The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
A model for intramembranous ossification during fracture healing
Open accessAbstract
We have developed a method to study the molecular basis of intramembranous fracture healing. Unlike intramedullary rods that permit rotation of the fractured bone segments, our murine model relies on an external fixation device to provide stabilization. In this study we compare stabilized fracture callus tissues with callus tissues from non‐stabilized fractures during the inflammatory, soft callus, hard callus, and remodeling stages of healing. Histological analyses indicate that stabilized fractures heal with virtually no evidence of cartilage whereas non‐stabilized fractures produce abundant cartilage at the fracture site. Expression patterns of collagen type IIa (colIIa) and osteocalcin (oc) reveal that mesenchymal cells at the fracture site commit to either a chondrogenic or an osteogenic lineage during the earliest stages of healing. The mechanical environment influences this cell fate decision, since mesenchymal cells in a stabilized fracture express oc and fail to express colIIa. Future studies will use this murine model of intramembranous fracture healing to explore, at a molecular level, how the mechanical environment exerts its influence on healing of a fracture. © 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
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Cites
Caplan, A. I. (1991) · Journal of Orthopaedic Research · doi:10.1002/jor.1100090504 · Cited by 6,548
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Self-citationThe Cell and Molecular Biology of Fracture Healing
Einhorn, T. A. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00003 · Cited by 1,278
Production of a standard closed fracture in laboratory animal bone
Bonnarens, F., & Einhorn, T. A. (1984) · Journal of Orthopaedic Research · doi:10.1002/jor.1100020115 · Cited by 888
Mechanobiology of Skeletal Regeneration
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Self-citationMesenchymal stem cells in bone development, bone repair, and skeletal regenaration therapy
Bruder, S. P., Fink, D. J., & Caplan, A. I. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240560303 · Cited by 716
Physical and biological aspects of fracture healing with special reference to internal fixation.
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Davies, J. E. (1991) · University of Toronto Press eBooks · doi:10.3138/9781442671508 · Cited by 644
Does adult fracture repair recapitulate embryonic skeletal formation?
Ferguson, C., Alpern, E., Miclau, T., & Helms, J. A. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00142-2 · Cited by 542
Self-citationAngiogenesis in Fracture Repair
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Cited by
Inflammation, fracture and bone repair
Loi, F., Córdova, L. A., Pajarinen, J., Lin, T.-H., Yao, Z., & Goodman, S. B. (2016) · Bone · doi:10.1016/j.bone.2016.02.020 · Cited by 1,293
Ho-Shui-Ling, A., Bolander, J., Rustom, L. E., Johnson, A. W., Luyten, F. P., & Picart, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.017 · Cited by 961
Malhotra, A., Walle, M., Paul, G. R., Kuhn, G. A., & Müller, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-81132-8 · Cited by 828
Cellular biology of fracture healing
Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., Miclau, T., Marcucio, R. S., & Hankenson, K. D. (2019) · Journal of Orthopaedic Research · doi:10.1002/jor.24170 · Cited by 577
Self-citationUnraveling macrophage contributions to bone repair
Wu, A. C., Raggatt, L. J., Alexander, K. A., & Pettit, A. R. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.107 · Cited by 256
Metadata
- Authors
- Thompson, Z., Miclau, T., Hu, D., & Helms, J. A.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 2002-09
- Volume
- 20
- Issue
- 5
- Pages
- 1091-1098
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W1987189093
- Cited by
- 277
- References
- 28
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thompson, Z., Miclau, T., Hu, D., & Helms, J. A. (2002). A model for intramembranous ossification during fracture healing. Journal of Orthopaedic Research. https://doi.org/10.1016/s0736-0266(02)00017-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
