Is Age-related Maculopathy Associated with Alzheimer's Disease?: The Rotterdam Study
Abstract
The authors examined the relation between age-related maculopathy and Alzheimer's disease in the Rotterdam Study, a prospective population-based study in the Netherlands. From 1990 to mid-1993, subjects aged 75 years or older (n = 1,438) were screened for the presence of age-related maculopathy and Alzheimer's disease, and follow-up examinations were conducted from mid-1 993 to the end of 1994. Subjects with advanced age-related maculopathy at baseline showed an increased risk of incident Alzheimer's disease (relative risk = 2.1, 95% confidence interval: 1.1, 4.3; adjusted for age and gender), but this risk decreased after additional adjustment for smoking and atherosclerosis (relative risk = 1.5, 95% confidence interval: 0.6, 3.5). These findings suggest that the neuronal degeneration occurring in age-related maculopathy and Alzheimer's disease may, to some extent, have a common pathogenesis.
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A prospective population-based study identified an increased risk of developing AD in individuals with advanced AMD.
“Additionally, a prospective population-based study identified an increased risk of developing AD in individuals with advanced AMD (88).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [88]
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- Authors
- Klaver, C. C. W., Ott, A., Hofman, A., Assink, J. J. M., Breteler, M. M. B., & de Jong, P. T. V. M.
- Affiliations
- Erasmus MC (NL)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-11-01
- Volume
- 150
- Issue
- 9
- Pages
- 963-968
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2156325413
- Cited by
- 162
- References
- 28
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 13 · 2012: 10
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Landelijke Stichting voor Blinden en Slechtzienden
- Stichting voor Ooglijders
- Stichting Blindenhulp
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- age-related maculopathy, Alzheimer's disease, smoking, atherosclerosis, neurodegeneration, pathogenesis, older adults
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Arteriosclerosis, Female, Humans, Macular Degeneration, Male, Mass Screening, Netherlands, Population Surveillance, Prospective Studies, Risk Factors, Severity of Illness Index, Smoking, Comorbidity, Incidence, Prevalence
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