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Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner

Yang, D.-S., Small, D.H., Seydel, U., Smith, J.D., Hallmayer, J., Gandy, S.E., Martins, R.N.·1999·Neuroscience
DOI 10.1016/s0306-4522(98)00561-2
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Abstract

The epsilon4 allele of apolipoprotein E gene is a major risk factor for Alzheimer's disease. However, the mechanism by which the E4 isoform of apolipoprotein E increases the risk of Alzheimer's disease is poorly understood. To determine whether the isoform-specific effects of apolipoprotein E may be mediated via clearance of bound beta-amyloid, we examined the uptake of beta-amyloid 1-40 into Chinese hamster ovary cells in the presence or absence of the apolipoprotein E isoforms E2, E3 and E4. Apolipoprotein E2 and E3 treatments were associated with higher association of beta-amyloid with cells as compared to treatment with E4. Heparin blocked the association of beta-amyloid with cells, as did an antibody to one of the apolipoprotein E receptors (the low-density lipoprotein receptor-related protein). Thus, the apolipoproteins E2 and E3, but not E4, may play important roles in the clearance of beta-amyloid from the extracellular space via the low-density lipoprotein receptor-related protein.

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Research works printed but not linked: 31

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Metadata

Authors
Yang, D.-S., Small, D. H., Seydel, U., Smith, J. D., Hallmayer, J., Gandy, S. E., & Martins, R. N.
Venue
Neuroscience
Publisher
Elsevier BV
Published
1999-06
Volume
90
Issue
4
Pages
1217-1226
ISSN
0306-4522
DOI
10.1016/s0306-4522(98)00561-2
Cited by
76
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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