Cited by 138Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

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Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor-LacZ reporter mouse

Gould, B.R, Zingg, H.H·2003·Neuroscience

DOI 10.1016/s0306-4522(03)00283-5

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Abstract

The hypothalamic nonapeptide oxytocin (OT) has an established role as a circulating hormone but can also act as a neurotransmitter and as a neuromodulator by interacting with its central OT receptor (OTR). To understand the role of the OTR in the mouse brain we investigated the expression of the OTR gene at the cellular level. We targeted the lacZ reporter gene to the OTR gene locus downstream of the endogenous OTR regulatory elements. Using lactating mouse mammary gland as a control for OTR promoter directed specificity of lacZ gene expression, X-gal histochemistry on tissue sections confirmed that gene expression was restricted to the myoepithelial cells. We also identified for the first time in mice the expression of the OTR gene in neighbouring adipocytes. Further, investigation in the mouse brain identified numerous nuclei containing neurons expressing the OTR gene. Whilst some of these regions had been described for rat or sheep, the OTR-LacZ reporter mouse enabled the identification of novel sites of central OTR gene expression. These regions include the accessory olfactory bulb, the medial septal nucleus, the posterolateral cortical amygdala nucleus, the posterior aspect of the basomedial amygdala nucleus, the medial part of the supramammillary nucleus, the dorsotuberomammillary nucleus, the medial and lateral entorhinal cortices, as well as specific dorsal tegmental, vestibular, spinal trigeminal, and solitary tract subnuclei. By mapping the distribution of OTR gene…

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Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study
Loup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378
Comparative Distribution of Vasopressin V1b and Oxytocin Receptor Messenger Ribonucleic Acids in Brain 1
Vaccari, C., Lolait, S. J., & Ostrowski, N. L. (1998) · Endocrinology · doi:10.1210/endo.139.12.6382 · Cited by 308
The comparative distribution of forebrain receptors for neurohypophyseal peptides in monogamous and polygamous mice
Insel, T. R., Gelhard, R., & Shapiro, L. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90321-e · Cited by 209
Gonadal steroids regulate oxytocin receptors but not vasopressin receptors in the brain of male and female rats. An autoradiographical study
Tribollet, E., Audigier, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90232-z · Cited by 203
Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus: partial sequence and immunocytochemical localization.
Adan, R. A., Van Leeuwen, F. W., Sonnemans, M. A., Brouns, M., Hoffman, G., Verbalis, J. G., & Burbach, J. P. (1995) · Endocrinology · doi:10.1210/endo.136.9.7649111 · Cited by 147
Previous maternal experience potentiates the effect of parturition on oxytocin receptor mRNA expression in the paraventricular nucleus
Broad, K. D., Lévy, F., Evans, G., Kimura, T., Keverne, E. B., & Kendrick, K. M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00782.x · Cited by 100
Structure and expression of the mouse oxytocin receptor gene
Kubota, Y., Kimura, T., Hashimoto, K., Tokugawa, Y., Nobunaga, K., Azuma, C., Saji, F., & Murata, Y. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(96)03923-8 · Cited by 93
Up-regulation of vasopressin and angiotensin II receptors in the thalamus and brainstem of inbred polydipsic mice
Tribollet, E., Ueta, Y., Heitz, F., Marguerat, A., Koizumi, K., & Yamashita, H. (2002) · Neuroendocrinology · doi:10.1159/000048227 · Cited by 20

Show all 0 references

Research works printed but not linked: 37

Adan, 1995, Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus, Endocrinology, 136, 4022, 10.1210/en.136.9.4022 · DOI · Paper page
Augert, 1988, Insulin and oxytocin effects on phosphoinositide metabolism in adipocytes, J Biol Chem, 263, 3600, 10.1016/S0021-9258(18)68967-7 · DOI
Breton C, Pechoux C, Morel G, Zingg H (1995) Oxytocin receptor messenger ribonucleic acid: characterization, regulation, and cellular localization in the rat pituitary gland endocrinology 136:2928–2963 · DOI
Champagne, 2001, Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors, Proc Natl Acad Sci USA, 98, 12736, 10.1073/pnas.221224598 · DOI · Paper page
Champagne, 2001, Like mother, like daughter, Prog Brain Res, 133, 287, 10.1016/S0079-6123(01)33022-4 · DOI · Paper page
Condes-Lara, 1994, Correlation between oxytocin neuronal sensitivity and oxytocin-binding sites in the amygdala of the rat, Brain Res, 637, 277, 10.1016/0006-8993(94)91245-9 · DOI
Egan, 1990, Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes, Proc Natl Acad Sci USA, 87, 1052, 10.1073/pnas.87.3.1052 · DOI
Freund-Mercier, 1987, Pharmacological characteristics and anatomical distribution of [3H]oxytocin-binding sites in the Wistar rat brain studied by autoradiography, Neuroscience, 20, 599, 10.1016/0306-4522(87)90113-8 · DOI · Paper page
Gimpl, 2001, The oxytocin receptor system, Physiol Rev, 81, 629, 10.1152/physrev.2001.81.2.629 · DOI · Paper page
Grottel, 1999, Bidirectional neurones in the cervical enlargement of the cat spinal cord with axons descending to sacral segments and ascending to the cerebellum and the lateral reticular nucleus, Exp Physiol, 84, 1059, 10.1017/S0958067099018989 · DOI
Insel, 1986, Postpartum increases in brain oxytocin binding, Neuroendocrinology, 44, 515, 10.1159/000124694 · DOI
Insel, 2001, Oxytocin, Prog Brain Res, 133, 59, 10.1016/S0079-6123(01)33005-4 · DOI
Insel, 1997, Central oxytocin and reproductive behaviours, Rev Reprod, 2, 28, 10.1530/ror.0.0020028 · DOI
Insel, 1993, Gonadal steroids have paradoxical effects on brain oxytocin receptors, J Neuroendocrinol, 5, 619, 10.1111/j.1365-2826.1993.tb00531.x · DOI · Paper page
Jurgens, 2002, Neural pathways underlying vocal control, Neurosci Biobehav Rev, 26, 235, 10.1016/S0149-7634(01)00068-9 · DOI
Le Mouellic, 1990, Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse chimeric embryos, Proc Natl Acad Sci USA, 87, 4712, 10.1073/pnas.87.12.4712 · DOI
McCrea, 2001, Current concepts of vestibular nucleus function, Ann NY Acad Sci, 942, 328, 10.1111/j.1749-6632.2001.tb03758.x · DOI
Nishimori, 1996, Oxytocin is required for nursing but is not essential for parturition or reproductive behavior, Proc Natl Acad Sci USA, 93, 11699, 10.1073/pnas.93.21.11699 · DOI · Paper page
Ostrowski, 1998, Oxytocin receptor mRNA expression in rat brain, Psychoneuroendocrinology, 23, 989, 10.1016/S0306-4530(98)00070-5 · DOI
Paban, 1998, The behavioral effect of vasopressin in the ventral hippocampus is antagonized by an oxytocin receptor antagonist, Eur J Pharmacol, 361, 165, 10.1016/S0014-2999(98)00704-3 · DOI
Pettibone, 1990, Identification of functional oxytocin receptors in lactating rat mammary gland in vitro, Eur J Pharmacol, 188, 235, 10.1016/0922-4106(90)90007-K · DOI
Popratiloff, 2001, Hypoglossal and reticular interneurons involved in oro-facial coordination in the rat, J Comp Neurol, 433, 364, 10.1002/cne.1145 · DOI
Rabhi, 1999, Historadioautographic localisation of oxytocin and vasopressin binding sites in the central nervous system of the merione (Meriones shawi), Brain Res Bull, 48, 147, 10.1016/S0361-9230(98)00158-0 · DOI
Sala, 1974, Relationship between ultrastructure and response to oxytocin of the mammary myoepithelium throughout pregnancy and lactation, Biol Reprod, 11, 7, 10.1095/biolreprod11.1.7 · DOI
Sharpe, 2001, Angular velocity and head direction signals recorded from the dorsal tegmental nucleus of gudden in the rat, Behav Neurosci, 115, 517
Shelat, 1998, Adrenal steroid regulation of central angiotensin II receptor subtypes and oxytocin receptors in the rat brain, Brain Res, 807, 135, 10.1016/S0006-8993(98)00794-X · DOI
Soloff, 1989, Vasopressin and oxytocin receptors on plasma membranes from rat mammary gland, Biochem Cell Biol, 67, 152, 10.1139/o89-023 · DOI
Soloff, 1983, Oxytocin receptors in rat involuting mammary gland, Can J Biochem Cell Biol, 61, 631, 10.1139/o83-079 · DOI
Tribollet, 1988, Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography, Brain Res, 442, 105, 10.1016/0006-8993(88)91437-0 · DOI · Paper page
Tribollet, 1992, Oxytocin receptors in the central nervous system, Rev Ann NY Acad Sci, 652, 29, 10.1111/j.1749-6632.1992.tb34343.x · DOI · Paper page
Wang, 1997, Ontogeny of oxytocin and vasopressin receptor binding in the lateral septum in prairie and montane voles, Dev Brain Res, 104, 191, 10.1016/S0165-3806(97)00138-7 · DOI
Whitten, 2002, Neurobehavioral actions of coumestrol and related isoflavonoids in rodents, Neurotoxicol Teratol, 24, 47, 10.1016/S0892-0362(01)00192-1 · DOI
Wilson, 1987, Effects of oxytocin and vasopressin on the preadipocyte 3T3-F442A cell line, Biochem Cell Biol, 65, 211, 10.1139/o87-027 · DOI
Yoshimura, 1993, Localization of oxytocin receptor messenger ribonucleic acid in the rat brain, Endocrinology, 133, 1239, 10.1210/en.133.3.1239 · DOI · Paper page
Yoshimura, 1996, Differential expression of oxytocin receptor mRNA in the developing rat brain, Neurosci Res, 24, 291, 10.1016/0168-0102(95)01003-3 · DOI
Young, 1996, Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition, J Neuroendocrinol, 8, 847, 10.1046/j.1365-2826.1996.05266.x · DOI · Paper page
Zingg HH (2002) Oxytocin. In: Hormones, brain and behavior, vol. 3 (Pfaff D, Arnold AP, Etger AM, Fahrbach SE, Rubin RT, eds), pp 779–803. San Diego: Academic Press · DOI

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Background
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Stoop, R. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.012 · Cited by 84
“Medial prefrontal cortex (mPFC) The mPFC also contains OT-sensitive neurons [41], abundantly expresses OT receptors [42,43] and receives long range axonal projections from OT producing neurons in the hypothalamus [9,44].”
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Oxytocin and vasopressin in the rodent hippocampus
Cilz, N. I., Cymerblit‐Sabba, A., & Young, W. S. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12535 · Cited by 92
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Background
Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas
Maejima, Y., Rita, R. S., Santoso, P., Aoyama, M., Hiraoka, Y., Nishimori, K., Gantulga, D., Shimomura, K., & Yada, T. (2015) · Neuroendocrinology · doi:10.1159/000371636 · Cited by 81
Oxytocin and behavior: lessons from knockout mice
Caldwell, H. K., Aulino, E. A., Freeman, A. R., Miller, T. V., & Witchey, S. K. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22431 · Cited by 79
The effects of acute social isolation on long-term social recognition memory
Leser, N., & Wagner, S. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.07.002 · Cited by 84
“Interestingly, Oxtr expression levels were found to be especially high in most regions associated with the main and accessory olfactory systems (Gimpl & Fahrenholz, 2001; Gould & Zingg, 2003).”
Oxytocin microinjected into the central amygdaloid nuclei exerts anti-aggressive effects in male rats
Calcagnoli, F., Stubbendorff, C., Meyer, N., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.012 · Cited by 77
Hindbrain Oxytocin Receptors Contribute to the Effects of Circulating Oxytocin on Food Intake in Male Rats
Ho, J. M., Anekonda, V. T., Thompson, B. W., Zhu, M., Curry, R. W., Hwang, B. H., Morton, G. J., Schwartz, M. W., Baskin, D. G., Appleyard, S. M., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1148 · Cited by 74
“OTRs are expressed on adipocytes (12, 55, 57) and OT elicits direct effects on these cells (56).”
Background
Intranasal Oxytocin May Improve High-Level Social Cognition in Schizophrenia, But Not Social Cognition or Neurocognition in General: A Multilevel Bayesian Meta-analysis
Bürkner, P., Williams, D. R., Simmons, T. C., & Woolley, J. D. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx053 · Cited by 82
Oxytocin in the medial prefrontal cortex attenuates anxiety: Anatomical and receptor specificity and mechanism of action
Sabihi, S., Dong, S. M., Maurer, S., Goodpaster, C. M., & Leuner, B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.024 · Cited by 87
“OTR are located in the mPFC (Duchemin et al., 2017; Gould and Zingg, 2003; Insel and Shapiro, 1992; Liu et al., 2005; Mak et al., 2012; Mitre et al., 2016; Nakajima et al., 2014; Smeltzer et al., 2006) although little is known about subregional differences in OTR density which may be another factor…”
Background
Lactation and its Hormonal Control
Anderson, S. M., MacLean, P. S., McManaman, J. L., & Neville, M. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00046-6 · Cited by 106
Oxytocin enhances cognitive control of food craving in women
Striepens, N., Schröter, F., Stoffel‐Wagner, B., Maier, W., Hurlemann, R., & Scheele, D. (2016) · Human Brain Mapping · doi:10.1002/hbm.23308 · Cited by 63
“In the frontal cortex, OXT receptors are expressed in a high density [Boccia et al., 2013; Gould and Zingg, 2003] and an OXT-mediated augmentation of prefrontal top-down control has been previously documented in the context of fear extinction [Eckstein et al.”
Coming Full Circle: Contributions of Central and Peripheral Oxytocin Actions to Energy Balance
Ho, J. M., & Blevins, J. E. (2012) · Endocrinology · doi:10.1210/en.2012-1751 · Cited by 67
Medial nucleus tractus solitarius oxytocin receptor signaling and food intake control: the role of gastrointestinal satiation signal processing
Ong, Z. Y., Alhadeff, A. L., & Grill, H. J. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00534.2014 · Cited by 62
“OT-Rs are widely expressed throughout the brain including the PVH, arcuate nucleus of the hypothalamus (Arc), ventral medial hypothalamus (VMH), ventral tegmental area (VTA), and medial nucleus tractus solitarius (mNTS) in the caudal hindbrain (19, 57, 62).”
Background
Brain region-specific methylation in the promoter of the murine oxytocin receptor gene is involved in its expression regulation
Harony-Nicolas, H., Mamrut, S., Brodsky, L., Shahar-Gold, H., Barki-Harrington, L., & Wagner, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.004 · Cited by 61
“To approach this question, we began by analyzing the cerebellum (Cer) and olfactory bulb (OB) because they are easily accessible for extraction, and were previously shown to exhibit marked differences in Oxtr expression (Gould and Zingg, 2003).”
Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome
Gemmel, M., Bögi, E., Ragan, C. M., Hazlett, M. F., Dubovický, M., van den Hove, D., Oberlander, T. F., Charlier, T. D., & Pawluski, J. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.023 · Cited by 68
“…observed in social and reproductive behavior; this would be in line with previous work showing a link between hippocampal neurogenesis, Re vi d m an u cri pt reproductive behaviors, and social interactions (Gould and Zingg, 2003; Hammels et al., 2015; Leuner et al., 2014; Leuner et al., 2010).”
Result
Oxytocin: A Conditional Anorexigen whose Effects on Appetite Depend on the Physiological, Behavioural and Social Contexts
Olszewski, P. K., Klockars, A., & Levine, A. S. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12376 · Cited by 56
Oxytocin facilitates the induction of long-term potentiation in the accessory olfactory bulb
Fang, L.-Y., Quan, R.-D., & Kaba, H. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.070 · Cited by 57
“Third, does OT act on the presynaptic or postsynaptic site of the mitral-to-granule cell synapse? The OT receptor-LacZ reporter mouse exhibited OT receptor-expressing neurons in regions that have not been described previously [15].”
The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine
Warfvinge, K., Krause, D. N., & Edvinsson, L. I. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-1079-8 · Cited by 60
The Regulation of Oxytocin Receptor Gene Expression during Adipogenesis
Yi, K., So, K., Hata, Y., Suzuki, Y., Kato, D., Watanabe, K., Aso, H., Kasahara, Y., Nishimori, K., Chen, C., et al. (2015) · Journal of neuroendocrinology · doi:10.1111/jne.12268 · Cited by 51
Central Oxytocin and Food Intake: Focus on Macronutrient-Driven Reward
Klockars, A., Levine, A. S., & Olszewski, P. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00065 · Cited by 46
“Numerous reports have shown widespread distribution of the OT receptor throughout the brain and, importantly, specific sites involved in reward processing, such as the nucleus accumbens and the ventral tegmental area, appear to be prominent central targets of OT signaling (39, 40).”
Background
Behavioural studies using temporal and spatial inactivation of the oxytocin receptor
LEE, H., CALDWELL, H., MACBETH, A., & YOUNGIII, W. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00407-x · Cited by 49
Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice
Amico, J. A., Vollmer, R. R., Karam, J. R., Lee, P. R., Li, X., Koenig, J. I., & McCarthy, M. M. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.04.006 · Cited by 46
Extinction of fear is facilitated by social presence: Synergism with prefrontal oxytocin
Brill-Maoz, N., & Maroun, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.003 · Cited by 45
“…reduction (e.g., Dumont et al., 2009; Uvnäs-Moberg, 1997; Uvnas-Moberg, 1998 however, see King et al., 1985), are abundantly expressed in the mPFC (Gould and Zingg, 2003; Liu et al., 2005; Ninan, 2011), suggesting that they may play a role in fear extinction (reviewed in (Maroun and Wagner,…”
Background
Autistic-like behaviours and associated brain structural plasticity are modulated by oxytocin in maternally separated rats
Mansouri, M., Pouretemad, H., Roghani, M., Wegener, G., & Ardalan, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112756 · Cited by 43
Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders
Quintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.004 · Cited by 39
“Brain regions known to be involved in appetite regulation, such as the dorsomedial and ventromedial hypothalamic nuclei, are also rich in OT receptors (Gould and Zingg, 2003).”
Background
Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions
Baudon, A., Creusot, E. C., Althammer, F., Schaaf, C. P., & Charlet, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102328 · Cited by 44
“It must be noted here that albeit OTR expression in neurons is observed in a myriad of species and brain regions (Gould and Zingg, 2003; Mitre et al., 2016; Newmaster et al., 2020; Young and Song, 2020), these studies did not investigate actual OTR expression levels in neurons on a quantitative,…”
Background
Hypothalamic Supramammillary Control of Cognition and Motivation
Kesner, A. J., Mozaffarilegha, M., Thirtamara Rajamani, K., Arima, Y., Harony-Nicolas, H., Hashimotodani, Y., Ito, H. T., Song, J., & Ikemoto, S. (2023) · The Journal of Neuroscience · doi:10.1523/jneurosci.1320-23.2023 · Cited by 35
Oxytocin activity in the paraventricular and supramammillary nuclei of the hypothalamus is essential for social recognition memory in rats
Rajamani, K. T., Barbier, M., Lefèvre, A., Niblo, K., Cordero, N., Netser, S., Grinevich, V., Wagner, S., & Harony‐Nicolas, H. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02336-0 · Cited by 44
Alpha-Melanocyte-Stimulating Hormone-Mediated Appetite Regulation in the Central Nervous System
Wu, Q., Chen, J., Hua, T., & Cai, J. (2023) · Neuroendocrinology · doi:10.1159/000530804 · Cited by 46
Novel oxytocin receptor variants in laboring women requiring high doses of oxytocin
Reinl, E. L., Goodwin, Z. A., Raghuraman, N., Lee, G. Y., Jo, E. Y., Gezahegn, B. M., Pillai, M. K., Cahill, A. G., Strong, C. D. G., & England, S. K. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.04.036 · Cited by 40
[125I]-Galanin binding in brain of wildtype, and galanin- and GalR1-knockout mice: strain and species differences in GalR1 density and distribution.
Jungnickel, S., & Gundlach, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.023 · Cited by 32
Oxytocin and Sensory Network Plasticity
Pekarek, B. T., Hunt, P. J., & Arenkiel, B. R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00030 · Cited by 40
“Notably, work in the hippocampus links local neuropeptide release to environmental and social learning stressors or enrichment (Ögren et al., 2010; Grégoire et al., 2014; Li et al., 2017).”
Background
Actions of feeding-related peptides on the mesolimbic dopamine system in regulation of natural and drug rewards
Dunigan, A. I., & Roseberry, A. G. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100011 · Cited by 28
The Neuropeptide Hormone Oxytocin in Eating Disorders
Plessow, F., Eddy, K. T., & Lawson, E. A. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0957-0 · Cited by 34
Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis
D’Addario, C., Pucci, M., Bellia, F., Girella, A., Sabatucci, A., Fanti, F., Vismara, M. E. M., Benatti, B., Ferrara, L., Fasciana, F., et al. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01264-0 · Cited by 31
Oxytocin as an Anti-obesity Treatment
Niu, J., Tong, J., & Blevins, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.743546 · Cited by 30
Diversity of central oxytocinergic projections
Jirikowski, G. F. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-2960-5 · Cited by 27
Unusual social behavior in HPC‐1/syntaxin1A knockout mice is caused by disruption of the oxytocinergic neural system
Fujiwara, T., Sanada, M., Kofuji, T., & Akagawa, K. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13634 · Cited by 27
“In humans, single nucleotide polymorphism variants in OXTR may be associated with social behavioral phenotypes (Tost et al. 2010), and high levels of methylation of OXTR, which decrease gene expression, may be associated with individual variability in social behavior (Jack et al. 2012).”
BackgroundInfluential
Blockade of pro-cognitive effects of angiotensin IV and physostigmine in mice by oxytocin antagonism
Gard, P. R., Naylor, C., Ali, S., & Partington, C. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.02.048 · Cited by 25
Localization of oxytocin receptors in the prairie vole (Microtus ochrogaster) neocortex
Duchemin, A., Seelke, A. M. H., Simmons, T. C., Freeman, S. M., & Bales, K. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.017 · Cited by 20
“…including but not limited to: rats, mice, several vole species, marmosets, coppery titi monkeys, rhesus macaques, and humans (Insel and Shapiro 1992, Freeman, et al. 2016, Vaccari, et al. 1998, Gould and Zingg 2003, Freeman, et al. 2014, Freeman, et al. 2014, Schorscher-Petcu, et al. 2009).”
Background
Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain
Freeman, S. M., Ngo, J., Singh, B., Masnaghetti, M., Bales, K. L., & Blevins, J. E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.07.037 · Cited by 37
The ventromedial hypothalamus oxytocin induces locomotor behavior regulated by estrogen
Narita, K., Murata, T., & Matsuoka, S. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.047 · Cited by 18
“Murata), Oxtr exists within various brain regions including the PVN, SON, septum, hippocampus, and olfactory bulb [11,21,42].”
Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models
Arakawa, H. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100011 · Cited by 27
Lesions of Hypothalamic Mammillary Body Desynchronise Milk‐Ejection Bursts of Rat Bilateral Supraoptic Oxytocin Neurones
Wang, Y.-F., Negoro, H., & Higuchi, T. (2013) · Journal of neuroendocrinology · doi:10.1111/j.1365-2826.2012.02368.x · Cited by 20
Using transgenic mouse models to study oxytocin's role in the facilitation of species propagation
Lee, H., Pagani, J. H., & Young, W. S. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.042 · Cited by 21
“We will focus on a subset, the knockout (KO) mouse, as various transgenic lines expressing reporter constructs based on the oxytocin or oxytocin receptor gene have not yet lead to significant advances (Gould and Zingg, 2003; Katoh et al., 2009; Young et al., 1990).”
A neuromodulatory role for oxytocin within the supramammillary nucleus.
Cumbers, M., Chung, S., & Wakerley, J. (2007) · Neuropeptides · doi:10.1016/j.npep.2007.04.004 · Cited by 17
Predicted role of secretin and oxytocin in the treatment of behavioral and developmental disorders: implications for autism
Welch, M. G., & Ruggiero, D. A. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)71012-6 · Cited by 16
Effects of Combined Oxytocin and Beta-3 Receptor Agonist (CL 316243) Treatment on Body Weight and Adiposity in Male Diet-Induced Obese Rats
Edwards, M. M., Nguyen, H. K., Dodson, A. D., Herbertson, A. J., Wietecha, T., Wolden‐Hanson, T., Graham, J. L., Honeycutt, M. K., Slattery, J. D., O’Brien, K. D., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.725912 · Cited by 16
Medial prefrontal cortex oxytocin-opioid receptors interaction in spatial memory processing in rats
Salighedar, R., Erfanparast, A., Tamaddonfard, E., & Soltanalinejad, F. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112599 · Cited by 15
Maternal Brain Adaptations in Pregnancy
Brunton, P. J., & Russell, J. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00044-2 · Cited by 18
Dose dependent effects of oxytocin on cognitive defects and anxiety disorders in adult rats following acute infantile maternal deprivation stress
Dayı, A., Kıray, M., Şişman, A. R., Özbal, S., Baykara, B., Aksu, İ., & Uysal, N. (2019) · Biotechnic & Histochemistry · doi:10.1080/10520295.2018.1528384 · Cited by 9
“The PFC possesses oxytocin-sensitive neurons (Ninan 2011) and expresses oxytocin receptors (Gould and Zingg 2003; Liu et al. 2005).”
Background
Attachment style: The neurobiological substrate, interaction with genetics and role in neurodevelopmental disorders risk pathways
Antonucci, L. A., Taurisano, P., Coppola, G., & Cassibba, R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.002 · Cited by 20
“Accordingly, OXTR is highly expressed in key brain regions for emotion processing and recognition, such as the amygdala (Gimpl and Fahrenholz, 2001; Skuse and Gallagher, 2009) and the prefrontal cortex (Gould and Zingg, 2003; Liu et al., 2005; Meyer-Lindenberg et al., 2011; Mitre et al., 2016).”
The role of oxytocin in shaping complex social behaviours: possible interactions with other neuromodulators
Paletta, P., Bass, N., Kavaliers, M., & Choleris, E. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0058 · Cited by 15
Chronic Ambient Ozone Exposure Aggravates Autism-Like Symptoms in a Susceptible Mouse Model
Ling, W., Ren, Z., Wang, W., Lü, D., Zhou, Q., Liu, Q. S., & Jiang, G. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c00607 · Cited by 14
Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects
Asker, M., Krieger, J., Liles, A., Tinsley, I. C., Borner, T., Marić, I., Doebley, S. A., Furst, C. D., Börchers, S., Longo, F., et al. (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14937 · Cited by 14
Oxytocin: A Potential Therapeutic for Obesity
Hong, S. M., Ko, J.-K., Moon, J., & Kim, Y. (2021) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes20098 · Cited by 13
Sex-dimorphic role of prefrontal oxytocin receptors in social-induced facilitation of extinction in juvenile rats
Maroun, M., Sarussi-Elyahu, A., Yaseen, A., Hatoum, O. A., & Kritman, M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01040-9 · Cited by 16

Authors: Gould, B. R., & Zingg, H. H.
Affiliations: Royal Victoria Hospital (CA)
Corresponding author: Zingg, H.H
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2003-11
Volume: 122
Issue: 1
Pages: 155-167
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/s0306-4522(03)00283-5
OpenAlex: W2035269878
Cited by: 138
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 11 · 2021: 11 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 10 · 2012: 4
FWCI: 3.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin receptor, gene expression mapping, myoepithelial cells, mammary gland, amygdala, accessory olfactory bulb, supramammillary nucleus, entorhinal cortex, oxytocinergic system, adipocytes
MeSH terms: Animals, Brain, Female, Lac Operon, Mammary Glands, Animal, Mice, Transgenic, Blotting, Southern, Gene Expression, Receptors, Oxytocin, Reverse Transcriptase Polymerase Chain Reaction, Mice

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Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor-LacZ reporter mouse

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