
Neuroscience
Publisher
Elsevier BV
Published
2003-11
Volume
122
Issue
1
Pages
155-167
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/s0306-4522(03)00283-5
OpenAlex
W2035269878
Cited by
138
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 11 · 2021: 11 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 10 · 2012: 4
FWCI
3.71
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
oxytocin receptor, gene expression mapping, myoepithelial cells, mammary gland, amygdala, accessory olfactory bulb, supramammillary nucleus, entorhinal cortex, oxytocinergic system, adipocytes
MeSH terms
Animals, Brain, Female, Lac Operon, Mammary Glands, Animal, Mice, Transgenic, Blotting, Southern, Gene Expression, Receptors, Oxytocin, Reverse Transcriptase Polymerase Chain Reaction, Mice

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